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Elsevier

Books in Life sciences

  • Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B

    • 1st Edition
    • Volume 180
    • English
    Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas.

  • Apoptosis in Health and Disease - Part A

    • 1st Edition
    • Volume 125
    • Rossen Donev
    • English
    Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed.

  • iPSCs for Modeling Central Nervous System Disorders, Volume 6

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into　Induced pluripotent stem cells　by the expression of specific transcription factors. These cells　are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field.

  • Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

    • 1st Edition
    • Moyra Smith
    • English
    Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

  • Transdisciplinary Case Studies on Design for Food and Sustainability

    • 1st Edition
    • Sonia Massari
    • English
    Transdisciplinary Case Studies on Design for Food and Sustainability, a volume in the Consumer Science and Strategic Marketing series, analyzes the interconnectivity of sustainability, food, and design, demonstrating the presence of food design in various food-related fields of study. Broken into six parts, the book begins with the theory behind food and design. The following five sections include several case studies highlighting the different forms and applications of food design, including the use of food design in production and distribution, in food and restaurant businesses, in territory-identity, in social food design, and with regard to post-consumption. Using a case study approach to meet the needs of both academics and practitioners, Transdisciplinary Case Studies on Design for Food and Sustainability includes practical examples to illustrate food system challenges, to explain phenomena, and to build theory.

  • Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus

    • 1st Edition
    • Volume 262
    • English
    Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus, Volume 262, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on current topics such as Cochlear implantation for patients with tinnitus – a systematic review, Event Related Potentials to Assess the Tinnitus complaint during drug treatment, The difference in post-stimulus suppression between residual inhibition and forward masking, Sleep, sleep apnea and tinnitus, A Bayesian brain in imbalance: medial, lateral and descending pathways in tinnitus and pain, Tinnitus features according to caffeine consumption, and much more.

  • Remodeling Forensic Skeletal Age

    Modern Applications and New Research Directions
    • 1st Edition
    • Bridget F.B. Algee‐Hewitt + 1 more
    • English
    Remodeling Forensic Skeletal Age: Modern Applications and New Research Directions presents a comprehensive understanding of the analytical frameworks and conceptual approaches surrounding forensic age estimation and the current state of the field. The book also includes a series of recommendations of best practice through chapter-examples that offer theory and guidance for data acquisition, technique and/or model development, and the assessment of impact of the adopted approaches. Written by leading, international experts, the book's contributors provide an introduction, conceptual understanding and taxonomy of statistical frameworks and computational approaches, including the Bayesian paradigm and machine learning techniques for age estimation.

  • Atlas of the Pig Gut

    Research and Techniques from Birth to Adulthood
    • 1st Edition
    • Romuald Zabielski + 1 more
    • English
    Atlas of the Pig Gut: Research and Techniques from Birth to Adulthood examines the development of the gastrointestinal tract in swine. It focuses on changes occurring during the developmental phase, with an emphasis on the gut that is reflected in alterations of the intestinal mucosa architecture. Led by leading experts in pig digestion research, the book contains descriptions and microphotographs of the most updated research. The changes occurring in the intestine are presented in a comprehensive order, from small magnifications of tissue structures to high magnifications of fragments of epithelium-building cell structures. Additionally, the book highlights the replacement mechanism of epithelial cells during the development of the small intestinal mucosa. This book is the ideal resource for animal science researchers and practitioners. In addition, swine veterinarians and academics will also find it useful due to its helpful, detailed graphics and organized structure.

  • Cyclospora and Cyclosporiasis

    Epidemiology, Diagnosis, Detection, and Control
    • 1st Edition
    • Long Zhang + 3 more
    • English
    Cyclospora cayetanensis is a microscopic parasite that can be transmitted via food or water sources and causes intestinal disease (Cyclosporiasis) in humans. Cyclospora and Cyclosporiasis: Epidemiology, Diagnosis, Detection, and Control reviews 22 species of Cyclospora and discusses C. cayetanensis infection in humans. This book offers comprehensive coverage that includes taxonomy and biology, molecular characteristics, and transmission of the parasite. It also provides researchers, clinicians, public health officials, and food safety officials with basic data for the epidemiology of the Cyclospora spp. or C. cayetanensis, as well as strategies to monitor large-scale outbreaks of Cyclospora spp. or C. cayetanensis. The book further covers clinical symptoms, diagnostic methods, and means of treatment and prevention of this disease and informs readers of the hazards of the parasite, common means of transmission, and self-protection measures.

