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Elsevier

Books in Life sciences

  • Shoulder and Elbow Trauma and its Complications

    Volume 1: The Shoulder
    • 1st Edition
    • Michael Greiwe
    • English
    Traumatic injuries to the shoulder remain a problem encountered by young and old alike. Trauma surgeons and shoulder and elbow specialists are called upon daily to improve the quality of life of injured individuals by restoring function, decreasing pain and returning individuals to their previous occupations and places in society. Such treatment provides both humanitarian and economic impact. Only recently have techniques and technology allowed surgeons to restore lives to such a degree following these injuries. Still, shoulder and elbow trauma remains a vexing problem for patients and surgeons alike. Many injuries result in lost work and serious debility including lack of function, post-traumatic arthritis and pain. This important textbook provides a systematic and comprehensive guide to the different types of shoulder trauma and the management of its associated complications. In Part One, the focus is on the most common types of shoulder trauma, with chapters covering anterior instability, traumatic rotator cuff tears, fractures, joint injuries and the floating shoulder and includes sections on the most common complications befalling each injury. Part II then reviews the management of the most common complications. Chapters include detailed analyses of persistent anterior shoulder instability, several forms of nonunion and malunion, failed acromioclavicular joint reconstruction, post-traumatic arthropathy and traumatic osteonecrosis, and failed arthroplasty for fracture.

  • Chinmedomics

    The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine
    • 1st Edition
    • Xijun Wang + 2 more
    • English
    Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future.

  • Logan Turner's Diseases of the Nose, Throat and Ear

    • 6th Edition
    • John P. Stewart
    • English
    Logan Turner's Diseases of the Nose, Throat, and Ear, Sixth Edition elaborates the treatment of malignant disease of the larynx and ear. This book covers relevant topics, including sulfa drugs and antibiotics, peroral endoscopy, and affections of the paranasal sinuses. Organized into 43 chapters, this edition begins with an overview of the functions of the larynx that vary in significance, including protection of the lungs, phonation, fixation of the chest, and a channel for respiration. This text then explores the various processes of examination of the cavities of the nose. Other chapters consider the deformity called saddle nose, which consists in a sinking-in of the dorsum of the nose. This book discusses as well the examination of chronic catarrh of the middle ear. The final chapter deals with the congenital defects of the labyrinth, which are responsible for the condition known as sporadic congenital deaf-mutism. This book is a valuable resource for clinicians.

  • Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

    • 1st Edition
    • Carrie Markgraf + 2 more
    • English
    Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability.

  • Centrosome and Centriole

    • 1st Edition
    • Volume 129
    • English
    This new volume of Methods in Cell Biology looks at methods for analyzing centrosomes and centrioles. Chapters cover such topics as methods to analyze centrosomes, centriole biogenesis and function in multi-ciliated cells, laser manipulation of centrosomes or CLEM, analysis of centrosomes in human cancers and tissues, proximity interaction techniques to study centrosomes, and genome engineering for creating conditional alleles in human cells.

  • Food Safety

    Emerging Issues, Technologies and Systems
    • 1st Edition
    • Steven Ricke + 2 more
    • English
    Food Safety: Emerging Issues, Technologies and Systems offers a systems approach to learning how to understand and address some of the major complex issues that have emerged in the food industry. The book is broad in coverage and provides a foundation for a practical understanding in food safety initiatives and safety rules, how to deal with whole-chain traceability issues, handling complex computer systems and data, foodborne pathogen detection, production and processing compliance issues, safety education, and more. Recent scientific industry developments are written by experts in the field and explained in a manner to improve awareness, education and communication of these issues.

  • Plant Transcription Factors

    Evolutionary, Structural and Functional Aspects
    • 1st Edition
    • Daniel H Gonzalez
    • English
    Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology. While the majority of information about transcription factors is based on mammalian systems, this publication discusses plant transcription factors, including the important aspects and unifying themes to understanding transcription factors and the important roles of particular families in specific processes.

  • Prodrug Design

    Perspectives, Approaches and Applications in Medicinal Chemistry
    • 1st Edition
    • Vivekkumar K Redasani + 1 more
    • English
    Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference.

  • Laboratory Animal Medicine

    • 3rd Edition
    • James G. Fox + 4 more
    • English
    Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.

