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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Neuropsychologie du vieillissement normal et pathologique
    • 1st Edition
    • Kathy Dujardin + 1 more
    • French
    Dans nos sociétés modernes, le nombre de personnes âgées ne cesse de croître, et certaines d'entre elles voient leurs fonctions cognitives décliner au point de perdre leur autonomie physique, psychique et sociale. Élucider les mécanismes de ce déclin pour permettre un diagnostic précoce constitue un défi pour de nombreuses équipes de recherche. Fruit de la contribution de chercheurs et d'universitaires du monde francophone, cet ouvrage a pour objectif d'aborder le vieillissement cognitif normal et pathologique, à la fois sous l'angle des neurosciences et de la psychologie cognitive. Les premiers chapitres proposent une synthèse des éléments d'épidémiologie et de neurobiologie indispensables à la compréhension de l'évolution liée à l'âge des fonctions cérébrales. Une mise au point des connaissances actuelles en matière de vieillissement cognitif permet ensuite de mieux cerner l'impact du vieillissement sur les grandes fonctions cognitives, avant d'étudier les différentes pathologies du vieillissement s'accompagnant d'un déclin cognitif (maladie d'Alzheimer, démences vasculaires, démences frontotemporales, syndromes parkinsoniens). La notion de « mild cognitive impairment » (ou trouble cognitif léger) est largement développée à travers l'analyse d'études récentes. Cette approche est complétée par des procédures d'évaluation des fonctions cognitives ainsi que par des perspectives de traitement (pharmacologique, rééducation, …).

  • Epilepsy in Women

    The Scientific Basis for Clinical Management
    • 1st Edition
    • Volume 83
    • Barry Gidal + 1 more
    • English
    This volume guides the practitioner in the current management of women with epilepsy, in a comprehensive and scientifically informed manner. Many chapters are devoted to the various aspects of pregnancy management for women with epilepsy, from reducing the risks of medication exposure to breast feeding. All female age groups are discussed and chapters on issues important for adolescents and the mature women are also included. The editors have included internationally recognized experts as contributors, to bring together a body of knowledge unparalleled in previous settings. This book should be a guide to management for women with epilepsy for years to come, due to its solid scientific basis and the comprehensive vision of the contributors.

  • Puzzling Cases of Epilepsy

    • 2nd Edition
    • Dieter Schmidt + 1 more
    • English
    Epilepsy is one of the most common neurological disorders, and original observations in the field are often the key to diagnosis and successful treatment. Physicians new to the field as well as seasoned practitioners will benefit from more than one hundred case vignettes that explore the universe of epilepsy as it presents in daily practice. Some of these cases challenge long-held views about epilepsy and others bring the reader to the limits of our understanding of epilepsy, both in clinical and basic science. To improve the interface of clinical and basic science in epilepsy, basic scientists comment on the potential mechanisms underlying clinical observations, and clinicians assess the potential impact of recent results of experiments in the laboratory. Puzzling Cases of Epilepsy highlights the importance that original observations have in inspiring both new treatments and continued research.

  • The Prefrontal Cortex

    • 4th Edition
    • Joaquin Fuster
    • Joaquin Fuster
    • English
    This is the fourth edition of the undisputed classic on the prefrontal cortex, the principal "executive" structure of the brain. Because of its role in such cognitive functions as working memory, planning, and decision-making, the prefrontal cortex is critically involved in the organization of behavior, language, and reasoning. Prefrontal dysfunction lies at the foundation of several psychotic and neurodegenerative disorders, including schizophrenia and dementia.

  • Using Eye Movements as an Experimental Probe of Brain Function

    A Symposium in Honor of Jean Büttner-Ennever
    • 1st Edition
    • Volume 171
    • R. John Leigh + 1 more
    • English
    This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts – both basic scientists and clinicians – the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.