  • Non-Canonical Autophagy

    Mechanisms and Pathophysiological Implications
    • 1st Edition
    • Giulia Petroni + 1 more
    • English
    Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies.

  • Rare-Earth Element Biochemistry: Characterization and Applications of Lanthanide-Binding Biomolecules

    • 1st Edition
    • Volume 651
    • English
    Rare-Earth Element Biochemistry: Characterization and Applications of Lanthanide-Binding Biomolecules, Volume 651 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Spectrophotometric methods to probe the solution chemistry of lanthanide complexes with macromolecules, Determination of affinities of lanthanide-binding proteins using chelator-buffered titrations, Electron Paramagnetic Resonance of Lanthanides, Characterization of lanthanoid binding proteins using NMR spectroscopy, Macromolecular crystallography for f-element complex characterization, Infrared spectroscopy probes ion binding geometries, Predicting lanthanide coordination structures in solution with molecular simulation, and much more. Additional sections cover the Characteristics of Gd(III) spin labels for the study of protein conformations, Lanthanide-based resonance energy transfer biosensors for live-cell applications, Yttrium-86 PET imaging, Aqueous Chemistry of the Smallest Rare Earth: Comprehensive Characterization of Radioactive and Non-radioactive Scandium Complexes for Biological Applications, and In vitro selection and application of lanthanide-dependent DNAzymes.

  • Practical Diabetes Care for Healthcare Professionals

    • 2nd Edition
    • Sora Ludwig
    • English
    Practical Diabetes Care for Healthcare Professionals, Second Edition, helps healthcare professionals get up-to-speed on type 2 diabetes care. Type 2 diabetes is multifaceted, affecting a person’s daily life, family and workplace. Beyond the usual health impact, diabetes may also carry significant psychological burdens. Successful care means whole [person] care which can be daunting for an individual healthcare provider. The complete assessment of people with diabetes must include a review of diabetes medications, blood glucose levels, nutritional intake, physical activity, and stress. Also important is a review of possible micro- and macrovascular complications. This practical guide translates research and evidence-based recommendations into everyday clinical practice, with the goal of helping all members of the healthcare team more effectively manage their diabetic patients.

  • Biotechnology of Terpenoid Production from Microbial Cell Factories

    • 1st Edition
    • Pratima Gupta + 1 more
    • English
    Biotechnology of Terpenoid Production from Microbial Cell Factories is a unique reference to help researchers, scientists and scholars explore available strategies involved in the production of terpenoid-based, value-added compounds from GRAS status (Generally Recognized as Safe by FDA) microbes to address the associated challenges for the industry. The book covers the most up-to-date information about microbial terpenoid production, including culture condition modulation for the improved and high-specificity production of terpenoid and their in-situ extraction. Each class of terpenoid is explained in detail, including their nutritional and pharmaceutical information and their molecular aspects.

  • Neurotoxicity of Metals: Old Issues and New Developments

    • 1st Edition
    • Volume 5
    • English
    The volume discusses novel issues associated with the neurotoxicity of select metals

  • Microbiome Stimulants for Crops

    Mechanisms and Applications
    • 1st Edition
    • James F. White + 2 more
    • English
    Microbiome Stimulants for Crops: Mechanisms and Applications provides the latest developments in the real-world development and application of these crop management alternatives in a cost-effective, yield protective way. Sections address questions of research, development and application, with insights into recent legislative efforts in Europe and the United States. The book includes valuable information regarding mechanisms and the practical information needed to support the growing microbial inoculant and biostimulant industry, thus helping focus scientific research in new directions.

  • Rare-earth element biochemistry: Methanol dehydrogenases and lanthanide biology

    • 1st Edition
    • Volume 650
    • English
    Methods in Enzymology, Volume 650 continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Biophysical methods to study lanthanide-protein interactions, Genetically encoded sensors to study lanthanide biology, Spectrophotometric methods to determine the stability constants of lanthanide-macromole... complexes, Lanthanide-based probes for amino acid modifications, In vitro selection and application of lanthanide-dependent DNAzymes, LRET biosensors for imaging protein interactions in living cells, Synthetic Modeling of the Structure and Function of the Lanthanide-Dependent... MDH Cofactor, EPR spectroscopy of lanthanides, Macromolecular crystallography for f-element complex characterization, and much more.

