Skip to main content
Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Handbook of the Neuroscience of Language

    • 1st Edition
    • Brigitte Stemmer + 1 more
    • English
    In the last ten years the neuroscience of language has matured as a field. Ten years ago, neuroimaging was just being explored for neurolinguistic questions, whereas today it constitutes a routine component. At the same time there have been significant developments in linguistic and psychological theory that speak to the neuroscience of language. This book consolidates those advances into a single reference. The Handbook of the Neuroscience of Language provides a comprehensive overview of this field. Divided into five sections, section one discusses methods and techniques including clinical assessment approaches, methods of mapping the human brain, and a theoretical framework for interpreting the multiple levels of neural organization that contribute to language comprehension. Section two discusses the impact imaging techniques (PET, fMRI, ERPs, electrical stimulation of language cortex, TMS) have made to language research. Section three discusses experimental approaches to the field, including disorders at different language levels in reading as well as writing and number processing. Additionally, chapters here present computational models, discuss the role of mirror systems for language, and cover brain lateralization with respect to language. Part four focuses on language in special populations, in various disease processes, and in developmental disorders. The book ends with a listing of resources in the neuroscience of language and a glossary of items and concepts to help the novice become acquainted with the field. Editors Stemmer & Whitaker prepared this book to reflect recent developments in neurolinguistics, moving the book squarely into the cognitive neuroscience of language and capturing the developments in the field over the past 7 years.

  • The Mouse Brain in Stereotaxic Coordinates, Compact

    The Coronal Plates and Diagrams
    • 3rd Edition
    • Keith B.J. Franklin + 1 more
    • English
    The Mouse Brain in Stereotaxic Coordinates is the most widely used and cited atlas of the mouse brain in print. It provides researchers and students with both accurate stereotaxic coordinates for laboratory use, and detailed delineations and indexing of structures for reference. The Compact 3rd edition is both a major revision and an expansion of previous compact editions. The 100 high resolution digital photographs of the coronal plane of section from the third full edition now complement the coronal drawings. The photographs of the sections and the intermediate sections are also provided on the accompanying CD. In addition, the compact version has a large introduction on stereotaxic surgery and the use of the atlas in the lab, as well as a number of panoramic simplified diagrams for student instruction. The Compact 3rd edition is in 8.5 x 11 format and is spiral bound suitable for positioning next to microscopes and cryotomes.

  • Computational Neuroscience in Epilepsy

    • 1st Edition
    • Ivan Soltesz + 1 more
    • English
    Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.

  • Models of Brain and Mind

    Physical, Computational and Psychological Approaches
    • 1st Edition
    • Volume 168
    • Rahul Banerjee + 1 more
    • English
    The phenomenon of consciousness has always been a central question for philosophers and scientists. Emerging in the past decade are new approaches to the understanding of consciousness in a scientific light. This book presents a series of essays by leading thinkers giving an account of the current ideas prevalent in the scientific study of consciousness. The value of the book lies in the discussion of this interesting though complex subject from different points of view ranging from physics and computer science to the cognitive sciences. Reviews of controversial ideas related to the philosophy of mind from western and eastern sources including classical Indian first person methodologies provide a breadth of coverage that has seldom been attempted in a book before. Additionally, chapters relating to the new approaches in computational modeling of higher order cognitive function and consciousness are included. The book is of great value for established as well as young researchers from a wide cross-section of interdisciplinary scientific backgrounds, aiming to pursue research in this field, as well as an informed public.

  • Fundamental Neuroscience

    • 3rd Edition
    • Larry Squire + 6 more
    • English
    Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers!

  • Cellular and Molecular Neurophysiology

    • 3rd Edition
    • Constance Hammond
    • English
    Cellular and Molecular Neurophysiology, Third Edition, is the new, thoroughly revised edition of the only current, established, and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. This version contains 80% new or updated material. Fifteen appendices describing neurobiological techniques are interspersed in the text. Now in full color throughout, the book has over 400 carefully selected and constructed illustrations. It includes an instructor website with all the images in electronic format, plus additional material. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While covering the important facts, the book also presents the background for how researchers arrived at this knowledge to provide a context for the field. It promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.

  • CNS Regeneration

    Basic Science and Clinical Advances
    • 2nd Edition
    • Jeffrey Kordower + 1 more
    • English
    This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury.

