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Elsevier

Books in Life sciences

  • Forensic Toxicology

    • 1st Edition
    • Max M. Houck
    • English
    Forensic Toxicology, the latest release in the Advanced Forensic Science Series that grew out of recommendations from the 2009 NAS Report, Strengthening Forensic Science: A Path Forward will serve as a graduate level text for those studying and teaching forensic toxicology. It is also an excellent reference for the forensic practitioner’s library or for use in their casework. Coverage includes a wide variety of methods used, along with pharmacology and drugs and professional issues they may encounter. Edited by a world-renowned, leading forensic expert, this updated edition is a long overdue solution for the forensic science community.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 83
    • English
    Advances in Clinical Chemistry, Volume 83, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest, most up-to-date technologies related to the field of clinical chemistry, with this release presenting comprehensive updates on Urinary Nucleosides and Deoxynucleosides, Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer, Liquid Biopsy: From Basic Research to Clinical Practice, Circulating Tumor Cells and Implications of the Epithelial-to-Mesenc... Transition, and more.

  • Forensic Odontology

    Principles and Practice
    • 1st Edition
    • Thomas J. David + 1 more
    • English
    Forensic Odontology: Principles and Practice details the aspects necessary to become an accomplished forensic odontologist, including an illustration of the skills necessary to become an expert witness. The book is ideal for both the experienced and novice forensic odontologist, covering many fields of expertise, including civil and criminal matters. The civil side involves standard of care and personal injury matters, while the criminal side involves not only dental identification, but management of mass fatality incidents, age assessment, child and elder abuse, and bitemark analysis.

  • Methods in Consumer Research, Volume 2

    Alternative Approaches and Special Applications
    • 1st Edition
    • Gaston Ares + 1 more
    • English
    Methods for Consumer Research, Volume Two: Alternative Approaches and Special Applications brings together world leading experts in global consumer research who provide a fully comprehensive state-of-the-art coverage of emerging methodologies and their innovative application. The book puts consumer research in-context with coverage of immersive techniques and virtual reality, while also looking at health-related Issues in consumer science, including sections on food intake and satiation. Other sections delve into physiological measurements within the context of consumer research and how to design studies for specific populations. In conjunction with the first volume, which covers new approaches to classical methodology, this book is an invaluable reference for academics working in the fields of in-sensory and consumer science, psychology, marketing and nutrition. With examples of the methodology being applied throughout, it serves as a practical guide to research and development managers in both food and non-food companies.

  • Handbook of Immunoassay Technologies

    Approaches, Performances, and Applications
    • 1st Edition
    • Sandeep K. Vashist + 1 more
    • English
    Handbook of Immunoassay Technologies: Approaches, Performances, and Applications unravels the role of immunoassays in the biochemical sciences. During the last four decades, a wide range of immunoassays has been developed, ranging from the conventional enzyme-linked immunosorbent assays, to the smartphone-based point-of-care formats. The advances in rapid biochemical procedures, novel biosensing schemes, fully integrated lab-on-a-chip platforms, prolonged biomolecular storage strategies, device miniaturization and interfacing, and emerging smart system technologies equipped with personalized mobile healthcare tools are paving the way to next-generation immunoassays, and are all discussed in this comprehensive text. Immunoassays play a prominent role in clinical diagnostics as they are the eyes of healthcare professionals, helping them make informed clinical decisions via confirmed disease diagnosis, and thus enabling favorable health outcomes. The faster and reliable diagnosis of infections will further control their spread to uninfected persons. Similarly, immunoassays play a prominent role in veterinary diagnostics, food analysis, environmental monitoring, defense and security, and other bioanalytical settings. Therefore, they enable the detection of a plethora of analytes, which includes disease biomarkers, pathogens, drug impurities, environmental contaminants, allergens, food adulterants, drugs of abuse and various biomolecules.

