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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Neurobiology of Learning and Memory

    • 2nd Edition
    • Raymond P. Kesner + 1 more
    • English
    The first edition of Neurobiology of Learning and Memory was published in 1998 to rave reviews. As before, this second edition will discuss anatomy, development, systems, and models though the organization and content is substantially changed reflecting advances in the field. Including information from both animal and human studies, this book represents an up-to-date review of the most important concepts associated with the basic mechanism that support learning and memory, theoretical developments, use of computational models, and application to real world problems. The emphasis of each chapter will be the presentation of cutting-edge research on the topic, the development of a theoretical perspective, and providing an outline that will aid a student in understanding the most important concepts presented in the chapter.

  • GABA and the Basal Ganglia

    • 1st Edition
    • Volume 160
    • J. M. Tepper + 2 more
    • English
    Over the past 25 years the amount of data pertaining to the GABAergic function in the basal ganglia has increased dramatically. GABA and the Basal Ganglia - From Molecules to Systems is a comprehensive review of the current state-of-the-art of knowledge about the neuroanatomy, neuropharmacology and neurophysiology of the basal ganglia, focusing on its GABAergic microcircuitry. It serves as a complete reference to the body of knowledge about the basal ganglia, its constituent neurons, and their interconnections. This volume is designed to serve as a convenient all-in-one review and reference for experienced basal ganglia researchers as well as an introduction to the functional organization of the basal ganglia and its GABAergic circuitry for students and researchers new to the field.

  • Neurobiology of Epilepsy and Aging

    • 1st Edition
    • Volume 81
    • English
    This volume in the International Review of Neurobiology series addresses the epidemiology, pathophysiology, and treatment of epilepsy in elderly patients. Demographically, the elderly comprise both the fastest-growing segment of the U.S. population and the adult age group with the highest incidence of epilepsy, yet there are relatively few publications devoted to this clinical subgroup. The intersection of these two complex processes—epilepsy and advancing age—will have an increasing impact on medical and community care. The etiology, prognosis, and differential diagnosis of epilepsy can all be affected by the normal aging process and by the frequent comorbidities encountered in an elderly population. Chapters in this book review the effects of aging on brain function and on drug metabolism and interactions, covering the gamut of research from animal models of aging and epilepsy to clinical trials and outcomes. Topics also include the dangers of misdiagnosing status epilepticus, the special issues encountered in recruiting and retaining elderly clinical trial participants, and the use of antiepileptic drugs in the elderly. In both the clinic and the research laboratory, a better understanding of how epilepsy may differ between younger and older patients will be valuable in determining the best possible care for geriatric patients with epilepsy.

  • Eye Movements

    A Window on Mind and Brain
    • 1st Edition
    • Roger PG van Gompel
    • English
    Eye-movement recording has become the method of choice in a wide variety of disciplines investigating how the mind and brain work. This volume brings together recent, high-quality eye-movement research from many different disciplines and, in doing so, presents a comprehensive overview of the state-of-the-art in eye-movement research. Sections include the history of eye-movement research, physiological and clinical studies of eye movements, transsaccadic integration, computational modelling of eye movements, reading, spoken language processing, attention and scene perception, and eye-movements in natural environments.

  • Integrating the Neurobiology of Schizophrenia

    • 1st Edition
    • Volume 78
    • English
    This book examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. It also reviews all neurotransmitters that have been implicated in schizophrenia, exploring the genetic data, clinical data implicating the transmitter, and the preclinical data exploring how a transmitter may interact with dopamine and contribute to the dopaminergic phenotype observed in the illness. This book will serve as an educational tool for instructors, a guide for clinicians, and be of interest to researchers. It is a good reference for researchers specialized in one particular area and interested in learning about other areas of pathology in schizophrenia and how they may all feed into each other. The book concludes with an overall integrative model assembling as many of these elements as possible.