  • The Auditory System in Sleep

    • 1st Edition
    • Ricardo Velluti
    • English
    The Auditory System in Sleep presents for the first time a view of a sensory system working in a different state-that of the sleeping brain. The auditory system is always “open” receiving information from the environment and the body itself (conscious and unconscious data). Even during sleep the auditory information is processed, although in a different way. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, etc., together with electrophysiological online data in order to depict how the auditory system single unit activity, recorded during sleep, revealed the possibility of sensory information participation in sleep processes.

  • Stress Hormones and Post Traumatic Stress Disorder

    Basic Studies and Clinical Perspectives
    • 1st Edition
    • Volume 167
    • E. Ronald de Kloet + 2 more
    • English
    Post-traumatic stress disorder (PTSD) arises from the experience of severe stressors and trauma. The disorder is characterized by recurrent recall of intrusive memories to the event, nightmares with insomnia, emotional numbing, hyperarousal, which are all long-lasting and relatively resistant to therapy. The focus of this book is on the question of how stress hormones are involved in PTSD. Recent evidence suggests that a dysregulation in stress hormones promotes the precipitation of PTSD and that correction of these hormones may ameliorate the disorder. This book combines state-of-the-art basic research on stress hormones from gene to behaviour with clinical research demonstrating the progress in understanding via imaging techniques, genetics, vulnerable phenotypes and co-morbidity with other disorders and physical illness.

  • The Senses: A Comprehensive Reference

    • 1st Edition
    • Allan I. Basbaum + 3 more
    • English
    This major new publishing event provides the first up-to-date, cutting-edge, comprehensive reference work combining volumes on all major sensory modalities in one set in three decades. Under the guidance of a distinguished team of international experts, 6 volumes collected 300 articles from all the top scientists laying out our current knowledge on the anatomy, physiology, and molecular biology of sensory organs. Topics covered include the perception, psychophysics, and higher order processing of sensory information, as well as disorders and new diagnostic and treatment methods. Written for a wide audience, this reference work provides students, scholars, medical doctors, and anyone interested in neuroscience a comprehensive overview of the knowledge accumulated on the function of sense organs, sensory systems, and how the brain processes sensory input. Leading scholars from around the world contributed articles, making The Senses a truly international portrait of sensory physiology. The set is the definitive reference on sensory neuroscience on the market, and will provide the ultimate entry point into the review and original literature in Sensory Neuroscience, and be a natural place for interested students and scientists to deepen their knowledge.

  • Ocular Therapeutics

    Eye on New Discoveries
    • 1st Edition
    • Thomas Yorio + 2 more
    • English
    Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future.

  • Atlas of the Human Brain

    • 3rd Edition
    • Juergen K Mai + 2 more
    • English
    High-resolution human imaging requires a high-resolution atlas. There is no atlas that approaches the accuracy and comprehensiveness of The Atlas of the Human Brain. This is the third, thoroughly revised, edition of the very successful atlas that received the Award of Excellence from the American Association of Publishers. Constructed by the recognized leaders in brain cartography, the atlas provides the most detailed and accurate delineations of brain structure available. It is intended as an atlas for day-to-day use in the research laboratory to identify macroscopic and microscopic structures in the human brain as collected in research data with a variety of methods. It will also be particularly useful for the interpretation of magnetic resonance imaging data. The atlas includes a DVD with not only the atlas in electronic format, providing electronic versions of drawings and photographs to facilitate use of atlas contents with researchers' own material, but also 3D visualisation software that allows easy browsing of the images, and a feature to allow direct retrieval of brain areas using coordinates obtained in magnetic resonance imaging.

  • Handbook of Neuro-Oncology Neuroimaging

    • 1st Edition
    • Herbert B. Newton + 1 more
    • English
    Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive, “single-source” books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.

  • Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment

    • 1st Edition
    • Scott D Mendelson
    • English
    Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

  • Anatomy of Neuropsychiatry

    The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness
    • 1st Edition
    • Lennart Heimer + 3 more
    • English
    Anatomy of Neuropsychiatry presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system—the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory—at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.