  • Quantitative EEG, Event-Related Potentials and Neurotherapy

    • 1st Edition
    • Juri D. Kropotov
    • English
    While the brain is ruled to a large extent by chemical neurotransmitters, it is also a bioelectric organ. The collective study of Quantitative ElectroEncephaloGrap... (QEEG-the conversion of brainwaves to digital form to allow for comparison between neurologically normative and dysfunctional individuals), Event Related Potentials (ERPs - electrophysiological response to stimulus) and Neurotherapy (the process of actually retraining brain processes to) offers a window into brain physiology and function via computer and statistical analyses of traditional EEG patterns, suggesting innovative approaches to the improvement of attention, anxiety, mood and behavior.The volume provides detailed description of the various EEG rhythms and ERPs, the conventional analytic methods such as spectral analysis, and the emerging method utilizing QEEG and ERPs. This research is then related back to practice and all existing approaches in the field of Neurotherapy - conventional EEG-based neurofeedback, brain-computer interface, transcranial Direct Current Stimulation, and Transcranial Magnetic Stimulation - are covered in full. While it does not offer the breadth provided by an edited work, this volume does provide a level of depth and detail that a single author can deliver, as well as giving readers insight into the personl theories of one of the preeminent leaders in the field.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 38
    • H. Jane Brockmann + 5 more
    • English
    Advances in the Study of Behavior was initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important "contribution to the development of the field" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields. Advances in the Study of Behavior is now available online at ScienceDirect — full-text online from volume 30 onward.

  • Human Learning: Biology, Brain, and Neuroscience

    • 1st Edition
    • Volume 139
    • Aaron S. Benjamin + 3 more
    • English
    Human learning is studied in a variety of ways. Motor learning is often studied separately from verbal learning. Studies may delve into anatomy vs function, may view behavioral outcomes or look discretely at the molecular and cellular level of learning. All have merit but they are dispersed across a wide literature and rarely are the findings integrated and synthesized in a meaningful way. Human Learning: Biology, Brain, and Neuroscience synthesizes findings across these levels and types of learning and memory investigation.Divide... into three sections, each section includes a discussion by the editors integrating themes and ideas that emerge across the chapters within each section. Section 1 discusses general topics in human learning and cognition research, including inhibition, short term and long term memory, verbal memory, memory disruption, and scheduling and learning. Section 2 discusses cognitive neuroscience aspects of human learning. Coverage here includes models, skill acquisition, declarative and non declarative memory, age effects on memory, and memory for emotional events. Section 3 focuses on human motor learning.This book is suitable for cognitive neuroscientists, cognitive psychologists, kinesthesiologists, and graduate courses in learning.

  • Handbook of Cognitive Science

    An Embodied Approach
    • 1st Edition
    • Paco Calvo + 1 more
    • English
    The Handbook of Cognitive Science provides an overview of recent developments in cognition research, relying upon non-classical approaches. Cognition is explained as the continuous interplay between brain, body, and environment, without relying on classical notions of computations and representation to explain cognition. The handbook serves as a valuable companion for readers interested in foundational aspects of cognitive science, and neuroscience and the philosophy of mind. The handbook begins with an introduction to embodied cognitive science, and then breaks up the chapters into separate sections on conceptual issues, formal approaches, embodiment in perception and action, embodiment from an artificial perspective, embodied meaning, and emotion and consciousness. Contributors to the book represent research overviews from around the globe including the US, UK, Spain, Germany, Switzerland, France, Sweden, and the Netherlands.

  • Animal Models in Eye Research

    • 1st Edition
    • Panagiotis Antonios Tsonis
    • English
    The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease.

  • The Senses: A Comprehensive Reference, Volume 5

    • 1st Edition
    • Allan I. Basbaum + 3 more
    • English
    This book presents the most current scientific understanding behind most common pain disorders. Clinical scientists involved in pain science will gain a basic understanding of the causes of many types of pain and will be able to discuss various therapies with patients. Researchers new to pain science will gain an overall understanding of pain pathophysiology and targets for pain treatments. Covering every major aspect of pain science, from molecular and cellular pathways of pain to pain disorders and their treatments, Science of Pain bridges basic and clinical research like no other book on the topic. Edited by world-renowned pain scientist and Editor-in-Chief of the journal PAIN, Allan Basbaum, this book is an in-depth reference for basic and clinical scientists in pain research who must understand the basic science of pain, and help develop new treatment strategies for pain disorders.

  • Neuromuscular Junction Disorders

    • 1st Edition
    • Volume 91
    • A. G. Engel
    • English
    This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular transmission. In addition, clinicians will find timely discussions on the various forms of these disorders that have been discovered due to increased study within the field. New observations into the immunopathogenesis of myasthenia gravis, and the molecular mechanisms underlying the links between activity and patterns of gene expression, particularly in muscle, are also explored, along with novel information on the understanding of the pathophysiology of the heterogeneous group of peripheral nerve hyperexcitability syndromes. Each of these valuable insights, and their accompanying explanations, provides a framework on which new therapeutic strategies can be built to aid in the enhancement and restoration of normal function in neuromuscular junction disorders.

  • Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease

    • 1st Edition
    • Volume 170
    • Rainer Landgraf + 1 more
    • English
    Vasopressin and oxytocin are the key hormones of the hypothalamo-neurohyp... system, and are well-known to be critically involved in antidiuresis, labor, and milk ejection. This book highlights the latest research on vasopressin and oxytocin, covering multiple biological aspects. The capacity of both hormones to regulate various aspects of social behaviours including pair-bonding, aggression, maternal love, and sexual behaviour, is a main focus, as are their interactions with a variety of other neuromodulators and transmitters. Moreover, the book illustrates the recent development of vasopressin and oxytocin agonists/antagonists as potential drugs to treat not only disturbances of body fluid homeostasis, but also mental disorders, including social phobia, autism, anxiety, and depression. The promising combination of basic and clinical research, comprising physiology, neuroendocrinology, behavioral biology, pharmacology, imaging and molecular genetics makes this book an essential addition to both experts and scientists new to the field alike.

  • Neurobiology of the Parental Brain

    • 1st Edition
    • Robert Bridges
    • English
    This book presents cutting edge research on the basic neurobiology of parental behavior as it relates to behavioral disorders, including postpartum depression, anxiety, and inadequate parental bonding to infants. Internationally recognized basic and clinical researchers present new research findings in humans and animals that elucidate the roles of the brain, physiological state, genes and environment in maternal and paternal care. By bridging the gap between basic and clinical research, new understandings of how the biology of the brain and the reproductive state of the parent impact their mental health and the successful rearing of young emerge.

  • The Hypothalamus-Pituitary-Adrenal Axis

    • 1st Edition
    • Volume 7
    • English
    The hypothalamic-pituita... axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease.

  • Psychiatric Controversies in Epilepsy

    • 1st Edition
    • Andres Kanner + 1 more
    • English
    Psychiatric Controversies in Epilepsy addresses controversial clinical issues of the psychiatric aspects of epilepsy. The book explores the reasons behind the poor communication between psychiatrists and neurologists and suggests potential remedies to this important problem, and two chapters are devoted to examining whether psychiatrists and neurologists are properly trained to recognize and treat conditions that both disciplines commonly encounter in clinical practice. Identification of the causes behind the high rate of comorbidity between epilepsy and mood, anxiety, psychotic and attention deficit disorders is given high priority in the volume, and a specific review of the evidence of common pathogenic mechanisms that may be operant in epilepsy and these psychiatric disorders is included. Recently identified bidirectional relationship between mood disorders and epilepsy and its implication in the course and response to treatment of the seizure disorder are also explored. Several chapters are devoted to rectify common misunderstandings of the use of psychotropic drugs in patients with epilepsy, including the use of antidepressant and central nervous system stimulants. Finally, one chapter explores the possibility of organic causes of psychogenic non-epileptic seizures.

  • Mathematical Difficulties

    Psychology and Intervention
    • 1st Edition
    • English
    This book examines the mathematical difficulties in typical and atypical populations. It discusses the behavioural, educational and neuropsychological characteristics of people with mathematical difficulties, and educational interventions to prevent, diagnose, treat or ameliorate such difficulties. The book brings together studies from different disciplines, including developmental psychology, neuroscience and education, and includes perspectives from practicing teachers.The book is divided into three major sections. The first includes chapters about the nature and characteristics of mathematical difficulties in the population as a whole, in relation to both psychology and education. The second deals with mathematical difficulties in children with other problems such as specific language impairment and dyslexia. The third discusses methods of interventions aimed at preventing, treating or ameliorating mathematical difficulties, and will include discussions of assessment and diagnosis.

  • Dementias

    • 1st Edition
    • Volume 89
    • Charles Duyckaerts + 1 more
    • English
    This volume provides a comprehensive understanding of the biology of dementias, including information on advancements in the way these disorders are perceived and studied. From earlier assumptions that cognitive deficits were simply age related, this handbook progresses into complex discussions of the diseases that affect the cortex of the human brain. Clinicians will find extensive diagnostic and research perspectives on a variety of interesting topics, including neuropathology, physiopathology, biology, clinics, and imaging information on all, or most, of the dementing disorders currently known. In addition, chapters devoted to legal and ethical issues give practitioners and health care workers an informative view on complex dementias and the way these disorders affect patients and families. Clinicians in all levels of expertise will find useful and synthetic information.

