Bioengineered Nanomaterials for Wound Healing and Infection Control

1st Edition - August 1, 2023
Editors: Hamed Barabadi, Muthupandian Saravanan, Ebrahim Mostafavi, Hossein Vahidi
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 3 7 6 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 8 3 5 - 6

Bioengineered Nanomaterials for Wound Healing and Infection Control is a key reference for those working in the fields of materials science, pharmacy, nanotechnology, biomed… Read more

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Bioengineered Nanomaterials for Wound Healing and Infection Control is a key reference for those working in the fields of materials science, pharmacy, nanotechnology, biomedical engineering and microbiology. Bioengineered nanomaterials have unique physicochemical properties which promote accelerated wound healing and treatment of infections. The biosynthesis of these nanomaterials also offers a clean, safe and renewable alternative to traditional nanomaterials, helping reduce environmental impact alongside antibacterial resistance.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editors
Preface
Chapter 1. An overview of antimicrobial resistance and its mechanisms
Abstract
1.1 Introduction
1.2 Origins and types of resistance to antimicrobial agents
1.3 The complex issues of antimicrobial resistance reversibility and fitness
1.4 Mechanisms of antimicrobial action
1.5 Mechanisms of antimicrobial resistance
1.6 Current challenges
1.7 Conclusion
Acknowledgment
References
Chapter 2. An overview of wound healing: wound types and current therapeutics
Abstract
2.1 Introduction
2.2 Physiology of wound healing
2.3 Wound classification
2.4 Factors impairing wound healing
2.5 Barriers to drug delivery to the wound
2.6 Current therapeutic approaches
2.7 Conclusion
References
Chapter 3. The role of biofilms and multidrug resistance in wound infections
Abstract
Abbreviations
3.1 Introduction
3.2 Multidrug resistance in wound infections
3.3 Prevention and control of wound infections
3.4 Conclusions and future directions
Acknowledgments
Conflict of interest
References
Chapter 4. Wound healing and nanotechnology: opportunities and challenges
Abstract
4.1 Introduction
4.2 Wound and its classification
4.3 Wound healing process
4.4 Current procedures in wound management
4.5 Conclusion and future perspectives
References
Chapter 5. Nanotechnology-based therapeutics to combat biofilms and antibacterial resistance in chronic wound infections
Abstract
5.1 Introduction
5.2 Development of chronic wound
5.3 Limitations in current wound therapy
5.4 Advancements in wound dressings and coatings
5.5 Nanotherapeutics for wound care
5.6 Nanoparticles with antimicrobial properties
5.7 Conclusion
References
Chapter 6. Smart nanosystems for wound healing and infection control
Abstract
6.1 Introduction
6.2 Classification of smart nanomaterials
6.3 Synthesis of smart nanomaterials
6.4 Recent methods for synthesis
6.5 Magnetic responsive nanomaterials
6.6 Light-responsive nanomaterials
6.7 Temperature-responsive nanomaterials
6.8 Electrical and electrochemical stimuli-responsive nanomaterials
6.9 pH-responsive nanomaterials
6.10 Redox-responsive nanomaterials
6.11 Enzyme/toxin-responsive nanomaterials
6.12 Biological functions of miRNA
6.13 Future directions
6.14 Conclusion
Acknowledgment
Conflict of interest
Authors’ contribution
References
Chapter 7. Bioengineering of nanomaterials using biological resources: biofabrication mechanisms, characterizations, and biomedical applications
Abstract
7.1 Introduction
7.2 Fabrication of metal-based nanomaterials
7.3 Large-scale production of biosynthesized nanomaterials
7.4 Characterization of biogenic metal–based nanomaterials
7.5 Advantages and limitations of biological methods in nanomaterials’ synthesis
7.6 Biomedical application of bioengineered metal–based nanomaterials: recent advances
