Sarcopenia
Molecular Mechanism and Treatment Strategies
- 1st Edition - July 22, 2021
- Imprint: Elsevier
- Editor: Kunihiro Sakuma
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 1 4 6 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 6 5 7 - 5
Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disa… Read more
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Request a sales quoteSarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment.
- Covers physical, dietary and pharmacological strategies to maintain adequate muscle mass to ensure healthy aging
- Provides a complete and up-to-date reference on molecular mechanisms of sarcopenia
- Presents a clear definition of sarcopenia, along with the latest research in one volume
Endocrinologists, general internists, geriatricians, rheumatologists, dieticians, physicians with interest on musculoskeletal diseases and ageing, biomedical scientists. Graduate students (biomedical and clinical sciences), nurses and allied health professionals involved in aged care, medical directors (practitioners at nursing homes)
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1: Linking mitochondrial dysfunction to sarcopenia
- Abstract
- Introduction
- Sarcopenia and mitochondrial function
- Potential sources of mitochondrial dysfunction in aging
- Mitochondria initiate and mediate cell death signaling in sarcopenia
- Mitochondrially regulated loss of motor function and mobility in sarcopenia
- PGC-1α regulation of mitochondria in sarcopenia
- Autophagy/mitophagy and mitochondrial dysfunction in sarcopenia
- Linking autophagy and apoptosis
- Mitochondria, mitophagy, and the ubiquitin-proteasome system
- Mitochondrial associated apoptosis, mitophagy, and UPS can be modulated by caloric restriction in sarcopenia
- Conclusions
- Chapter 2: The role of the neuromuscular junction in sarcopenia
- Abstract
- Introduction
- Age-related structural adaptations of the NMJ
- Age-related functional adaptations of the NMJ
- Preventing and managing the effects of aging on the NMJ
- Role of NMJ in sarcopenia
- Chapter 3: Dietary approaches to maintaining muscle mass
- Abstract
- Introduction
- Dietary protein quality
- Dietary protein quantity
- Dietary considerations for older adults
- Dietary approaches to preserving and gaining muscle mass in those with sarcopenia
- Conclusions and future work
- Chapter 4: Role of muscle stem cells in sarcopenia
- Abstract
- Acknowledgment
- Introduction
- Muscle stem cells
- Support cells that influence the satellite cell activity during regeneration
- Satellite cell function in aging
- Satellite cells and muscle adaptation
- Satellite cells and exercise to combat sarcopenia
- Concluding remarks
- Chapter 5: Sarcopenia and the inflammatory cytokines
- Abstract
- Histology of skeletal muscle
- Composition of skeletal muscle
- Inflammatory response in skeletal muscle
- Mediators of inflammation
- Myostatin
- Interactions between myofibers and adipocytes
- Proresolving lipid mediators
- Concluding remarks
- Chapter 6: Molecular mechanisms of exercise providing therapeutic rationale to counter sarcopenia
- Abstract
- Acknowledgment
- Introduction
- Gene set analysis of exercise that oppose sarcopenia
- Exercise-induced molecular signaling in skeletal muscle
- Systemic functions of myokines induced by exercise
- Exercise mimetics targeting AMPK and PPARβ/δ pathway
- Anabolic hormones effects on skeletal muscle
- Roles of autophagy pathway in skeletal muscle
- Conclusion
- Chapter 7: Myokines: A potential key factor in development, treatment, and biomarker of sarcopenia
- Abstract
- Introduction
- The role of myokines in myogenesis
- The role of myokines in protein anabolism and catabolism
- MicroRNAs and metabolites as myokines
- Perspective
- Chapter 8: Defect of autophagy signaling in sarcopenic muscle
- Abstract
- Acknowledgments
- Introduction
- Autophagy-dependent signaling
- Autophagic adaptation in sarcopenic muscle
- Factors modulating autophagic defect in sarcopenia
- Several therapeutic strategies attenuating sarcopenia due to autophagic-activation
- Concluding remarks
- Chapter 9: Mitophagy in sarcopenic muscle and practical recommendations for exercise training
- Abstract
- Introduction
- Autophagy and mitochondrial dysfunction during aging
- Parkin pathway in sarcopenia
- Mul1 and Mdm2 in skeletal muscle mitophagy: Perspectives in sarcopenia
- Exercise modalities and practical recommendations for aging people
- Conclusions and perspectives
- Chapter 10: Underlying mechanisms of sarcopenic obesity
- Abstract
- Introduction
- Diagnostic criteria
- Pathogenesis of sarcopenic obesity
- Intervention strategies in sarcopenic obesity
- Conclusion
- Chapter 11: Vascular aging and sarcopenia: Interactions with physiological functions during exercise
- Abstract
- Introduction
- Role of peripheral blood flow during exercise
- Loss of vascular functions relevant to sarcopenia
- Other factors resulting in circulatory impairments related to aging
- Possible counteractions to vessel aging
- Summary
- Chapter 12: Dysphagia of cachexia and sarcopenia
- Abstract
- Introduction
- Cachexia
- Sarcopenia
- Dysphagia
- Conclusions
- Chapter 13: Mechanisms of decline in muscle quality in sarcopenia
- Abstract
- Introduction
- A decline in muscle quality in sarcopenia
- Age-related alterations in intracellular activation-contraction pathway in skeletal muscle fibers
- Decreased Ca2 + release from the sarcoplasmic reticulum in skeletal muscle fiber from aged subjects
- Reduced myofibrillar Ca2 + sensitivity in skeletal muscle fiber from aged subjects
- Decreased ability of the cross-bridges to generate force in skeletal muscle fiber from aged subjects
- Mechanisms behind intrinsic contractile dysfunction in skeletal muscle fiber from aged subjects: Role of disuse
- Mechanisms behind intrinsic contractile dysfunction in skeletal muscle fiber from aged subjects: Role of reactive oxygen/nitrogen species (ROS/RNS)
- Interventions to counteract the age-related loss of muscle quality
- Concluding remarks
- Index
- Edition: 1
- Published: July 22, 2021
- No. of pages (Paperback): 342
- No. of pages (eBook): 342
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780128221464
- eBook ISBN: 9780128226575
KS
Kunihiro Sakuma
Professor Kunihiro Sakuma is a Physiologist working in the field of skeletal muscle at the Tokyo Institute of Technology in Japan. He began his scientific career in the Department of Physiology, Aichi Human Science Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and the attenuating strategy of sarcopenia (age-related muscle atrophy). Preventing sarcopenia is critical for maintaining a high quality of life in the aged population.
Affiliations and expertise
Physiologist, Tokyo Institute of Technology, JapanRead Sarcopenia on ScienceDirect