Inter-Organellar Ca2+ Signaling in Health and Disease - Part B
- 1st Edition, Volume 363 - August 3, 2021
- Imprint: Academic Press
- Editors: Lorenzo Galluzzi, Saverio Marchi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 0 3 6 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 0 3 7 - 3
International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaini… Read more
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Request a sales quoteInternational Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists.
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- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Ca2 + in health and disease
- Acknowledgments
- Conflict of interest statement
- Chapter One: Calcium signaling and endoplasmic reticulum stress
- Abstract
- 1: Introduction
- 2: ER/SR resident Ca2 + binding proteins
- 3: UPR, an ER stress coping response
- 4: The UPR and the ER luminal environment
- 5: Outlook
- Acknowledgments
- Chapter Two: Ca2 + dysregulation in the pathogenesis of amyotrophic lateral sclerosis
- Abstract
- 1: Introduction
- 2: ALS preclinical models to identify Ca2 +-related targets
- 3: Ca2 + dysfunction in ALS
- 4: Ca2 +−dependent toxicity in ALS
- 5: Conclusions and perspectives
- Acknowledgments
- Chapter Three: The ER-mitochondria Ca2 + signaling in cancer progression: Fueling the monster
- Abstract
- 1: Introduction
- 2: Determinants of ER-mitochondrial calcium signaling
- 3: ER-mitochondrial Ca2 + signaling and its role in the hallmarks of cancer
- 4: Therapeutic interventions
- 5: Concluding remarks
- Acknowledgments
- Chapter Four: Store operated calcium channels in cancer progression
- Abstract
- 1: Introduction
- 2: Store operated calcium entry
- 3: SOCE in cancer progression
- 4: Conclusions
- Acknowledgment
- Chapter Five: Role of mitochondria-associated endoplasmic reticulum membrane (MAMs) interactions and calcium exchange in the development of type 2 diabetes
- Abstract
- 1: Introduction
- 2: Key role of ER and mitochondria in β cell function
- 3: Physiological roles of MAMs
- 4: MAMs and T2D
- 5: Conclusion
- Acknowledgments
- Funding
- Credit authorship contribution statement
- Declaration of competing interest
- Chapter Six: Endolysosomal Ca2 + signaling in cardiovascular health and disease
- Abstract
- 1: Introduction
- 2: The EL Ca2 + store
- 3: EL Ca2 + signaling in cardiac myocytes
- 4: EL Ca2 + signaling in VSMCs
- 5: EL Ca2 + signaling in vascular endothelial cells and endothelial colony forming cells (ECFCs)
- 6: Targeting TPC1–2 to treat infection of the CV system by SARS-CoV-2
- 7: Conclusions
- Acknowledgments
- Edition: 1
- Volume: 363
- Published: August 3, 2021
- No. of pages (Hardback): 286
- No. of pages (eBook): 286
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128240366
- eBook ISBN: 9780128240373
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USASM
Saverio Marchi
Saverio Marchi obtained his PhD in ‘Pharmacology and Molecular Oncology’ from University of Ferrara (Italy), under the supervision of Prof. Rosario Rizzuto, where he investigated the role of Ca2+ signalling and mitochondrial dynamics in cancer. He did a short term research stay at the Gustave Roussy Institute (Paris, France) in the Guido Kroemer’s lab, for the study of the mechanisms of autophagy regulation. On 2011 he joined the Laboratory of Dr. Paolo Pinton at the University of Ferrara (Italy) where he carried out his postdoctoral studies. During his postdoctoral training, he studied the implications of Endoplasmic Reticulum-mitochondria connection in diseases, especially cancer. In 2014, he was the recipient of the Young Researcher award, which allowed him to work at the Cancer Center, University of Hawai’i (Prof. Michele Carbone’s lab), where he was introduced to the study of the signalling pathways regulating mesothelioma progression. Now, he is associate professor at the Marche Polytechnic University, where he leads his own group. He is interested in the involvement of the MCU complex and mitochondrial Ca2+ in the evolution of cancer. More recently, he has become interested in the alteration of mitochondrial dynamics during bacterial infection.
He published 77 papers on “peer-reviewed” journals (h-index: 41; n° of citations > 5800. Source: Scopus).
Affiliations and expertise
Dept. of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, ItalyRead Inter-Organellar Ca2+ Signaling in Health and Disease - Part B on ScienceDirect