  • Disorders of Consciousness

    • 1st Edition
    • Volume 90
    • G. Bryan Young + 1 more
    • English
    This volume encompasses a variety of topics pertaining to patients with altered levels of consciousness, including valuable differences between disorders. Neurologists, researchers, and clinicians will find a comprehensive accounting of the distinctions between disorders that cause these altered states. Beginning with basic concepts of consciousness and neurobiology, this handbook progresses into more targeted and complex areas of discussion, including important technological advancements that have occurred in neuroimaging. Neurologists who are frequently called upon for prognostication and to guide management of patients with these disorders will find invaluable information, including chapters discussing comatose states in children and pregnant women, encephalopathic patients, nutrition disorders, and vegetative and minimally conscious states. In addition, chapters devoted to philosophical backgrounds and ethical implications involving patients with impaired consciousness, are thoroughly presented.

  • The Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 49
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Volume 49 contains chapters on short-term memory, theory and measurement of working memory capacity limits, development of perceptual grouping in infancy, co-constructing conceptual domains through family conversations and activities, the concrete substrates of abstract rule use, ambiguity, accessibility, and a division of labor for communicative success, and lexical expertise and reading skill.

  • Handbook of Motivation and Cognition Across Cultures

    • 1st Edition
    • Richard Sorrentino + 1 more
    • English
    In recent years there has been a wealth of new research in cognition, particularly in relation to supporting theoretical constructs about how cognitions are formed, processed, reinforced, and how they then affect behavior. Many of these theories have arisen and been tested in geographic isolation. It remains to be seen whether theories that purport to describe cognition in one culture will equally prove true in other cultures. The Handbook of Motivation and Cognition Across Cultures is the first book to look at these theories specifically with culture in mind. The book investigates universal truths about motivation and cognition across culture, relative to theories and findings indicating cultural differences. Coverage includes the most widely cited researchers in cognition and their theories- as seen through the looking glass of culture. The chapters include self-regulation by Tory Higgins, unconscious thought by John Bargh, attribution theory by Bernie Weiner, and self-verification by Bill Swann, among others. The book additionally includes some of the best new researchers in cross-cultural psychology, with contributors from Germany, New Zealand, Japan, Hong Kong, and Australia. In the future, culture may be the litmus test of a theory before it is accepted, and this book brings this question to the forefront of cognition research.

  • Neurologie du comportement

    La dimension neurologique de la neuropsychologie
    • 1st Edition
    • Armin Schnider
    • French
    À la confluence de la neurologie, de la neuropsychologie et de la psychiatrie, la neurologie comportementale est une spécialité qui s'intéresse aux troubles cognitifs, émotionnels et comportementaux dus à des atteintes cérébrales. Elle explore les mécanismes, la base anatomique et les étiologies des dysfonctionnements des fonctions supérieures du cerveau, telles que la mémoire, le langage, la pensée spatiale et le raisonnement. Conçu dans une approche clinique, cet ouvrage constitue une introduction approfondie à la neurologie du comportement. Après un rappel des bases anatomiques du cerveau, chaque chapitre traite successivement des principaux troubles : • État confusionnel et troubles de l'attention • Syndromes frontaux • Aphasies et syndromes apparentés • Troubles du traitement spatial • Agnosies • Troubles mnésiques • Syndromes calleux • Démences Ces troubles sont d'abord définis, puis passés au crible de l'analyse anatomoclinique afin d'en examiner les causes et l'évolution. Pour chacune de ces pathologies, les techniques d'évaluation sont détaillées en fonction du contexte clinique. Aussi, cet ouvrage présente un réel intérêt pratique et pédagogique à travers l'étude de nombreux cas cliniques, des propositions de tests adaptés, et de multiples schémas anatomiques et tableaux récapitulatifs.

  • Cytokines and the Brain

    • 1st Edition
    • Volume 6
    • English
    This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.