  • Manuel d'EEG de l'adulte

    Veille et sommeil
    • 1st Edition
    • Chantal Hausser-Hauw
    • French
    Quelle est la place, aujourd'hui, de l'électroencéphalogr... ? Non invasif et peu coûteux, l'EEG rend compte de l'activité électrique cérébrale du patient à l'instant même où elle est enregistrée et apporte une analyse immédiate du fonctionnement correct du cerveau ou de son atteinte. Sa place dans l'étude du sommeil est primordiale. L'EEG nécessite un minimum de compréhension des principes physiques et des techniques d'enregistrement des rythmes cérébraux et du sommeil. Cet ouvrage a été conçu chapitre par chapitre pour familiariser le lecteur à l'intérêt de l'EEG dans le diagnostic des épilepsies, des complications neurologiques des maladies systémiques, des encéphalopathies, de l'éthylisme, de la grossesse et des effets médicamenteux, des traumatismes crâniens en phase aiguë et chronique. Le rôle médico-légal de l'EEG dans l'anoxie et la mort cérébrale et son aide dans le diagnostic des démences sont également détaillés. L'étude du sommeil des maladies dégénératives est particulièrement développée. Les maladies pour lesquelles l'EEG offre un supplément d'information par rapport à l'imagerie en cas de crises épileptiques, de confusion ou de troubles de la vigilance sont exposées. Une partie est consacrée à l'intérêt de l'EEG en psychiatrie. Enfin, l'ouvrage détaille l'usage de l'EEG lors d'événements transitoires comme la migraine, l'ictus amnésique, la plongée, la privation sensorielle et lors des états volontairement modifiés de la conscience (biofeedback, méditation, hypnose).

  • Handbook of Microdialysis

    Methods, Applications and Perspectives
    • 1st Edition
    • Volume 16
    • English
    Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience.

  • The Pharmacology of Neurogenesis and Neuroenhancement

    • 1st Edition
    • Volume 77
    • English
    Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume. Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well. The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research. Consequently, this will be an indispensable resource for many years to come.

  • Appetite and Body Weight

    Integrative Systems and the Development of Anti-Obesity Drugs
    • 1st Edition
    • Tim Kirkham + 1 more
    • English
    There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.

  • Research Funding in Neuroscience

    A Profile of the McKnight Endowment Fund
    • 1st Edition
    • Gabrielle Strobel
    • Sylvia Lindman
    • English
    The book is a history of the McKnight Endowment Fund for Neuroscience and an assessment of its effectiveness in advancing neuroscience. The book discusses the Fund's early and steady commitment to basic science as well as it's tradition of leveraging relatively modest dollars to make a big difference in careers and the field overall. The fund exists strictly to give awards and create a community of peers through an annual conference dedicated to research. In near unison, scientists who have received awards say they were able to test a risky idea, get their career off the ground, or make a significant change in their career because of McKnight's flexible dollars. The book consists of three parts: (1) origins--including both the funder and the scientists who shaped the program; (2) a review of the science to show how McKnight awardees have advanced the field; and (3) 10 keys to success. We also have an interview with Julius Axelrod (one of the early advisors, done shortly before his death in 2004) and stories of how awardees used their McKnight grants, plus other information.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 36
    • H. Jane Brockmann + 5 more
    • English
    The aim of Advances in the Study of Behavior is to serve scientists engaged in the study of animal behavior, including psychologists, neuroscientists, biologists, ethologists, pharmacologists, endocrinologists, ecologists, and geneticists. Articles in the series present critical reviews of significant research programs with theoretical syntheses, reformulation of persistent problems, and/or highlighting new and exciting research concepts. Advances in the Study of Behavior is now available online at ScienceDirect — full-text online of volumes 30 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier’s extensive researcher network. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.scie...

  • Signal Processing for Neuroscientists

    An Introduction to the Analysis of Physiological Signals
    • 1st Edition
    • Wim van Drongelen
    • English
    Signal Processing for Neuroscientists introduces analysis techniques primarily aimed at neuroscientists and biomedical engineering students with a reasonable but modest background in mathematics, physics, and computer programming. The focus of this text is on what can be considered the ‘golden trio’ in the signal processing field: averaging, Fourier analysis, and filtering. Techniques such as convolution, correlation, coherence, and wavelet analysis are considered in the context of time and frequency domain analysis. The whole spectrum of signal analysis is covered, ranging from data acquisition to data processing; and from the mathematical background of the analysis to the practical application of processing algorithms. Overall, the approach to the mathematics is informal with a focus on basic understanding of the methods and their interrelationships rather than detailed proofs or derivations. One of the principle goals is to provide the reader with the background required to understand the principles of commercially available analyses software, and to allow him/her to construct his/her own analysis tools in an environment such as MATLAB®.

