Steroids in the Laboratory and Clinical Practice
- 1st Edition - August 3, 2023
- Latest edition
- Author: John William Honour
- Language: English
Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addres… Read more
- Addresses the normal production of steroids and concentrations found in biological fluids and tissues
- Presents the changes in steroid concentrations at life events as reference points for clinical investigations
- Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation
Part 1 steroid biochemistry and endocrinology
1.1. Chemistry
1.2. Sources of steroids
1.3. Biosynthesis
1.4. Regulation
1.5. Steroids in blood and tissues
1.6. Recognition of steroids
1.7. Physiological effects
1.8. Breakdown and clearance
PART 2 Laboratory investigations
2.1. Samples
2.2 Sample preparation
2.3 Purification of extracts
2.4 Purification of steroids
2.5 Concentrations of steroids in blood
2.6. Concentrations of steroids in urine, other biological fluids and tissues
2.7 Confirmatory tests
Part 3. Clinical investigations
3.1 Defects of cortisol
3.1.1 Hypercortisolism
3.1.2 Hypocortisolism
3.2. Defects of aldosterone
3.2.1. Hyperaldosteronism
3.2.2. Hypoaldosteronism
3.3. Defects of gonadal steroids
3.3.1. Hypergonadism
3.3.2. Hypogonadism
This book is illuminated by many Tables and Figures, again extremely well thought out and highly useful, taking into account the needs of the reader. What is truly remarkable is the timing of such a well written book. As an example, the coverage of the conjugation and de-conjugation, of steroids and steroid hormone metaboites, including DHEA-S and DHEA, has been carefully considered and is so relevant; as are so many of the sections on mechanisms of steroid hormone action. This book, Steroids in the Laboratory and Clinical Practice, is not only timely but absolutely needed as a new era of interest in the function of steroids is unveiled. This seminal textbook will be used as a guide for the emerging field of steroids, steroid hormones and their metabolites, once considered inert, but now all playing important pivotal functional roles."—David J Morris D.Phil., Emeritus Professor of Pathology and Laboratory Medicine
"…a comprehensive reference book that addresses the specificity of steroid determinations that can clarify confusion clinicians face with abnormal laboratory results….includes all the information needed to understand key concepts of steroid synthesis, action, and biological effects.…covers both basic and analytical applications of steroids to medicine in one source…..this book should be the “go-to” book for clinicians, researchers, pathologists, laboratorians, analytical biochemists, and students…” —Derek Bagley, Endocrine News
*5 stars* "...a comprehensive reference for understanding the structure and function of each steroid in the human body...[and] would greatly benefit anyone who is interested in the field of steroid metabolism, disorders, or pharmacology...The organization of this book is quite impressive as three separate sections cover every feature of a steroid's existence. The diagram, tables and indices are very clear and useful...[It] intends to teach readers about a complicated topic in an organized, easily digestible, and actually enjoyable fashion."—©Doody’s Review Service, 2024, Prathayini Subarajan, MD (Loyola University Medical Center)
- Edition: 1
- Latest edition
- Published: August 3, 2023
- Language: English
JH