Metabolic-associated fatty liver disease, An Issue of Endocrinology and Metabolism Clinics of North America

1st Edition, Volume 52-3 - July 25, 2023
Editors: Joseph M. Pappachan, Sherouk Fouda
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 4 0 7 - 9
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 4 0 8 - 6

In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Sherouk Fouda and Joseph M. Pappachan bring their considerable expertise to the topic of… Read more

Metabolic-associated fatty liver disease, An Issue of Endocrinology and Metabolism Clinics of North America

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In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Sherouk Fouda and Joseph M. Pappachan bring their considerable expertise to the topic of Metabolic Associated Fatty Liver Disease. Top experts address the various ways metabolic associated fatty liver disease is related to other conditions such as diabetes, sarcopenia, PCOS, and more, as well as the management of MAFLD and cardiovascular implications.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Pathobiology of Metabolic-Associated Fatty Liver Disease
Key points
Introduction
Pathobiology of metabolic-associated fatty liver disease
Risk factors for metabolic-associated fatty liver disease
Dietary intake
Sedentary lifestyle
Viral infection and gut microbiota
Childhood and adolescent associations
Clinical association of metabolic-associated fatty liver disease with metabolic/nonmetabolic disorders
Summary
Clinics care points
Metabolic-Associated Fatty Liver Disease in Childhood and Adolescence
Key points
Introduction
Epidemiologic burden
Cause
Pathophysiology
Pathology and classification
Evaluation and diagnosis
Management and limitations
Evolving treatments
Summary
Clinics care points
Disclosures
Lean Metabolic-Associated Fatty Liver Disease
Key points
Introduction
Definition of lean metabolic-associated fatty liver disease
Prevalence
Pathophysiologic characteristics
Treatments
Research
Summary
Clinics care points
Disclosure
Lipid Disorders and Metabolic-Associated Fatty Liver Disease
Key points
Introduction
Summary
Clinics care points
Disclosure
Cardiovascular Implications of Metabolic Dysfunction-Associated Fatty Liver Disease
Key points
Introduction
Epidemiological evidence
Evidence for a causal relationship
Implications for treatment of nonalcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease
Implications for prevention of cardiovascular disease
Areas of uncertainty/emerging concepts
Summary
Clinics care points
Declaration of Interests
Metabolic-Associated Fatty Liver Disease and Diabetes: A Double Whammy
Key points
Introduction
Problem statement of metabolic-associated fatty liver disease and diabetes
Liver pancreas cross talk
Metabolic syndrome and metabolic-associated fatty liver disease
Exercise-related interventions for the management of metabolic-associated fatty liver disease with diabetes
Pharmacotherapy for the management of metabolic-associated fatty liver disease in patients with type 2 diabetes mellitus
The utility of other drugs (not antidiabetic agents) in the management of metabolic-associated fatty liver disease
Bariatric surgery and intragastric procedures
Management of metabolic-associated fatty liver disease among patients with diabetes in special situations
Outcomes of metabolic-associated fatty liver disease in patients with diabetes as compared with those without diabetes
Summary
Clinics care points
Metabolic-Associated Fatty Liver Disease and the Gut Microbiota
Key points
Introduction
Summary and future directions
Clinics care points
Conflict of interest and financial disclosure
Funding
Metabolic-Associated Fatty Liver Disease and Sarcopenia
Key points
Introduction
The interlink between sarcopenia and metabolic-associated fatty liver disease
Cause-effect relationship
Metabolic-associated fatty liver disease and sarcopenic obesity
Screening and diagnosis (assessing muscle composition, strength, and performance in metabolic-associated fatty liver disease)
Complications (especially when both entities coexist, including cardiovascular risk)
Therapeutic and lifestyle interventions
Summary
Clinics care points
A Bidirectional Association Between Obstructive Sleep Apnea and Metabolic-Associated Fatty Liver Disease
Key points
Introduction
Epidemiology
Diagnostic approach
Obstructive sleep apnea and metabolic-associated fatty liver disease
Pathophysiology
Management algorithm
Clinics care points
Summary
Disclosure
Pregnancy and Metabolic-Associated Fatty Liver Disease
Key points
Introduction
Preclinical models for maternal metabolic-associated fatty liver disease and effects on maternal outcomes during pregnancy
Effect of metabolic-associated fatty liver disease on maternal outcomes during pregnancy: clinical evidence
Research evidence on the effects of maternal metabolic-associated fatty liver disease on offspring outcomes
Clinical evidence on the effect of maternal metabolic-associated fatty liver disease on progeny
Management of metabolic-associated fatty liver disease in pregnancy
Summary and future directions
Clinics care points
Disclosure
Funding
The Interlink Between Metabolic-Associated Fatty Liver Disease and Polycystic Ovary Syndrome
Key points
Introduction
Pathophysiology of polycystic ovary syndrome
The interlink between polycystic ovary syndrome and metabolic-associated fatty liver disease
The coexistence of polycystic ovary syndrome and metabolic-associated fatty liver disease
Diagnostic workup
Complication profile, including cardiovascular risks
Current management strategies and therapeutics
Summary
Clinics care points
Declaration of Interests
Management of Metabolic-Associated Fatty Liver Disease
Key points
Introduction
Screening and diagnosis
Clinical management of MAFLD
Clinical management of advanced MAFLD
Summary
Clinics care points

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Metabolic-associated fatty liver disease, An Issue of Endocrinology and Metabolism Clinics of North America

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Joseph M. Pappachan

Sherouk Fouda