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Cellular Lipid in Health and Disease
- 1st Edition - August 3, 2023
- Editor: James Mukasa Ntambi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 8 2 2 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 8 3 - 6
Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology. This book is organized in four par… Read more
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Request a sales quoteCellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology.
This book is organized in four parts covering the foundational concepts of lipid biology all the way to the therapeutic opportunities they present. The first part is dedicated to the basic concepts of cellular lipid, the roles it plays in the cell, structure and physiology, regulation mechanisms, storage, and utilization. The second part is focused on lipid metabolism, covering the organelles involved in lipid trafficking, metabolism in aging, cholesterol homeostasis, lipid droplets (LDs), and lipid oxidation. Part three is dedicated to the roles lipids play in specific disease states including renal, metabolic, cardiovascular, and fatty liver diseases. Other conditions include cancer, neurodegenerative diseases, and the intricate relationship between cellular lipids and autophagy. The final part covers therapeutic opportunities, including drug carrier systems, modeling lipid metabolism, and prevention therapeutics.
Cellular Lipid in Health and Disease is a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry, and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities.
- Offers a complete and systematic coverage of lipid biology
- Provides foundational content and establishes the needed connections to translational aspects of the research in this area
- Includes chapters on the therapeutic opportunities presented by lipids
Graduate students, researchers in the adjacent fields of Biochemistry, Pharmacology, Physiology and Cell Biology, Research Physicians in areas where Lipids plays a key role in disease states
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1. Structure and function of mammalian sphingolipids in health and disease
- 1. Sphingolipids
- 2. The biological space of sphingolipid structures
- 3. Metabolism of sphingolipids in mammalian cells
- 4. Physiological functions of sphingolipids
- 5. Diseases caused by dysregulated sphingolipid metabolism
- Chapter 2. Intracellular lipid storage and utilization in adipocytes
- 1. Introduction
- 2. LD-associated protein families
- 3. Lipid hydrolysis
- 4. Other LD-associated proteins
- 5. Conclusions
- Chapter 3. Metabolic control by lipid droplet proteins
- 1. Lipid droplet coat proteins
- 2. Proteins involved in lipid synthesis
- 3. Cytosolic lipases
- 4. Lysosomal lipolysis
- 5. LD–mitochondria interaction
- 6. LD–peroxisome interaction
- 7. Lipid droplet-endoplasmic reticulum association
- 8. Expansion, fission, and motility of LDs
- 9. Transcriptional control of metabolism by LD-localized proteins
- Chapter 4. From endoplasmic reticulum to nucleus: the fate of cellular fatty acids
- 1. Introduction
- 2. Fatty acids
- 3. De novo synthesis versus beta-oxidation
- 4. Proteins modification by FA
- 5. Triacylglycerol
- 6. Phospholipids
- 7. Conclusion
- Abbreviations
- Chapter 5. Lipid trafficking and signaling in adipocytes
- 1. Lipid droplets in adipocyte
- 2. The development of lipid droplets and adipocytes
- 3. Developmental origin of adipose tissue
- 4. Lipid metabolism and signaling
- Chapter 6. Cell and molecular basis for maintenance of cholesterol homeostasis
- 1. Feedback-mediated regulation of cholesterol synthesis
- Chapter 7. Interplay between Phospholipid signaling and autophagy
- 1. Introduction
- 2. Crosstalk between phosphoinositides and mTOR in regulation of autophagy
- 3. Phosphoinositides and their effectors in autophagy
- 4. Phosphatidic acid and phospholipase D
- 5. Autophagy regulation by sphingolipids
- 6. Conclusion
- Chapter 8. The role of cellular lipid metabolism in aging
- 1. Introduction
- 2. TG storage in LDs and aging
- 3. TG mobilization and aging
- 4. Deregulation of lipid metabolism during cellular aging
- 5. Lipid composition changes during cellular senescence
- 6. Bioactive lipids as senescence SASP factors
- 7. Reprograming of mitochondrial and lipid metabolism in senescent cells
- 8. Mitochondrial dysfunction in senescence SASP
- 9. Future directions
- Chapter 9. Plasma lipid trafficking in type 2 diabetes
- 1. Introduction
- 2. Methods of plasma lipid measurements
- 3. Lipid contribution to type 2 diabetes and insulin signaling
- 4. Perspectives: advances in lipid quantification and mechanisms
- Chapter 10. Lipotoxicity in the pathogenesis of chronic kidney disease complications
- 1. Lipotoxicity in kidney diseases and complications of kidney diseases
- 2. The role of lipids and lipotoxicity in proximal tubular cells
- 3. Lipotoxicity induces vascular calcification and endoplasmic reticulum stress
- 4. SFAs induce vascular calcification through ER stress
- 5. A complex of cyclin-dependent kinase 9/Cyclin T1 mediates SFA-induced ER stress in VSMCs
- 6. SFAs inhibit autophagy in vascular calcification