  • Psychophysiological States

    The Ultradian Dynamics of Mind-Body Interactions
    • 1st Edition
    • Volume 80
    • David S. Shannahoff-Khalsa
    • English
    Our understanding of psychophysiological states are now more broadly defined by the inclusion of the lateralized ultradian rhythms of the autonomic and central nervous systems (ANS and CNS) that play a key regulatory role in mind-body states. These neural rhythms are a unique step in the evolution of the nervous system that have mostly been ignored or missed in our understanding of physiology, mental activities, brain rhythms, and in the treatment of psychiatric disorders. The multivariate physiological experiments reviewed in this book provide a new “big picture” for how the body’s major systems (ANS, CNS, neuroendocrine, cardiovascular, fuel-regulatory, gastrointestinal, immune) are regulated, integrated, and coordinated by the ANS via the hypothalamus during both waking and sleep. This discovery has implications for psychiatrists, psychologists, stress physiologists, cardiologists, sleep researchers, neuroscientists, neuroendocrinologist... cognitive scientists, and those interested in performance, anxiety, depression, schizophrenia, autism, and addictive and impulse control disorders. This book includes the translational neuroscience aspect of this discovery, including implications for vagal nerve stimulation studies.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 37
    • H. Jane Brockmann + 5 more
    • English
    Advances in the Study of Behavior was initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important "contribution to the development of the field" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields. This volume reflects many of the current themes in animal behavior including the evolution of social behavior, sexual selection and communication. It also reflects controversial topics on which the authors provide interesting, new insights. Advances in the Study of Behavior is now available online at ScienceDirect — full-text online from volume 30 onwards.

  • Tinnitus: Pathophysiology and Treatment

    • 1st Edition
    • Volume 166
    • Aage R. Moller + 4 more
    • English
    Understanding tinnitus and treating patients with tinnitus must involve many disciplines of basic science and clinical practice. The book provides comprehensive coverage of a wide range of topics related to tinnitus including its pathophysiology, etiology and treatment. The chapters are written by researchers and clinicians who are active in the areas of basic science such as neurophysiology and neuroanatomy and in clinical specialties of psychology, psychiatry, audiology and otolaryngology.

  • Computational Neuroscience: Theoretical Insights into Brain Function

    • 1st Edition
    • Volume 165
    • Paul Cisek + 2 more
    • English
    Computational neuroscience is a relatively new but rapidly expanding area of research which is becoming increasingly influential in shaping the way scientists think about the brain. Computational approaches have been applied at all levels of analysis, from detailed models of single-channel function, transmembrane currents, single-cell electrical activity, and neural signaling to broad theories of sensory perception, memory, and cognition. This book provides a snapshot of this exciting new field by bringing together chapters on a diversity of topics from some of its most important contributors. This includes chapters on neural coding in single cells, in small networks, and across the entire cerebral cortex, visual processing from the retina to object recognition, neural processing of auditory, vestibular, and electromagnetic stimuli, pattern generation, voluntary movement and posture, motor learning, decision-making and cognition, and algorithms for pattern recognition. Each chapter provides a bridge between a body of data on neural function and a mathematical approach used to interpret and explain that data. These contributions demonstrate how computational approaches have become an essential tool which is integral in many aspects of brain science, from the interpretation of data to the design of new experiments, and to the growth of our understanding of neural function.

  • The Psychology of Learning and Motivation

    Skill and Strategy in Memory Use
    • 1st Edition
    • Volume 48
    • English
    The view of memory use as skilled performance embraces the interactive nature of memory and higher order cognition. In considering the contexts in which memory is used, this book helps to answer such questions as: If asked where I live, how do I decide on a street address or city name? What influences my selection in a criminal lineup besides actual memory of the perpetrator? Why do expert golfers better remember courses they've played than amateur golfers? Chapters in this volume discuss strategies people use in responding to memory queries- whether and how to access memory and how to translate retrieved products into responses. Coverage includes memory for ongoing events and memory for prospective events-how we remember to do future intended actions. Individual differences in memory skill is explored across people and situations, with special consideration given to the elderly population and how strategies at encoding and retrieval can offset what would otherwise be declining memory.