  • Gut Microbiota

    Interactive Effects on Nutrition and Health
    • 1st Edition
    • Edward Ishiguro + 2 more
    • English
    Gut Microbiota: Interactive Effects on Nutrition and Health focuses on the fascinating intestinal microbiome as it relates to nutrition. The book covers the core science in the microbiome field and draws links between the microbiome and nutrition in medicine. Reflecting the most current state of evidence available in the field, the early chapters introduce key concepts about the microbiome, and the latter focus on the application of the gut microbiome and nutrition science. Both human studies and animal studies (where appropriate) are discussed throughout the work. Addressing topics such as gut microbiota throughout the lifespan, gut microbiota in health and disease, and genetic and environmental influences on gut microbiota, this book will provide scientists and clinicians who have an interest in the microbiome with an understanding of the future potential and limitations of this tool as they strive to make use of evidence-based diet information for the maintenance of good health.

  • Sustainable Food Systems from Agriculture to Industry

    Improving Production and Processing
    • 1st Edition
    • Charis M. Galanakis
    • English
    Sustainable Food Systems from Agriculture to Industry: Improving Production and Processing addresses the principle that food supply needs of the present must be met without compromising the ability of future generations to meet their needs. Responding to sustainability goals requires maximum utilization of all raw materials produced and integration of activities throughout all production-to-consum... stages. This book covers production stage activities to reduce postharvest losses and increase use of by-products streams (waste), food manufacturing and beyond, presenting insights to ensure energy, water and other resources are used efficiently and environmental impacts are minimized. The book presents the latest research and advancements in efficient, cost-effective, and environmentally friendly food production and ways they can be implemented within the food industry. Filling the knowledge gap between understanding and applying these advancements, this team of expert authors from around the globe offer both academic and industry perspectives and a real-world view of the challenges and potential solutions that exist for feeding the world in the future. The book will guide industry professionals and researchers in ways to improve the efficiency and sustainability of food systems.

  • Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases

    Overview of Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine
    • 1st Edition
    • Emilija Veljkovic + 7 more
    • English
    Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Tourette’s syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development.

  • Albinism in Africa

    Historical, Geographic, Medical, Genetic, and Psychosocial Aspects
    • 1st Edition
    • Jennifer Kromberg + 1 more
    • English
    Albinism in Africa: Historical, Geographic, Medical, Genetic, and Psychosocial Aspects provides the first in-depth reference for understanding and treating patients of human albinism in Africa. Leading international contributors examine the historical, geographic, psychosocial, genetic and molecular considerations of importance in effectively and sensitively managing this genetic disorder. Foundational chapters covering the historical and psychosocial aspects of albinism are supplemented by discussions of the pathobiology of the disease, as well as a thorough analysis of the genetics of skin pigmentation, eye pigmentation, hair pigmentation, and incidents of skin cancer involved in the manifestations of this disorder. New prenatal diagnostics and genetic testing methods, genetic risk assessment for individuals, families, and communities, and novel genetic markers that may be used for developing new therapeutics for treating albinism are also discussed in detail. The book provides care management approaches that may be applied to instances of albinism in other regions, along with guiding principles for treating rare genetic disorders and stigmatized patient populations across the globe.

  • Food Neophobia

    Behavioral and Biological Influences
    • 1st Edition
    • Steve Reilly
    • English
    Food Neophobia: Behavioral and Biological Influences brings together academic and applied studies to give a comprehensive overview of this topic in both sensory and consumer science and pediatric psychology. The effects of food neophobia can have a huge impact on children’s lives and an influence across their lifespan. Split into two main sections, the book focuses on both the environmental and biological aspects of food neophobia. It covers social, contextual and psychosocial factors that affect food neophobia. Sensory aspects of food neophobia are covered with chapters on disgust and sensation seeking, and genetic and evolutionary influences are also thoroughly discussed. The book is essential reading for academic researchers studying food neophobia from a sensory, consumer science and psychological perspective. It will also be of value to food product developers, especially those working on products for children. Finally, healthcare professionals treating patients suffering from food neophobia will be able to gain greater insight into this condition.

