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Elsevier

Books in Life sciences

  • Innovation of Food Products in Halal Supply Chain Worldwide

    • 1st Edition
    • Aishah Bujang + 2 more
    • English
    Innovation of Food Products in the Halal Supply Chain Worldwide covers the fundamentals and food guidelines of halal food production. Unlike other texts on the halal food market and halal certification, this book promotes halal product innovation by presenting exciting newly developed ingredients that are substitutions of non-halal ingredients with halal alternatives, such as lard substituted with modified vegetable fats, pig with halal goat/beef/camel/fish gelatin/collagen, alternative meat substitute or even additives. Innovations in halal processing technologies cover the latest techniques in halal production and authentication, halal tracking/traceabilit... in halal transport and logistics, a vast area at the end of a supply chain. All chapters are written by acknowledged experts in their field, thus the book brings together the top researchers in this essential topic of importance to a huge percentage of the world’s population.

  • Pulping and Papermaking of Nonwood Plant Fibers

    • 1st Edition
    • Z.M.A. Ainun + 2 more
    • English
    Pulping and Papermaking of Non-wood Plant Fibres presents the latest technologies associated with the papermaking process. With chapters specific to each non-wood species, the book provides step-by-step guidance on processes such as pulping, bleaching, blending and beating. Non-wood fibers are practical for pulp and paper production due to their chemical content of cellulose, hemicellulose and lignin percentages. Beginning with a general overview of non-wood fibers in the papermaking process, chapters then take a deep dive into different raw materials and their processes, including bamboo, corn stalk, pineapple leaves and sugarcane. This book is an essential resource for researchers, scientists and industry specialists.

  • Diversity, Distribution, and Current Status

    • 1st Edition
    • A.K. Tiwari + 4 more
    • English
    Diversity, Distribution, and Current Status is the first volume in a three-volume series dedicated to the analysis of this important group of plant pathogens across Asia with a particular focus on geographic distribution. This book offers updated data on the most prevalent phytoplasma diseases specific to each region. Phytoplasmas are emerging plant pathogens all around the world, causing significant economic losses to crops, as well as affecting international trade. The chapters in Volume 1 look closely at different countries and regions across Asia, providing data on country-wide distribution, phytoplasma groups, insect vectors and transmission. The Phytoplama Diseases in Asian Countries series will be an essential read for university students, researchers and agriculturalists interested in Plant Pathology. Volume 1 will be of particular interest to those needing the latest data on the distribution and transmission rates specific to the various regions of Asia.

  • Nutraceuticals

    Sources, Processing Methods, Properties, and Applications
    • 1st Edition
    • Tariq Altalhi + 2 more
    • English
    Nutraceuticals: Sources, Processing Methods, Properties, and Applications explores the impact of nutraceutical compounds on human health and their main pharmacological contributions. Organized into three parts, this book addresses nutraceutical production, applications for disease prevention and treatment, and current trends, especially the role of nutraceuticals in cosmeceutical. Nutraceuticals are a class of products that can help people improve their health, reduce the risk of disease, extend their lives, and control the structure and functioning of their bodies. However, due to multiple hurdles that prevent nutraceuticals from circulating in an active form in the body, their use is associated with diminished therapeutic efficacy. Recognizing this problem, the book explores the root of the nutraceutical delivery system and its codelivery methods with a focus on medicines. With contributions from experienced nutraceutical experts, this book serves as a valuable reference for nutrition researchers, food scientists, pharmacologists, and those who are researching and studying in related areas.

  • The Eye

    • 1st Edition
    • Volume 4
    • Eman E. Taher + 1 more
    • English
    The Eye, Volume Four, the latest release in the Stem Cell Innovation in Health and Disease series, addresses the recent data accumulated on the potential applications of stem cells to treat eye diseases. This volume highlights the recent development of cutting-edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure eye diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. This is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album on the fast-moving field of regenerative medicine and stem cell therapeutics.

  • MRI and Traumatic Brain Injury, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 33-2
    • Pejman Jabehdar Maralani + 1 more
    • English
    In this issue of Neuroimaging Clinics, guest editors Drs. Pejman Jabehdar Maralani and Sean Symons bring their considerable expertise to the topic of Neurotrauma. Top experts in the field cover key topics such as conventional MRI in trauma management in adults and children; imaging approach to concussion; clinical updates on concussion; the current state of DWI/DTI for trauma prognostication; the current state of fMRI/rs-fMRI for trauma prognostication; and more.