  • The Evolution of Hemispheric Specialization in Primates

    • 1st Edition
    • Volume 5
    • William D. Hopkins
    • English
    Hemispheric specialization, and lateralized sensory, cognitive or motor function of the left and right halves of the brain, commonly manifests in humans as right-handedness and left hemisphere specialization of language functions. Historically, this has been considered a hallmark of, and unique to, human evolution. Some theories propose that human right-handedness evolved in the context of language and speech while others that it was a product of the increasing motor demands associated with feeding or tool-use. In the past 20-25 years, there has been a plethora of research in animals on the topic of whether population-level asymmetries in behavioral processes or neuro-anatomical structures exist in animals, notably primates and people have begun to question the historical assumptions that hemispheric specialization is unique to humans. This book brings together various summary chapters on the expression of behavioral and neuro-anatomical asymmetries in primates. Several chapters summarize entire families of primates while others focus on genetic and non-genetic models of handedness in humans and how they can be tested in non-human primates. In addition, it makes explicit links between various theoretical models of the development of handedness in humans with the observed patterns of results in non-human primates. A second emphasis is on comparative studies of handedness in primates. There is now enough data in the literature across different species to present an evolutionary tree for the emergence of handedness (and perhaps other aspects of hemispheric specialization, such as neuro-anatomical asymmetries) and its relation to specific morphological and ecological adaptations in various primate species.

  • The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications

    • 1st Edition
    • Volume 163
    • Helen E. Scharfman
    • English
    The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators, plasticity, and clinical relevance.

  • Forensic Neuropathology

    A Practical Review of the Fundamentals
    • 1st Edition
    • Hideo H. Itabashi MD + 4 more
    • English
    Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encounter... clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys. Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals.

  • Neurotrauma: New Insights into Pathology and Treatment

    • 1st Edition
    • Volume 161
    • John T. Weber + 1 more
    • English
    Neurotrauma is the leading cause of death and disability in young adults, and the incidence in older patients is increasing. Neurotrauma is also a field in medicine with one of the highest unmet needs. Concentrated, focused and multidisciplinary efforts are required to combat this important disease. Exciting findings from basic research open opportunities for improving treatment results. This volume presents a unique and comprehensive overview of the latest findings and insights on translational research in neurotrauma. This book should be a must for any TBI or SCI researcher interested in translating their work to the clinic, as well as to clinicians interested in the latest research findings which could provide novel treatment strategies for their patients.

  • The Chick Brain in Stereotaxic Coordinates

    An Atlas featuring Neuromeric Subdivisions and Mammalian Homologies
    • 1st Edition
    • Luis Puelles + 4 more
    • English
    The chicken is the standard model for avian and vertebrate brain anatomy, particularly in development. The Chick Brain in Stereotaxic Coordinates contains 200 coronal plates and diagrams, 40 sagittal plates and diagrams, and 20 horizontal plates and diagrams, illustrated in stereotaxic coordinates. This book is essential for anyone studying the physiology and function of the chick brain.

  • Neuro-inflammation in Neuronal Death and Repair

    • 1st Edition
    • Volume 82
    • Stuart Lipton + 1 more
    • English
    Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies.

  • Molecular Neurology

    • 1st Edition
    • Stephen Waxman
    • English
    Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.

  • HIV/AIDS and the Nervous System

    • 1st Edition
    • Volume 85
    • Peter Portegies + 1 more
    • English
    This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others. Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies. In addition, the socioeconomic and political constraints that hinder treatment and disease management in developing parts of the world are presented.

  • Myopathies and Muscle Diseases

    • 1st Edition
    • Volume 86
    • Frank L. Mastaglia + 1 more
    • English
    This volume provides a comprehensive guide to myopathies, including breakthroughs that have led to a wider appreciation of the nature of these muscle diseases. Chapters on congenital muscle disorders, biological changes, and diseases associated with aging are included, along with detailed discussions of mitochondrial myopathies, disorders of carbohydrate and lipid metabolism, and the role of heredity, amongst others. Neurologists, myopathologists, and other professionals dealing with this broad group of diseases will find state-of-the-art information on the clinical investigation and management of patient care, as well as the latest information on the pathological basis and molecular pathogenesis of these diseases.

