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Metal-Containing Enzymes
1st Edition - November 20, 2014
Editor: Christo Christov
Hardback ISBN:9780128000120
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eBook ISBN:9780128007884
9 7 8 - 0 - 1 2 - 8 0 0 7 8 8 - 4
Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new… Read more
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
Describes advances in metal-containing enzymes
Chapters are written by authorities in their field
Targeted to a wide audience of researchers, specialists, and students
The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables
researchers and specialists in metal-containing enzymes
4 X-ray Crystallographic Structural Data of PPOs and Hemocyanins
5 Conclusions and Outlook Acknowledgments Two: Biophysical Studies of Matrix Metalloproteinase/Triple-Helix Complexes Abstract
1 MMPs and Collagen Hydrolysis
2 Structures of Full-Length, Collagenolytic MMPs in Solution and in the Solid State
3 Structural Evaluation of MMP Interactions with Collagen
4 Mechanism of Collagenolysis
5 Heterogeneity in MMP Structures Acknowledgment Three: Catalytic Mechanisms of Metallohydrolases Containing Two Metal Ions Abstract
1 Introduction
2 Metallo-β-Lactamases, Major Culprits in the Emergence of Antibiotic Resistance
3 Methionine Aminopeptidase, a Target for Novel Anticancer Drugs
4 Glycerophosphodiesterase, a Very Promiscuous Potential Bioremediator
5 PAP, an Alternative Target to Treat Osteoporosis
6 Conclusions and Outlook: Agmatinase, an Emerging Target for Biotechnological Applications Acknowledgments Four: Applications of Quantum Mechanical/Molecular Mechanical Methods to the Chemical Insertion Step of DNA and RNA Polymerization Abstract
1 Introduction
2 Methods for Describing Reactive Pathways
3 DNA Polymerase β
4 Application of QM/MM to Systems Similar to Pol β
5 RNA Polymerase
6 Thoughts for Future QM/MM Simulations on Ternary Substrate Complexes of Nucleic Acid Polymerases
7 Conclusions Acknowledgments Five: Monitoring the Biomolecular Interactions and the Activity of Zn-Containing Enzymes Involved in Conformational Diseases: Experimental Methods for Therapeutic Purposes Abstract
1 Zn-Metalloproteases and Conformational Diseases
2 Analytical Techniques Used to Study ZnMPs-Substrate/Inhibitors Interactions
3 Conclusions and Future Perspectives Author Index Subject Index
No. of pages: 174
Language: English
Published: November 20, 2014
Imprint: Academic Press
Hardback ISBN: 9780128000120
eBook ISBN: 9780128007884
CC
Christo Christov
Dr. Christo Z. Christov teaches at Northumbria University, Ellison Building, Newcastle-upon-Tyne, UK
Affiliations and expertise
Department of Chemistry, Michigan Technological University, Houghton, MI, USA