  • A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates

    • 1st Edition
    • Kadharbatcha S. Saleem + 1 more
    • English
    This atlas maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This book presents the detailed mapping of the architectonic areas in the horizontal plane of sections with reference to the MRI that has not been reported previously in macaque monkeys. In the second part of the atlas, the coronal plane is presented using the same technique. A third part shows the quick identification of several important cortical and subcortical areas (around 30 areas) in horizontal, coronal and sagittal MR images. This atlas is unlike anything else available as it includes and compares each section to imaging data. This is a significant progress, as the vast majority of research in the field now routinely work with fMRI images.

  • Temporal Lobe Epilepsy and the Mind-Brain Relationship: A New Perspective

    • 1st Edition
    • Volume 76
    • Shirley Ferguson
    • English
    This book is devoted to the surgical treatment of epilepsy and its consequences, and provides an extraordinary perspective on the fascinating question of the relationship between brain and mind. Contrary to the current emphasis on statistics and objectivity, this book is dedicated to understanding the whole person, the life and experiences of the individual. It reports on cutting-edge technical skills provided with a human touch. This book reflects the understanding that the temporolimbic seizure originates in tissue providing the substrate for the emotional life and memory. Finally, it emphasizes the value of clinical research – here, conducted in the course of the diagnosis and surgical treatment of epilepsy – in helping to elucidate the relationship between brain and mind.

  • The Rat Brain in Stereotaxic Coordinates

    Hard Cover Edition
    • 6th Edition
    • George Paxinos + 1 more
    • English
    This completely revised edition of The Rat Brain in Stereotaxic Coordinates, the second most cited book in science, represents a dramatic update from the previous edition. Based on a single rat brain, this edition features an entirely new coronal set of tissue cut in regular 120 micron intervals with accompanying photographs and drawings of coronal, horizontal and sagittal sections of this new set. The use of the single brain allows for greater consistency between sections, while advances in histochemistry techniques provides increased refinement in the definition of brain areas, making this the most accurate and detailed stereotaxic rat atlas produced to date. The atlas will also include a CD-ROM featuring all of the graphics and text. Every lab working with the rat as an experimental animal model will want to use this book as their atlas of choice.This book is also available in a softcover spiral binding at the same price.

  • The Fly Neuromuscular Junction: Structure and Function

    Second Edition
    • 1st Edition
    • Volume 75
    • Vivian Budnik + 1 more
    • English
    The Drosophila larval neuromuscular junction (NMJ) has become one of the most powerful model systems to ask key neurobiological questions. This synapse is unparalleled by its accessibility, its simplicity, and the ability to manipulate genes important for synapse development and function. Its synapses have properties shared by many organisms including humans. The vast majority of genes that when mutated cause congenital disorders of the nervous system in humans, are present in the fruit fly genome, and fly models of human disorders are available. Thus, this preparation is a powerful tool to understand the normal function of these genes. This book reviews outstanding work by recognized leaders in the fields of Drosophila cellular neurogenetics including developmental neurobiology, mechanisms of synaptic function, and experience dependent changes at synapses. The book also includes step-by-step protocols to study the cellular biology of the NMJ, making it a vital resource for researchers beginning their investigations with this system, for those who are training students and postdoctoral fellows in this area, or simply as a general reference material for neuroscientists and neuroscience professors in general.

  • Atlas of the Developing Mouse Brain at E17.5, P0 and P6

    • 1st Edition
    • English
    This atlas provides an accurate and detailed depiction of all brain structures at fetal stage E17.5, Day of birth, and Day 6 postnatal. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs. It is an indispensable guide for the interpretation of nervous system changes in gene knockout and transgenic mice. The authors are recognized leaders in brain cartography, and the delineations and graphics link the atlas with other highly successful Paxinos atlases, complementing the catalog of brain atlases of highest quality available from Elsevier. There is currently no alternative of similar quality and extent on the market.

  • Neurobiology of Disease

    • 1st Edition
    • Sid Gilman
    • English
    Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.

  • Reprogramming the Brain

    • 1st Edition
    • Volume 157
    • Aage R. Moller
    • English
    The brain is plastic and it can change its function to adapt to changing demands of various kinds. The brain can also re-organize and change its function to better utilize its resources when parts of the brain have been damaged through injuries and diseases. This means that the brain is not “hard wired” but can be reprogrammed when needed. This book describes different aspects of how the plasticity can become activated and how it can benefit the individual person. This book provides in-depth coverage of many important aspects of neural plasticity and how it applies to trauma, including strokes and disorders of the central nervous system that affect memory and cognition. The book also discusses how neural plasticity is involved in aphasia, pain and tinnitus. The roles of neural plasticity in motor rehabilitation and in adaptation to prostheses such as cochlear and cochlear nucleus implants are also topics of the book.

