ROBOTICS & AUTOMATION
Empowering Progress
Up to 25% off Essentials Robotics and Automation titles

Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology i… Read more
ROBOTICS & AUTOMATION
Up to 25% off Essentials Robotics and Automation titles
Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies.
This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments.
Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied. In addition, the book highlights how modeling and systems biology relate to studies of RNA, DNA, and genome instability, mechanisms of DNA damage signaling and repair, and the effect of the environment on genome stability.
Section I: Introduction
Section II: Where Am I? Genomic Features and DNA Sequence Principles Defining Sites of Epigenetic Regulation: Machine Learning
Chapter 1. Computational Identification of Polycomb/Trithorax Response Elements
Chapter 2. Modeling Chromatin States
Chapter 3. Crossing Borders: Modeling Approaches to Understand Chromatin Domains and Their Boundaries
Chapter 4. Inferring Chromatin Signaling From Genome-Wide ChIP-seq Data
Section III: Everything’s Moving: In Vivo Dynamics of Epigenetic Regulators: Kinetic Models Based on Ordinary Differential Equations
Chapter 5. “In Vivo Biochemistry”: Absolute Quantification and Kinetic Modeling Applied to Polycomb and Trithorax Regulation
Chapter 6. Modeling Distributive Histone Modification by Dot1 Methyltransferases: From Mechanism to Biological Insights
Section IV: Reconciling Randomness and Precision: Bistable Epigenetic Memory and Switching: Stochastic Models
Chapter 7. Modeling Bistable Chromatin States
Chapter 8. Quantitative Environmentally Triggered Switching Between Stable Epigenetic States
Section V: The Third and Fourth Dimensions: Chromosomal Long Range Interactions: Polymer Models
Chapter 9. On the Nature of Chromatin 3D Organization: Lessons From Modeling
Chapter 10. From Chromosome Conformation Capture to Polymer Physics and Back: Investigating the Three-Dimensional Structure of Chromatin Within Topological Associating Domains
Chapter 11. A Combination Approach Based on Live-Cell Imaging and Computational Modeling to Further Our Understanding of Chromatin, Epigenetics, and the Genome
Chapter 12. Capturing Chromosome Structural Properties From Their Spatial and Temporal Fluctuations
LR