  • Diagnostic Atlas of Gastroesophageal Reflux Disease

    A New Histology-based Method
    • 1st Edition
    • Parakrama T. Chandrasoma
    • English
    Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux.Unfortunately... this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.At present, there is no histologic test that has any practical value in the diagnosis of reflux disease. The only histologic diagnostic criteria are related to changes in the squamous epithelium which are too insensitive and nonspecific for effective patient management. It is widely recognized that columnar metaplasia of the esophagus (manifest histologically as cardiac, oxyntocardiac and intestinal epithelia) is caused by reflux. However, except for intestinal metaplasia, which is diagnostic for Barrett esophagus, these columnar epithelia are not used to diagnose reflux disease in biopsies. The reason for this is that these epithelial types are indistinguishable from "normal" "gastric" cardiac mucosa. In standard histology texts, this "normal gastric cardia" is 2-3 cm long.In the mid-1990s, Dr. Chandrasoma and his team at USC produced autopsy data suggesting that cardiac and oxyntocardiac mucosa is normally absent from this region and that their presence in biopsies was histologic evidence of reflux disease. From this data, they determined that the presence of cardiac mucosa was a pathologic entity caused by reflux and could therefore be used as a highly specific and sensitive diagnostic criterion for the histologic diagnosis of reflux disease. They call this entity "reflux carditis". In addition, the length of these metaplastic columnar epithelia in the esophagus was an accurate measure of the severity of reflux disease in a given patient.At present, there is some controversy over whether cardiac mucosa is totally absent or present normally to the extent of 0-4 mm. While this should not be a deterrent to changing criteria which are dependent on there normally being 20-30 cm of cardiac mucosa, there has been little mainstream attempt to change existing endoscopic and pathologic diagnostic criteria in the mainstream of either gastroenterology or pathology. The ATLAS will be the source of easily digestible practical information for pathologists faced with biopsies from this region. It will also guide gastroenterologists as they biopsy these patients.

  • Parkinson's Disease and Related Disorders, Part II

    • 1st Edition
    • Volume 84
    • William C. Koller + 1 more
    • English
    This volume provides comprehensive information on Parkinson’s disease and related disorders, a group of diseases that are among the most common in the field of neurodegenerative study. Through a high-level presentation of new research regarding these diseases, this handbook will give clinicians and neuroscientists alike a better understanding of the dramatic pharmacological advances made in the management of Parkinson’s disease, and the profound observations that have altered the medical community’s approach to other degenerative disorders of the nervous system. Practitioners, researchers, and medical personnel will gain exciting insights into recent developments that form the basis for new therapeutic strategies and management protocols for the various neurological disorders that present with Parkinsonism.

  • Trisomie et handicaps génétiques associés

    Potentialités, compétences, devenir
    • 5th Edition
    • French
    Destiné aux professionnels de santé médicaux et paramédicaux, cet ouvrage aborde de manière concrète et pragmatique tous les aspects de la prise en charge d'un patient atteint de trisomie ou d'un handicap génétique associé. Avec une symptomatologie actualisée, un suivi médical étape par étape et des conseils validés, le lecteur trouvera ici un outil indispensable et à jour pour le suivi de son patient et pour apporter toute l'aide nécessaire à la famille. L'auteur a particulièrement développé dans ce nouvel ouvrage tous les aspects pratiques de l'aide à apporter aux patients atteints de trisomies pour améliorer leur qualité de vie ainsi que des réponses précises aux questions que se posent les parents tout au long des étapes de vie de l'enfant et de la personne concernée (prise en charge précoce, scolarisation, développement affectif et sexuel, activités sportives, relations avec les adolescents et la fratrie, formation professionnelle, loisirs, tabac, alcool, liberté de déplacement, permis de conduire, relation avec l'argent, protection juridique, revenus, habitat, vie en couple, contraception, vieillissement …). En réponse à une forte demande, cet ouvrage, 5e édition totalement renouvelée, étudie notamment la prise en charge des oro praxies, le vieillissement et introduit la notion nouvelle de « périodes phares ou charnières » qui déterminent l'avenir du patient atteint de trisomie.

  • The Neurobiology of Multiple Sclerosis

    • 1st Edition
    • Volume 79
    • English
    Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the “cause” and the “cure” for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.

  • Functional and Dysfunctional Sexual Behavior

    A Synthesis of Neuroscience and Comparative Psychology
    • 1st Edition
    • Anders Ågmo
    • English
    Functional and Dysfunctional Sexual Behavior explores the full consequences of the dissociation between sexual behaviors and reproduction. Among the themes covered is the difference between the stereotyped sexual behaviors in non-human mammals and the astounding variety of human sexual behaviors. The role of learning in shaping sexual behaviors is explained, and it is shown how particular sexual experiences may be at the origin of common human sexual dysfunctions. Chapters on sexual incentives and a summary of the endocrine and central nervous control of sexual behaviors are included.

