Advances in Clinical Chemistry
- 1st Edition, Volume 67 - November 20, 2014
- Imprint: Academic Press
- Editor: Gregory S. Makowski
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 2 2 6 7 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 2 4 6 6 - 9
Volume 67 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research… Read more
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Request a sales quoteVolume 67 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.
- Expertise of international contributors
- Latest cutting-edge technologies
- Comprehensive in scope
Clinical Laboratory Professionals, Physicians and Research Scientists
- Preface
- Chapter One: Biomarkers of Tobacco Smoke Exposure
- Abstract
- 1 Introduction
- 2 Definitions
- 3 Types of Biomarkers
- 4 Biomarkers of Smoking Versus Biomarkers of Biological State
- 5 From Smoke to Disease: Genomics and Novel Molecular Pathways
- 6 Modulating Factors
- 7 Biomarker Uses
- 8 Validation and Qualification
- 9 Conclusions
- Disclaimer
- Chapter Two: Ethyl Glucuronide and Ethyl Sulfate
- Abstract
- 1 Introduction
- 2 Metabolism of Alcohol
- 3 Stability
- 4 Cutoff Values
- 5 Detection Times
- 6 Methods for Measurement of EtG and EtS
- 7 Applications
- 8 Confounders Causing False-Positive or False-Negative Results
- 9 Conclusions
- Declarations
- Chapter Three: Ammonia Metabolism and Hyperammonemic Disorders
- Abstract
- 1 Introduction
- 2 Solubility of Ammonia and Transport Across Cell Membranes
- 3 Sources of Ammonia
- 4 Disposal of Ammonia
- 5 Ammonia Metabolism in Liver
- 6 Ammonia Metabolism in Brain
- 7 Ammonia and Arginine Production in the Kidneys
- 8 Toxicity of Ammonia
- 9 The Pathogenesis of Hyperammonemic Encephalopathy
- 10 Clinical Disorders with HA: Overview
- 11 Inherited Hyperammonemic Disorders
- 12 Liver Disease
- 13 Sodium Valproate
- 14 Urinary Tract Disorders
- 15 Miscellaneous Causes
- 16 Conclusions
- Chapter Four: 5-Methylcytosine and Its Derivatives
- Abstract
- 1 Introduction
- 2 Global Detection of 5-mC and Its Oxidation Derivatives
- 3 Location Analysis of 5-mC and Its Derivatives
- 4 Conclusions and Perspectives
- Acknowledgments
- Chapter Five: Circulating microRNAs as Promising Tumor Biomarkers
- Abstract
- 1 Introduction
- 2 miRNA Biogenesis
- 3 miRNAs and Cancer
- 4 Origin and Function of Circulating miRNAs
- 5 Detection of Circulating miRNAs
- 6 Circulating miRNAs as Cancer Biomarkers
- 7 Conclusions
- Chapter Six: Proteomics in Transplantation
- Abstract
- 1 Introduction
- 2 History
- 3 Sample Sources
- 4 Proteomic Technology
- 5 Proteomic Studies
- 6 Future Aspects, Quo Vadis?
- Chapter Seven: Fibulins and Their Role in Cardiovascular Biology and Disease
- Abstract
- 1 Introduction
- 2 Genes, Expression and Biochemistry
- 3 Genetically Modified Animals
- 4 Expression of Fibulins in Heart and Vasculature During Development
- 5 Fibulins in Arterial Disease
- 6 Fibulins and Heart Disease
- 7 Circulating Fibulins
- 8 Fibulins and Hemostasis
- 9 Fibulins and Possible Mechanism of Regulation
- 10 Conclusions and Perspectives
- Index
- Edition: 1
- Volume: 67
- Published: November 20, 2014
- No. of pages (Hardback): 284
- No. of pages (eBook): 284
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128022672
- eBook ISBN: 9780128024669
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board-certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President Clinical Laboratory Services Hartford HealthCare in Connecticut.
Affiliations and expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USARead Advances in Clinical Chemistry on ScienceDirect