  • Advances in Cell and Molecular Diagnostics

    • 1st Edition
    • P.B. Raghavendra + 1 more
    • English
    Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare.

  • Sleep, Epilepsies, and Cognitive Impairment

    • 1st Edition
    • Peter Halasz + 1 more
    • English
    Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy.

  • Biosynthesis & Integration of Cell Metabolism

    • 1st Edition
    • B C Currell + 1 more
    • English
    Biotechnology by Open Learning: Biosynthesis and the Integration of Cell Metabolism focuses on the structure and activities of cells, including nitrogen fixation, biosynthesis, and metabolic pathways. The manuscript takes a look at precursor molecules for biosynthesis, uptake of nutrients, and nitrogen and sulfur assimilation. Discussions focus on the importance of nitrogen fixation in nature, assimilation of sulfate, ammonia, nitrate, and molecular nitrogen, passive diffusion through protein channels, nutritional requirements of cells, and membranes as permeability barriers. The book then explores amino acid and nucleotide biosynthesis and biosynthesis of lipids. Topics include commercial importance of polysaccharides of micro-organisms, biosynthesis of disaccharides, oligosaccharides and polysaccharides, occurrence of carbohydrates in living systems, and metabolic links between amino acid biosynthesis and the biosynthesis of purines and pyrimidines. The text examines the integration and regulation of metabolism and control of metabolic pathway flux, including patterns of regulation of metabolic pathways, coupling agents in metabolism, integration and regulation of metabolism, and maintenance of metabolic homeostasis through energy coupling. The manuscript is a valuable source of data for biotechnologists and researchers interested in biosynthesis and integration of cell metabolism.

  • Sixth International Congress of Neurology

    Brussels, 21–28 July 1957
    • 1st Edition
    • L. van Bogaert + 1 more
    • English
    Neurology, Volume 1 presents the proceedings of the First International Congress of Neurological Sciences, held in Brussels, Belgium, on July 21–28, 1957. This book provides information pertinent to the fundamental aspects of neurology. Organized into 107 chapters, this compilation of papers begins with an overview of the significance of genetic factors in multiple sclerosis wherein its occurrence in more than one member of a family have a very limited value. This text then examines the two common disorders, namely, cervical spondylosis and disseminated sclerosis. Other chapters explain the mechanism of demyelination problem in considering the pathology of multiple sclerosis or any of the degenerative diseases of the nervous system. This book discusses as well the commonest types of headaches observed, including tension headache, migraine headache, post-traumatic headache, and those associated with hypertension. The final chapter deals with cerebellar ataxia, chronic respiratory infection, and telangiectasia. This book is a valuable resource for neurologists, psychiatrists, and neuropsychiatrists.

  • The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence

    Proceedings of the Society for the Study of Addiction, London, 1 and 2 September 1966
    • 1st Edition
    • C. W. M. Wilson
    • English
    The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence is a collection of proceedings presented at the International Symposium on the Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence, held in London on September 1-2, 1966 under the auspices of the Society for the Study of Addiction to Alcohol and Other Drugs. The symposium provided a forum for discussing the pharmacological and epidemiological aspects of drug dependence in adolescents. Comprised of 10 chapters, this volume begins with an overview of the chemistry and pharmacology of narcotic drugs in adolescence, as well as narcotic addiction in young people in the United States. The discussion then turns to pharmacology and clinical observations on stimulant drugs and hallucinogenic drugs; the epidemiology and social pharmacology of drugs of dependence; and features of adolescent drug dependence. Regulations aimed at controlling drugs of dependence are also analyzed in relation to the national incidence of adolescent dependence in certain countries such as Britain, Belgium, Israel, and the Netherlands. The remaining chapters focus on the language, evidence, and patterns of drug abuse, together with research in relation to drugs of dependence. This book will be of interest to pharmacologists, epidemiologists, and policymakers concerned with drug dependence.

