Endocrine-Disrupting Chemicals

1st Edition, Volume 92 - August 13, 2021
Imprint: Academic Press
Editors: Laura Vandenberg, Judith Turgeon
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 4 6 6 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 4 6 7 - 9

Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of… Read more

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Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Cover image
Title page
Table of Contents
Copyright
Contributors
Endocrine disrupting chemicals: Understanding what matters
1 Introduction
2 What are EDCs?
3 The key characteristics of EDCs
4 The breadth and depth of the endocrine system
5 Why timing matters
6 Why dose matters
7 The consensus on EDCs
8 In this book
Chapter One: Endocrine disruptor global policy
Abstract
1 Introduction
2 Current approaches to regulating EDCs
3 Economic implications of EDC exposures
4 Conclusion
Chapter Two: Toxicity testing and endocrine disrupting chemicals
Abstract
1 Introduction
2 Introduction to EDC testing
3 Introduction to the endocrine disruptor screening program (EDSP)
4 In vitro screening tests
5 In vivo screening tests
6 Long-term in vivo screening tests
7 Improving toxicity testing for EDCs
8 Conclusion
Chapter Three: Epigenetics, estrogenic endocrine-disrupting chemicals (EDCs), and the brain
Abstract
1 Introduction
2 Hormones and sex differences in the developing brain
3 Endocrine-disrupting chemicals
4 Hormones and epigenetic mechanisms in the brain
5 Epigenetics and EDCs
6 Conclusion
Chapter Four: Endocrine disrupting chemicals (EDCs) and the neuroendocrine system: Beyond estrogen, androgen, and thyroid
Abstract
1 Introduction
2 The EDC landscape
3 The emergence of the neuroendocrine disruption concept
4 The neuroendocrine system
5 Development and sexual differentiation of the neuroendocrine system
6 Neuroendocrine disruption of the structure and function of the HPG axis
7 Neuroendocrine disruption and metabolic programming
8 Beyond EA&T: Emerging areas of neuroendocrine disruption
9 Conclusion
Conflict of interest statement
Chapter Five: Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models
Abstract
1 Introduction
2 Female reproductive disorders
3 Male reproductive disorders
4 Conclusion
Conflict of interest statement
Chapter Six: Endocrine disrupting chemicals (EDCs) and sex steroid receptors
Abstract
1 Introduction
2 The sex steroid receptors (ERs, PRs, AR) as cellular targets for EDC action
3 Sex steroid receptor general MOA
4 EDCs that interact with SSRs
5 Molecular mechanisms of EDC action on sex steroid receptors
6 Pathological consequences of EDC action on sex steroid receptors
7 Conclusions
Conflict of interest
Chapter Seven: Endocrine disrupting chemicals and the mammary gland
Abstract
1 Introduction
2 Overview of mammary gland biology
3 Lactation is important to the baby and the mother
4 The role of hormones in mammary gland development
5 Developmental origins of adult diseases
6 EDCs and mammary gland development
7 EDCs and sensitization of the mammary gland
8 EDCs and lactation
9 EDCs and gynecomastia
10 Conclusions
Conflict of interest statement
Chapter Eight: Impact of gestational exposure to endocrine disrupting chemicals on pregnancy and birth outcomes
Abstract
1 Introduction
2 Endocrine disrupting chemicals (EDCs)
3 Mechanisms of EDC action during pregnancy
4 Modulation of EDCs effects
5 Long term implications of gestational EDC exposure
6 Limitations of available human data
7 Conclusion
Chapter Nine: Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development
Abstract
1 Introduction
2 Placental formation
3 Placenta functions
4 The placenta as a neuroendocrine organ
5 Conclusion
Chapter Ten: Endocrine disrupting chemicals and thyroid hormone action
Abstract
1 Introduction
2 Thyroid hormone and development
3 Polychlorinated biphenyls (PCBs) and thyroid hormone
4 Perchlorate and thyroid hormone
5 Bisphenol A (BPA)
6 Conclusion
Chapter Eleven: Inappropriately sweet: Environmental endocrine-disrupting chemicals and the diabetes pandemic
Abstract
1 Introduction
2 Pathogenesis of type 2 diabetes mellitus
3 Endocrine-disrupting chemicals (EDCs)
4 EDCs and pathways to environmentally-mediated diabetes
5 EDCs and type 1 diabetes
6 EDCs and gestational diabetes
7 EDCs, diabetes disparities, and health justice
8 Crosstalk between clinical care and EDC exposure
9 Bridging the gap to address ecosystems of diabetes risk
10 Data gaps and the need for further studies
11 Conclusion
Chapter Twelve: The new kids on the block: Emerging obesogens
Abstract
1 Introduction
2 Adipose tissue: An overview
3 Obesogens, environmental factors that interfere with adipose tissue metabolism
4 Emerging obesogens: The new kids on the block
5 Approaches and reproducibility
6 Conclusions and future directions
Chapter Thirteen: Endocrine disrupting chemicals and breast cancer cells
Abstract
1 Introduction
2 EDCs as risk factors for breast cancer
3 Epidemiological studies of EDCs and breast cancer
4 EDCs and the hallmarks of cancer
5 The tumor microenvironment
6 The importance of considering long-term exposures
7 Epigenetic mechanisms in long-term EDC actions
8 Conclusion
Chapter Fourteen: EDCs and male urogenital cancers
Abstract
1 Introduction
2 Conclusion

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Laura Vandenberg

Judith Turgeon

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