7.7 Future challenges and conclusion
References
Chapter 8. Bacteria-derived nanobiomaterials: exploration of their wound healing, antimicrobial, and biofilm inhibitory activities
Abstract
8.1 Introduction
8.2 Synthesis of nanoparticles
8.3 Physicochemical properties of bacteria-synthesized nanoparticles
8.4 Potential use of biogenic nanoparticles
8.5 Prospects for the use of bacteria-synthesized nanoparticles: current status and prediction
8.6 Final remarks
References
Chapter 9. Mycosynthesis of nanobiomaterials and their wound healing, antimicrobial, and biofilm inhibitory activities
Abstract
9.1 Introduction
9.2 Synthesis of nanomaterials
9.3 Factors affecting the mycosynthesis of nanobiomaterials
9.4 Characterization of nanobiomaterials
9.5 Activities of mycosynthesized nanobiomaterials and applications
9.6 Limitations and challenges
9.7 Conclusive remarks and future perspectives
References
Chapter 10. Bioengineering of nanomaterials using micro- and macroalgae and their wound healing, antimicrobial, and biofilm inhibitory activities
Abstract
10.1 Introduction
10.2 Microalgae- and macroalgae-mediated biosynthesis of nanomaterials and their characterization
10.3 Potential of algal nanotechnology in wound healing, antimicrobial, and biofilm inhibition activities
10.4 Challenges in the clinical development of phycosynthesized nanomaterials
10.5 Conclusion and future perspectives
References
Chapter 11. Phytonanotechnology: a greener approach for bioengineering of nanomaterials and their wound healing, antimicrobial, and biofilm inhibitory activities
Abstract
11.1 Phytonanotechnology: emerging paradigms
11.2 The interface of nanotechnology, plant, and microbes
11.3 Production of green nanomaterials from plant extracts
11.4 Optimization and characterization of biological nanomaterials
11.5 The antibacterial and wound healing potential of phytonanotechnology
11.6 Challenges in clinical development of biogenic nanobiomaterials
11.7 Conclusion and prospective development
References
Chapter 12. Bioengineered silver nanoparticles for antimicrobial therapeutics
Abstract
12.1 Introduction
12.2 Microbial resistance; a global concern
12.3 Current nanotherapeutics to combat microbial resistance
12.4 Green nanotechnology: an overview
12.5 Bioengineering of silver nanomaterials
12.6 Antimicrobial potential of bioengineered silver nanomaterials
12.7 Conclusion and future outlook
References
Chapter 13. Bioengineered gold nanoparticles for antimicrobial therapeutics
Abstract
13.1 Nanoscience and nanotechnology: an introduction
13.2 Nanomaterials: types, properties, and applications
13.3 Resistance to antibiotics: a global threat
13.4 Nanostrategies to prevent microbial infections
13.5 Gold nanoparticles: properties and biomedical applications
13.6 Biological synthesis of gold nanoparticles
13.7 Antimicrobial performance of biosynthesized gold nanoparticles
13.8 Conclusions and future outlook
References
Chapter 14. Green nanotechnology–based selenium and titanium dioxide nanomaterials for antimicrobial applications
Abstract
14.1 Nanobiotechnology: an overview
14.2 Selenium nanomaterials: properties, characteristics, and applications
14.3 Titanium dioxide nanomaterials: properties, characteristics, and applications
14.4 Green nanotechnology–based approaches for the biosynthesis of selenium and titanium dioxide nanomaterials
14.5 Antimicrobial performance of biogenic selenium nanomaterials
14.6 Antimicrobial performance of biogenic titanium dioxide nanomaterials
14.7 Conclusions and future outlook
References
Chapter 15. Opportunities and challenges for bioengineered metallic nanoparticles as future nanomedicine
Abstract
15.1 Introduction
15.2 A brief history of biologically synthesized metal nanoparticles
15.3 Market prospects and opportunities
15.4 Challenges and future perspectives
15.5 Conclusion
Acknowledgment
References
Index