  • Inmunología

    • 9th Edition
    • David Male + 2 more
    • Spanish
    Novena edición que ofrece una aproximación bien ilustrada y cuidadosamente estructurada que incluye todos los conceptos básicos y clínicos necesarios para la preparación de los cursos de la especialidad. La obra ha sido editada y redactada por expertos docentes e investigadores, por lo que proporciona un contenido coherente y de vanguardia que vincula el laboratorio y la práctica clínica. Presenta un contenido reorganizado que muestra la inmunología en el orden en que se suele enseñar y aprender, integrando mejor la inmunología básica y la clínica. Aborda nuevos temas, como las células linfocíticas innatas, los tratamientos basados en anticuerpos y la ingeniería de anticuerpos, la inmunidad innata y sus componentes, la genética de las enfermedades con base inmunitaria, la medicina personalizada y los fármacos inmunoterapéuticos para el tratamiento del cáncer. Con un formato fácil de usar y codificado con colores, incluye cuadros con conceptos clave, diagramas explicativos y casi 200 fotografías para ayudar a comprender y memorizar de forma visual los conceptos más difíciles. Además ofrece resúmenes de capítulo, cuadros de razonamiento crítico y preguntas basadas en casos clínicos que facilitan una revisión rápida y eficaz para la preparación de los exámenes. Explica los componentes básicos del sistema inmunitario (células, órganos y moléculas receptoras principales), así como la activación y las acciones de la respuesta inmunitaria, especialmente en el contexto clínico y proporciona la información clínica más actualizada, incluidos los más recientes abordajes clínicos de la inmunología del cáncer, el trasplante, la autoinmunidad y la hipersensibilidad, entre otros. Incluye el acceso a la versión electrónica del libro en Student Consult, que cuenta con textos ampliados, figuras y tablas adicionales, un banco de preguntas de autoevalución complementario y un total de 16 vídeos. El contenido incluido en Student Consult está íntegramente en inglés.

  • Machine Learning and the Internet of Medical Things in Healthcare

    • 1st Edition
    • Krishna Kant Singh + 3 more
    • English
    Machine Learning and the Internet of Medical Things in Healthcare discusses the applications and challenges of machine learning for healthcare applications. The book provides a platform for presenting machine learning-enabled healthcare techniques and offers a mathematical and conceptual background of the latest technology. It describes machine learning techniques along with the emerging platform of the Internet of Medical Things used by practitioners and researchers worldwide. The book includes deep feed forward networks, regularization, optimization algorithms, convolutional networks, sequence modeling, and practical methodology. It also presents the concepts of the Internet of Things, the set of technologies that develops traditional devices into smart devices. Finally, the book offers research perspectives, covering the convergence of machine learning and IoT. It also presents the application of these technologies in the development of healthcare frameworks.

  • Dendrimer-Based Nanotherapeutics

    • 1st Edition
    • Prashant Kesharwani
    • English
    Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields.

  • Autophagy and Senescence in Cancer Therapy

    • 1st Edition
    • Volume 150
    • English
    Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.

  • Pituitary Tumors

    A Comprehensive and Interdisciplinary Approach
    • 1st Edition
    • Jürgen Honegger + 2 more
    • English
    Pituitary Tumors: A Comprehensive and Interdisciplinary Approach provides the latest information on preclinical issues, diagnostic procedures, treatment options and post-treatment care for patients with pituitary tumors. The book includes basic and advanced knowledge for a broad audience, including physicians, endocrinologists, neurosurgeons, neuro-radiologists, neuro-ophthalmologis... neuro-pathologists, oncologists, radiotherapists and researchers who are investigating pituitary tumors. Readers will find the latest research surrounding progress on uncoding the molecular mechanisms involved in tumor genesis. In addition, standard treatment modalities, including surgery, medical treatment and radiosurgery are explored.