  • Essence of Memory

    • 1st Edition
    • Volume 169
    • Wayne S. Sossin + 3 more
    • English
    This selection of reviews gives an up-to-date picture of memory research. Great progress has been made in identifying the memory trace at the molecular and cellular level and individual reviews address the major mechanisms by which changes in synaptic strength can persist. Exciting research at the systems level is also reviewed including the growing importance of changes in inhibitory interneurons and how they play a role in memory formation. Finally, reviews present cognitive and neurobiological models of human memory that explain, characterize and organize the act of memory within a coherent framework.

  • Neuropsychology and Behavioral Neurology

    • 1st Edition
    • Volume 88
    • Georg Goldenberg + 1 more
    • English
    This volume presents a comprehensive guide to one of the most important goals of neuroscience, establishing precision structure-function relationships in the brain. Progressing from the early stages of research, specifically the advent of computerized tomography and later, magnetic resonance imaging, this invaluable resource will take clinicians on an all encompassing journey into the ways different fields of neurology can work together to advance our understanding of brain disorders. Complex topics including the neurochemistry of cognition, neuropsychology of aging and dementia, disorders of semantic memory, working memory, and the dysexecutive syndromes, amongst others, are thoroughly discussed and presented. Clinicians will find a state-of-the-art reference guide that can be used to further understand how the fields of neuropsychology and behavioral neurology can complement each other to produce advancements in the neurosciences.

  • Atlas of the Developing Rat Nervous System

    • 3rd Edition
    • Ken Ashwell
    • English
    The Atlas of the Developing Rat Nervous System, 3rd edition builds on the many excellent features of the second edition by increasing the number of ages represented and by the inclusion of colour plates. The third edition now contains over 20% more plates with the added material depicting early ages not well covered in earlier editions and yet is presented in a concise easy-to-use format. The Atlas provide the most comprehensive depiction not just of structures in the brain and spinal cord but also of peripheral nervous system elements and their target organs that are important for developmental neurobiologists. This allows the user to follow seamlessly neural structures through the developing embryo in both time and space. The nomenclature and identification of structures in the third edition has been thoroughly updated to ensure accuracy and compatibility with modern developmental biology findings and terminology.

  • The Limits of Dream

    A Scientific Exploration of the Mind / Brain Interface
    • 1st Edition
    • J. F. Pagel
    • English
    Approx.250 pages

  • Handbook of the Neuroscience of Language

    • 1st Edition
    • Brigitte Stemmer + 1 more
    • English
    In the last ten years the neuroscience of language has matured as a field. Ten years ago, neuroimaging was just being explored for neurolinguistic questions, whereas today it constitutes a routine component. At the same time there have been significant developments in linguistic and psychological theory that speak to the neuroscience of language. This book consolidates those advances into a single reference. The Handbook of the Neuroscience of Language provides a comprehensive overview of this field. Divided into five sections, section one discusses methods and techniques including clinical assessment approaches, methods of mapping the human brain, and a theoretical framework for interpreting the multiple levels of neural organization that contribute to language comprehension. Section two discusses the impact imaging techniques (PET, fMRI, ERPs, electrical stimulation of language cortex, TMS) have made to language research. Section three discusses experimental approaches to the field, including disorders at different language levels in reading as well as writing and number processing. Additionally, chapters here present computational models, discuss the role of mirror systems for language, and cover brain lateralization with respect to language. Part four focuses on language in special populations, in various disease processes, and in developmental disorders. The book ends with a listing of resources in the neuroscience of language and a glossary of items and concepts to help the novice become acquainted with the field. Editors Stemmer & Whitaker prepared this book to reflect recent developments in neurolinguistics, moving the book squarely into the cognitive neuroscience of language and capturing the developments in the field over the past 7 years.

