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Arthropod Vector: Controller of Disease Transmission, Volume 1
Vector Microbiome and Innate Immunity of Arthropods
- 1st Edition - April 25, 2017
- Editors: Stephen K. Wikel, Serap Aksoy, George Dimopoulos
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 0 5 3 5 0 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 9 2 3 7 - 8
Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone… Read more
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Request a sales quoteArthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures.
The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host.
These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.
- Includes such major areas of coverage as host-derived factors, innate immunity of arthropod presentations and the arthropod microbiome/symbionts
- Features expertly curated topics, ensuring appropriate scope of coverage and aid integration of concepts and content
- Provides the necessary scientific background for the development of the research and discussions that have laid the groundwork for future efforts, including the Keystone Symposium and relevant meetings at NIAID/NIH
A broad market consisting of medical and veterinary entomologists, vector biologists, parasitologists, global public health specialists, medical and veterinary infectious disease researchers, medical and veterinary immunologists, biotechnologists, vaccine development researchers, entrepreneurs, and government regulators facing the challenges of implementing policies regarding emerging and novel disease control technologies
Chapter 1. The Site of the Bite: Addressing Knowledge Gaps in Vector Transmission of Diseases
Adriana Costero-Saint Denis
- Vectors: The Neglected Part of the Equation
- Identifying the Research Gaps
- Role of Immune Cell Subsets in the Establishment of Vector-Borne Infections
- Effect of Vector Innate Immunity and Human-Derived Immune Molecules on the Transmission of Vector-Borne Pathogens
- Drosophila—a Useful Model for Vectors?
- Arthropod Vectors and Disease Transmission: Translational Aspects
- Translational Considerations for Novel Vector Management Approaches
- Keystone Symposia on Molecular and Cellular Biology–the Arthropod Vector: The Controller of Transmission
- Conclusions
Chapter 2. Conservation and Convergence of Immune Signaling Pathways With Mitochondrial Regulation in Vector Arthropod Physiology
Shirley Luckhart
- Historical Importance of Insects in Our Understanding of Disease
- The Blood-Feeding Interface
- Ancient Regulatory Pathways of Homeostasis: IIS, TGF-β, MAPK
- Mitochondrial Dynamics Controls Diverse Physiologies That Are Key to Vector Competence
- Summary
Chapter 3. Wolbachia-Mediated Immunity Induction in Mosquito Vectors
Zhiyong Xi
- Introduction
- Wolbachia-Mediated Immune Inductions
- The Role of Wolbachia-Induced Immunity in Pathogen Interference
- The Role of Wolbachia-Induced Immunity in Symbiosis Formation
- The Impact of Wolbachia-Induced Immunity on Microbiota
- Evolution of Wolbachia-Mediated Immune Inductions and Its Impact on Disease Control
- Translational Opportunities for Disease Control and Prevention
- Future Research Directions
Chapter 4. Modulation of Mosquito Immune Defenses as a Control Strategy
Kristin Michel
- Introduction
- The Genetic Basis of Vector Competence and Its Link to Mosquito Immunity
- Current Knowledge of Antiparasite Immune Reactions in the Mosquito Vector
- The Regulation of Anti-Parasite Immunity by Canonical Signal Transduction Pathways
- Creating Malaria-Refractory Mosquitoes in the Laboratory: The Proof of Principle
- The Challenges and Opportunities for Boosting Mosquito Immunity in the Field
Chapter 5. Molecular Mechanisms Mediating Immune Priming in Anopheles gambiae Mosquitoes
Jose Luis Ramirez
- Introduction
- Essential Components in the Establishment of Immune Memory
- Mosquito–Parasite Compatibility and the Strength of the Priming Response
- Molecular Factors Mediating the Establishment and Maintenance of Innate Immune Priming
- Conclusions and Future Perspectives
- Take-Home messages
Chapter 6. The Mosquito Immune System and Its Interactions With the Microbiota: Implications for Disease Transmission
George Christophides
- Introduction
- The Mosquito Innate Immune System
- The Mosquito Microbiota
- Microbiota–Immune System Interactions
- Perspective
Chapter 7. Using an Endosymbiont to Control Mosquito-Transmitted Disease
Luciano Moreira and E. Caragata
- The Biology of Wolbachia pipientis
- The Use of Wolbachia in Mosquito Control Programs
- Prerelease Considerations
- Field Deployment
- Selecting the Right Wolbachia Strain
- Pathogen Interference Versus Pathogen Enhancement
- The Future
Chapter 8. Effect of Host Blood–Derived Antibodies Targeting Critical Mosquito Neuronal Receptors and Other Proteins: Disruption of Vector Physiology and Potential for Disease Control
Brian Foy
- Background
- Current Advances in Antimosquito Antibody Development
- Future Research Directions
- Conclusion
Chapter 9. Role of the Microbiota During Development of the Arthropod Vector Immune System
Brian Weiss
- Spectrum of Vector–Microbe Interactions
- Environmentally Acquired Commensal Bacteria Support Their Host’s Development
- Microbiome Influences on Arthropod Host Vector Competence
- Mutualistic Endosymbionts Support Their Host’s Development
- The Tsetse Fly as a Model System for Studying Symbiont Contributions to Host Immune System Development
- Summary and Concluding Thoughts
Chapter 10. Host–Microbe Interactions: A Case for Wolbachia Dialogue
Sassan Asgari
- Introduction
- Impact of Wolbachia on Mosquito Small RNAs
- Manipulation of Host miRNAs as Regulators of Genes Involved in Wolbachia Maintenance
- Effect of Alterations of Host miRNAs by Wolbachia on Host–Virus Interactions
- Small RNAs as Mediators of Dialogue Between Host and Wolbachia
- Conclusions
Chapter 11. The Gut Microbiota of Mosquitoes: Diversity and Function
Michael Strand
- Introduction
- Acquisition and Community Diversity of the Mosquito Gut Microbiota
- Functions of the Gut Microbiota in Mosquitoes
- Concluding Remarks
Chapter 12. Targeting Dengue Virus Replication in Mosquitoes
Carol Blair
- Introduction: Why Target Dengue Virus in Mosquitoes?
- Mosquitoes Naturally Target Dengue Virus Replication
- Strategies to Enhance Targeting of Dengue Virus Replication in Mosquitoes
- Summary and Future Directions
Chapter 13. Paratransgenesis Applications: Fighting Malaria With Engineered Mosquito Symbiotic Bacteria
Marcelo Jacobs-Lorena
- Introduction
- Genetic Manipulation of Mosquito Vectorial Competence
- Anopheles Gut Microbiota
- Impact of Microbiota on Anopheles Physiology and Pathogen Transmission
- Fighting Malaria Transmission With Paratransgenesis
- Conclusion and Remarks
Chapter 14. Insulin-Like Peptides Regulate Plasmodium falciparum Infection in Anopheles stephensi
Jose Pietri
- Introduction
- The Biology of the Insulin-Like Peptides
- Regulation of Insulin-Like Peptide Synthesis During Plasmodium Infection
- Insulin-Like Peptide Regulation of Anopheles stephensi Physiology During Plasmodium Infection
- Insulin-Like Peptide Regulation of Anopheles stephensi Behavior and Plasmodium falciparum Transmission
- Conclusions and Future Directions
- No. of pages: 270
- Language: English
- Edition: 1
- Published: April 25, 2017
- Imprint: Academic Press
- Paperback ISBN: 9780128053508
- eBook ISBN: 9780128092378
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Stephen K. Wikel
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Serap Aksoy
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