  • Netter's Neurology

    • 3rd Edition
    • Jayashri Srinivasan + 3 more
    • English
    Perfect for residents, medical students, generalists, nurses, and other healthcare professionals who need a practical, working knowledge of neurology, Netter's Neurology, 3rd Edition, provides a concise overview highlighted by unique, memorable Netter illustrations. This award-winning visual resource showcases the well-known work of Frank H. Netter, MD, and his successor, Carlos Machado, MD, a physician who has created clear, full-color illustrations in the Netter tradition.

  • Vitamin D

    Volume 1: Biochemistry, Physiology and Diagnostics
    • 4th Edition
    • Martin Hewison + 3 more
    • English
    Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.

  • Vitamin D

    Volume 2: Health, Disease and Therapeutics
    • 4th Edition
    • Martin Hewison + 3 more
    • English
    Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus.

  • Bladder Cancer

    • 1st Edition
    • Ja Hyeon Ku
    • English
    Bladder Cancer is designed for researchers and clinicians involved in urologic practice, including urologists, medical oncologists, pathologists and radiologists. It provides comprehensive guidance for treating and understanding bladder cancer and serves as an up-to-date reference reflecting evidence-based research. The biological behavior of this disease entity shows a heterogeneous pattern with diverse morbidity and mortality depending on a variety of factors, such as tumor characteristics (tumor stage, grade, size, number, shape, and histologic subtypes) and applied treatment modalities (surgery or non-surgical management). This book presents the substantial academic developments in the field of bladder cancer in one convenient reference.

  • Circuits, Signals, and Systems for Bioengineers

    A MATLAB-Based Introduction
    • 3rd Edition
    • John Semmlow
    • English
    Circuits, Signals and Systems for Bioengineers: A MATLAB-Based Introduction, Third Edition, guides the reader through the electrical engineering principles that can be applied to biological systems. It details the basic engineering concepts that underlie biomedical systems, medical devices, biocontrol and biomedical signal analysis, providing a solid foundation for students in important bioengineering concepts. Fully revised and updated to better meet the needs of instructors and students, the third edition introduces and develops concepts through computational methods that allow students to explore operations, such as correlations, convolution, the Fourier transform and the transfer function. New chapters have been added on image analysis, noise, stochastic processes and ergodicity, and new medical examples and applications are included throughout the text.

  • The Rat Brain in Stereotaxic Coordinates: Compact

    • 7th Edition
    • George Paxinos + 1 more
    • English
    The Rat Brain in Stereotaxic Coordinates Compact, Seventh Edition is a smaller sized (8.5 x 11inch), abridged version of the most referenced work in neuroscience (over 35,000 citations). The compact edition provides the coronal plates and diagrams of the current seventh edition in a smaller, more convenient spiral format and at a student friendly price. This book includes an introduction on current concepts in neuroanatomy, such as neuromeres and brain development. Students and seasoned researchers will find the first major unified nomenclature ontology tree based on development that features coronal photographic plates and juxtaposed diagrams.

  • Heart Failure in the Child and Young Adult

    From Bench to Bedside
    • 1st Edition
    • Joseph Rossano + 4 more
    • English
    Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 1st Edition
    • Rebecca Sheets
    • English
    Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. This book will provide multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions. With numerous case studies, learning activities, and real-world examples across several classes of biotechnological products, this book is a valuable and comprehensive resource for graduate students, professors, regulatory officials, and industry scientists working with biologicals.

  • Omics Technologies and Bio-engineering

    Volume 1: Towards Improving Quality of Life
    • 1st Edition
    • Debmalya Barh + 1 more
    • English
    Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 1 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care.

  • Boorman's Pathology of the Rat

    Reference and Atlas
    • 2nd Edition
    • Andrew W. Suttie + 6 more
    • English
    Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations.

  • Die Design for Extrusion of Plastic Tubes and Pipes

    • 1st Edition
    • Sushil Kainth
    • English
    This book is a step-by-step guide to die design for tubes and pipes. It offers unique coverage of the topic from a highly practical perspective. Written for plastics processing and design engineers, technical and manufacturing managers, die designers and manufacturers. This comprehensive guide includes worked examples to illustrate problem solving and detailed drawings of complete dies for various applications. It covers mono- and multilayers pipes, as well as important melt flow variables (e.g., pressure drop, shear stress, shear rate, temperature variations, distribution variations) of key materials determined using FEM software.