- 7. Conclusion
- Chapter 11. Cellular lipids in the molecular pathogenesis of obesity
- 1. Obesity
- 2. Diabetes mellitus
- 3. Insulin resistance
- 4. Molecular alterations in obesity, T2DM, and insulin resistance
- 5. Physical activity, healthy diet, and drugs as an intervention
- Chapter 12. Effects of cellular lipids on heart in pathology and physiology
- 1. Introduction
- 2. Fatty acid uptake in the heart
- 3. Regulation of lipogenesis in the heart
- 4. Lipolysis and cardiac metabolism
- 5. Fatty acid oxidation and cardiac physiology and pathology
- 6. Cytotoxic effects of diacylglycerols and ceramides in cardiomyocytes
- 7. Other sphingolipids and cardiolipin as regulators of heart metabolism
- 8. Conclusion
- Chapter 13. Uncoupling of fat deposition and inflammation during nonalcoholic fatty liver disease
- 1. Introduction
- 2. NAFLD pathogenesis
- 3. Uncoupling of fat deposition and inflammation during NAFLD pathogenesis
- 4. Uncoupling of fat deposition and inflammation during NAFLD management
- 5. Perspective
- Chapter 14. Cellular lipids and colorectal cancer
- 1. Biological aspects of colorectal cancer
- 2. Lipid metabolism and obesity in the cancer microenvironment
- 3. Lipid signaling pathways in CRC and pharmacological/nutraceutical chemoprevention strategy
- Chapter 15. Lipid metabolism in neurodegenerative diseases
- 1. Introduction
- 2. Brain cholesterol
- 3. Brain fatty acids
- 4. Conclusions
- Chapter 16. Cellular lipids in B cell immunity, inflammation, and cancer
- 1. Introduction
- 2. Cellular lipids in B cell development and maturation
- 3. Lipids in B cell activation and plasma cell differentiation
- 4. Cellular lipid in regulatory B cell differentiation
- 5. Dysregulated cellular lipid in B cell autoimmune pathogenesis
- 6. Cellular lipid in B cell dysregulation during allergic disorders
- 7. Lipids in B cell antitumor immune response
- 8. Conclusions and perspectives
- Chapter 17. Role of cellular fatty acids in combating the corona virus
- 1. Introduction
- 2. EPA and DHA's helpful effects in preventing COVID-19
- 3. Fatty acid defense against viral infection
- 4. Fatty acids antimicrobial activity
- 5. EPA and DHA's impact
- 6. Final thoughts and potential directions for future research
- Chapter 18. Cellular lipids and viral infection
- 1. Introduction
- 2. Attachment and entry
- 3. Replication
- 4. Assembly
- 5. Therapeutics
- Chapter 19. Acetyl-CoA and acetylation in biology and disease
- 1. Introduction
- 2. Biosynthesis and transport of acetyl-CoA
- 3. Protein acetylation
- 4. ER acetylation
- 5. ER acetylation, proteostasis, and metabolic crosstalk
- 6. Dysfunctional ER acetylation and diseases
- 7. SLC25A1, SLC13A5, and the citrate/acetyl-CoA pathway
- 8. ER acetylation and translation
- 9. Mitochondrial acetylation
- 10. Nuclear acetylation
- 11. Cytosolic acetylation
- 12. O-acetylation of gangliosides
- 13. Conclusive remarks
- Chapter 20. Role of omega-3 and -6 fatty acids in the inflammatory processes of obesity, hypertension, and autoimmunity
- 1. Structure, nomenclature, and synthesis of fatty acids
- 2. Modulation of inflammation by lipid-derived molecules [7]
- 3. Inflammatory response
- 4. Antiinflammatory diets
- 5. Dietary intervention in metabolic diseases
- 6. Inflammation in metabolic diseases
- 7. Obesity and inflammation
- 8. Rheumatic diseases and inflammation
- 9. Rheumatoid arthritis
- 10. Systemic lupus erythematosus
- 11. Sjögren’s syndrome
- 12. Gout
- Index
- No. of pages: 556
- Language: English
- Edition: 1
- Published: August 3, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443218224
- eBook ISBN: 9780323955836
JN
James Mukasa Ntambi
Dr. James M. Ntambi is a Professor of Biochemistry and the Steenbock Professor of Nutritional Sciences, at the University of Wisconsin-Madison, as well as an Adjunct Professor of Biological Chemistry at Johns Hopkins University School of Medicine. The focus of Dr. Ntambi’s research is to understand the genetic regulation of metabolism, adipocyte biology, and differentiation. He is specifically interested in the genetic basis of obesity, cardiovascular disease, insulin resistance, and diabetes and how dietary factors, hormones, and environmental factors influence these disease states. Recently, his team has genetically engineered mice that are born without the stearoyl-CoA desaturase gene-1, and found that these mice resist obesity, diabetes, and fatty liver disease. Most recent work has focused on the role monounsaturated fatty acids in diet induced de novo lipogenesis, obesity, and insulin resistance. Dr. Ntambi also conducts research on obesity and diabetes and other noncommunicable metabolic diseases in developing countries. Dr. Ntambi has published more than 230 scientific articles in such journals including Journal of Biological Chemistry, Journal of Lipid Research, PNAS, Science, Cell Metabolism, Hepatology journal, BBRC, JCI, BBA, PLoS, Journal of Nutrition, and American Journal of Physiology-Endocrinology and Metabolism, among others.
Affiliations and expertise
Department of Biochemistry, Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USARead Cellular Lipid in Health and Disease on ScienceDirect