  • Food Waste Recovery

    Processing Technologies and Industrial Techniques
    • 1st Edition
    • Charis M. Galanakis
    • English
    Food Waste Recovery: Processing Technologies and Industrial Techniques acts as a guide to recover valuable components of food by-products and recycle them inside the food chain, in an economic and sustainable way. The book investigates all the relevant recovery issues and compares different techniques to help you advance your research and develop new applications. Strong coverage of the different technologies is included, while keeping a balance between the characteristics of current conventional and emerging technologies. This is an essential reference for research outcomes.

  • Biosensors and Bioelectronics

    • 1st Edition
    • Chandran Karunakaran + 2 more
    • English
    Biosensors and Bioelectronics presents the rapidly evolving methodologies that are relevant to biosensors and bioelectronics fabrication and characterization. The book provides a comprehensive understanding of biosensor functionality, and is an interdisciplinary reference that includes a range of interwoven contributing subjects, including electrochemistry, nanoparticles, and conducting polymers. Authored by a team of bioinstrumentation experts, this book serves as a blueprint for performing advanced fabrication and characterization of sensor systems—arming readers with an application-based reference that enriches the implementation of the most advanced technologies in the field.

  • Epigenetic Cancer Therapy

    • 1st Edition
    • Steven Gray
    • English
    Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

  • Land Plants - Trees

    • 1st Edition
    • Volume 74
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 74th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology. This volume features reviews on the advances in knowledge for the main traits important in fruit trees and forest trees, the advances in tools and resources for genetics and genomics in these species, and the knowledge developed in three rather separated communities of researchers: forest, fruit trees, and grapevines.

  • The Ore Minerals Under the Microscope

    An Optical Guide
    • 2nd Edition
    • Volume 3
    • Bernhard Pracejus
    • English
    The Ore Minerals Under the Microscope: An Optical Guide, Second Edition, is a very detailed color atlas for ore/opaque minerals (ore microscopy), with a main emphasis on name and synonyms, short descriptions, mineral groups, chemical compositions, information on major formation environments, optical data, reflection color/shade comparison with four common/standard minerals of a similar color or grey shade, and up to five high-quality photos for each mineral with scale. In addition, the atlas contains a compilation from some of the prominent publications in the field of ore microscopy presented on a list of 431 minerals.

  • Biochemistry for Medical Professionals

    • 1st Edition
    • Tsugikazu Komoda + 1 more
    • English
    Biochemistry for Medical Professionals contains pivotal advances in the biochemistry field and provides a resource for professionals across medicine, dentistry, pharmaceutical sciences and health professions who need a concise, topical biochemistry reference. Relevant, well-illustrated coverage begins with the composition of the human body and then goes into the technical detail of the metabolism of the human body and biochemistry of internal organs before featuring a biotechnology study inclusive of numerous methods and applications. The work is written at a consistently high level, with technical notes added to aid comprehension for complex topics.

  • Hair Analysis in Clinical and Forensic Toxicology

    • 1st Edition
    • Pascal Kintz + 2 more
    • English
    Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair.

  • Medicinal Plants

    Chemistry, Biology and Omics
    • 1st Edition
    • Da-Cheng Hao + 2 more
    • English
    Medicinal Plants: Chemistry, Biology and Omics reviews the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plant tribes and genera, and their relevance to drug efficacy. Medicinal plants provide a myriad of pharmaceutically active components, which have been commonly used in traditional Chinese medicine and worldwide for thousands of years. Increasing interest in plant-based medicinal resources has led to additional discoveries of many novel compounds, in various angiosperm and gymnosperm species, and investigations on their chemotaxonomy, molecular phylogeny and pharmacology. Chapters in this book explore the interrelationship within traditional Chinese medicinal plant groups and between Chinese species and species outside of China. Chapters also discuss the incongruence between chemotaxonomy and molecular phylogeny, concluding with chapters on systems biology and “-omics” technologies (genomics, transcriptomics, proteomics, and metabolomics), and how they will play an increasingly important role in future pharmaceutical research.