Hamed Barabadi

Hamed Barabadi (PharmD, PhD) works as an assistant professor at the Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. He received a PhD degree from Shahid Beheshti University of Medical Sci-ences, Tehran, Iran, in 2019. He graduated as a Doctor of Pharmacy (PharmD) from Mazandaran University of Medical Sciences, Sari, Iran, in 2014. He owns to his credit a number of research papers, book chapters, and edited books with more than 3000 citations and h-index of 38. He has received many awards such as IET—Nanobiotech¬nology Premium Awards two times continuously in the years 2019 and 2020. Dr. Barabadi has been featured among the World’s Top 2% scientists list, according to a Stanford University study 2020 and 2022. He is the guest editor/editor for various reputed indexed journals such as Current Nanomedicine, Nanoscience and Nanotechnology-Asia, Frontiers in Pharmacology, MDPI International Journal of Molecular Sciences, MDPI Molecules, and a few other prestigious journals. His research interests lie in the area of pharmaceutical nanobiotechnology, ranging from green synthesis, characterization, and optimization of nanobiomaterials to their pharmaceutical potential evaluations, such as anticancer, antimicrobial, antioxidant, etc. Moreover, he has collaborated actively with researchers in several other disciplines of pharmaceutical sciences, particularly the nanoformulation of drugs for drug delivery systems and nanomedicine.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Muthupandian Saravanan

Dr. Muthupandian Saravanan is currently a Professor in the Department of Pharmacology at Saveetha University, SIMATS, Chennai, India. He has a degree in Microbiology from Madurai Kamaraj University and a Doctorate with Specialization in Medical Microbiology and Nanomedicine from Sathyabama University, India. As a Post-Doctoral Researcher at the Hebrew University of Jerusalem, he studied nano-biomaterials and their biomedical applications. He later worked as Associate Professor, under the United Nation Development Program in Department of Medical Microbiology and Immunology at Mekelle University in Ethiopia. He has published papers in high impact journals such as the Lancet and Nature. He has participated in more than 75 national and international conferences and reviewed of more than 100 international peer-reviewed journals. He has served as guest editor/ co-editor for reputed PubMed and Scopus indexed journals. He has received many fellowships and awards, notably the IET- Nanobiotechnology premium Awards in 2019 and 2020.

Affiliations and expertise

Professor, AMR and Nanotherapeutics Lab, Department of Pharmacology Saveetha Institute of Medical and Technical Sciences (SIMATS)

Ebrahim Mostafavi

Dr. Ebrahim Mostafavi has so far received training at Stanford University School of Medicine (PostDoc), Northeastern University (PhD), Harvard Medical School (Researcher), and University of Tehran (MSc and BSc). His research interests revolve around the engineering and development of (nano)biomaterials, nanocarriers, and 3D in vitro models (hydrogels, 3D bioprinted constructs, nanofibrous scaffolds, organoids, vascular grafts, and microfluidic systems) to create biologically complex systems for a range of applications such as cancer diagnostics and therapeutics, tissue engineering and regenerative medicine, biosensing, and infectious diseases. Dr. Mostafavi serves as an associate editor-in-chief of several prestigious and high-impact journals within Elsevier, Springer, Cell Press, Dove Medical Press, T&F, Frontiers, and so on He is also an editorial board member of more than 30 impactful and prestigious biomedical and materials science journals. His scholarly work comprises more than 200 publications with an H-index of 36 (i10-index of 105), including papers published in The Lancet family (i.e., Oncology, Infectious Diseases, Public Health, and Global Health) journals. So far, he has edited several books such as “Pharmaceutical Nanobiotechnology for Targeted Therapy” and “Emerging Nanomaterials and Nano-Based Drug Delivery Approaches to Combat Antimicrobial Resistance”. He has also contributed to leading more than 45 introductory book chapters in a very multidisciplinary field of bio/medical engineering, biotechnology, nanotechnology, materials science, and regenerative/ translational medicine.

Affiliations and expertise

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA

Hossein Vahidi

Hossein Vahidi (PharmD, PhD) is a Professor and head of the Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Iran. He is currently head of the School of Pharmacy and Director-in-Charge of the Iranian Journal of Pharmaceutical Research (IJPR). His research interests lie in the area of bioprocessing and fermentation of microorganisms for the production of bioactive compounds, optimization of fermentation, and growth of industrial microorganisms.

Affiliations and expertise

Professor and Head, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Iran

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Bioengineered Nanomaterials for Wound Healing and Infection Control

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Hamed Barabadi

Muthupandian Saravanan

Ebrahim Mostafavi

Hossein Vahidi