  • Global Perspectives on Astaxanthin

    From Industrial Production to Food, Health, and Pharmaceutical Applications
    • 1st Edition
    • Gokare A. Ravishankar + 1 more
    • English
    Global Perspectives on Astaxanthin: From Industrial Production to Food, Health, and Pharmaceutical Applications explores the range of practical applications for this molecule, focusing on nutraceutical, pharmaceutical and cosmeceutical products, along with food and feed. This volume brings together the most relevant research, background and future thinking on astaxanthin, focusing on its health benefits. Chapters cover phytopharmaceuticals... industrial production, feeds, downstream processing, regulations, products, color, pigment, cosmetics, bioactive compounds, relationships to other carotenoids, and skin care. The detailed information on its production, processing, utilization and future applications will be of particular use to academic and industry researchers in pharmaceutical sciences, pharmacology and nutrition.

  • Epidemiology of Brain and Spinal Tumors

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors.

  • Memory Loss, Alzheimer's Disease and Dementia

    A Practical Guide for Clinicians
    • 3rd Edition
    • Andrew E. Budson + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 with "Essential Purchase" designation in Geriatrics**With a focus on the practical, day-to-day tools needed by neurologists, psychiatrists, geriatricians, and others who work with the elderly, Memory Loss, Alzheimer's Disease and Dementia, 3rd Edition, is an indispensable, easy-to-read resource in this growing area. Clinical experts Drs. Andrew Budson and Paul Solomon cover the essentials of physical and cognitive examinations and laboratory and imaging studies for dementia and related illnesses, giving you the guidance you need to make accurate diagnosis and treatment decisions with confidence.

  • Handbook of Computational Intelligence in Biomedical Engineering and Healthcare

    • 1st Edition
    • Janmenjoy Nayak + 3 more
    • English
    Handbook of Computational Intelligence in Biomedical Engineering and Healthcare helps readers analyze and conduct advanced research in specialty healthcare applications surrounding oncology, genomics and genetic data, ontologies construction, bio-memetic systems, biomedical electronics, protein structure prediction, and biomedical data analysis. The book provides the reader with a comprehensive guide to advanced computational intelligence, spanning deep learning, fuzzy logic, connectionist systems, evolutionary computation, cellular automata, self-organizing systems, soft computing, and hybrid intelligent systems in biomedical and healthcare applications. Sections focus on important biomedical engineering applications, including biosensors, enzyme immobilization techniques, immuno-assays, and nanomaterials for biosensors and other biomedical techniques. Other sections cover gene-based solutions and applications through computational intelligence techniques and the impact of nonlinear/unstructur... data on experimental analysis.

  • Pragmatic Randomized Clinical Trials

    Using Primary Data Collection and Electronic Health Records
    • 1st Edition
    • Cynthia J. Girman + 1 more
    • English
    Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation, and dissemination of pragmatic randomized trials, also sometimes referred to as practical or hybrid randomized trials. While less restrictive and more generalizable than traditional randomized controlled trials, such trials have specific challenges which are addressed in this book. The book contains chapters encompassing common designs along with advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize pragmatic randomized trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed.This comprehensive resource is valuable not only for pharmacoepidemiologi... biostatisticians and clinical researchers, but also across the biomedical field for those who are interested in applying pragmatic randomized clinical trials in their research.

  • Metal and Nutrient Transporters in Abiotic Stress

    • 1st Edition
    • Aryadeep Roychoudhury + 2 more
    • English
    Metal and Nutrient Transporters in Abiotic Stress focuses on the different forms of environmental stress related to heavy metal, metalloid and nutrient deficiency that have the potential to inflict major damages to crop plants, leading to a massive decrease in crop yield and productivity. The book presents the current state of knowledge of the biochemical and molecular regulation of several classes of membrane transporters related to the uptake of metals/metalloids and nutrient elements during different stresses and their probable mechanisms of operation in plant stress tolerance. Metal and Nutrient Transporters in Abiotic Stress provides a comprehensive discussion that will help in mitigating multiple forms of stresses utilizing transporter proteins. Edited by leading experts and written by a global team of knowledgeable contributors, this book will further stimulate research in the field of transporter proteins and will foster further interests for researchers, academicians and scientists worldwide. It is complimented by its companion book titled Transporters and Plant Osmotic Stress.