  • PACE Yourself

    Alcohol, Addiction and Exercise
    • 1st Edition
    • Megan Johnson Mccullough
    • English
    PACE Yourself: Alcohol, Addiction and Exercise provides qualitative research about the influence of exercise on alcohol use disorder (AUD) recovery. In addition, the author explains how someone can benefit from exercise and explores how the PACE method could help keep new addictions at bay. PACE is an acronym for Proactive Awareness Controlling Excess. The author has developed an app of the same name which is available in the Apple store. Exercise is medicine when it comes to the recovering body and mind of an alcoholic. Physiological and psychological changes as a result of moving the body contribute to prolonged sobriety and deter the cyclical threat the nature of alcohol abuse can pose upon person in recovery. The struggle to never become powerless to alcohol again can be kept at bay when the benefits of exercise over power the benefits alcohol used to have. However, the addictive mind can find a new habit to replace the old one. The PACE method proposes steps to become aware of replacement type behaviors with the understanding that anyone can become addicted to anything.

  • Ionizing Radiation and the Immune Response - Part A

    • 1st Edition
    • Volume 376
    • English
    Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flashtherapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and more. Additional sections touch on the Effect of low dose radiation on radio-induced immune response, Role of Dendritic cells in radiation-induced immune response, Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunot... combination+A23, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination.

  • Ophthalmic Pathology

    The Evolution of Modern Concepts
    • 1st Edition
    • Curtis E. Margo
    • English
    Ophthalmic Pathology: The Evolution of Current Concepts examines how our current understanding of morphologic disease, nomenclature and classification over the last century came about. The book explores the historical context and the modern trends of ocular nosology, emphasizing the science of disease classification. Chapters highlight major studies and developments surrounding approximately 50 disorders whose diagnoses are established by pathology, corresponding to a historical road map of current nomenclature, methods of disease classification, and the role of diagnostic morphology. Using a streamlined, highly illustrated format, this book provides a unique historic and evolutionary perspective into current views on the morphology of eye disease.

  • Food Safety Management

    A Practical Guide for the Food Industry
    • 2nd Edition
    • Veslemøy Andersen + 2 more
    • English
    Food Safety Management: A Practical Guide for the Food Industry, Second Edition continues to present a comprehensive, integrated and practical approach to the management of food safety throughout the production chain. While many books address specific aspects of food safety, no other book guides you through the various risks associated with each sector of the production process or alerts you to the measures needed to mitigate those risks. This new edition provides practical examples of incidents and their root causes, highlighting pitfalls in food safety management and providing key insights into different means for avoiding them. Each section addresses its subject in terms of relevance and application to food safety and, where applicable, spoilage. The book covers all types of risks (e.g., microbial, chemical, physical) associated with each step of the food chain, making it an ideal resource.

  • Smart Anticorrosive Materials

    Trends and Opportunities
    • 1st Edition
    • Chandrabhan Verma + 4 more
    • English
    Smart Anticorrosive Materials: Trends and Opportunities covers new developments in nanoscale coatings and their current applications. The book addresses fundamental characteristics, synthesis, inhibition mechanisms and applications of green nanomaterials for educational (academic) as well as industrial purposes and provides a chronological overview of the growth of the field. The book concludes with discussions about commercialization, economics and environmental considerations. This will be an indispensable reference for scholars, chemical engineers, chemists and materials scientists working in R&D and academia who want to understand corrosion systems and modern advancements on smart coatings.

  • Cardiovascular Endocrinology and Metabolism

    Theory and Practice of Cardiometabolic Medicine
    • 1st Edition
    • Andrew J. Krentz + 1 more
    • English
    Cardiovascular Endocrinology and Metabolism: Theory and Practice of Cardiometabolic Medicine discusses the close intersection between metabolic disorders and cardiovascular disease, covering the basic science and pathophysiology of disease and the latest research in pharmacological approaches and translational therapeutic options. This book is a valuable resource for the vascular and endocrinology clinical and research communities in need of knowledge and potential outcomes. The global increase in the prevalence of cardiometabolic disorders, and the introduction of therapeutic options for treating metabolic disease that also lower cardiovascular risk, is bringing endocrinologists and cardiologists together in a shared clinical experience.

