Appetite and Body Weight
Integrative Systems and the Development of Anti-Obesity Drugs
- 1st Edition - December 11, 2006
- Imprint: Academic Press
- Editors: Tim Kirkham, Steven J Cooper
- Language: English
- Paperback ISBN:9 7 8 - 0 - 0 8 - 0 9 7 5 6 3 - 4
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 7 0 6 3 3 - 1
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 4 6 6 4 6 - 0
There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide co… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteThere is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems.
Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.
- Provides an integrative view of the many systems involved in appetite how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.)
- Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts
- Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds
Neuroscientists, psychologists and pharmacologists undertaking research into mechanisms of action of anti-obesity drugs and the underlying psychological and physiological controls of appetite and body weight). This book is also written at a level that is approprite for ostgraduate classes (Masters), research students (PhD) and research fellows in these areas. In addition, this will appeal to established investigators in psychology, pharmacology, clinical medicine, and the pharmaceutical industry – specifically pharmacologists who are engaged in development work on novel anti-obesity compounds.
- Edition: 1
- Published: December 11, 2006
- No. of pages (Hardback): 384
- No. of pages (eBook): 384
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780080975634
- Hardback ISBN: 9780123706331
- eBook ISBN: 9780080466460
TK
Tim Kirkham
Affiliations and expertise
University of Liverpool, UKSC
Steven J Cooper
Affiliations and expertise
University of Liverpool, UKRead Appetite and Body Weight on ScienceDirect