  • Functional Marine Biomaterials

    Properties and Applications
    • 1st Edition
    • Se-Kwon Kim
    • English
    Functional Marine Biomaterials: Properties and Applications provides readers with the latest information on the diverse marine environment as a resource for many new substances, including biopolymers, bioceramics, and biominerals. As recent advances and funding has enabled scientists to begin harnessing many of these materials for biomedical applications from drug delivery to bone tissue engineering and biosensors, this important new text provides readers with a comprehensive review of these materials and their functional applications in the biomedical field. Chapters discuss the properties of the main classes of functional marine biomaterials, applications of marine products in tissue engineering, applications in drug delivery systems, and the role of marine derived materials in medical devices.

  • Advances in Virus Research

    • 1st Edition
    • Volume 93
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

  • Healthy Babies Are Worth The Wait

    A Partnership to Reduce Preterm Births in Kentucky through Community-based Interventions 2007 - 2009
    • 1st Edition
    • Edward R.B. McCabe
    • English
    Healthy Babies Are Worth the Wait®: A Collaborative Partnership to Reduce Preterm Births in Kentucky through Community-based Interventions 2007 – 2009 provides readers with an overview of the problem of preterm birth in the US, also describing in detail the design, implementation, evaluation, and outcomes of the Healthy Babies Are Worth the Wait initiative conducted in Kentucky between 2007 and 2009. The reader will learn about a unique research approach employing a mixed ecologic design that compared outcomes between intervention sites and comparison sites and the use of qualitative surveys and quantitative methods using state vital records data to evaluate outcomes. Consumer messaging and educational materials are discussed, along with the challenges of implementation and key lessons learned.

  • Specialty Oils and Fats in Food and Nutrition

    Properties, Processing and Applications
    • 1st Edition
    • Geoff Talbot
    • English
    Specialty Oils and Fats in Food and Nutrition: Properties, Processing and Applications examines the main specialty oils and fats currently in use in food processing, as well as those with significant potential. Specialty oils and fats have an increasing number of applications in the food industry, due to growing consumer interest in “clean label” functional foods and the emerging markets in “free-from” and specialist foods. Part One of this book covers the properties and processing of specialty oils and fats, with a focus on the chemistry, extraction, and quality of different fats and oils, including chapters on shea butter, tropical exotic oils, and structured triglycerides. Part Two looks at the applications of specialty oils and fats in different food and nutraceutical products, such as confectionary, ice cream, and margarine. Specialty Oils and Fats in Food and Nutrition is a key text for R&D managers and product development personnel working in the dairy, baking, and dairy analogue sectors, or any sector using fats and oils. It is a particularly useful reference point for companies reformulating their products or developing new products to alter fat content, as well as academics with a research interest in the area, such as lipid scientists or food scientists.

  • RGS Protein Physiology and Pathophysiology

    • 1st Edition
    • Volume 133
    • English
    RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 127
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including taxane-anti-androgen... cross-resistance in advanced prostate cancer and proteasome inhibitors in the treatment of multiple myeloma.

  • Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

    • 1st Edition
    • Michael Aschner + 1 more
    • English
    Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience.

  • Research Regulatory Compliance

    • 1st Edition
    • Mark A. Suckow + 1 more
    • English
    Research Regulatory Compliance offers the latest information on regulations and compliance in the laboratory. With the increasing complexity of regulations and need for institutional infrastructure to deal with compliance of animal use issues, as well as a requirement surrounding human subjects, this publication provides reputable guidance and information. The book is extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and is also a great asset for faculty or new researchers coming in to the laboratory environment. It will help prepare users for the deluge of regulatory and compliance issues they will face while conducting their scientific programs. The book is edited and authored by known leaders in the field of compliance and regulations, and contains extensive research on the topics. It represents the new standard for information in every laboratory.

  • Success Strategies From Women in STEM

    A Portable Mentor
    • 2nd Edition
    • Peggy A. Pritchard + 1 more
    • English
    Success Strategies from Women in Stem: A Portable Mentor, Second Edition, is a comprehensive and accessible manual containing career advice, mentoring support, and professional development strategies for female scientists in the STEM fields.This updated text contains new and essential chapters on leadership and negotiation, important coverage of career management, networking, social media, communication skills, and more. The work is accompanied by a companion website that contains annotated links, a list of print and electronic resources, self-directed learning objects, frequently asked questions, and more.With an increased focus on international relevance, this comprehensive text contains shared stories and vignettes that will help women pursuing or involved in STEM careers develop the necessary professional and personal skills to overcome obstacles to advancement.

