Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms
- 1st Edition - August 14, 2021
- Imprint: Academic Press
- Editors: Xinyu Liu, Yu Sun
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 9 9 0 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 2 4 3 - 8
Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently… Read more
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Request a sales quoteMicro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.
- Comprehensive coverage of micro and nano-system technology and application to biophysical studies of cells and small organisms.
- Highlights the most recent advances in cellular and organismal biophysics enabled by micro and nano systems.
- Insightful outlook on future directions and trends in each chapter covering a sub-area of the book topic.
Researchers and graduate students in disciplines of biomedical engineering, mechanical engineering, electrical engineering, biological, physics and biology, who are interested in learning the state-of-the-art technologies on micro and nano systems for studying biophysics of biological cells and small organisms. University instructors of graduate level courses in disciplines of biological and biomedical engineering, mechanical engineering, electrical engineering, and physics. Industrial practitioners (job role: R&D scientist, engineer, and manager) in sectors such as microelectromechanical systems (MEMS), nanotechnology, biotechnology, and medical devices.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Micro systems for probing cellular forces and cellular mechanical properties
- Abstract
- 1.1: Introduction
- 1.2: Cellular force measurements
- 1.3: High-throughput mechanical characterization of cells
- 1.4: Challenges and opportunities
- Chapter 2: Force-sensing micropillar arrays for cell mechanics and mechanobiology
- Abstract
- 2.1: Introduction
- 2.2: Fabrication of micropost and micropillar arrays
- 2.3: Functionalization of micropost and micropillar arrays
- 2.4: Applications in cell mechanobiology research
- 2.5: Conclusion and future perspective
- Chapter 3: Vertical nanostructures for probing live cells
- Abstract
- Acknowledgments
- 3.1: Introduction
- 3.2: Fabrication of vertical nanostructures
- 3.3: Examining the interactions between cells and vertical nanostructures
- 3.4: Mechanisms underlying the interactions between cells and vertical nanostructures
- 3.5: Applications of vertical nanostructures for probing live cells
- 3.6: Future outlook
- Chapter 4: Probing tissue mechanics at the cellular-length scale in cancer microenvironments
- Abstract
- 4.1: Introduction
- 4.2: Current challenges in biomechanical characterization
- 4.3: Potential impact in cancer mechanobiology
- 4.4: Contributors to tissue stiffness in the cellular microenvironment
- 4.5: Overview of mechanical characterization theory
- 4.6: Techniques to measure solid mechanics in cells and tissues
- 4.7: Picking the right technique for the right purpose
- 4.8: Future outlook
- Chapter 5: Advanced microfluidic devices for cell electroporation and manipulation
- Abstract
- Acknowledgments
- 5.1: Introduction
- 5.2: High-throughput electroporation in vitro and in vivo
- 5.3: Microfluidic device for high-throughput cell manipulation
- 5.4: Conclusion
- Chapter 6: High-throughput three-dimensional cellular platforms for screening biophysical microenvironmental signals
- Abstract
- 6.1: Introduction
- 6.2: High-throughput approaches for 3D cell screening
- 6.3: High-throughput platforms for screening biophysical stimuli
- 6.4: Conclusions and future perspectives
- Chapter 7: Acoustofluidic technology for cell biophysics
- Abstract
- 7.1: Introduction to acoustofluidics
- 7.2: Modern acoustofluidics in cell biophysical characterization
- 7.3: Conclusions and perspectives
- Chapter 8: Microfluidic devices for neutrophil migration studies
- Abstract
- Acknowledgments
- 8.1: Introduction
- 8.2: Microfluidic gradient generation devices
- 8.3: Microfluidic devices for different purposes of neutrophil chemotaxis studies
- 8.4: Microfluidic devices for neutrophil migration studies other than chemotaxis
- 8.5: Concluding remarks
- Chapter 9: Field-controlled micro-nano manipulations and micro-nano robots
- Abstract
