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Profiles of Drug Substances, Excipients, and Related Methodology
- 1st Edition, Volume 42 - April 19, 2017
- Editor: Harry G. Brittain
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 2 2 2 6 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 2 2 2 7 - 3
Profiles of Drug Substances, Excipients, and Related Methodology, Volume 42 presents comprehensive reviews of drug substances and additional materials, with critical review ch… Read more
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Request a sales quoteProfiles of Drug Substances, Excipients, and Related Methodology, Volume 42 presents comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients, thus meeting the needs of the pharmaceutical community and allowing for the development of a timely vehicle for publishing review materials on the topic. This latest release covers a variety of substances, including Cinacalcet Hydrochloride, Clenbuterol Hydrochloride, Gliclazide, Lomefloxacin, Olmesartan, Propranolol, and Tolterodine Tartrate.
The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories, Physical profiles of drug substances and excipients, Analytical profiles of drug substances and excipients, Drug metabolism and pharmacokinetic profiles of drug substances and excipients, Methodology related to the characterization of drug substances and excipients, Methods of chemical synthesis, and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.
- Contains contributions from leading authorities
- Informs and updates on all the latest developments in the field
Medicinal, pharmaceutical, and analytical chemists; pharmacologists
Chapter One: Cinacalcet Hydrochloride
- Abstract
- 1 Description
- 2 Uses and Applications
- 3 Methods of Preparation
- 4 Physical Characteristics
- 5 Methods of Analysis
- 6 Stability
- 7 Metabolism
- 8 Pharmacokinetics and Pharmacodynamics
- Acknowledgments
Chapter Two: Clenbuterol Hydrochloride
- Abstract
- 1 Description
- 2 Methods of Preparation
- 3 Physical Characteristics
- 4 Methods of Analysis
- 5 Stability
- 6 Pharmacokinetics, Metabolism, and Excretion
- 7 Pharmacology
Chapter Three: Gliclazide
- Abstract
- 1 Description
- 2 Methods of Preparation
- 3 Physical Characteristics
- 4 Methods of Analysis
- 5 Biological Analysis
- 6 Stability
- 7 Pharmacokinetics
- 8 Pharmacology
- 9 Adverse Effects
- 10 Drug Interactions
- 11 Toxicology
- Acknowledgment
Chapter Four: Lomefloxacin
- Abstract
- 1 Physical Profile of Lomefloxacin
- 2 Analytical Profile of Lomefloxacin
- 3 ADME Profiles of Drug Substances and Excipients
- 4 Methodology Related to the Characterization of Lomefloxacin
- 5 Methods of Chemical Synthesis
- Acknowledgments
Chapter Five: Olmesartan
- Abstract
- 1 Description
- 2 Synthesis
- 3 Physical Characteristics
- 4 Methods of Analysis
- 5 Stability
- 6 Clinical Applications
Chapter Six: Propranolol
- Abstract
- 1 Description
- 2 Methods of Preparation
- 3 Physical Characteristics
- 4 Methods of Analysis
- 5 Stability
- 6 Pharmacokinetics, Metabolism, and Excretion
- 7 Pharmacology
Chapter Seven: Tolterodine Tartrate
- Abstract
- 1 General Information
- 2 Physical Profile
- 3 Methods of Chemical Synthesis
- 4 Stability
- 5 Analytical Profile
- 6 ADME Profile
- Acknowledgments
- No. of pages: 424
- Language: English
- Edition: 1
- Volume: 42
- Published: April 19, 2017
- Imprint: Academic Press
- Hardback ISBN: 9780128122266
- eBook ISBN: 9780128122273
HB
Harry G. Brittain
Dr. Brittain is presently the Institute Director of the Center for Pharmaceutical Physics, a research and consulting institute he established in 1999 for the study of substances having pharmaceutical interest. His research interest include all areas of pharmaceutical physics and physical pharmacy, including preformulation, formulation design, product characterization, polymorphism, solvatomorphism, and cocrystals of drug substances. Formerly, Dr. Brittain was Vice President for Pharmaceutical Development of Discovery Laboratories, Inc., he served as Director of Pharmaceutical Development at Ohmeda, Inc., and also led a variety of groups within the Analytical R&D department at Bristol-Myers Squibb.
Dr. Brittain is a graduate of Queens College (B.A. in chemistry, 1970; M.A. in physical chemistry 1972), and of the City University of New York (Ph.D. in physical chemistry, 1975). He was a postdoctoral fellow at the University of Virginia, and has held full-time faculty positions at Ferrum College (Assistant Professor of Chemistry) and Seton Hall University (Associate Professor of Physical and Inorganic Chemistry). He has been Adjunct Professor of Pharmaceutics at Rutgers University, and both Adjunct Professor of Chemistry and Visiting Research Scientist at Lehigh University.
Dr. Brittain has authored over 340 research publications and book chapters, and has presented over 175 invited lectures and short courses in the pharmaceutical field. He has edited the monographs Analytical Applications of Circular Dichroism, Physical Characterization of Pharmaceutical Solids, Polymorphism in Pharmaceutical Solids (first and second editions), Spectroscopy of Pharmaceutical Solids, and Preformulation in Solid Dosage Form Development. He is also the Editor-In-Chief of the book series Profiles of Drug Substances, Excipients, and Related Methodology, having edited 23 published volumes in the series that is now published annually by Elsevier. Dr. Brittain is also an Editor of Physical Pharmacy for the Journal of Pharmaceutical Sciences, and is a co-author of 22 issued United States patents.
During his academic tenure at Seton Hall University, in 1980 Dr. Brittain was named as one of the Teacher-Scholars of the Camille and Henry Dreyfus Foundation. Dr. Brittain was elected as a Fellow of the American Association of Pharmaceutical Sciences (AAPS) in 1991, and received the AAPS Research Achievement Award in Analysis and Pharmaceutical Quality in 1998. He is also a Fellow of the Royal Society of Chemistry.
Affiliations and expertise
Center for Pharmaceutical Physics, Milford, NJ, USARead Profiles of Drug Substances, Excipients, and Related Methodology on ScienceDirect