  • Aquatic Ecotoxicology

    Advancing Tools for Dealing with Emerging Risks
    • 1st Edition
    • Claude Amiard-Triquet + 2 more
    • English
    Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants. This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species. The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments.

  • Interpreting Biomedical Science

    Experiment, Evidence, and Belief
    • 1st Edition
    • Ülo Maiväli
    • English
    Interpreting Biomedical Science: Experiment, Evidence, and Belief discusses what can go wrong in biological science, providing an unbiased view and cohesive understanding of scientific methods, statistics, data interpretation, and scientific ethics that are illustrated with practical examples and real-life applications. Casting a wide net, the reader is exposed to scientific problems and solutions through informed perspectives from history, philosophy, sociology, and the social psychology of science. The book shows the differences and similarities between disciplines and different eras and illustrates the concept that while sound methodology is necessary for the progress of science, we cannot succeed without a right culture of doing things.

  • Strategies to Modify the Drug Release from Pharmaceutical Systems

    • 1st Edition
    • Marcos Luciano Bruschi
    • English
    Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed.

  • Adrenal Cortical Neoplasia, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 44-2
    • Alice Levine
    • English
    This issue of Endocrinology and Metabolism Clinics, edited by Dr. Alice Levine, is devoted to Adrenal Disease. This issue will be broken down into 3 sections: Overview of Adrenal Cortical Development, Steroidogenesis, Comparative Anatomy and Molecular Pathophysiology; Benign Adrenal Tumors; and Adrenal Cortical Carcinoma. Articles in this issue include: Adrenal Cortical Zonal Development; Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia; Animal Models of Adrenocortical Tumorigenesis; Genetics of Adrenal Cortical Tumors; Adrenal Incidentalomas; Aldosteronomas – Challenges in Diagnosis and Management; Mild Hypercortisolism Due to Adrenal Adenomas – Definitions and Therapeutic Options; Management of Adrenal Tumors in Pregnancy; Pathology of ACC; Diagnosis and Medical Management of ACC; and Surgical Management of ACC.

  • Advances in Immunology

    • 1st Edition
    • Volume 127
    • Frederick W. Alt
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Laboratory Methods in Enzymology: Protein Part D

    Laboratory Methods in Enzymology
    • 1st Edition
    • Volume 559
    • English
    The critically acclaimed laboratory standard for almost 50 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 520 volumes and 40,000 chapters in the collection, much of the material is still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research, and genetics, just to name a few. In this volume, number 545, we have brought together a number of core protocols concentrating on protein, carefully written and edited by experts.

  • Research in Medical and Biological Sciences

    From Planning and Preparation to Grant Application and Publication
    • 1st Edition
    • Petter Laake + 2 more
    • English
    Research in Medical and Biological Sciences covers the wide range of topics that a researcher must be familiar with in order to become a successful biomedical scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences, this publication discusses a broad range of topics that are common yet not traditionally considered part of formal curricula, including philosophy of science, ethics, statistics, and grant applications. The information presented in this book also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects.

  • Peptide and Protein Vaccines

    • 1st Edition
    • Volume 99
    • Rossen Donev
    • English
    Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

  • Freshwater Algae of North America

    Ecology and Classification
    • 2nd Edition
    • John D. Wehr + 2 more
    • English
    Freshwater Algae of North America: Ecology and Classification, Second Edition is an authoritative and practical treatise on the classification, biodiversity, and ecology of all known genera of freshwater algae from North America. The book provides essential taxonomic and ecological information about one of the most diverse and ubiquitous groups of organisms on earth. This single volume brings together experts on all the groups of algae that occur in fresh waters (also soils, snow, and extreme inland environments). In the decade since the first edition, there has been an explosion of new information on the classification, ecology, and biogeography of many groups of algae, with the use of molecular techniques and renewed interest in biological diversity. Accordingly, this new edition covers updated classification information of most algal groups and the reassignment of many genera and species, as well as new research on harmful algal blooms.

  • Data Mining for Bioinformatics Applications

    • 1st Edition
    • He Zengyou
    • English
    Data Mining for Bioinformatics Applications provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. The text uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems, containing 45 bioinformatics problems that have been investigated in recent research. For each example, the entire data mining process is described, ranging from data preprocessing to modeling and result validation.