  • Event-Related Dynamics of Brain Oscillations

    • 1st Edition
    • Volume 159
    • Christa Neuper + 1 more
    • English
    Research on brain oscillations and event-related electroencephalograp... (EEG) and event-related (de-) synchronization (ERD/ERS) in particular became a rapidly growing field in the last decades. A large number of laboratories worldwide are using ERD/ERS to study cognitive and motor brain function and the importance of this tool in neurocognitive research is widely recognized. This book is a summary of the most current research, methods, and applications of the study of event-related dynamics of brain oscillations. Facing the rapid progress in this field, it brings together, on the one side, fundamental questions of the underlying events, which still remain to be clarified and, on the other side, some of the most significant novel findings, which point to the key topics for future research. In particular, the chapters of this volume cover the neurophysiological fundamentals and models (Section I), new methodological approaches (Section II), current ERD research related to cognitive (Section III) and sensorimotor brain function (Section IV), invasive approaches and clinical applications (Section V), and novel developments of EEG-based brain-computer interfaces and neurofeedback (Section IV).

  • The Psychology of Learning and Motivation

    Categories in Use
    • 1st Edition
    • Volume 47
    • English
    Volume 47 of The Psychology of Learning and Motivation offers a discussion of the different factors that influence one's development as a mature and capable person. This is the latest release in this well-received and highly credible series of publications. Broad topics including linguistics, the art of design, categorization of the social world, conversation, and classification are explored to provide the reader with an understanding of these steps one must take during his or her personal and social development. This title is a valuable resource for both psychology researchers and their students.

  • Functional Genomics and Proteomics in the Clinical Neurosciences

    • 1st Edition
    • Volume 158
    • Scott E. Hemby + 1 more
    • English
    The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses.

  • Visual Perception Part 2

    Fundamentals of Awareness, Multi-Sensory Integration and High-Order Perception
    • 1st Edition
    • Volume 155
    • Susana Martinez-Conde + 4 more
    • English
    This book presents a collection of articles reflecting state-of-the-art research in visual perception, specifically concentrating on neural correlates of perception. Each section addresses one of the main topics in vision research today. Part 2: Fundamentals of Awareness, Multi-Sensory Integration and High-Order Perception covers topics from filling-in to visual awareness to crossmodal interactions. A variety of methodological approaches are represented, including single-neuron recordings, fMRI and optical imaging, psychophysics, eye movement characterization and computational modelling. The contributions will provide the reader with a valuable perspective on the current status of vision research, and more importantly, with critical insight into future research directions and the discoveries yet to come.

  • Statistical Parametric Mapping: The Analysis of Functional Brain Images

    • 1st Edition
    • William D. Penny + 4 more
    • English
    In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalograp... Critically, Statistical Parametric Mapping provides a widely accepted conceptual framework which allows treatment of all these different modalities. This rests on an understanding of the brain's functional anatomy and the way that measured signals are caused experimentally. The book takes the reader from the basic concepts underlying the analysis of neuroimaging data to cutting edge approaches that would be difficult to find in any other source. Critically, the material is presented in an incremental way so that the reader can understand the precedents for each new development. This book will be particularly useful to neuroscientists engaged in any form of brain mapping; who have to contend with the real-world problems of data analysis and understanding the techniques they are using. It is primarily a scientific treatment and a didactic introduction to the analysis of brain imaging data. It can be used as both a textbook for students and scientists starting to use the techniques, as well as a reference for practicing neuroscientists. The book also serves as a companion to the software packages that have been developed for brain imaging data analysis.

  • Visual Perception Part 1

    Fundamentals of Vision: Low and Mid-Level Processes in Perception
    • 1st Edition
    • Volume 154
    • Susana Martinez-Conde + 4 more
    • English
    This book presents a collection of articles reflecting state-of-the-art research in visual perception, specifically concentrating on neural correlates of perception. Each section addresses one of the main topics in vision research today. Volume 1 Fundamentals of Vision: Low and Mid-Level Processes in Perception covers topics from receptive field analyses to shape perception and eye movements. A variety of methodological approaches are represented, including single-neuron recordings, fMRI and optical imaging, psychophysics, eye movement characterization and computational modelling. The contributions will provide the reader with a valuable perspective on the current status of vision research, and more importantly, with critical insight into future research directions and the discoveries yet to come.