- 9.1: Introduction
- 9.2: Results
- Chapter 10: Robotic optical tweezers for cell biophysics
- Abstract
- 10.1: Introduction
- 10.2: Materials and methods
- 10.3: Results and discussion
- 10.4: Conclusion
- Chapter 11: Robotic and microfluidic systems for single cell injection
- Abstract
- 11.1: Introduction
- 11.2: Robotic systems for single cell microinjection
- 11.3: Microfluidic systems for single cell injection
- 11.4: Conclusion and outlook
- Chapter 12: Biophysical phenotyping of C. elegans in a microfluidic chip for high-throughput drug screening
- Abstract
- 12.1: Introduction: C. elegans in disease modeling and drug screening
- 12.2: Microfluidic chips for force assay
- 12.3: Conclusions
- Chapter 13: Microfluidic devices for imaging and manipulation of C. elegans
- Abstract
- 13.1: Introduction
- 13.2: Microfluidic immobilization techniques
- 13.3: Microfluidic imaging techniques
- 13.4: Microfluidic devices for animal sorting
- 13.5: Microfluidic devices for animal culture
- 13.6: Microfluidic devices for microinjection
- 13.7: Microfluidic devices for phenotypic and drug screening
- 13.8: Microfluidic devices for lifespan studies
- 13.9: Microfluidic devices for developmental studies
- 13.10: Microfluidic devices for mechanical stimulus
- 13.11: Microfluidic devices for chemical stimulus
- 13.12: Microfluidic devices for studying electrophysiology
- 13.13: Microfluidic devices for studying behavior
- 13.14: Concluding remarks
- Chapter 14: Micro systems for the study of behavioral responses of C. elegans to various physical and chemical stimuli
- Abstract
- Acknowledgments
- 14.1: Introduction
- 14.2: Behavioral responses of C. elegans to various physical and chemical stimuli
- 14.3: Microfluidic devices for various behavioral responses
- 14.4: Conclusions and perspectives
- Chapter 15: Microfluidic devices to study the effect of electric fields on C. elegans and Danio rerio
- Abstract
- 15.1: Introduction
- 15.2: Electric field in microchannels
- 15.3: C. elegans
- 15.4: D. rerio
- 15.5: Conclusions and future perspectives
- Chapter 16: Force-controlled robotic systems for mechanical stimulation of Drosophila larvae
- Abstract
- 16.1: Introduction
- 16.2: A force-controlled robotic system for mechanical stimulation and neuron calcium imaging of Drosophila larvae
- 16.3: An advanced force control scheme for robotic stimulation of Drosophila larvae
- 16.4: Robotic system for behavioral studies of freely moving Drosophila larvae under mechanical stimulation
- 16.5: Conclusion
- Index
- Edition: 1
- Published: August 14, 2021
- No. of pages (Paperback): 404
- No. of pages (eBook): 404
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128239902
- eBook ISBN: 9780128242438
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Xinyu Liu
Xinyu Liu is the Percy Edward Hart Professor of Mechanical and Industrial Engineering at the University of Toronto. Prior to joining the University of Toronto, he was an Associate Professor and the Canada Research Chair in Microfluidics and BioMEMS in the Department of Mechanical Engineering at McGill University. His research focuses on microfluidics, bioMEMS, and soft and micro robotics, with applications primarily in medicine and biology. He received the Canadian Rising Star in Global Health Award, the Douglas R. Colton Metal for Research Excellence, the McGill Christophe Pierre Award for Research Excellence, the MINE Outstanding Young Researcher Award, and seven best paper awards at major engineering and biomedical conferences. He is a fellow of the American Society of Mechanical Engineers.
Affiliations and expertise
Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CanadaYS
Yu Sun
Dr. Yu Sun is a Professor at the University of Toronto. He holds a Tier I Canada Research Chair and is the founding Director of Robotic Institute at the University of Toronto. His Advanced Micro and Nanosystems Laboratory specializes in developing innovative robotic and AI technologies for reproductive medicine. His techniques have been applied in clinical centers from multiple countries.
Affiliations and expertise
Professor, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CanadaRead Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms on ScienceDirect