  • FDA's Drug Review Process and the Package Label

    Strategies for Writing Successful FDA Submissions
    • 1st Edition
    • Tom Brody
    • English
    FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label.

  • Comprehensive Toxicology

    • 3rd Edition
    • Charlene McQueen
    • English
    Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology.

  • Advances in Poultry Welfare

    • 1st Edition
    • English
    Advances in Poultry Welfare provides a targeted overview of contemporary developments in poultry welfare. The reviews in the volume address topical issues related to poultry welfare research and assessment, with a focus on identifying practical strategies for improvement as well as information gaps that remain to be filled. Part One provides an introduction to poultry production systems and gives a broad overview of current poultry welfare issues. Part Two moves on to review several aspects of poultry management, focusing on hatchery practices, early rearing, and slaughter. Part Three deals with welfare assessment on the farm, while Part Four explores continuing challenges, such as feather pecking and skeletal problems. This is followed in Part Five by a discussion of emerging issues, with chapters covering alternative parasite control methods, backyard poultry production, mass depopulation, and genetic approaches to reducing the impact of environmental stressors on welfare. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs, and poultry. With its expert editor and international team of contributors, Advances in Poultry Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of poultry.

  • Imaging of Brain Concussion, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 28-1
    • Roy Riascos + 1 more
    • English
    This issue of Neuroimaging Clinics of North America focuses on Imaging of Brain Concussion, and is edited by Drs. Roy Riascos and Eliana E. Bonfante-Mejia. Articles will include: Traumatic Brain Injury: definition, neurosurgery, trauma-orthopedics, neuroimaging, and psychology-psychiatr... Multimodality advanced imaging for brain concussions; Perfusion weighted images in brain concussion; PET and SPECT in brain concussion; Imaging of chronic concussion; Imaging of concussion in young athletes; Imaging on concussion in blast injury; Conventional CT and MR in brain concussion; Structural imaging: structural MRI in concussion; Susceptibility weighted imaging and MR spectroscopy in concussion; Functional imaging fMRI – BOLD and resting state techniques in mTBI; Diffusion Weighted and Diffusion Tensor Imaging in mTBI; and more!

  • Drosophila Cells in Culture

    • 2nd Edition
    • Guy Echalier + 2 more
    • English
    Drosophila Cells in Culture, Second Edition, includes comprehensive coverage of cell lines, methods for creating cell lines, methods for genome engineering, and the use of cell lines for genome wide rNAi screens. This publication summarizes over thirty years of experience in the handling of in vitro cultured Drosophila cells alongside recent methods and functional screens. Early and experienced researchers studying drosophila in developmental biology, genetics, neuroscience, and across the biological and biomedical sciences will benefit from this expert knowledge.

  • Advances in Agricultural Animal Welfare

    Science and Practice
    • 1st Edition
    • Joy Mench
    • English
    Advances in Agricultural Animal Welfare fully explores developments in the key areas of agricultural animal welfare assessment and improvement. Analyzing current topical issues, as well as reviewing the historical welfare issues, the volume is a comprehensive review of the field. Divided into five sections, the book opens in Part One by reviewing advances in animal welfare science, examining cognitive psychology, genetics and genomics. Part Two then looks at transdisciplinary research in animal welfare, with coverage of bioethics, welfare and sustainability from both environmental and food safety perspectives. Part Three explores the process of translating science into policy and practice, followed by discussion on the global achievability of welfare standards in Part Four. Finally, Part Five highlights some emerging issues in agricultural animal welfare. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs, poultry and aquaculture. With its expert editor and international team of contributors, Advances in Agricultural Animal Welfare is a key reference tool for welfare research scientists and students, practicing vets involved in welfare assessment, and indeed anyone with a professional interest in the welfare of agricultural animals.