  • Understanding Emotions

    • 1st Edition
    • Volume 156
    • English
    Emotions shape all aspects of our thinking and behavior, particularly when we communicate with others. How does our brain respond to emotions conveyed by picture media, human faces, voices, and written language? How do we integrate this information in social interaction? What goes wrong in the brains of people suffering from emotional disorders? This book reviews modern neuroscientific and psychological research providing answers to these questions. In this volume, leading researchers give comprehensive overviews of the current knowledge on different aspects of emotional perception and the underlying brain mechanisms and highlight outstanding research questions for the future. This book provides essential information for other researchers in the fields of affective and cognitive neuroscience as well as for advanced students.

  • Psychoneuroimmunology

    • 4th Edition
    • Robert Ader
    • English
    Psychoneuroimmunolog... is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; most chapters cover active areas of research that have not previously been reviewed. As illustrated in this fourth edition, interdisciplinary research continues to provide evidence that the brain and immune system represent a single, integrated system of defense.

  • Hearing

    Anatomy, Physiology, and Disorders of the Auditory System
    • 2nd Edition
    • Aage R. Moller
    • English
    Hearing: Anatomy, Physiology and Disorders of the Auditory System provides detailed information about the anatomy and physiology of the entire auditory system and it describes important aspects of disorders of the middle ear, the cochlea, and the nervous system in a comprehensive manner. Most other textbooks on Hearing are focused on either the periphery or the central nervous system and rarely integrate anatomy and physiology with clinical issues. In the past years, it has become apparent that pathologies of the peripheral parts of the auditory system affect the function of the nervous system, and vice versa. It is thus more and more important to view the peripheral and central parts of the auditory system in an integrative way. This book integrates descriptions of disorders of the ear and the nervous system and provides a comprehensive coverage of anatomy and physiology of the entire auditory system. The book introduces the role of neural plasticity in the symptoms of disorders such as tinnitus, hyperacusis and phonophobia. A separate chapter discusses cochlear and auditory brainstem implants.

  • Hypothalamic Integration of Energy Metabolism

    • 1st Edition
    • Volume 153
    • A. Kalsbeek + 5 more
    • English
    The prevalence of obesity in developed countries is fast becoming a health issue on par with infectious diseases and malnutrition. Research in this area has grown substantially and includes the neurochemical pathways of the hypothalamus and its role in regulating energy expenditures in the body. This volume in the Progress in Brain Research series examines the emerging role of the hypothalamus as a crucial link between the sensing of nutrients and the control of insulin sensitivity, glucose uptake, and glucose production, the integrative role of the hypothalamus in thyroid and bone metabolism, the interaction between circadian information and energy metabolism, and the important interplay between the immune system and energy metabolism.

  • GABA

    • 1st Edition
    • Volume 54
    • English
    A great deal of progress has been made in defining GABA (gamma-aminobutyric acid) transmission in the brain. Volume 54 of the Advances in Pharmacology series has also provided new insights into fundamental features of neurotransmission in general, such as the importance of allosterism and coincident signaling in regulating receptor function and overall cellular activity. These studies have led to the design and development of new drugs and potential therapeutic agents. Given the successes achieved over the first 50 years of GABA research, it is certain the 6th decade will yield its share of surprising discoveries and new insights. Published in this volume are articles providing thoughts and perspectives on this topic, some with the benefit of hindsight, others in the context of recent findings, but all with a hint, or prediction, of what the future holds as the secrets of GABA neurotransmission continue to unfold.Advances in Pharmacology is available online on ScienceDirect — full-text online of volumes 48 onwards.

  • Genetic Instabilities and Neurological Diseases

    • 2nd Edition
    • Robert D. Wells + 1 more
    • English
    Genetic Instabilities and Neurological Diseases covers DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students.