  • Learning and Memory: A Comprehensive Reference

    • 1st Edition
    • John H. Byrne
    • English
    The study of Learning and Memory is a central topic in Neuroscience and Psychology. It is also a very good example of a field that has come into maturity on all levels - in the protein chemistry and molecular biology of the cellular events underlying learning and memory, the properties and functions of neuronal networks, the psychology and behavioural neuroscience of learning and memory. Many of the basic research findings are directly applicable in the treatment of diseases and aging phenomena, and have found their way into educational theory and praxis. Learning and Memory: A Comprehensive Reference is the most comprehensive source of information about learning and memory ever assembled, and the definitive reference work on the topic. In four volumes, Editor-in-Chief John H. Byrne (University of Texas), together with volume editors Howard Eichenbaum (Boston University) for Systems and Neuroscience, Randolf Menzel (Freie Universität Berlin) for Behavioral Approaches, Henry Roediger (Washington University) for Cognitive Psychology, and David Sweatt (University of Alabama, Birmingham) for Molecular Mechanisms, have put together a truly authoritative collection of overview articles in 159 chapters on over 3000 pages. Learning and Memory: A Comprehensive Reference presents an extensive, integrated summary of the present state of research in the neurobiology and psychology of learning and memory and covers an enormous range of intellectual territory. With topics ranging from the neurochemistry and neurobiology of learning at the cellular and synaptic levels, systems neurobiology, the study of remarkable capabilities in animals (such as homing), ethological and behavioristic analyses, mechanisms, psychology, and disorders of learning and memory in humans, the work broadly covers all topics in the neurobiology and psychology of learning and memory. There is no other handbook with such a comprehensive coverage and depth. The authors selected are the leading scholars for the particular topics on which they write.

  • The Mouse Brain in Stereotaxic Coordinates, Compact

    The Coronal Plates and Diagrams
    • 3rd Edition
    • Keith B.J. Franklin + 1 more
    • English
    The Mouse Brain in Stereotaxic Coordinates is the most widely used and cited atlas of the mouse brain in print. It provides researchers and students with both accurate stereotaxic coordinates for laboratory use, and detailed delineations and indexing of structures for reference. The Compact 3rd edition is both a major revision and an expansion of previous compact editions. The 100 high resolution digital photographs of the coronal plane of section from the third full edition now complement the coronal drawings. The photographs of the sections and the intermediate sections are also provided on the accompanying CD. In addition, the compact version has a large introduction on stereotaxic surgery and the use of the atlas in the lab, as well as a number of panoramic simplified diagrams for student instruction. The Compact 3rd edition is in 8.5 x 11 format and is spiral bound suitable for positioning next to microscopes and cryotomes.

  • Handbook of Anxiety and Fear

    • 1st Edition
    • Volume 17
    • D. Caroline Blanchard + 2 more
    • English
    This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena.

  • Computational Neuroscience in Epilepsy

    • 1st Edition
    • Ivan Soltesz + 1 more
    • English
    Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.

  • Models of Brain and Mind

    Physical, Computational and Psychological Approaches
    • 1st Edition
    • Volume 168
    • Rahul Banerjee + 1 more
    • English
    The phenomenon of consciousness has always been a central question for philosophers and scientists. Emerging in the past decade are new approaches to the understanding of consciousness in a scientific light. This book presents a series of essays by leading thinkers giving an account of the current ideas prevalent in the scientific study of consciousness. The value of the book lies in the discussion of this interesting though complex subject from different points of view ranging from physics and computer science to the cognitive sciences. Reviews of controversial ideas related to the philosophy of mind from western and eastern sources including classical Indian first person methodologies provide a breadth of coverage that has seldom been attempted in a book before. Additionally, chapters relating to the new approaches in computational modeling of higher order cognitive function and consciousness are included. The book is of great value for established as well as young researchers from a wide cross-section of interdisciplinary scientific backgrounds, aiming to pursue research in this field, as well as an informed public.

  • Fundamental Neuroscience

    • 3rd Edition
    • Larry Squire + 6 more
    • English
    Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers!

  • Cellular and Molecular Neurophysiology

    • 3rd Edition
    • Constance Hammond
    • English
    Cellular and Molecular Neurophysiology, Third Edition, is the new, thoroughly revised edition of the only current, established, and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. This version contains 80% new or updated material. Fifteen appendices describing neurobiological techniques are interspersed in the text. Now in full color throughout, the book has over 400 carefully selected and constructed illustrations. It includes an instructor website with all the images in electronic format, plus additional material. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While covering the important facts, the book also presents the background for how researchers arrived at this knowledge to provide a context for the field. It promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.

  • CNS Regeneration

    Basic Science and Clinical Advances
    • 2nd Edition
    • Jeffrey Kordower + 1 more
    • English
    This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury.

