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Advances in Bacterial Pathogen Biology
- 1st Edition, Volume 65 - November 11, 2014
- Editor: Robert K. Poole
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 0 1 4 2 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 0 3 0 5 - 3
This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on bi… Read more
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Request a sales quoteThis volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included.
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
Microbiologists, biochemists, biotechnologists, and those interested in physiology, microbial biochemistry and its applications.
Chapter One: Energetics of Pathogenic Bacteria and Opportunities for Drug Development
- Abstract
- 1 Introduction
- 2 Bacterial Energetics as a Target Space for Drug Development
- 3 Conclusions and Future Perspectives
- Acknowledgements
Chapter Two: The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile
- Abstract
- 1 Introduction to Clostridium difficile and CDI
- 2 Introns
- 3 IStrons
- 4 Mobilisable Transposons
- 5 Conjugative Transposons
- 6 Other Integrative MGEs in C. difficile
- 7 The skinCd Element
- 8 Bacteriophages
- 9 Transfer of the PaLoc
- 10 Conclusions
Chapter Three: Metal Ion Homeostasis in Listeria monocytogenes and Importance in Host–Pathogen Interactions
- Abstract
- 1 Introduction
- 2 Overview of Listeria monocytogenes Disease Progression
- 3 Control of Metal Levels in Bacteria
- 4 L. monocytogenes and Zinc
- 5 L. monocytogenes and Copper
- 6 Concluding Remarks
Chapter Four: The Role of Macrophages in the Innate Immune Response to Streptococcus pneumoniae and Staphylococcus aureus: Mechanisms and Contrasts
- Abstract
- 1 Introduction
- 2 S. pneumoniae Virulence Factors Impede Phagocytosis and Its Consequences
- 3 S. aureus Virulence Factors Subvert Multiple Innate Immune Responses Including Intracellular Killing
- 4 Origins of Macrophages
- 5 The Spectrum of Macrophage Activation
- 6 Epigenetic Regulation of Macrophage Function
- 7 Mechanisms of Macrophage Phagocytosis
- 8 Phagocytosis of S. pneumoniae and S. aureus
- 9 Intracellular Localisation of Bacteria
- 10 Microbial Killing by Macrophages
- 11 Apoptosis-Associated Killing Complements Clearance of S. pneumoniae
- 12 Macrophage Killing of S. aureus
- 13 Macrophage Orchestration of the Inflammatory Response
- 14 Pattern Recognition Receptors in the Recognition of S. pneumoniae and S. aureus
- 15 Conclusion
- Conflict of Interest
Chapter Five: Aeromonas Flagella and Colonisation Mechanisms
- Abstract
- 1 Introduction
- 2 Flagella
- 3 Lipopolysaccharide and Capsules
- 4 Pili
- 5 Outer-Membrane Proteins and S-Layer
- 6 Aeromonad Colonisation and Host Response
- 7 Conclusions and Outlook
Chapter Six: Physiological Adaptations of Key Oral Bacteria
- Abstract
- 1 Introduction
- 2 Key Oral Environmental Niches
- 3 The Major Infections of the Oral Cavity
- 4 Bacterial Adaptations in the Oral Cavity
- 5 Surface Adhesins as Colonisation Factors of Oral Bacteria
- 6 Stress Responses of Import in Colonisation and Infection by Oral Bacteria
- 7 Summary and Future Perspectives
- Acknowledgements
Chapter Seven: Virulence Factors of Uropathogenic E. coli and Their Interaction with the Host
- Abstract
- 1 Introduction
- 2 Pathogenesis of Urinary Tract Infection
- 3 Adhesins
- 4 Toxins
- 5 Iron-Acquisition Systems
- 6 Immune Evasion Mechanisms
- 7 Conclusion
- No. of pages: 448
- Language: English
- Edition: 1
- Volume: 65
- Published: November 11, 2014
- Imprint: Academic Press
- Hardback ISBN: 9780128001424
- eBook ISBN: 9780128003053
RP
Robert K. Poole
Professor Robert K Poole is Emeritus Professor of Microbiology at the University of Sheffield, UK. He was previously West Riding Professor of Microbiology at Sheffield and until 1996 held a Personal Chair in Microbiology at King’s College London. During his long career, he has been awarded several research Fellowships, and taken sabbatical leave at the Australian National University, Kyoto University and Cornell University. His career-long interests have been in the areas of bacterial respiratory metabolism, metal-microbe interactions and bioactive small gas molecules. In particular, he has made notable contributions to bacterial terminal oxidases and resistance to nitric oxide with implications for bacterial pathogenesis. He co-discovered the flavohaemoglobin Hmp, now recognised as the preeminent mechanism of nitric oxide resistance in bacteria. He has served as Chairman of numerous research council grant committees, held research grants for over 40 years and published extensively (h-index, 2024 = 70). He served on several Institute review panels in the UK and overseas. He is a Fellow of the Royal Society of Chemistry and the Royal Society of Biology.
Affiliations and expertise
West Riding Professor of Microbiology, Department of Molecular Biology and Biotechnology, University of Sheffield, UKRead Advances in Bacterial Pathogen Biology on ScienceDirect