Chapter One: Energetics of Pathogenic Bacteria and Opportunities for Drug Development
- Abstract
- 1 Introduction
- 2 Bacterial Energetics as a Target Space for Drug Development
- 3 Conclusions and Future Perspectives
- Acknowledgements
Chapter Two: The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile
- Abstract
- 1 Introduction to Clostridium difficile and CDI
- 2 Introns
- 3 IStrons
- 4 Mobilisable Transposons
- 5 Conjugative Transposons
- 6 Other Integrative MGEs in C. difficile
- 7 The skinCd Element
- 8 Bacteriophages
- 9 Transfer of the PaLoc
- 10 Conclusions
Chapter Three: Metal Ion Homeostasis in Listeria monocytogenes and Importance in Host–Pathogen Interactions
- Abstract
- 1 Introduction
- 2 Overview of Listeria monocytogenes Disease Progression
- 3 Control of Metal Levels in Bacteria
- 4 L. monocytogenes and Zinc
- 5 L. monocytogenes and Copper
- 6 Concluding Remarks
Chapter Four: The Role of Macrophages in the Innate Immune Response to Streptococcus pneumoniae and Staphylococcus aureus: Mechanisms and Contrasts
- Abstract
- 1 Introduction
- 2 S. pneumoniae Virulence Factors Impede Phagocytosis and Its Consequences
- 3 S. aureus Virulence Factors Subvert Multiple Innate Immune Responses Including Intracellular Killing
- 4 Origins of Macrophages
- 5 The Spectrum of Macrophage Activation
- 6 Epigenetic Regulation of Macrophage Function
- 7 Mechanisms of Macrophage Phagocytosis
- 8 Phagocytosis of S. pneumoniae and S. aureus
- 9 Intracellular Localisation of Bacteria
- 10 Microbial Killing by Macrophages
- 11 Apoptosis-Associated Killing Complements Clearance of S. pneumoniae
- 12 Macrophage Killing of S. aureus
- 13 Macrophage Orchestration of the Inflammatory Response
- 14 Pattern Recognition Receptors in the Recognition of S. pneumoniae and S. aureus
- 15 Conclusion
- Conflict of Interest
Chapter Five: Aeromonas Flagella and Colonisation Mechanisms
- Abstract
- 1 Introduction
- 2 Flagella
- 3 Lipopolysaccharide and Capsules
- 4 Pili
- 5 Outer-Membrane Proteins and S-Layer
- 6 Aeromonad Colonisation and Host Response
- 7 Conclusions and Outlook
Chapter Six: Physiological Adaptations of Key Oral Bacteria
- Abstract
- 1 Introduction
- 2 Key Oral Environmental Niches
- 3 The Major Infections of the Oral Cavity
- 4 Bacterial Adaptations in the Oral Cavity
- 5 Surface Adhesins as Colonisation Factors of Oral Bacteria
- 6 Stress Responses of Import in Colonisation and Infection by Oral Bacteria
- 7 Summary and Future Perspectives
- Acknowledgements
Chapter Seven: Virulence Factors of Uropathogenic E. coli and Their Interaction with the Host
- Abstract
- 1 Introduction
- 2 Pathogenesis of Urinary Tract Infection
- 3 Adhesins
- 4 Toxins
- 5 Iron-Acquisition Systems
- 6 Immune Evasion Mechanisms
- 7 Conclusion