Advances in Virus Research

Chapter One: Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns
P.A. Thibault, R.E. Watkinson, A. Moreira-Soto, J.F. Drexler and B. Lee

• Abstract
• 1 Introduction
• 2 Known Highly Lethal Emergent Paramyxoviruses: Nipah Virus and Hendra Virus
• 3 Unknown Zoonotic Potential of Paramyxoviruses
• 4 Ecological Factors Driving Zoonotic Paramyxovirus Emergence
• 5 Virus–Host Molecular Interactions Affecting Paramyxovirus Emergence
• 6 Summary
• Acknowledgments

Chapter Two: Metabolomics: Strategies to Define the Role of Metabolism in Virus Infection and Pathogenesis
M. Manchester and A. Anand

• Abstract
• 1 Introduction
• 2 Metabolomics Analytical Strategy and Study Design
• 3 Using Metabolomics to Characterize Viral Infections
• 4 Metabolomics to Discover Target Networks for Broad Spectrum Antivirals
• 5 Conclusions and Future Trends

Chapter Three: The Envelope Proteins of the Bunyavirales
P. Guardado-Calvo and F.A. Rey

• Abstract
• 1 Introduction
• 2 Bunyavirus Entry Into Cells
• 3 Bunyavirus Gc Is a Class II Fusion Protein
• 4 The Target Membrane-Interacting Region
• 5 pH-Sensing Mechanisms
• 6 Lipid Sensing
• 7 The Stem Region
• 8 Newly Identified pGc-Like Envelope Proteins
• 9 Projections for Gc From Other Members of the Bunyavirales Order
• 10 Hantavirus Gn Is Homologous to Alphavirus E2
• 11 Discussion

Chapter Four: Insect-Specific Viruses: A Historical Overview and Recent Developments
C.M. Roundy, S.R. Azar, S.L. Rossi, S.C. Weaver and N. Vasilakis

• Abstract
• 1 Introduction
• 2 Background
• 3 Biological Characteristics of Value
• 4 Specific Viral Families
• 5 Conclusions and Future Perspectives
• Acknowledgments