  • Personalized Predictive Modeling in Type 1 Diabetes

    • 1st Edition
    • Eleni I. Georga + 2 more
    • English
    Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures.

  • Textbook of Nephro-Endocrinology

    • 2nd Edition
    • Ajay K. Singh + 1 more
    • English
    Textbook of Nephro-Endocrinology... Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology... investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypoca... and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid–base disturbances, and pregnancy.

  • Cheetahs: Biology and Conservation

    Biodiversity of the World: Conservation from Genes to Landscapes
    • 1st Edition
    • English
    Cheetahs: Biology and Conservation reports on the science and conservation of the cheetah. This volume demonstrates the interdisciplinary nature of research and conservation efforts to study and protect the cheetah. The book begins with chapters on the evolution, genetics, physiology, ecology and behavior of the species, as well as distribution reports from range countries. These introductory chapters lead into discussions of the challenges facing cheetah survival, including habitat loss, declining prey base, human-wildlife conflict, illegal trade, and newly-emerging threats, notably climate change. This book also focuses on conservation strategies and solutions, including environmental education and alternative livelihoods. Chapters on the role of captive cheetahs to conservation and the long-term research of the species are included, as are a brief discussion of the methods and analyses used to study the cheetah. The book concludes with the conservation status and future outlook of the species. Cheetahs: Biology and Conservation is a valuable resource for the regional and global communities of cheetah conservationists, researchers, and academics. Although cheetah focussed the book provides information relevant to the study of broader topics such as wildlife conservation, captive breeding, habitat management, conservation biology and animal behaviour. Cover photograph by Angela Scott

  • Dyneins

    Dynein Mechanics, Dysfunction, and Disease
    • 2nd Edition
    • Stephen M. King
    • English
    Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.

  • Artemisinin-Based and Other Antimalarials

    Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them
    • 1st Edition
    • Guoqiao Li + 3 more
    • English
    Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology.

  • Advances in Cattle Welfare

    • 1st Edition
    • Cassandra Tucker
    • English
    Advances in Cattle Welfare provides a targeted overview of contemporary issues in dairy and beef cattle welfare. The volume addresses welfare-related topics in both research and on-farm applications. Opening with an introduction to cattle production systems, the book covers the three major areas of cattle welfare; on-farm welfare assessment, behavioral priorities of cattle and novel perspectives on specific aspects of management. Chapters examine the key issues within each area, including such topics as the goals and measures included in welfare assessments, the importance to cattle of access to pasture and engaging in social behavior, human-animal interactions, painful procedures, and disease and metabolic challenge. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep and pigs. With its expert editor and international team of contributors, Advances in Cattle Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of cattle.

  • Multiple Sclerosis, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 36-1
    • Darin T. Okuda
    • English
    This issue of Neurologic Clinics, edited by Dr. Darin T. Okuda, focuses on Multiple Sclerosis. Topics include, but are not limited to, Myelin and Axonal Repair Strategies in Multiple Sclerosis; Common Clinical and Imaging Conditions Misdiagnosed as Multiple Sclerosis; Topographical Model for Multiple Sclerosis: A Novel Approach to Understanding Clinical Phenotypes and Disease Activity; Incidental Anomalies Characteristic of CNS Demyelination: Radiologically Isolated Syndrome; Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management; Progressive Forms of Multiple Sclerosis: Distinct Entity or Time Dependent Phenomena; Advanced Symptom Management Strategies in Multiple Sclerosis, Ethnic Considerations and Multiple Sclerosis Disease Variability; The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease; Spinal Cord Imaging in Relation to Clinical Status in Multiple Sclerosis, and more.