  • Clocking the Mind

    Mental Chronometry and Individual Differences
    • 1st Edition
    • Arthur R. Jensen
    • English
    Mental Chronometry (MC) comprises a variety of techniques for measuring the speed with which the brain processes information.First developed in mid-1800, MC was subsequently eclipsed by more complex and practically useful types of psychometric tests stemming from Alfred Binet. This class of mental tests, however, has no true metric relating the test scores to any specific properties of the brain per se. The scores merely represent an ordinal scale, only ranking individuals according to their overall performance on a variety of complex mental tasks. The resulting scores represent no more than ranks rather than being a true metrical scale of any specific dimension of brain function. Such an ordinal scale, which merely ranks individuals in some defined population, possesses no true scale properties, possessing neither a true zero or equal intervals throughout the scale. This deficiency obstructs the development of a true natural science of mental ability. The present burgeoning interest in understanding individual differences in mental abilities in terms of the natural sciences, biology and the brain sciences in particular, demands direct measures that functionally link brain and behavior. One such natural ratio scale is time itself - the time it takes the brain to perform some elementary cognitive task, measured in milliseconds. After more than 25 years researching MC, Jensen here presents results on an absolute scale showing times for intake of visual and auditory information, for accessing short-term and long-term memory, and other cognitive skills, as a function of age, at yearly intervals from 3 to 80 years. The possible uses of MC in neurological diagnosis and the monitoring of drug effects on cognition, the chronometric study of special time-sensitive talents such as musical performance, and presents a theory of general intelligence, or g, as a function of the rate of oscillation of neural action potentials as measured by chronometric methods. Finally, Jensen urges the world-wide standardization of chronometric methods as necessary for advancing MC as a crucial branch of biopsychological science.

  • The Boundaries of Consciousness: Neurobiology and Neuropathology

    • 1st Edition
    • Steven Laureys
    • English
    Consciousness is one of the most significant scientific problems today. Renewed interest in the nature of consciousness - a phenomenon long considered not to be scientifically explorable, as well as increasingly widespread availability of multimodal functional brain imaging techniques (EEG, ERP, MEG, fMRI and PET), now offer the possibility of detailed, integrated exploration of the neural, behavioral, and computational correlates of consciousness. The present volume aims to confront the latest theoretical insights in the scientific study of human consciousness with the most recent behavioral, neuroimaging, electrophysiological... pharmacological and neuropathological data on brain function in altered states of consciousness such as: brain death, coma, vegetative state, minimally conscious state, locked-in syndrome, dementia, epilepsy, schizophrenia, hysteria, general anesthesia, sleep, hypnosis, and hallucinations. The interest of this is threefold. First, patients with altered states of consciousness continue to represent a major clinical problem in terms of clinical assessment of consciousness and daily management. Second, the exploration of brain function in altered states of consciousness represents a unique lesional approach to the scientific study of consciousness and adds to the worldwide effort to identify the "neural correlate of consciousness". Third, new scientific insights in this field have major ethical and social implications regarding our care for these patients.

  • Introduction to Electrophysiological Methods and Instrumentation

    • 1st Edition
    • Franklin Bretschneider + 1 more
    • English
    Introduction to Electrophysiological Methods and Instrumentation covers all topics of interest to electrophysiologists... neuroscientists and neurophysiologists, from the reliable penetration of cells, the behaviour and function of the equipment, to the mathematical tools available for analysing data. It discusses the pros and cons of techniques and methods used in electrophysiology and how to avoid their pitfalls.Particularl... in an era where high quality off-the-shelf solutions are readily available, it is important for the electrophysiologist to understand how his or her equipment manages the acquisitions and analysis of low voltage biological signals. Introduction to Electrophysiological Methods and Instrumentation addresses this need. The book presents the basics of the passive and active electronic components and circuitry used in apparatuses such as (voltage-clamp) amplifiers, addressing the strong points of modern semiconductors as well as the limitations inherent to even the highest-tech equipment. It concisely describes the theoretical background of the biological phenomena. The book includes a very useful tutorial in electronics, which will introduce students and physiologists to the important basics of electronic engineering needed to understand the function of electrophysiological setups. The vast terrain of signal analysis is dealt with in a way that is valuable to both the uninitiated and the expert. For example, the utility of convolutions and (Fourier, Pascal) transformations in signal detection, conditioning and analysis is presented both in an easy to grasp graphical form as well as in a more rigorous mathematical way.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 73
    • Ronald J. Bradley + 2 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include chromosome 22 deletion syndrome and schizophrenia; characterization of proteome of human cerebrospinal fluid; hormonal pathways regulating intermale and interfemale aggression; neuronal gap junctions; effects of genes and stress on the neurobiology of depression; quantitative imaging with teh MicroPET small-animal PET tomograph; understanding myelination through studying its evolution.