  • Fibroblast Growth Factor 23

    • 1st Edition
    • Christian Faul + 2 more
    • English
    Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23.

  • Pancreatic B Cell Biology in Health and Disease

    • 1st Edition
    • Volume 359
    • English
    Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more. Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease.

  • Neurology of Vision and Visual Disorders

    • 1st Edition
    • Volume 178
    • English
    Neurology of Vision and Visual Disorders, Volume 178 in the Handbooks of Neurology series provides comprehensive summaries of recent research on the brain and nervous system. This volume reviews alterations in vision that stem from the retina to the cortex. Coverage includes content on vision and driving derived from the large amount of time devoted in clinics to determining who is safe to drive, along with research on the interplay between visual loss, attention and strategic compensations that may determine driving suitability. The title concludes with vision therapies and the evidence behind these approaches. Each chapter is co-written by a basic scientist collaborating with a clinician to provide a solid underpinning of the mechanisms behind the clinical syndromes.

  • The Complex Interplay Between Gut-Brain, Gut-Liver, and Liver-Brain Axes

    • 1st Edition
    • Cristina Stasi
    • English
    The Complex Interplay Between Gut–Brain, Gut–Liver, and Liver–Brain Axes provides current and wide-ranging information in the field of gastrointestinal, liver, and brain interactions that can be used in resolving important clinical issues. This book is systematically split into three distinct sections. The first section introduces the pathophysiology of the gut–brain connection, including the causative effect of the interactions between the gut and brain in gastrointestinal and psychiatric/neurolog... disorders, and the role of serotonin and its pathways in gastrointestinal disorders. The second section examines the pathophysiology of the gut–liver connection along with the interactions between gut microbiota and liver in chronic liver diseases, with special focus on the role of serotonin and its pathways in hepatic fibrogenesis. Finally, the third section describes the pathophysiology of the liver–brain connection, including the role of gut microbiota in hepatic encephalopathy, as well as dietary and therapeutic interventions that target the gut microbiome.

  • Tumor Microenvironment Regulation of Tumor Expansion

    • 1st Edition
    • Domenico Ribatti
    • English
    Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.

  • Cellular Networks in Development

    • 1st Edition
    • Volume 143
    • English
    Current Topics in Developmental Biology, Volume 143, the latest release in this acclaimed series, highlights new advances in the field, with this new volume presenting new sections on Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells, Biomechanics of Amphibian Morphogenesis, Planar cell polarity during neural tube closure, Left-right asymmetry research in Xenopus: Questions solved and new frontiers, Xenopus neural crest and its relevance to human disease, Endoderm organogenesis, From egg to embryo in marsupial frogs, Evo-devo lessons from the analysis of Xenopus genomes, Transcriptional regulation during zygotic genome activation, and much more.

  • Reciprocal Translation Between Pathophysiology and Practice in Health and Disease

    • 1st Edition
    • Peter B. Soeters + 1 more
    • English
    Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.With contributions from Petronella L.M. Reijven.

  • Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations Part 2

    • 1st Edition
    • Volume 33
    • English
    Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations, Part Two, Volume 33 in the Advances in Biomembranes and Lipid Self-Assembly series, highlights new advances in the field, with sections in this new release covering Biomembranes of extracellular vesicles: The protein component, Protocol for isolation of Microvesicles form blood plasma, Urinary Extracellular vesicles at single patient level for clinical research, Treatment of chronic wounds with platelet and extracellular vesicles enriched plasma, Liposome loading and imaging, The Potential of Extracellular Vesicles for Brain Repair, Nucleic acids cargo of extracellular vesicles: Analysis and physiological function, Propolis flavonoids and terpenes, and much more.