  • The Auditory System in Sleep

    • 1st Edition
    • Ricardo Velluti
    • English
    The Auditory System in Sleep presents for the first time a view of a sensory system working in a different state-that of the sleeping brain. The auditory system is always “open” receiving information from the environment and the body itself (conscious and unconscious data). Even during sleep the auditory information is processed, although in a different way. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, etc., together with electrophysiological online data in order to depict how the auditory system single unit activity, recorded during sleep, revealed the possibility of sensory information participation in sleep processes.

  • Stress Hormones and Post Traumatic Stress Disorder

    Basic Studies and Clinical Perspectives
    • 1st Edition
    • Volume 167
    • E. Ronald de Kloet + 2 more
    • English
    Post-traumatic stress disorder (PTSD) arises from the experience of severe stressors and trauma. The disorder is characterized by recurrent recall of intrusive memories to the event, nightmares with insomnia, emotional numbing, hyperarousal, which are all long-lasting and relatively resistant to therapy. The focus of this book is on the question of how stress hormones are involved in PTSD. Recent evidence suggests that a dysregulation in stress hormones promotes the precipitation of PTSD and that correction of these hormones may ameliorate the disorder. This book combines state-of-the-art basic research on stress hormones from gene to behaviour with clinical research demonstrating the progress in understanding via imaging techniques, genetics, vulnerable phenotypes and co-morbidity with other disorders and physical illness.

  • The Senses: A Comprehensive Reference

    • 1st Edition
    • Allan I. Basbaum + 3 more
    • English
    This major new publishing event provides the first up-to-date, cutting-edge, comprehensive reference work combining volumes on all major sensory modalities in one set in three decades. Under the guidance of a distinguished team of international experts, 6 volumes collected 300 articles from all the top scientists laying out our current knowledge on the anatomy, physiology, and molecular biology of sensory organs. Topics covered include the perception, psychophysics, and higher order processing of sensory information, as well as disorders and new diagnostic and treatment methods. Written for a wide audience, this reference work provides students, scholars, medical doctors, and anyone interested in neuroscience a comprehensive overview of the knowledge accumulated on the function of sense organs, sensory systems, and how the brain processes sensory input. Leading scholars from around the world contributed articles, making The Senses a truly international portrait of sensory physiology. The set is the definitive reference on sensory neuroscience on the market, and will provide the ultimate entry point into the review and original literature in Sensory Neuroscience, and be a natural place for interested students and scientists to deepen their knowledge.

  • Ocular Therapeutics

    Eye on New Discoveries
    • 1st Edition
    • Thomas Yorio + 2 more
    • English
    Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future.

  • Atlas of the Human Brain

    • 3rd Edition
    • Juergen K Mai + 2 more
    • English
    High-resolution human imaging requires a high-resolution atlas. There is no atlas that approaches the accuracy and comprehensiveness of The Atlas of the Human Brain. This is the third, thoroughly revised, edition of the very successful atlas that received the Award of Excellence from the American Association of Publishers. Constructed by the recognized leaders in brain cartography, the atlas provides the most detailed and accurate delineations of brain structure available. It is intended as an atlas for day-to-day use in the research laboratory to identify macroscopic and microscopic structures in the human brain as collected in research data with a variety of methods. It will also be particularly useful for the interpretation of magnetic resonance imaging data. The atlas includes a DVD with not only the atlas in electronic format, providing electronic versions of drawings and photographs to facilitate use of atlas contents with researchers' own material, but also 3D visualisation software that allows easy browsing of the images, and a feature to allow direct retrieval of brain areas using coordinates obtained in magnetic resonance imaging.

  • Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment

    • 1st Edition
    • Scott D Mendelson
    • English
    Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

  • Handbook of Neuro-Oncology Neuroimaging

    • 1st Edition
    • Herbert B. Newton + 1 more
    • English
    Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive, “single-source” books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.

  • Anatomy of Neuropsychiatry

    The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness
    • 1st Edition
    • Lennart Heimer + 3 more
    • English
    Anatomy of Neuropsychiatry presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system—the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory—at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.