  • Aspects of Knowing

    Epistemological Essays
    • 1st Edition
    • English
    AcknowledgementsCont... Introduction: The art of precise epistemology Stephen HetheringtonPart A. Epistemology as scientific?2. A problem about epistemic dependence Tim Oakley3. Accounting for commitments: A priori knowledge, ontology, and logical entailments Michaeli... Michael4. Epistemic bootstrappingPeter Forrest5. More praise for Moore’s proofRoger White6. Lotteries and the Close Shave principle John Collins7. Skepticism, self-knowledge, and responsibilityDavid Macarthur8. A reasonable contextualism (or, Austin reprised)A. B. Dickerson9. Questioning contextualism Brian WeathersonPart B. Understanding knowledge?10. Truthmaking and the Gettier problemAdrian Heathcote11. Is knowing having the right to be sure?André Gallois12. Knowledge by intention? On the possibility of agent’s knowledge Anne Newstead13. Gettier’s theoremJohn Bigelow14. Knowledge that works: A tale of two conceptual models Stephen Hetherington

  • The Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 46
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Volume 46 contains chapters on category learning, prototypes, prospective memory, event memory, memory models, and musical prosody.

  • The Neurobiology of Painting

    International Review of Neurobiology
    • 1st Edition
    • Volume 74
    • Ronald J. Bradley + 3 more
    • English
    The book presents a basis for the interaction of the brain and nervous system with painting, music and literature, and a discussion of art from multiple facets – such as anatomy, migraine, illusion and evolutionary biology. The book explores several aspects of the neurobiology of painting, including evolutionary neurobiology, sensation vs. perception, the visual brain and how the mind works, and also explores the affects of brain disorders and trauma on artist, with a concluding chapter on Frida Kahlo and the spinal cord injury that influenced her painting.

  • Catatonia in Autism Spectrum Disorders

    • 1st Edition
    • Volume 72
    • Dirk Marcel Dhossche
    • English
    The study of catatonia in Autism Spectrum Disorders is a novel and controversial topic. Catatonia is a motor disorder characterized by stereotypy, rigidity, mutism, and posturing. These motor signs are also characteristic of autism. The interest in the relation between autism and catatonia stems from clinical observations that autistic and catatonic symptoms overlap, that some people with autism develop full-blown catatonia, and that anti-catatonic treatments bring relief in some of those patients. Catatonia in Autism Spectrum Disorders explores the question of if the two syndromes have a common pathophysiology. It also examines whether the successful treatment of catatonia be applied to patients with both autism and catatonia. The book concludes with blueprints for the assessment, treatment, and future study of catatonia in Autism Spectrum Disorders. These blueprints aim to increase early recognition and treatment of catatonia in patients with autism, show the urgency of controlled treatment trials and increased collaborative and interdisciplinary research into the co-occurrence of these two enigmatic disorders.

  • The Neurobiology of C. elegans

    • 1st Edition
    • Volume 69
    • English
    The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.

  • Mental Models and the Mind

    Current developments in Cognitive Psychology, Neuroscience and Philosophy of Mind
    • 1st Edition
    • Volume 138
    • Carsten Held + 2 more
    • English
    "Cognitive psychology," "cognitive neuroscience," and "philosophy of mind" are names for three very different scientific fields, but they label aspects of the same scientific goal: to understand the nature of mental phenomena. Today, the three disciplines strongly overlap under the roof of the cognitive sciences. The book's purpose is to present views from the different disciplines on one of the central theories in cognitive science: the theory of mental models. Cognitive psychologists report their research on the representation and processing of mental models in human memory. Cognitive neuroscientists demonstrate how the brain processes visual and spatial mental models and which neural processes underlie visual and spatial thinking. Philosophers report their ideas about the role of mental models in relation to perception, emotion, representation, and intentionality. The single articles have different and mutually complementing goals: to introduce new empirical methods and approaches, to report new experimental results, and to locate competing approaches for their interpretation in the cross-disciplinary debate. The book is strongly interdisciplinary in character. It is especially addressed to researchers in any field related to mental models theory as both a reference book and an overview of present research on the topic in other disciplines. However, it is also an ideal reader for a specialized graduate course.