  • Neurology, An Issue of Primary Care: Clinics in Office Practice

    • 1st Edition
    • Volume 42-2
    • Paula Gregory
    • English
    This issue of Primary Care: Clinics in Office Practice, edited by Dr. Paula Gregory, is devoted to Neurology. Articles in this issue include: Dementia; Guillain Barre Syndrome; Multiple Sclerosis; Migraine and Migraine Variants: Keys to Diagnosis and Management; Medication and Toxin-Induced Neurological Syndrome; Approach to the Patient with Parkinson's Disease; Neurootologic Disease: Presentation, Diagnosis, and Management; Epilepsy: Current Evidence-Based Paradigms for Diagnosis and Treatment; Vertigo and the Dizzy Patient; and Sports-related Traumatic Brain Injury.

  • Cerebrovascular Diseases: Controversies and Challenges, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 33-2
    • William J. Powers
    • English
    Cerebrovascular disease results in huge health expenditures, multiple recurring physician visits, and a great number of surgical and non-surgical treatments along with research into causes and prevention. This issue addresses therapies, early therapies, diagnoses, and prevention. Topics include: Endovascular Treatment of Acute Ischemic Stroke; Acute Treatment of Blood Pressure after Ischemic Stroke and Intracerebral Hemorrhage; Diagnostic Evaluation for Non-traumatic Intracerebral Hemorrhage; Prevention of Recurrent Stroke in Patients with Patent Foramen Ovale; Management of Asymptomatic Carotid Stenosis; Stenting or Endarterectomy for Patients with Symptomatic Carotid Stenosis; The Therapeutic Value of Laboratory Testing for Hypercoagulable States in Secondary Stroke Prevention; Diagnosis and Treatment of Carotid and Vertebral Artery Dissection; Recurrent Stroke while on Anti-platelet Therapy; Anti-platelet and Anti-coagulant Therapy after Intracerebral Hemorrhage; Diagnosis and Treatment of Isolated Central Nervous System Angiitis/Vasculitis; Statins for Aneurysmal Subarachnoid Hemorrhage; Expansion of IV-tPA eligibility beyond NINDS and ECASS III criteria; and Treatment of Unruptured Arteriovenous Malformations. William J Powers MD, renowned for his clinical work with Stroke and Research in Cerebral blood flow and metabolism, and stroke treatment and prevention, leads this issue of Neurologic Clinics, with authors renown in the field.

  • Food Safety and Quality Systems in Developing Countries

    Volume One: Export Challenges and Implementation Strategies
    • 1st Edition
    • André Gordon
    • English
    Food Safety and Quality Systems in Developing Countries, Volume One: Export Challenges and Implementation Strategies considers both the theoretical and practical aspects of food safety and quality systems implementation by major world markets and new and emerging markets in developing countries. This reference examines issues facing exporters and importers of traditional foods the characteristics of the food and its distribution channels, and market access from a historical and current context to present best practices. This must-have reference offers real-life, practical approaches for foods from around the world, offering help to those who have found it difficult to implement sustainable, certifiable food safety and quality systems into their businesses and provides scientifically sound solutions to support their implementation.

  • Anti-Angiogenesis Drug Discovery and Development

    Volume 2
    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

  • Recent Advances in Medicinal Chemistry, Volume 1

    • 1st Edition
    • Atta-ur Rahman + 2 more
    • English
    Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

  • Drug Design and Discovery in Alzheimer’s Disease

    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of β-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