  • Organ-Specific Parasitic Diseases of Dogs and Cats

    • 1st Edition
    • Tanmoy Rana
    • English
    Organ-Specific Parasitic Diseases of Dogs and Cats takes an organ-specific approach to the impact of parasitic diseases in dogs and cats. This book provides a detailed description of the key role that parasites play in the pathogenesis of diseases, explores the manifestation of symptoms and diagnosis, and offers prevention and treatment strategies to counteract parasitic infections. An introduction by the editor is followed by chapters from various authors covering parasitic diseases in specific organs and organ systems. The book also provides an overview on the diagnostic evaluation of parasitic diseases. Parasite control, travel management, therapeutic measures, and disease control strategies round out the discussion. With contributions from experts in the field, this book serves as a useful resource to researchers, academics, and postgraduates who wish to expand their knowledge on parasitic diseases, diagnosis, and treatment, and as a reference for scientists looking to develop new antiparasitic drugs.

  • Biomechanical Mapping of the Female Pelvic Floor

    • 1st Edition
    • Vladimir Egorov
    • English
    Biomechanical Mapping of the Female Pelvic Floor explores new technological advances in women’s healthcare intended to improve pelvic floor characterization, diagnosis and prediction of treatment outcomes. The book describes biomechanical approaches and clinical examples to demonstrate how one can evaluate the changes in the pelvic floor to gain a better understanding of an individual patient’s pelvic floor dysfunctions, such as prolapse, incontinence, chronic pelvic pain, and even conditions leading to spontaneous preterm delivery and predicting maternal birth trauma. This book is a valuable resource for researchers focused on gynecology, urogynecology or obstetrics, clinicians, graduate students and biomedical scientists and bioengineers who need to better understand the technological advances in biomechanical characterization and how they can be used not only for diagnosis but also for monitoring several OBGYN-related conditions.

  • Developing Sustainable and Health-Promoting Cereals and Pseudocereals

    Conventional and Molecular Breeding
    • 1st Edition
    • Marianna Rakszegi + 2 more
    • English
    Developing Sustainable and Health Promoting Cereals and Pseudocereals: Conventional and Molecular Breeding reviews the most recent developments in the fields of cereal and pseudocereal breeding, with particular emphasis on the latest biotechnological techniques likely to lead to breakthrough changes in plant breeding. The book provides comprehensive information on the use of genetic resources or pre-breeding activities to improve health-related properties of cereals and pseudocereals. The text also explores targeted field-management practices and the latest in biotechnological methodologies, and offers a cohesive overview necessary for understanding the potential impacts and benefits of improved production of cereals and pseudocereals with high-nutritional value.

  • Unleashing the Potentials of Blockchain Technology for Healthcare Industries

    • 1st Edition
    • Amar Das + 4 more
    • English
    Unleashing the Potentials of Blockchain Technology for Healthcare Industries discusses blockchain and its adaptation in healthcare industries to provide a secured framework to safeguard healthcare data, both patient and hospital data. The book integrates key pillars of blockchain such as foundations, architecture, smart contracts, adoption, standards, service (BaaS), security, consensus algorithms, drug discovery process, among others, for fortifying the current practices in the healthcare industries. In addition, it offers solutions to the pressing issues currently being faced by the healthcare processes due to the COVD-19 pandemic. This will be a valuable resource for medical informaticians, researchers, healthcare professionals and members of the biomedical field who are interested in learning more about the potentials of blockchain in healthcare.

  • Epigenetic Regulation of Cancer in Response to Chemotherapy

    • 1st Edition
    • Volume 158
    • English
    Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting chapters on timely topics, including Epigenetically Programmed Resistance to Chemotherapy and Promotion of Immune Evasion in Cancer, A Role for the Epigenome in Cancer Cell Drug Tolerance, Histone Methylation and X Chromosomal Genes in Metastasis of Breast Cancer, Targeting Epigenetic Regulation Using Small Molecule Inhibitors, Histone Deacetylase Inhibitors as Sanguine Epigenetic Therapeutics against Pugnacious Lung Cancer, From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia), and more. Additional chapters cover Predictive Models of Chemoresistance Generated by Crunching the Public Drug Screen, Epigenomic and Genomic Profiling Datasets via Regression-, Machine Learning, and Knowledge-Based Methods, Probing on the Mechanisms of lncRNAs on Cancer Drug Resistance, Drug Tolerant Persister Cells in Cancer: Current Knowledge and Therapeutic Perspectives, and much more.