  • Rational Machines and Artificial Intelligence

    • 1st Edition
    • Tshilidzi Marwala
    • English
    Intelligent machines are populating our social, economic and political spaces. These intelligent machines are powered by Artificial Intelligence technologies such as deep learning. They are used in decision making. One element of decision making is the issue of rationality. Regulations such as the General Data Protection Regulation (GDPR) require that decisions that are made by these intelligent machines are explainable. Rational Machines and Artificial Intelligence proposes that explainable decisions are good but the explanation must be rational to prevent these decisions from being challenged. Noted author Tshilidzi Marwala studies the concept of machine rationality and compares this to the rationality bounds prescribed by Nobel Laureate Herbert Simon and rationality bounds derived from the work of Nobel Laureates Richard Thaler and Daniel Kahneman. Rational Machines and Artificial Intelligence describes why machine rationality is flexibly bounded due to advances in technology. This effectively means that optimally designed machines are more rational than human beings. Readers will also learn whether machine rationality can be quantified and identify how this can be achieved. Furthermore, the author discusses whether machine rationality is subjective. Finally, the author examines whether a population of intelligent machines collectively make more rational decisions than individual machines. Examples in biomedical engineering, social sciences and the financial sectors are used to illustrate these concepts.

  • Recent Advances in iPSC Technology

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies.Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more.The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

  • Handbook of Decision Support Systems for Neurological Disorders

    • 1st Edition
    • D. Jude Hemanth
    • English
    Handbook of Decision Support Systems for Neurological Disorders provides readers with complete coverage of advanced computer-aided diagnosis systems for neurological disorders. While computer-aided decision support systems for different medical imaging modalities are available, this is the first book to solely concentrate on decision support systems for neurological disorders. Due to the increase in the prevalence of diseases such as Alzheimer, Parkinson’s and Dementia, this book will have significant importance in the medical field. Topics discussed include recent computational approaches, different types of neurological disorders, deep convolution neural networks, generative adversarial networks, auto encoders, recurrent neural networks, and modified/hybrid artificial neural networks.

  • What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology

    • 1st Edition
    • Volume 158
    • English
    What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more. Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal’s decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.

  • Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A

    • 1st Edition
    • Volume 179
    • English
    Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics.

  • Web Semantics

    Cutting Edge and Future Directions in Healthcare
    • 1st Edition
    • Sarika Jain + 2 more
    • English
    Web Semantics strengthen the description of web resources to exploit them better and make them more meaningful for both humans and machines, thereby contributing to the development of a knowledgeintensive data web. The world is experiencing the movement of concept from data to knowledge and the movement of web from document model to data model. The underlying idea is making the data machine understandable and processable. In the light of these trends, conciliation of Semantic and the Web is of paramount importance for further progress in the area. Web Semantics: Cutting Edge and Future Directions in Healthcare describes the three major components of the study of Semantic Web, namely Representation, Reasoning, and Security with a special focus on the healthcare domain. This book summarizes the trends and current research advances in web semantics, emphasizing the existing tools and techniques, methodologies, and research solutions. It provides easily comprehensible information on Web Semantics including semantics for data and semantics for services.

  • Carcinogen-Driven Mouse Models of Oncogenesis

    • 1st Edition
    • Volume 163
    • English
    Carcinogen-Driven Mouse Models of Oncogenesis, Volume 163 contains a series of protocols written by world-leading experts in the field. Each manuscript provides a detailed methodological description to drive carcinogen-mediated oncogenesis in mice. Chapters in this new release include Chemical carcinogenesis in mice as a model of human cancer: Pros and cons, MPA/DMBA-driven mammary carcinomas, Dimethylbenz(a)anthr... Mammary Tumorigenesis in mice, Urethane-induced lung carcinogenesis, Methylcholanthrene-i... fibrosarcomas, BBN-driven bladder carcinomas, Oral squamous cell carcinomas driven by 4NQO, Analyzing skin tumor development in mice by the DMBA/TPA model, and much more. Other sections cover DSS/AOM-driven colorectal carcinomas, Diethylnitrosamine-i... liver tumorigenesis in mice, Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induc... lung carcinogenesis in mice, Lung carcinomas induced by NNK and LPS, Pristane-induced mammary carcinomas, The 4-NQO mouse model: an update on a well-established in vivo model of oral carcinogenesis, and more.

  • Recent Highlights in the Discovery and Optimization of Crop Protection Products

    • 1st Edition
    • Peter Maienfisch + 1 more
    • English
    Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete. Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.