  • Person-Centered Communication with Older Adults

    The Professional Provider's Guide
    • 1st Edition
    • Timothy A. Storlie
    • English
    Providers serving older adults face a growing problem. Older adults are becoming increasingly dissatisfied with service quality citing deficits in provider communication and relationship skills. The author argues this dissatisfaction is largely related to three widespread issues: ageism, use of professional jargon, and age-related changes in the older adult. To address these concerns, Dr. Storlie advocates adoption of an evidence-based, person-centered approach to communication. The benefits of person-centered communication are many. They can increase older adult satisfaction with provider services, enhance mutual respect and understanding, improve accuracy of information exchanged, positively impact service outcomes, increase compliance with provider recommendations, and reduce the frustration and stress often experienced by both provider and older adult. Rare to this genre, readers are introduced to several under-explored topics within the field of communication, along with methods for applying concepts from research findings into these topics to enhance the quality of interpersonal communication. Topics include the role of mental imagery in the communication process, the influence of neurocardiology on relationships, and controversial findings from research into quantum physics. The book concludes by highlighting progress made in narrowing the interpersonal communication gap and forecasts how communications-orien... technological advances might improve quality of life for 21st century older adults and the providers who serve them. Utilizing interdisciplinary case studies to illustrate common problematic situations, this book provides detailed exercises that explain how providers can integrate person-centered communication into their practices to improve provider-older adult interactions. Written in a style designed to maximize learning, it helps providers find the information they need, understand what they read, and apply what they’ve learned to improve professional communication. Person-Centered Communication with Older Adults is an essential guide for today’s healthcare professionals and other aging-services providers, and also for the educators who help to prepare the providers of tomorrow.

  • Gene Therapy for Viral Infections

    • 1st Edition
    • Patrick Arbuthnot
    • English
    Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology.

  • Knowledge Driven Development

    Private Extension and Global Lessons
    • 1st Edition
    • Yuan Zhou + 1 more
    • English
    Knowledge Driven Development: Private Extension and Global Lessons uses actual cases written specifically to study the role and capacity of private companies in knowledge sharing and intensification through agricultural extension. Descriptions of specific models and approaches are teased out of complex situations exhibiting a range of agricultural, regulatory, socio-economic variables. Illustrative cases focus on a particular agricultural value chain and elaborate the special feature of the associated private extension system. Chapters presenting individual cases of private extension also highlight specific areas of variations and significant deviance. Each chapter begins with a section describing the background and agricultural context of the case, followed by a description of the specific crop value chain. Based on understanding of this context, extension models and methods by private companies receive deeper analysis and definition in the next section. This leads to a discussion of the private extension with respect to its relevance, efficiency, effectiveness, equity, sustainability and impact. Following that, comparison with public extension, the uniqueness of the knowledge intensification model, and lessons for its replication and scaling up are elaborated. The final chapter summarizes the major results from the ten cases presented, looking at the trends, commonalities and differences of various extension approaches and the general lessons for success or failure. It concludes with a set of messages around value creation, integrated services, market links, inclusive innovation, and capacity development.

  • Epigenetic Technological Applications

    • 1st Edition
    • Yujun George Zheng
    • English
    Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm.

  • Contextual Inquiry for Medical Device Design

    • 1st Edition
    • Mary Beth Privitera
    • English
    Contextual Inquiry for Medical Device Design helps users understand the everyday use of medical devices and the way their usage supports the development of better products and increased market acceptance. The text explains the concept of contextual inquiry using real-life examples to illustrate its application. Case studies provide a frame of reference on how contextual inquiry is successfully used during product design, ultimately producing safer, improved medical devices.

  • The Comprehensive Sourcebook of Bacterial Protein Toxins

    • 4th Edition
    • Joseph E. Alouf + 2 more
    • English
    The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

  • Trigeminocardiac Reflex

    • 1st Edition
    • Tumul Chowdhury + 1 more
    • English
    Trigeminocardiac Reflex is a comprehensive tutorial reference to the science, diagnosis, and possible treatment of the trigeminocardiac reflex (TCR) that is usually initiated when the trigeminal nerve is disturbed during intercranial surgery. Since first reported in 1999 by co-Editor Bernhard Schaller, the research focused on TCR is expanding. While its instance is rare, new discoveries are not only increasing diagnosis, but also providing more effective treatment protocols. This text is ideal as a reference for clinical and research neurologists, as a general introduction for clinical presentation, and as a foundation for new research.

  • MRI/DTI Atlas of the Rat Brain

    • 1st Edition
    • George Paxinos + 4 more
    • English
    MRI/DTI Atlas of the Rat Brain offers two major enhancements when compared with earlier attempts to make MRI/DTI rat brain atlases. First, the spatial resolution at 25µm is considerably higher than previous data published. Secondly, the comprehensive set of MRI/DTI contrasts provided has enabled the authors to identify more than 80% of structures identified in The Rat Brain in Stereotaxic Coordinates.

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