  • Endocrinology of the Aging Patient, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 52-2
    • Rita Rastogi Kalyani
    • English
    In this issue, guest editors bring their considerable expertise to this important topic.

  • Wnt Signaling in Development and Disease

    • 1st Edition
    • Volume 153
    • English
    Wnt Signaling in Development and Disease, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer.

  • Polymeric Nanosystems

    Theranostic Nanosystems, Volume 1
    • 1st Edition
    • Md Saquib Hasnain + 2 more
    • English
    Polymeric Nanosystems: Theranostic Nanosystems, Volume One examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glyco... polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials. It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

  • Human Reproductive and Prenatal Genetics

    • 2nd Edition
    • Peter C.K. Leung + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic.This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.

  • Development and Commercialization of Biopesticides

    Costs and Benefits
    • 1st Edition
    • Opender Koul
    • English
    Development and Commercialization of Biopesticides: Costs and Benefits provides a uniquely comprehensive view of the commercial production of biopesticides, from research to application, featuring case studies in various developed and developing countries of the world. The book offers guidance for future strategies to researchers, along with considerations for the industry’s economic concerns, i.e., costs and benefits compared to conventional pesticides, future perspectives for application strategies, bioavailability and environmental safety, and impacts on intellectual property issues during commercialization. Finally, the book covers why the development of this industry must be strategic, comprehensive and forward-looking in order to be an accepted, safe and sustainable. There is no doubt that biopesticides are now in large-scale use, and a variety of novel techniques have been used to improve or modify existing biopesticides, which will further accelerate their development.

  • Advanced Nanoformulations

    Theranostic Nanosystems, Volume 3
    • 1st Edition
    • Md Saquib Hasnain + 2 more
    • English
    Advanced Nanoformulations: Theranostic Nanosystems, Volume Three examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glyco... polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials. It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

  • Inorganic Nanosystems

    Theranostic Nanosystems, Volume 2
    • 1st Edition
    • Md Saquib Hasnain + 2 more
    • English
    Inorganic Nanosystems: Theranostic Nanosystems, Volume Two examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glyco... polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials. It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

  • Translational Surgery

    • 1st Edition
    • Adam E.M. Eltorai
    • English
    Translational Surgery covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control studies, prospective cohort studies, randomized trials, and reliability studies. Investigators will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in surgical research, and know what is needed for collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the translational research navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in surgery, allowing the reader to learn how to evaluate the quality of such studies. Thus, they will improve at measuring outcomes; making effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every surgeon or surgical researcher who has ever had a good clinical idea, but not the knowledge of how to test it.

  • Myeloid-Derived Suppressor Cells

    • 1st Edition
    • Volume 375
    • English
    Myeloid-Derived Suppressor Cells, Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Chapters in this new release include Cancer-cell-intrinsi... mechanisms regulate myeloid-derived suppressor cells through cytokine networks, Role of myeloid-derived suppressor cells in head and neck cancer, Role of myeloid-derived suppressor cells in breast cancer, Role of myeloid-derived suppressor cells in endometriosis, Role of myeloid-derived suppressor cells in ovarian cancer, Role of myeloid-derived suppressor cells in sarcoma, and more.

  • Psychophysics and Experimental Phenomenology of Pattern Cognition

    • 1st Edition
    • Jiro Hamada
    • English
    Psychophysics and Experimental Phenomenology of Pattern Cognition examines the cognitive transformations that underly this cognitive system and the specialized subsystems for processing these transformations. Sections cover symmetry cognition, contour perception and geometric illusion. Weight sensation is also discussed, as are repetitive and dot patterns. By incorporating elements of both psychophysics and experimental phenomenology, pattern cognition is examined from both the physical and mental sensory perspective, thus providing a comprehensive view of this cognitive system.

  • One Health Meets the Exposome

    Human, Wildlife, and Ecosystem Health
    • 1st Edition
    • Mary Ann Ottinger + 1 more
    • English
    One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health brings together the two powerful conceptual frameworks of One Health and the Exposome to comprehensively examine the myriad of biological, environmental, social, and cultural challenges impacting the interrelated health of humans, wildlife, and ecosystems. One Health as an encompassing concept and collaborative framework recognizes the interconnections among humans, wildlife, and our shared environment with the goal of optimizing health outcomes for all. The Exposome is more specifically oriented to human health and considers cumulative environmental exposures affecting individuals, communities, and populations. This book will provide the broadened and integrative view that considers a more holistic approach needed to confront the complex issues facing us today. One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health is a valuable and cutting-edge resource for researchers and practitioners in medicine, public health, animal science, wildlife and field biology, and for any reader looking to better understand the relationships among human health and the environment.