  • Psychophysiological States

    The Ultradian Dynamics of Mind-Body Interactions
    • 1st Edition
    • Volume 80
    • David S. Shannahoff-Khalsa
    • English
    Our understanding of psychophysiological states are now more broadly defined by the inclusion of the lateralized ultradian rhythms of the autonomic and central nervous systems (ANS and CNS) that play a key regulatory role in mind-body states. These neural rhythms are a unique step in the evolution of the nervous system that have mostly been ignored or missed in our understanding of physiology, mental activities, brain rhythms, and in the treatment of psychiatric disorders. The multivariate physiological experiments reviewed in this book provide a new “big picture” for how the body’s major systems (ANS, CNS, neuroendocrine, cardiovascular, fuel-regulatory, gastrointestinal, immune) are regulated, integrated, and coordinated by the ANS via the hypothalamus during both waking and sleep. This discovery has implications for psychiatrists, psychologists, stress physiologists, cardiologists, sleep researchers, neuroscientists, neuroendocrinologist... cognitive scientists, and those interested in performance, anxiety, depression, schizophrenia, autism, and addictive and impulse control disorders. This book includes the translational neuroscience aspect of this discovery, including implications for vagal nerve stimulation studies.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 37
    • H. Jane Brockmann + 5 more
    • English
    Advances in the Study of Behavior was initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important "contribution to the development of the field" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields. This volume reflects many of the current themes in animal behavior including the evolution of social behavior, sexual selection and communication. It also reflects controversial topics on which the authors provide interesting, new insights. Advances in the Study of Behavior is now available online at ScienceDirect — full-text online from volume 30 onwards.

  • Tinnitus: Pathophysiology and Treatment

    • 1st Edition
    • Volume 166
    • Aage R. Moller + 4 more
    • English
    Understanding tinnitus and treating patients with tinnitus must involve many disciplines of basic science and clinical practice. The book provides comprehensive coverage of a wide range of topics related to tinnitus including its pathophysiology, etiology and treatment. The chapters are written by researchers and clinicians who are active in the areas of basic science such as neurophysiology and neuroanatomy and in clinical specialties of psychology, psychiatry, audiology and otolaryngology.

  • Computational Neuroscience: Theoretical Insights into Brain Function

    • 1st Edition
    • Volume 165
    • Paul Cisek + 2 more
    • English
    Computational neuroscience is a relatively new but rapidly expanding area of research which is becoming increasingly influential in shaping the way scientists think about the brain. Computational approaches have been applied at all levels of analysis, from detailed models of single-channel function, transmembrane currents, single-cell electrical activity, and neural signaling to broad theories of sensory perception, memory, and cognition. This book provides a snapshot of this exciting new field by bringing together chapters on a diversity of topics from some of its most important contributors. This includes chapters on neural coding in single cells, in small networks, and across the entire cerebral cortex, visual processing from the retina to object recognition, neural processing of auditory, vestibular, and electromagnetic stimuli, pattern generation, voluntary movement and posture, motor learning, decision-making and cognition, and algorithms for pattern recognition. Each chapter provides a bridge between a body of data on neural function and a mathematical approach used to interpret and explain that data. These contributions demonstrate how computational approaches have become an essential tool which is integral in many aspects of brain science, from the interpretation of data to the design of new experiments, and to the growth of our understanding of neural function.

  • From Action to Cognition

    • 1st Edition
    • Volume 164
    • Claes Von Hofsten + 1 more
    • English
    Extensive neurophysiological and neuropsychological evidence show that perception, action, and cognition are closely related in the brain and develop in parallel to one another. Thus, perception, cognition, and social functioning are all anchored in the actions of the child. Actions reflect the motives, the problems to be solved, and the constraints and possibilities of the child’s body and sensory-motor system. The developing brain accumulates experiences, which it translates into knowledge used in planning future actions. Such knowledge is available because events are governed by rules and regulations. The present volume discusses all these aspects of how action and cognition are related in development.

  • The Psychology of Learning and Motivation

    Skill and Strategy in Memory Use
    • 1st Edition
    • Volume 48
    • English
    The view of memory use as skilled performance embraces the interactive nature of memory and higher order cognition. In considering the contexts in which memory is used, this book helps to answer such questions as: If asked where I live, how do I decide on a street address or city name? What influences my selection in a criminal lineup besides actual memory of the perpetrator? Why do expert golfers better remember courses they've played than amateur golfers? Chapters in this volume discuss strategies people use in responding to memory queries- whether and how to access memory and how to translate retrieved products into responses. Coverage includes memory for ongoing events and memory for prospective events-how we remember to do future intended actions. Individual differences in memory skill is explored across people and situations, with special consideration given to the elderly population and how strategies at encoding and retrieval can offset what would otherwise be declining memory.

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