Mitochondrial Metabolism

An Approach to Disease Management

1st Edition - July 28, 2021
Imprint: Academic Press
Editors: Jalal Pourahmad, Mohsen Rezaei
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 4 1 6 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 4 0 9 - 0

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduct… Read more

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Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more.

This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Mitochondria as balancers of reduction/oxidation for intracellular environment
Abstract
1: Introduction
2: Mitochondrial ROS in pathological condition
3: Mitochondrial antioxidant defense
Chapter 2: Mitochondria as biosynthetic centers and targeted therapeutics
Abstract
1: Introduction
2: Role of mitochondria in the metabolism of biomolecules
3: Pharmacological options to target mitochondrial function
4: Prospects
Chapter 3: Mitochondrial contribution to cell death
Abstract
1: Role of mitochondria in cell death
2: Cell death pathways
3: Caspases
4: Apoptotic proteins
5: Mitochondrial permeability transition (MPT)
6: Mitophagy
7: Calcium2 + role in the cell death pathway
8: Conclusion
Chapter 4: Mitochondrial response to environmental toxicants
Abstract
1: Introduction
2: Accumulation of environmental toxicants in mitochondria
3: Vulnerability mitochondria to environmental toxicants
4: Mitochondrial toxicity by environmental toxicants
5: Inhibition of the mitochondrial electron transport chain by environmental toxicants
6: mtDNA damage and mitochondrial dysfunction induced by environmental toxicants
7: Bioenergetic imbalance and mitochondrial dysfunction induced by environmental toxicants
8: Oxidative stress and mitochondrial dysfunction induced by environmental toxicants
9: Environmental and occupational toxicants induce mitochondrial dysfunction in human
10: Environmental toxicants and diseases with mitochondrial dysfunction
11: Summary
Chapter 5: Updates on mitochondria, calorie restriction, and aging
Abstract
1: Introduction
2: Aging and mitochondria
3: Calorie restriction, intermittent fasting, and age-related diseases
4: Calorie restriction, intermittent fasting, and mitochondria
5: Diet, calorie restriction, and life span
6: Diet, calorie restriction, and mitochondria
7: Conclusion
Chapter 6: Mitochondrial metabolism and carcinogenesis
Abstract
Acknowledgments
1: Introduction
2: Tumor initiation and mitochondrial function
3: Mitochondrial function during tumor promotion
4: Tumor progression and mitochondrial function
5: Mitochondrial defects and cancer
6: Mitochondria and interorganellar communication in cancers
7: Mitochondrial metabolic pathways and potential therapeutic targets
8: Reactive oxygen species and mitochondria in cancer
Chapter 7: Mitochondria and cancer therapy
Abstract
1: Introduction
2: Small molecules interfering with mitochondrial signaling
3: Mitochondrially targeted formulations
Chapter 8: Mitochondrial metabolism in diabetes
Abstract
1: Introduction
2: Medicinal plants in diabetes
Chapter 9: Mitochondrial abnormalities in neurological disorders
Abstract
1: Mitochondrial function
2: Mitochondrial and neurological disorders
3: Conclusion
Chapter 10: Mitochondrial abnormalities in psychological disorders
Abstract
Acknowledgment
1: Introduction
2: Mitochondrial abnormalities
3: Mitochondrial abnormalities and psychological disorders
4: Conclusion
Chapter 11: Mitotherapy, an attractive avenue for the future medicine
Abstract
1: Introduction
2: Mitotherapy in diseases
3: Mitochondria internalization mechanisms and their functionality
4: Immune reactions in mitotherapy
5: Mitochondrial modification for transplantation
Index

Jalal Pourahmad

Jalal Pourahmad - Professor, Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences. Received his Masters and PhD degrees from the University of Toronto, Canada. His current research interests are exploring ways of decreasing the toxicity of drugs and increasing their therapeutic specificity. These methods include the use of less toxic drug analogues, antidotes, improving the nutritional status of the patient and targeting of the drug to the tissue that requires therapy. The biochemical research techniques used include the monitoring of changes in biomolecules and cellular metabolism when drugs are administered in vivo, perfused intact organs, or incubated with intact cells or subcellular fractions. His studies on the sequence of events for drug induced cytotoxicity have shown that mitochondrial toxicity and sometimes lysosomal toxicity occurs. Mitochondrial toxicity causes both reductive stress and ATP depletion which releases iron and activates oxygen. The latter causes the lysosomal reactive oxygen species formation and lysosomal membrane rupture which leads to release of deadly proteases and phospholipases. The objective of his research is to provide a useful working hypothesis to understand various disease states as well as help design safer drugs and better methods for treating diseases.

Affiliations and expertise

Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Iran

Mohsen Rezaei

Mohsen Rezaei, Associate Professor, Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Received his PhD from the same university. His research interests include cellular and molecular mechanisms of cell injury and programmed cell death (Mitochondria related), subcellular organelle evaluations in programmed cell death, excitotoxicity and Neuroprotection, mitochondria associated pathogenesis and treatment of Diabetes, genotoxicity and Carcinogenicity, chemoprevention and Cancer treatment (Mitochondria related), novel derivatives of natural and nutraceuticals for dealing with chronic mitochondria related diseases.

Affiliations and expertise

Associate Professor, Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health