  • Essentials of Pharmatoxicology in Drug Research, Volume 1

    Toxicity and Toxicodynamics
    • 1st Edition
    • Rakesh K. Tekade
    • English
    Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

  • Cilia: From Mechanisms to Disease–Part A

    • 1st Edition
    • Volume 175
    • English
    Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. Sections in this new release include Protocols to induce and study ciliogenesis, Flow Cytometry-Based Approach for the study of primary Cilia, Microscopic observation of human airway ciliary movement using wheat germ agglutinin, Time-lapse imaging of primary cilia behavior with physiological expression of fluorescent ciliary proteins, Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method, and much more. Other sections cover Studying the morphology, composition and function of the photoreceptor primary cilium in zebrafish, Visualizing Multiciliated Cells in the Zebrafish, Isolation of Ciliary Ectosomes and Analysis of Peptide-mediated Chemotaxis in Chlamydomonas, Using Paramecium as a Model for Ciliopathies, Using organoids to study cilia, Using in vivo cerebellar electroporation to study neuronal cell proliferation and differentiation in a Joubert syndrome mouse model, and more.

  • Plant RNA Viruses

    Molecular Pathogenesis and Management
    • 1st Edition
    • Rajarshi Kumar Gaur + 2 more
    • English
    Plant RNA Viruses: Molecular Pathogenesis and Management provides wide-ranging coverage on the recognition and signaling events between plants and RNA viruses. The book examines the molecular biology of signaling, host-virus interaction, RNA virus diversity, and how plants and cellular pathogens interact. Sections cover Virus Diversity and Diagnosis, Virus-Host Interactions and Virus Management. Specific chapters discuss classification and nomenclature of viruses, detail the molecular characteristics of viral genomes, highlight the viral manipulation of cellular key regulatory systems for successful virus infection, and discuss the movement of plant viruses into plant cells. Additional topics include RNA plant viruses and host interaction, detection and diversity of plant RNA viruses, and strategies for combating and management of plant viruses. With contributions from an international group of experts, the book is a comprehensive reference for those in research, academia, industry and anybody engaging in the study of plant viruses at the molecular level.

  • Mathematical Modeling, Simulations, and AI for Emergent Pandemic Diseases

    Lessons Learned From COVID-19
    • 1st Edition
    • Esteban A. Hernandez-Vargas + 1 more
    • English
    Mathematical Modeling, Simulations, and Artificial Intelligence for Emergent Pandemic Diseases: Lessons Learned from COVID-19 includes new research, models and simulations developed during the COVID-19 pandemic into how mathematical methods and practice can impact future response. Chapters go beyond forecasting COVID-19, bringing different scale angles and mathematical techniques (e.g., ordinary differential and difference equations, agent-based models, artificial intelligence, and complex networks) which could have potential use in modeling other emergent pandemic diseases. A major part of the book focuses on preparing the scientific community for the next pandemic, particularly the application of mathematical modeling in ecology, economics and epidemiology. Readers will benefit from learning how to apply advanced mathematical modeling to a variety of topics of practical interest, including optimal allocations of masks and vaccines but also more theoretical problems such as the evolution of viral variants.

  • Probability and Statistics for Cereals and Grains

    A Guide to Measurement and Analysis
    • 1st Edition
    • Terry C Nelsen
    • English
    **Association of American Publishers (AAP) PROSE Award Finalist in Mathematics and Statistics, 2024**Probability and Statistics for Cereals and Grains: A Guide to Measurement and Analysis is a guide to help technical people be more efficient users of statistics. Author Terry C. Nelsen uses examples from his 35-plus years of experience in the field and presents the appropriate statistics and graphics to use when evaluating data. Researchers, academicians, students, technicians, processors, laboratory personnel, and those working in QA/QC will benefit from this much needed reference.

