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Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to… Read more
LIMITED OFFER
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.
This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.
Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
Academic researchers, clinicians, and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology, and neurotoxicology
Chapter 1: Biometals and Alzheimer’s Disease
Alexandra I. Mot and Peter J. Crouch
Chapter 2: Copper in Alzheimer’s Disease
Rosanna Squitti, Mariacarla Ventriglia, Mariacristina Siotto and Carlo Salustri
Chapter 3: The Role of Selenium in Neurodegenerative Diseases
Bárbara R. Cardoso, Dominic J. Hare and Ashley I. Bush
Chapter 4: Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?
Anne M. Nixon and James R. Connor
Chapter 5: Chemical Elements and Oxidative Status in Neuroinflammation
Michela Ferraldeschi, Silvia Romano, Maria Chiara Buscarinu, Arianna Fornasiero, Rosella Mechelli, Benedetta Cerasoli, Anna Pino, Sonia Brescianini, Carlo Mattei, Maria Antonia Stazi, Alessandro Alimonti, Marco Salvetti and Giovanni Ristori Sr.
Chapter 6: Metals and Neuroinflammation
Stephen C. Bondy
Chapter 7: Metals and Prions: Twenty Years of Mining the Awe
David R. Brown
Chapter 8: Manganese and Neurodegeneration
Dinamene Marques dos Santos, Michael Aschner and Ana Paula Marreilha dos Santos
Chapter 9: Zinc in Autism
Stefanie Grabrucker and Andreas Grabrucker
Chapter 10: Metals and Motor Neuron Disease
Per M. Roos
Chapter 11: Metals and Lysosomal Storage Disorders
H. Konttinen, K. Lejavová, T. Malm and Katja Kanninen
Chapter 12: Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration
Lucio G. Costa
Chapter 13: Metal Biology Associated with Huntington’s Disease
Terry Jo Vetters Bichell, Timothy C. Halbesma, K. Grace Tipps and Aaron Bowman
Chapter 14: Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production
Melisa del Barrio, Valentina Borghesani, Christelle Hureau and Peter Faller
Chapter 15: Metals and Mitochondria in Neurodegeneration
Germán Plascencia-Villa, Miguel José Yacamán and George Perry
Chapter 16: Metal Transporters in Neurodegeneration
Hong Jiang
Chapter 17: Metal Imaging in the Brain
David C. Dorman
Chapter 18: Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases
A. Ramírez Muñoz, M. A. Greenough, Ashley I. Bush and C. M. Opazo
Chapter 19: Metals and Autophagy in Neurotoxicity
Peng Su, Michael Aschner, Jingyuan Chen and Wenjing Luo
Chapter 20: An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases
Frank W. Lewis and David Tétard
Chapter 21: Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases
Katja Kanninen and Anthony R. White
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