Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling

Chapter One: Biochemical and Biological Attributes of Matrix Metalloproteinases
N. Cui, M. Hu and R.A. Khalil

• Abstract
• 1 Introduction
• 2 MMP Structure
• 3 Sources and Tissue Distribution of MMPs
• 4 MMP Activation
• 5 MMP Substrates
• 6 MMPs, ECM Degradation, and Tissue Remodeling
• 7 MMPs and Cell Signaling
• 8 Special Attributes of Specific MMPs
• 9 MMP/TIMP Ratio
• 10 Concluding Remarks
• Acknowledgments

Chapter Two: Matrix Metalloproteinases in Myocardial Infarction and Heart Failure
K.Y. DeLeon-Pennell, C.A. Meschiari, M. Jung and M.L. Lindsey

• Abstract
• 1 Introduction
• 2 MMPs as Biomarkers for Heart Failure
• 3 Clinical Use of MMP Inhibitors Post-MI
• 4 Future Directions
• 5 Conclusion
• Acknowledgments

Chapter Three: The Balance Between Metalloproteinases and TIMPs: Critical Regulator of Microvascular Endothelial Cell Function in Health and Disease
M.G. Masciantonio, C.K S. Lee, V. Arpino, S. Mehta and S.E. Gill

• Abstract
• 1 Introduction
• 2 Metalloproteinases
• 3 Tissue Inhibitor of Metalloproteinases
• 4 Microvascular Endothelial Cells
• 5 MVEC Dysfunction
• 6 Metalloproteinases in Endothelial Dysfunction
• 7 TIMPs in Endothelial Dysfunction
• 8 Conclusion

Chapter Four: Matrix Metalloproteinases and Platelet Function
P. Gresele, E. Falcinelli, M. Sebastiano and S. Momi

• Abstract
• 1 Platelets: Structure and Function
• 2 Expression of MMPs by Platelets and Megakaryocytes
• 3 Functions of MMPs in Platelets and Megakaryocytes
• 4 Role of Platelet-Derived MMPs in Disease
• 5 Conclusions

Chapter Five: Matrix Metalloproteinases and Leukocyte Activation
K.S. Smigiel and W.C. Parks

• Abstract
• 1 Introduction
• 2 Inflammation and Tissue Remodeling
• 3 Neutrophils, Macrophages, and Lymphocytes
• 4 MMP Regulation of Leukocyte Activity
• 5 Concluding Remarks

Chapter Six: Evidence for the Involvement of Matrix-Degrading Metalloproteinases (MMPs) in Atherosclerosis
B.A Brown, H. Williams, and S.J George

• Abstract
• 1 Atherosclerosis and Cardiovascular Disease
• 2 Introduction to MMPs
• 3 TIMPs
• 4 Conclusion

Chapter Seven: The Role Matrix Metalloproteinases in the Production of Aortic Aneurysm
S.W Rabkin

• Abstract
• 1 Introduction
• 2 TAA and Dissection (TAD)
• 3 Abdominal Aortic Aneurysm (AAA)
• 4 Putative Signaling Pathways Involved in Aortic Aneurysm Development: Relationship to MMPs
• 5 Cigarettes and AAA Development
• 6 MMP Substrates and Pathogenesis of Aortic Aneurysm
• 7 Summary

Chapter Eight: Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease
Y. Chen, W. Peng, J.D. Raffetto and R.A. Khali

• Abstract
• 1 Introduction
• 2 Chronic Venous Disease (CVD)
• 3 Structural and Functional Abnormalities in VVs
• 4 MMP Levels in VVS
• 5 Potential MMP Inducers/Activators in VVs
• 6 Mechanisms of MMP Actions in VVs
• 7 Management of VVs
• 8 Potential Benefits of MMP Inhibitors in VVs
• 9 Concluding Remarks
• Acknowledgments