  • Examining Ecology

    Exercises in Environmental Biology and Conservation
    • 1st Edition
    • Paul A. Rees
    • English
    Examining Ecology: Exercises in Environmental Biology and Conservation explains foundational ecological principles using a hands-on approach that features analyzing data, drawing graphs, and undertaking practical exercises that simulate field work. The book provides students and lecturers with real life examples to demonstrate basic principles. The book helps students, instructors, and those new to the field learn about the principles of ecology and conservation by completing a series of problems. Prior knowledge of the subject is not assumed; the work requires users to be able to perform simple calculations and draw graphs. Most of the exercises in the book have been used widely by the author’s own students over a number of years, and many are based on real data from published research. Exercises are succinct with a broad number of options, which is a unique feature among similar books on this topic. The book is primarily intended as a resource for students, academics, and instructors studying, teaching, and working in zoology, ecology, biology, wildlife conservation and management, ecophysiology, behavioural ecology, population biology and ecology, environmental biology, or environmental science. Students will be able to progress through the book attempting each exercise in a logical sequence, beginning with basic principles and working up to more complex exercises. Alternatively they may wish to focus on specific chapters on specialist areas, e.g., population dynamics. Many of the exercises introduce students to mathematical methods (calculations, use of formulae, drawing of graphs, calculating simple statistics). Other exercises simulate fieldwork projects, allowing users to ‘collect’ and analyze data which would take considerable time and effort to collect in the field.

  • Encyclopedia of Cardiovascular Research and Medicine

    • 1st Edition
    • Volume 4
    • Douglas B. Sawyer + 1 more
    • English
    Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focus... basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine.

  • Manual of Chronic Total Occlusion Interventions

    A Step-by-Step Approach
    • 2nd Edition
    • Emmanouil Brilakis
    • English
    Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach, Second Edition, is an easy to read reference for coronary chronic total occlusion interventions (CTO). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and troubleshooting tactics necessary for coronary chronic total occlusion interventions (CTO). This second edition is updated with new developments in the field. The 2nd edition covers techniques like the Carlino technique, "scratch and go", "BASE", double-blind stick and swap, and subintimal crush, along with tips about how to use the latest complex PCI equipment. It also covers recently published trials, CTO scores and hybrid series. Written to bring a practical and easy to read approach, this book is perfect for interventional cardiologists, interventional and general cardiology fellows, cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff,industry professionals and everyone else interested in understanding the cutting edge and rapidly evolving field of coronary CTO interventions.　　

  • Hazard Analysis and Risk Based Preventive Controls

    Building a (Better) Food Safety Plan
    • 1st Edition
    • Patricia A. Wester
    • English
    Hazard Analysis and Risk Based Preventive Controls: Building a (Better) Food Safety Plan is directed to those food safety professionals charged with ensuring or assisting with FSMA’s preventative controls (PC) implementation and compliance in their routine job duties. The target audience includes those currently involved in the development, management, and execution of HACCP and/or other advanced food safety management systems, as well as those interested in advancing their knowledge base to gain a more thorough comprehension of HARPC requirements. FSMA topics covered include: identifying the food safety team and PCQI; creating the HARPC implementation strategy; starting the food safety plan; conducting a thorough hazard analysis; identifying adequate preventive control measures; determining appropriate PC management components; recognizing applicable verification and validation activities; supply chain management program; recall plans. Other operational topics include: document control systems; internal audit programs; third party audit management; regulatory visit preparation; and maintaining compliance.

  • Starch in Food

    Structure, Function and Applications
    • 2nd Edition
    • Malin Sjöö + 1 more
    • English
    Starch in Food: Structure, Function and Applications, Second Edition, reviews starch structure, functionality and the growing range of starch ingredients used to improve the nutritional and sensory quality of food. The new edition is fully updated and brings new chapters on starch and health, isolation, processing and functional properties of starch. Part One illustrates how plant starch can be analyzed and modified, with chapters on plant starch synthesis, starch bioengineering and starch-acting enzymes. Part Two examines the sources of starch, from wheat and potato, to rice, corn and tropical supplies. Part Three looks at starch as an ingredient and how it is used in the food industry, with chapters on modified starches and the stability of frozen foods, starch-lipid interactions and starch-based microencapsulation. Part Four covers starch as a functional food, investigating the impact of starch on physical and mental performance, detecting nutritional starch fractions and analyzing starch digestion. The book is a standard reference for those working in the food industry, especially to starch scientists, food researchers, post-docs, practitioners in the starch area and students.

