Stress and Inflammation in Disorders

Chapter One: Oxidative Stress: Love and Hate History in Central Nervous System
Sánchez-González, A.L Sánchez-López, L. Sánchez-Romero, E.I Díaz-Barba, J.F. Santoscoy-Gutiérrez and P. Rivero-Moragrega

• Abstract
• 1 Introduction
• 2 Oxidative Stress and Neuropathology
• 3 PD and ROS
• 4 Cerebral Ischemia and ROS
• 5 Multiple Sclerosis

Chapter Two: Neuroinflammation in Alzheimer's Disease: The Preventive and Therapeutic Potential of Polyphenolic Nutraceuticals
Y. Sawikr, N.S. Yarla, I. Peluso, M.A. Kamal, G. Aliev and A. Bishayee

• Abstract
• 1 Introduction
• 2 Neuroinflammation in AD (Alzheimer's Disease)
• 3 Astrogliosis in AD
• 4 Advanced Glycation End Products in AD
• 5 Polyphenolic Nutraceuticals Targeting Neuroinflammation for Prevention and Therapy of AD
• 6 Conclusions and Future Directions

Chapter Three: Inflammation in Epileptic Encephalopathies
O. Shandra, S.L. Moshé and A.S. Galanopoulou

• Abstract
• 1 Introduction
• 2 Inflammation and Neuroinflammation: Definitions, Targets, and Role in Epilepsy and Seizures
• 3 Does Activation of the Inflammatory Pathways in the Brain Cause Epilepsy in WS?
• 4 Does Activation of the Inflammatory Pathways in the Brain Contribute to the Associated Comorbidities and Progression?
• 5 Can Activation of Certain Inflammatory Pathways Be a Compensatory or Protective Event?
• 6 Are There Interactions Between Inflammation and the Neuroendocrine System That Contribute to the Pathogenesis of WS?
• 7 Does Activation of Brain Inflammatory Signaling Pathways Contribute to the Transition of WS to LGS?
• 8 Are There Any Lead Candidates or Unexplored Targets for Future Therapy Development for WS Targeting Inflammation?
• 9 Concluding Remarks
• Acknowledgments

Chapter Four: Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach
P. Sneha, D. Thirumal Kumar, Sugandhi Saini, Kreeti Kajal, R. Magesh , R. Siva and C. George Priya Doss

• Abstract
• 1 Introduction
• 2 Materials and Methods
• 3 Results
• 4 Discussion
• 5 Conclusion
• Acknowledgments

Chapter Five: A Computational Approach to Identify the Biophysical and Structural Aspects of Methylenetetrahydrofolate Reductase (MTHFR) Mutations (A222V, E429A, and R594Q) Leading to Schizophrenia
H. Tanwar, P. Sneha, D. Thirumal Kumar, R. Siva, C.E.J. Walter and C. George Priya Doss

• Abstract
• 1 Introduction
• 2 Materials and Methods
• 3 Results
• 4 Discussion
• 5 Conclusion
• Acknowledgments

Chapter Six: Stress-Induced NLRP3 Inflammasome in Human Diseases
E. Alcocer-Gómez, B. Castejón-Vega and M.D. Cordero

• Abstract
• 1 Introduction
• 2 Inflammatory Diseases and Stress
• 3 The Inflammasomes
• 4 The Inflammasome in the Psychiatric Diseases
• 5 NLRP3 Inflammasome and Neuroinflammation in Neurodegenerative Diseases
• 6 Inflammasome and Cancer
• 7 NLRP3 and CVD
• 8 Future Perspectives

Chapter Seven: Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation
M.R. Amoroso, D.S Matassa, I. Agliarulo, R. Avolio, F. Maddalena, V. Condelli, M. Landriscina and F. Esposito

• Abstract
• 1 Introduction
• 2 Linking OXPHOS, Inflammation, EMT, and Chemoresistance in Cancer
• 3 TRAP1 as a Novel Player in Ovarian Cancer Biology
• 4 Concluding Remarks

Chapter Eight: Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy
J.M.-W. Chua, B.Y.-J. Chua, S. Mishra, X. Dai, J. Magae, S.-C. Ng, A.P Kumar and G. Sethi

• Abstract
• 1 Introduction
• 2 Pharmacological Properties of ASC and Its Derivatives
• 3 Anticancer Effects of ASC and Its Derivatives
• 4 Conclusion
• Acknowledgments

Chapter Nine: Cardiokines as Modulators of Stress-Induced Cardiac Disorders
A. Planavila, J. Fernández-Solà and F. Villarroya

• Abstract
• 1 Introduction
• 2 The Heart as a Secretory Organ
• 3 Cardiokines and Cardiac Stress
• 4 Cardiokines: Autocrine/Paracrine Signaling
• 5 Endocrine Functions of Cardiokines
• 6 Cardiokines as Biomarkers for Cardiac Disorders
• 7 Conclusions
• Acknowledgments