Advances in Microbial Physiology

1st Edition, Volume 83 - July 26, 2023
Editors: Robert K. Poole, David J. Kelly
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 3 3 6 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 3 3 7 - 8

Advances in Microbial Physiology, Volume 83 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is wri… Read more

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Advances in Microbial Physiology, Volume 83 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include RidA paradigm, Targeting the cell envelope to overcome antimicrobial resistance, Biosynthesis and function of microbial methylmenaquinones, Antibiotic efficacy, Role of central metabolism/bacterial physiology on tolerance to cell wall-acting antibiotics, and Physiology of diazotrophs.

Cover image
Title page
Table of Contents
Advances in MICROBIAL PHYSIOLOGY
Copyright
Contributors
Preface
Chapter One: Biosynthesis and function of microbial methylmenaquinones
Abstract
Abbreviations
1 Introduction
2 Biosynthesis pathways of MK and MMK
3 Structure, function and specificity of MK methyltransferases
4 Quinone pool engineering by homologous and heterologous (over)production of MK methyltransferases
5 Bioinformatic analysis of the MenK/MqnK/MenK2 enzyme cluster and the widespread potential of MMK production in bacteria and archaea
6 Examples of electron transport chains using MMK
7 Conclusion and outlook
Acknowledgements
References
Chapter Two: Molecular discoveries in microbial DMSP synthesis
Abstract
Abbreviations
1 Introduction
2 How is DMSP synthesised
3 Molecular studies to infer the role of DMSP
4 Predicting DMSP production and levels in organisms
5 Environmental abundance of DMSP synthesis genes
6 Future avenues
Acknowledgements
References
Chapter Three: Modulators of a robust and efficient metabolism: Perspective and insights from the Rid superfamily of proteins
Abstract
1 Introduction
2 Microbial metabolism is a complex system
3 Cellular metabolites influence physiology
4 Key challenges in modeling metabolism
5 Description of the Rid (YjgF/YER057c/UK114) superfamily of proteins
6 The RidA protein subfamily: From unknown function to metabolic understanding
7 2-Aminoacrylate is an endogenously generated metabolite stressor
8 The 2-aminoacrylate stress paradigm
9 Rid family function beyond RidA and 2-aminoacrylate stress
10 General model for the Rid superfamily and remaining questions
11 Insights gained, and lessons learned from studies of the Rid superfamily
12 Concluding remarks
Acknowledgments
References
Chapter Four: Bacterial metabolism and susceptibility to cell wall-active antibiotics
Abstract
Abbreviations
1 Introduction
2 Growth state and antibiotic susceptibility
3 Link between energy state and CWA susceptibility
4 Dividing the loot: Metabolic resource allocation and antibiotic susceptibility
5 Metabolism in the infection environment
6 Conclusions
Acknowledgements
References
Chapter Five: Making a chink in their armor: Current and next-generation antimicrobial strategies against the bacterial cell envelope
Abstract
Abbreviations
1 Introduction
2 Outer and plasma membranes
3 Biogenesis of the cell envelope
4 Peptidoglycan cell wall
5 Protein homeostasis
6 Antimicrobial resistance
7 Concluding remarks
Funding information
References
Chapter Six: On the evolution of natural product biosynthesis
Abstract
1 Introduction
2 Diversity of natural products
3 Primary, secondary and specialised metabolism
4 Evolution of metabolic pathways
5 Architecture of biosynthetic gene clusters
6 Evolutionary models for emergence of new natural product biosynthetic clusters
7 Reconciling the constraints of current BGC evolution models
8 Considerations for expanding the evolutionary models of biosynthetic gene clusters
9 Placing biosynthetic gene clusters into an ecology–evolution–developmental (eco–evo–devo) biology framework
10 Future perspectives
References

Robert K. Poole

Professor Robert Poole is West Riding Professor of Microbiology at the University of Sheffield. He has >35 years’ experience of bacterial physiology and bioenergetics, in particular O2-, CO- and NO-reactive proteins, and has published >300 papers (h=48, 2013). He was Chairman of the Plant and Microbial Sciences Committee of the UK Biotechnology and Biological Sciences Research Council and has held numerous grants from BBSRC, the Wellcome and Leverhulme Trusts and the EC. He coordinates an international SysMO systems biology consortium. He published pioneering studies of bacterial oxidases and globins and discovered the bacterial flavohaemoglobin gene (hmp) and its function in NO detoxification He recently published the first systems analyses of responses of bacteria to novel carbon monoxide-releasing molecules (CORMs) and is a world leader in NO, CO and CORM research.

Affiliations and expertise

West Riding Professor of Microbiology, Department of Molecular Biology and Biotechnology, University of Sheffield, UK

David J. Kelly

Professor David Kelly is Emeritus Professor of Microbial Physiology at the University of Sheffield. He has >35 years research expertise in bacterial physiology and biochemistry, membrane protein transport processes and bioenergetics, and has worked with the zoonotic food-borne pathogen Campylobacter jejuni for >25 years. His laboratory has been engaged in a major program to study C. jejuni physiology, in particular the responses to oxygen, many aspects of carbon metabolism and functional analysis of the electron transport chains. He has long-standing interests in membrane transport mechanisms and in the 1990s discovered an entirely new class of periplasmic binding-protein dependent prokaryotic solute transporters, the TRAP transporters, now known to be common in a diverse range of bacteria and archaea. He has published >150 papers (h=42, 2021), held numerous grants, served on grant committees and has been a regular invited speaker at national and international conferences.

Affiliations and expertise

Professor of Microbiology, Department of Molecular Biology and Biotechnology, University of Sheffield, UK