  • The Book of Fructans

    • 1st Edition
    • Wim Van den Ende + 1 more
    • English
    After more than 30 years, The Book of Fructans represents the first and most comprehensive coverage of fructans generated by pioneer glycoscientists from the field. It outlines the fundamentals of all fructan types, their terminology, chemical and structural-functiona... features, biosynthetic enzymes that make and break them, their presence and possible roles in nature, their evolutionary aspects and their microbial, enzymatic, and plant-based production. Additional sections cover the applications of fructans, specifically, the agro/chemical and biomedical applications, health, pharmaceutical and cosmetic applications, fructans in food and feed, fructan nanotechnology, the immunomodulatory and antiviral effects of fructans and the perspectives for fructans in circular economies and sustainable societies. Intended for scientists, entrepreneurs, academicians and students working in related fields, this book will be a useful resource for all who wish to learn more about these extraordinary carbohydrates.

  • Safe Water in Healthcare

    A Practical and Clinical Guide
    • 1st Edition
    • James T. Walker + 3 more
    • English
    Safe Water in Healthcare: A Practical and Clinical Guide enables users from different disciplines to understand all types of waterborne hazards that can pose a risk to those who might be exposed, the events which cause them to be present, what may precipitate an increase in their levels that may cause harm, and how they can be avoided or managed to reduce risk. The handbook highlights microorganisms that can cause infections, modes of transmission, the infections they cause, and risks. The book's authors draw from their extensive practical experience assisting with day-to-day problems that range from minor issues to outbreaks. The book includes case studies on the growth of biofilms and where they cause problems in water systems as well as providing practical answers to a majority of issues that arise in healthcare water and drainage systems. This is an accessible handbook that fills the gaps for those without technical knowledge for a complex but important area of infection control. It provides practical guidance for professionals who are required to design, manage and maintain water systems and help them manage associated infection outbreaks.

  • Fruit and Vegetable Waste Utilization and Sustainability

    • 1st Edition
    • Sachin A. Mandavgane + 2 more
    • English
    Fruit and Vegetable Waste Utilization and Sustainability presents strategies to address the fruit and vegetable waste generated from agriculture and industrial processing. Beginning with the introduction of waste management, this book is divided into three sections. Section one addresses the valorization of fruit and vegetable waste for high-value products. Section two focuses on the techno-economic and environmental impact assessment of fruit and vegetable waste biorefinery through real-life examples of the life cycle assessment. Section three presents integrated biorefineries, policies, and case studies. This book is a valuable resource for food scientists, nutrition researchers, food industry professionals, academicians, and students in related fields.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 82
    • English
    Advances in Microbial Physiology, Volume 82 in this serial that highlights new advances in the field, presents interesting chapters on a variety of topics, including Protein secretion via the Type I secretion system, Purine utilization by enterobacteria, Microbiology of Algae, Growth of enteric bacteria in the intestine on C4DCs: Governance of C4DC transporters in metabolic adaptation and genetic control, Biological functions of bacterial lysophospholipids, and much more.

  • Integrated Methods in Protein Biochemistry: Part C

    • 1st Edition
    • Volume 682
    • Arun K. Shukla
    • English
    Integrated Methods in Protein Biochemistry: Part C, Volume 679 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including NanoBiT-based methods to monitor the activation and modulation of RTKs, The interplay of G-protein βγ subunit and PLC-β enzyme in PIP2 hydrolysis and downstream signaling, Biochemical Analysis of Protein-Protein Interfaces underlying the regulation of Bacterial Secretion Systems, Probing the structure and function of N-acetylmannosamine-... 2-epimerase, Spectroscopic analysis of cysteine dioxygenase: a mammalian thiol-dioxygenase, DeGlyPHER: MS-based analysis of viral spike N-glycoforms, and more. Other sections cover Covalent protein painting: MS-based protein footprinting, Characterization of GPCR signaling complexes using negative-staining electron microscopy, Probing protein misfolding and dissociation with free electron laser, Optimized protocol for the characterization of Cas12a activities, Proximity proteomics for the identification and characterization of extracellular vesicles, Functional characterization of lytic polysaccharide monooxygenases (LPMOs), Characterization of RRE domain in RiPP biosynthesis, The Preparation of Recombinant Arginyltransferase 1 (ATE1) for Structural and Biophyiscal Characterizations, Testing anti-cancer drugs with Holographic Incoherent-light-sou... Quantitative Phase Imaging, and more.

  • Advances in Parasitology

    • 1st Edition
    • Volume 120
    • David Rollinson + 1 more
    • English
    Advances in Parasitology, Volume 120, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history.