  • Encyclopedia of Marine Mammals

    • 3rd Edition
    • Bernd Würsig + 2 more
    • English
    The Encyclopedia of Marine Mammals, Third Edition covers the ecology, behavior, conservation, evolution, form and function of whales, dolphins, seals, sea lions, manatees, dugongs, otters and polar bears. This edition provides new content on anthropogenic concerns, latest information on emerging threats such as ocean noise, and impacts of climate change. With authors and editors who are world experts, this new edition is a critical resource for all who are interested in marine mammals, especially upper level undergraduate and graduate students, researchers, and managers, and is a top reference for those in related fields, from oceanographers to environmental scientists.

  • Hepatitis C in Developing Countries

    Current and Future Challenges
    • 1st Edition
    • Sanaa M. Kamal
    • English
    Hepatitis C in Developing Countries: Current and Future Challenges explores the current state of HCV in several countries, including Africa, Asia and South America. It maintains a dedicated focus on the epidemiology, clinical patterns, virologic diversity, coinfections, natural history and progression, complications, and response to standard of care (SOC) pegylated interferon and ribavirin therapy of HCV with recommendations specific to middle and low income countries. Readers will find detailed information on the burden of HCV infection from a global health and economic perspective, along with data from multicenter trials on DAAs that have enrolled patients infected with HCV non-genotype 1.

  • Inhaled Pharmaceutical Product Development Perspectives

    Challenges and Opportunities
    • 1st Edition
    • Anthony J. Hickey
    • English
    Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future.

  • Neurofeedback

    Tools, Methods and Applications
    • 1st Edition
    • Pascale Vincent
    • English
    The artificial intelligence of robots capable of learning from their errors and modifying their behavior accordingly is modeled on the activity of neurons in the brain.Emotional stress, traffic accidents, bereavement; these are all factors that can disrupt this neural activity, sometimes to the point of generating suffering that can be difficult to relieve. Neurofeedback, derived from neuroscience, is a computerized technique for training and re-balancing the brain’s electrical activity using neuroplasticity, which allows the brain to self-correct and regain a stable equilibrium, thus promoting recovery from traumas and a return to well-being. Neurofeedback: Tools, Methods and Applications deals with neurofeedback, explaining the functioning of the tool, its action on the equilibration of neural activity, and the differences between classical and dynamic systems. The results of the author's research and observations, the applications of these two tools, and the effects produced on the patients are explored, along with testimonies that describe and explain concepts in detail.Different neurofeedback tools are presented in this book, together with their function and explicit specificities adapted to the needs of each user. Their applications to psychological and cognitive disorders make neurofeedback an efficient and promising neurotherapy technique.

  • Dyneins

    The Biology of Dynein Motors
    • 2nd Edition
    • Stephen M. King
    • English
    Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

  • The Cardiovascular System

    Development, Plasticity and Physiological Responses
    • 1st Edition
    • Volume 36B
    • A. Kurt Gamperl + 3 more
    • English
    The Cardiovascular System: Phenotypic and Physiological Responses, Volume 37, part of a two-volume set, provides comprehensive coverage of the current state of knowledge in this very active and growing field of research, also highlighting the tremendous diversity in cardiovascular morphology and function among the various fish taxa and the anatomical and physiological plasticity shown by this system when faced with various abiotic and biotic challenges. Specific chapters in this updated book include Research Technologies/Methodo... for Studying Fish Cardiovascular Function, Cardiovascular Development in Embryonic and Larval Fishes, Cardiovascular Responses to Limiting Oxygen Levels, and Temperature and the Cardiovascular System. The book's chapters integrate molecular and cellular data with the growing body of knowledge on heart and in vivo cardiovascular function, and as a result, provide insights into some of the most interesting, and important, questions that still need to be answered in this field.

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