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Elsevier

Lahita's Systemic Lupus Erythematosus

  • 6th Edition - July 23, 2021
  • Latest edition
  • Editor: Robert G. Lahita
  • Language: English

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system,… Read more

Description

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission.

Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.

To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.

A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Key features

  • Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists
  • Full-color presentation throughout the book
  • Provides the latest information available on diagnosis and treatment
  • Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Readership

Primary audience is basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists

Table of contents

Part I: Basis of the Disease
Section A: Genetics and epigenetics

1. Major histocompatibility complex and SLE

2. Lupus Susceptibility genes

3. Epigenetics in systemic lupus erythematosus and the integration of molecular pathways

Section B: Immunopathogenesis

4. Autoantigens, antigenic mimicry, and immune complexes

5. B-cell Biology, tolerance and autoantibodies

6. T-Cell Biology, tolerance and regulation

7. Polymorphonuclear cells

8. Metabolic and mitochondrial dysfunction in SLE

9. Immunopathogenesis: the role of mucosal and skin microbiota in SLE

Section C: Disease effectors and modifiers

10. Complement and SLE

11. Interferons and cytokines in SLE pathogenesis and therapy

12. Innate immunity in SLE pathogenesis

13. Sex bias in SLE

Section D: Tissue injury—the Biology

14. Mechanisms of tissue injury in lupus nephritis

15. The skin

16. The brain in SLE: mechanisms and detection of injury and therapeutic strategies

17. The role of infections in SLE pathogenesis

18. Tissue injurydthe biology: SLE-associated vascular disease and antiphospholipid syndrome

Part II: Clinical presentation of disease
Section A: Clinical presentation

19. Epidemiology of SLE and related diseases: incidence, prevalence, and mortality

20. The clinical presentation of systemic lupus erythematosus and laboratory diagnosis

21. Passively acquired lupus in the fetus and neonate

22. Systemic lupus erythematosus in children

23. Environmental and drug-induced lupus

24. Reproductive health

25. Monitoring disease activity

26. Overlap syndromes

Section B: Specific organ involvement and clinical presentation

27. Nervous system

28. Skin

29. Kidney disease

30. Cardiovascular disease in lupus

31. Pulmonary manifestations of systemic lupus erythematosus

32. GI hepatic and nonhepatic diseases

33. Musculoskeletal system: articular disease, myositis, and bone metabolism

34. Clinical presentation of antiphospholipid syndrome

35. Hematology: cytopenias

36. Malignancy risk and screening

Section C: Treatment of systemic llupus erythematosus

37. Antimalarial drugs (and lupus)

38. Glucocorticoids

39. Immunosuppressive therapy in SLE

40. Pipeline therapies and future drug development

41. Challenges of systemic lupus clinical trials

Review quotes

"This sixth edition offers up-to-date information pertaining to various aspects of systemic lupus erythematosus (SLE)....The book focuses on updating rheumatology specialists with recent discoveries in genetics, immunology, microbiology, and microbiome, and expands on how these discoveries pertain to the pathogenesis of SLE....The second part focuses on clinical SLE and later explores the potential of new treatments based on these findings. This book is definitely needed given the significant findings that help to explain SLE. The chapters are well written and meet the objectives of updating specialists about SLE. This book is targeted to specialists in rheumatology given the complexity and detail of each chapter....Each chapter is well written and supported by up-to-date references....Diagrams are well visualized and interpreted for readers. Overall, this is an excellent book and very much needed given the recent discoveries. This book is a must-read for rheumatologists." —Joseph S Yusin, MD(VA Greater Los Angeles Healthcare System)

Product details

  • Edition: 6
  • Latest edition
  • Published: July 27, 2021
  • Language: English

About the editor

RL

Robert G. Lahita

Dr. Robert Lahita is Clinical Professor of Medicine at Rutgers University, and the Director of the Institute for Autoimmune and Rheumatic Diseases. He is a fellow of the ACP and the Royal College, and a master of the ACR. Dr. Lahita is the author of more than 16 books and 150 scientific publications in the field of autoimmunity. He is the editor of the standard textbook Systemic Lupus Erythematosus and the Senior Editor of the Textbook of Autoimmunity, and the author of Lupus: Q and A for patients and Autoimmunity in Women.
Affiliations and expertise
Professor of Medicine, Adjunct Professor of Biochemistry and Molecular Biology UMDNJ, New Jersey Medical School Vice President and Chairman of Medicine Newark Beth Israel Medical Center Newark, NJ, USA

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