  • Natural Plant Products in Inflammatory Bowel Diseases

    Preventive and Therapeutic Potential
    • 1st Edition
    • Roberto de Paula do Nascimento + 6 more
    • English
    Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential organizes all evidence to understand which natural products are the first steps of investigation and which have strong evidence of their effects in inflammatory bowel diseases, have been tested in clinical trials, and have received approval to be officially used. In addition to providing information regarding the research with natural products in inflammatory bowel diseases, this reference will also highlight the molecular mechanisms behind the effects of natural products in inflammatory bowel diseases with the aid of figures, video animations and dynamic tables. Compiled from research group members from different parts of the world and specialized in inflammatory bowel diseases and related topics, this important reference will be useful to health professionals, researchers, professors, and industry managers as it provides helpful information on the subject, with the potential to inspire health care, relevant research and product innovation.

  • Next Generation Nanochitosan

    Applications in Animal Husbandry, Aquaculture and Food Conservation
    • 1st Edition
    • Charles Oluwaseun Adetunji + 3 more
    • English
    Next Generation Nanochitosan: Applications in Animal Husbandry, Aquaculture and Food Conservation provides comprehensive and state-of-the-art-inf... on the application of nanochitosan for improving products, especially for the evaluation of biological active molecules, disease therapeutics, transport vehicle for DNA, targeted drug delivery, gene therapy, development of smart and high performance of fish, preservation of foods, tissue engineering, and improving the taste of aquatic and animal feeds as fish growth promoter. this book will be especially useful for industrial fisheries who deal with wild capture fishing and aquafarming and scientists and engineers working on post-capture processing stages. Details on the application of nanochitosan as an effective delivery of vaccines, hormones, vitamins, nutrients and antioxidants, biological active constituents and their wider application for the protection and management of farm animals and fishes against disease-causing pathogens are provided.

  • IRM pratique en neuroradiologie

    • 3rd Edition
    • Françoise Héran + 1 more
    • French
    La grande originalité de cet ouvrage, écrit pour aider la réalisation et l’interprétation des IRM neuroradiologiques, repose sur son approche sémiologique et thématique. Elle le distingue des livres classiques présentant les pathologies par rubriques séparées, obligeant le radiologue à savoir à l’avance à laquelle appartiennent les lésions.Ce livre facilite la compréhension des techniques avancées devenues usuelles, comme par exemple la perfusion, les angiographies dynamiques ou la spectro RM, séquences indispensables au bilan de nombreuses pathologies du système nerveux central.Facile à consulter, avec une iconographie riche et récente, il présente deux parties ; encéphale d’une part, moelle et rachis d’autre part, avec le même plan d’analyse :• comment réaliser une IRM ;• sémiologie élémentaire ;• orientation diagnostique en fonction des caractéristiques des images.En fin d’ouvrage, de courts chapitres regroupent les éléments indispensables à la connaissance des territoires vasculaires et de pathologies intéressantes soit par leur fréquence, comme les inflammations de la substance blanche, soit par leur relative complexité comme les maladies dégénératives, ou les affections rares du système nerveux central.Ce livre s’adresse aux radiologues généralistes, et aux neuroradiologues en formation, désireux d’apprendre la sémiologie IRM neuroradiologique et constitue un outil précieux du DPC. Les manipulateurs y trouveront de précieuses informations sur la réalisation pratique des examens. Il devrait intéresser aussi les cliniciens prescripteurs d’IRM du système nerveux central, en particulier neurologues et neurochirurgiens, qu’il aidera à mieux comprendre les images et les comptes-rendus.Pour cette 3ème édition, en plus du contenu et de l’iconographie entièrement actualisés avec les dernières recommandations des sociétés savantes, cet ouvrage s’accompagne d’une banque d’images en ligne qui vous permet de visualiser + de 900 iconographies.

  • Nicotinic Acetylcholine Receptors in Health and Disease

    • 1st Edition
    • R. Thomas Boyd
    • English
    Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders.

  • House Dust Mites

    Natural History, Control and Research Techniques
    • 1st Edition
    • Rob de Boer
    • English
    House Dust Mites: Natural History, Control, and Research Techniques presents a complete synthesis of biological information on dust mites from both an ecological and evolutionary perspective. This book allows readers to consume current knowledge on house dust mite biology as well as methods and techniques to conduct personal research. Written by an expert on house dust mite biological research, this book begins with an explanation of the medical importance of understanding dust mites due to their human health repercussions, including asthma and bronchial hyperresponsiveness. It discusses various species, exposure effects, best practices for habitat reduction and preventative options. The book then goes on to detail the house dust mite’s biology and behavior, such as food and nutrition, water intake, reproduction, colonization and preferred climates. This is an ideal resource for entomologists and acarologists, as well as medical professionals seeking knowledge on insect-borne allergens.