  • 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part B

    • 1st Edition
    • Volume 261
    • English
    The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Biofertilizers

    Volume 1: Advances in Bio-inoculants
    • 1st Edition
    • Amitava Rakshit + 4 more
    • English
    Biofertilizers, Volume One: Advances in Bio-inoculants provides state-of-the-art descriptions of various approaches, techniques and basic fundamentals of BI used in crop fertilization practices. The book presents research within a relevant theoretical framework to improve our understanding of core issues as applied to natural resource management. Authored by renowned scientists actively working on bio-inoculant, biofertilizer and bio-stimulant sciences, the book addresses the scope of inexpensive and energy neutral bio-inoculant technologies and the impact regulation has on biofertilizer utilization. This book is a valuable reference for agricultural/environ... scientists in academic and corporate environments, graduate and post-graduate students, regulators and policymakers.

  • Probiotics and Prebiotics in Foods

    Challenges, Innovations, and Advances
    • 1st Edition
    • Adriano Gomes da Cruz + 3 more
    • English
    Probiotic and Prebiotics in Foods: Challenges, Innovations, and Advances reviews recent advances, innovations, and challenges in probiotics/prebiotic... in food and beverages. The book presents up-to-date, novel and extensive information regarding recent research and applications in probiotics and prebiotics in food. Sections address probiotics, prebiotics, paraprobiotics and postbiotics, probiotics, prebiotics and bucal health, probiotics, prebiotics and obesity, probiotics, prebiotics and sleep quality, in vitro and in vivo assays for selection of probiotics, probiotics and mycotoxins, edible films added to probiotic and prebiotics, predictive microbiology applied to development of probiotic foods, non-bovine milk products as probiotic and prebiotic foods, emerging technologies, and much more. Written for food scientists, nutritionists, health professionals, food product developers, microbiologists, those working in food safety, and graduate students and researchers working in academia, this book is a welcomed resource on the topics discussed.

  • The Evolutionary Biology of Extinct and Extant Organisms

    • 1st Edition
    • Subir Ranjan Kundu
    • English
    The Evolutionary Biology of Extinct and Extant Organisms offers a thorough and detailed narration of the journey of biological evolution and its major transitional links to the biological world, which began with paleontological exploration of extinct organisms and now carries on with reviews of phylogenomic footprint reviews of extant, living fossils. This book moves through the defining evolutionary stepping stones starting with the evolutionary changes in prokaryotic, aquatic organisms over 4 billion years ago to the emergence of the modern human species in Earth’s Anthropocene. The book begins with an overview of the processes of evolutionary fitness, the epicenter of the principles of evolutionary biology. Whether through natural or experimental occurrence, evolutionary fitness has been found to be the cardinal instance of evolutionary links in an organism between its ancestral and contemporary states. The book then goes on to detail evolutionary trails and lineages of groups of organisms including mammalians, reptilians, and various fish. The final section of the book provides a look back at the evolutionary journey of "nonliving" or extinct organisms, versus the modern-day transition to "living" or extant organisms. The Evolutionary Biology of Extinct and Extant Organisms is the ideal resource for any researcher or advanced student in evolutionary studies, ranging from evolutionary biology to general life sciences.

  • Bradley and Daroff's Neurology in Clinical Practice, 2-Volume Set

    • 8th Edition
    • Joseph Jankovic + 2 more
    • Nancy J. Newman
    • English
    **Selected for Doody’s Core Titles® 2024 in Neurology**A practical, dynamic resource for practicing neurologists, clinicians and trainees, Bradley and Daroff's Neurology in Clinical Practice, Eighth Edition, offers a straightforward style, evidence-based information, and robust interactive content supplemented by treatment algorithms and images to keep you up to date with all that’s current in this fast-changing field. This two-volume set is ideal for daily reference, featuring a unique organization by presenting symptom/sign and by specific disease entities—allowing you to access content in ways that mirror how you practice. More than 150 expert contributors, led by Drs. Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy, and Nancy J. Newman, provide up-to-date guidance that equips you to effectively diagnose and manage the full range of neurological disorders.

  • The Neuroscience of Depression

    • 1st Edition
    • Colin R. Martin + 4 more
    • English
    The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

  • Diagnosis and Management of Hereditary Cancer

    Tabular-Based Clinical and Genetic Aspects
    • 1st Edition
    • John W. Henson + 1 more
    • English
    Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families.

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