  • Human Neuroanatomy

    • 1st Edition
    • James R. Augustine
    • English
    Human Neuroanatomy provides a thorough and comprehensive overview of the human brain and spinal cord for medical and graduate students as well as residents in the clinical neurosciences. Standing on the shoulders of training from outstanding scientist-teacher mentors and based on more than 30 years of experience teaching about the brain and spinal cord to medical and graduate students, this single authored text presents everything the reader would need as they begin their study of the nervous system. At the same time the experienced neuroscientist will find much useful and valuable information in these pages that is based almost exclusively on studies in experimental primates and observations in humans. Every effort has been made to present the complexities of the nervous system as simply and clearly as possible. The careful reader will discover a clarity and depth of coverage that makes the reading both instructional and enjoyable. Topics are presented logically and the text in an easy-to-read style. The accompanying line drawings emphasize important concepts in a clear and uncluttered manner. Topics presented: Neurons, glial cells, degeneration, regeneration, axonal transport Review of the development of the human nervous system Overview of the anatomy of the spinal cord, brain stem and forebrain General sensory paths (pain, temperature, touch, pressure, proprioception) Special sensory systems (auditory, vestibular, visual, olfactory and gustatory) Eye movements and visual reflexes Comprehensive presentation of the regions involved in motor activity including the clinical manifestation of injuries to these motor areas Limbic system, hypothalamus and the autonomic nervous system Lobes of the brain, clinically important cortical areas and the results of lesions in these areas Blood supply to the spinal cord, brain stem, and brain including classical brain stem syndromes The meninges and the ventricular system Numerous helpful clinical correlations that emphasize the practical application of basic anatomical information

  • Handbook of Neuroemergency Clinical Trials

    • 1st Edition
    • Wayne M. Alves + 1 more
    • English
    During the 1990’s, scientific advances in understanding the mechanisms and pathophysiology of acute central nervous system injury were offset by a history of disappointing results from Phase III clinical trials of novel neuroprotective drugs. Numerous novel compounds were “tested,” and seemingly fell by the wayside. This book is intended to focus on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. The authors explore the issues facing research in this area and the strategies that might lead to future success in this critical area of unmet medical need. It represents a compendium of information gained from over 20 years of clinical trial experience in areas of acute neurology and neurosurgery. From the knowledge of clinical assessment using standardized tools, to the intricate design of difficult hyper-acute neuroemergencies trials, the reader will benefit from the authors’ perspectives.

  • Handbook of Brain Tumor Chemotherapy

    • 1st Edition
    • Herbert B. Newton
    • English
    Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including “targeted” agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease.Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.

  • The Biology of the Eye

    • 1st Edition
    • Volume 10
    • Jorge Fischbarg
    • English
    Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research.

  • Gaba in Autism and Related Disorders

    • 1st Edition
    • Volume 71
    • English
    Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 35
    • Peter J.B. Slater + 4 more
    • English
    The aim of Advances in the Study of Behavior is to serve scientists engaged in the study of animal behavior, including psychologists, neuroscientists, biologists, ethologists, pharmacologists, endocrinologists, ecologists, and geneticists. Articles in the series present critical reviews of significant research programs with theoretical syntheses, reformulation of persistent problems, and/or highlighting new and exciting research concepts. Volume 35 is an eclectic volume that includes the mechanisms and evolution of arthropod and anuran communal sexual displays, a functional analysis of feeding, the sexual behavior and breeding system of tufted capuchin monkeys, acoustic communication in noise, ethics and behavioral biology, prenatal sensory ecology and experience, conflict and cooperation in chimpanzees, and the tradeoffs in the adaptive use of social and asocial learning.

  • Auditory Spectral Processing

    • 1st Edition
    • Volume 70
    • Manuel S. Malmierca + 1 more
    • English
    All natural auditory signals, including human speech and animal communication signals, are spectrally and temporally complex, that is, they contain multiple frequencies and their frequency composition, or spectrum, varies over time. The ability of hearers to identify and localize these signals depends on analysis of their spectral composition. For the overwhelming majority of human listeners spoken language is the major means of social communication, and this communication therefore depends on spectral analysis. Spectral analysis begins in the cochlea, but is then elaborated at various stages along the auditory pathways in the brain that lead from the cochlea to the cerebral cortex. The broad purpose of Auditory Spectral Processing is to provide a comprehensive account of the way in which spectral information is processed in the brain and the way in which this information is used by listeners to identify and localize sounds.

  • The Somatotrophic Axis in Brain Function

    • 1st Edition
    • Fred Nyberg
    • English
    The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.

  • Gene Therapy of the Central Nervous System: From Bench to Bedside

    • 1st Edition
    • Michael G. Kaplitt + 1 more
    • English
    Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis.

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