  • The Regulatory Genome in Adaptation, Evolution, Development, and Disease

    • 1st Edition
    • Moyra Smith
    • English
    The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.

  • LiDAR Principles, Processing and Applications in Forest Ecology

    • 1st Edition
    • Qinghua Guo + 2 more
    • English
    LiDAR Principles, Processing and Applications in Forest Ecology introduces the principles of LiDAR technology and explains how to collect and process LiDAR data from different platforms based on real-world experience. The book provides state-of the-art algorithms on how to extract forest parameters from LiDAR and explains how to use them in forest ecology. It gives an interdisciplinary view, from the perspective of remote sensing and forest ecology. Because LiDAR is still rapidly developing, researchers must use programming languages to understand and process LiDAR data instead of established software. In response, this book provides Python code examples and sample data. Sections give a brief history and introduce the principles of LiDAR, as well as three commonly seen LiDAR platforms. The book lays out step-by-step coverage of LiDAR data processing and forest structure parameter extraction, complete with Python examples. Given the increasing usefulness of LiDAR in forest ecology, this volume represents an important resource for researchers, students and forest managers to better understand LiDAR technology and its use in forest ecology across the world. The title contains over 15 years of research, as well as contributions from scientists across the world.

  • Phytohormones and Stress Responsive Secondary Metabolites

    • 1st Edition
    • Munir Ozturk + 5 more
    • English
    Phytohormones and Stress Responsive Secondary Metabolites provides a deep dive into the signaling pathways associated with phytohormones and phytometabolites. With a strong focus on plant stress responses and DNA technology, the book highlights plant biotechnology and metabolic engineering principles. Biotechnology, by using DNA editing technologies, allows the expression of plant genes into other plant species with desirable modulation on plant behavior. Beginning with an overview of phytohormone signaling, growth and abiotic and biotic stresses, subsequent chapters explore DNA modification strategies, epigenetic and epigenomic regulation, and miRNA regulation. This book will be an essential resource for students, researchers and agriculturalists interested in plant physiology, plant genetics and plant biotechnology.

  • Green Products in Food Safety

    • 1st Edition
    • Bhanu Prakash + 1 more
    • English
    Green Products in Food Safety explores the potential of green chemicals in the sustainable management of food biodeterioration agents and addresses the current existing limitations of green products for their sustainable application. The book summarizes food loss by biodeterioration agents (bacteria, fungi, mycotoxin, and insect pest); novel detection methods for hazardous food contaminants; different sources of green chemicals, their origin, extraction, and characterization methods; and bioactivity of green products against biodeterioration agents with their molecular sites of action. Also included are discussions of pharmacological properties of green chemicals, metabolic engineering of green chemical biosynthesis, natural therapy for bovine mastitis, the role of molecular modeling and dynamics in food science, nanocarriers for application in the food system, elucidation of novel site of action, toxicity prediction, ecological perception, Intellectual Property Right (IPR), regulations, and perspectives on the commercial application of green products. This book covers basic and translational aspects that prove to be beneficial for food scientists, researchers, students, and young professionals.

  • Intellectually Impaired People

    The Ongoing Battle
    • 1st Edition
    • Klaus Rose
    • English
    Intellectually Impaired People: The Ongoing Battle addresses challenges against the background of history, changing societal environments, and current intellectual approaches and attitudes toward persons with disabilities. The book discusses national and international conventions, societal attitudes, sheltered workshops, the right of intellectually impaired persons for self-responsibility and its limitations, and the place of mentally impaired persons in the public image. Additionally, the book attempts to capture the forces that drive the changes of our conceptual frameworks. The US Tuskegee study which withheld antibiotics from black men with syphilis was not ended by scientific criticism but by a courageous man, press reports, and a changed social perception. The non-hiding of handicapped children is not the result of government orders, there are many non-resolvable dilemmas and tension between supporting, understanding, and patronizing a complex situation with many potential future avenues.

  • Managing the Drug Discovery Process

    Insights and advice for students, educators, and practitioners
    • 2nd Edition
    • Susan Miller + 5 more
    • English
    Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharma... industry.

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