  • Cognition, Brain, and Consciousness

    Introduction to Cognitive Neuroscience
    • 1st Edition
    • Bernard J. Baars + 1 more
    • Bernard J. Baars + 1 more
    • English
    A textbook for psychology, neuroscience, pre-medical students, and everybody interested in the neuroscience of cognition. A wave of new research is transforming our understanding of the human mind and brain. Many educational fields now require a basic understanding of the new topic of cognitive neuroscience. However, available textbooks are written more for biology audiences than for psychology and related majors. This text aims to bridge that gap. A background in biology of neuroscience is not required. The thematic approach builds on widely understood concepts in psychology, such as working memory, selective attention, and social cognition. Edited by two leading experts in the field, the book guides the reader along a clear path to understand the latest findings. FEATURES: Written specifically for psychology, pre-medical, education and neuroscience undergraduate and graduate students The thematic approach builds on on accepted concepts, not presuming a background in neuroscience or biology Includes two Appendices on brain imaging and neural networks written by Thomas Ramsoy and Igor Aleksander Introduces the brain in a step-by-step, readable style, with gradually increasing sophistication Richly illustrated in full color with clear and detailed drawings that build the brain from top to bottome, simplifying the layout of the brain for students Pedagogy includes exercises and study questions at the end of each chapter

  • Neurobiology of Learning and Memory

    • 2nd Edition
    • Raymond P. Kesner + 1 more
    • English
    The first edition of Neurobiology of Learning and Memory was published in 1998 to rave reviews. As before, this second edition will discuss anatomy, development, systems, and models though the organization and content is substantially changed reflecting advances in the field. Including information from both animal and human studies, this book represents an up-to-date review of the most important concepts associated with the basic mechanism that support learning and memory, theoretical developments, use of computational models, and application to real world problems. The emphasis of each chapter will be the presentation of cutting-edge research on the topic, the development of a theoretical perspective, and providing an outline that will aid a student in understanding the most important concepts presented in the chapter.

  • GABA and the Basal Ganglia

    • 1st Edition
    • Volume 160
    • J. M. Tepper + 2 more
    • English
    Over the past 25 years the amount of data pertaining to the GABAergic function in the basal ganglia has increased dramatically. GABA and the Basal Ganglia - From Molecules to Systems is a comprehensive review of the current state-of-the-art of knowledge about the neuroanatomy, neuropharmacology and neurophysiology of the basal ganglia, focusing on its GABAergic microcircuitry. It serves as a complete reference to the body of knowledge about the basal ganglia, its constituent neurons, and their interconnections. This volume is designed to serve as a convenient all-in-one review and reference for experienced basal ganglia researchers as well as an introduction to the functional organization of the basal ganglia and its GABAergic circuitry for students and researchers new to the field.

  • Neurobiology of Epilepsy and Aging

    • 1st Edition
    • Volume 81
    • English
    This volume in the International Review of Neurobiology series addresses the epidemiology, pathophysiology, and treatment of epilepsy in elderly patients. Demographically, the elderly comprise both the fastest-growing segment of the U.S. population and the adult age group with the highest incidence of epilepsy, yet there are relatively few publications devoted to this clinical subgroup. The intersection of these two complex processes—epilepsy and advancing age—will have an increasing impact on medical and community care. The etiology, prognosis, and differential diagnosis of epilepsy can all be affected by the normal aging process and by the frequent comorbidities encountered in an elderly population. Chapters in this book review the effects of aging on brain function and on drug metabolism and interactions, covering the gamut of research from animal models of aging and epilepsy to clinical trials and outcomes. Topics also include the dangers of misdiagnosing status epilepticus, the special issues encountered in recruiting and retaining elderly clinical trial participants, and the use of antiepileptic drugs in the elderly. In both the clinic and the research laboratory, a better understanding of how epilepsy may differ between younger and older patients will be valuable in determining the best possible care for geriatric patients with epilepsy.

  • Eye Movements

    A Window on Mind and Brain
    • 1st Edition
    • Roger PG van Gompel
    • English
    Eye-movement recording has become the method of choice in a wide variety of disciplines investigating how the mind and brain work. This volume brings together recent, high-quality eye-movement research from many different disciplines and, in doing so, presents a comprehensive overview of the state-of-the-art in eye-movement research. Sections include the history of eye-movement research, physiological and clinical studies of eye movements, transsaccadic integration, computational modelling of eye movements, reading, spoken language processing, attention and scene perception, and eye-movements in natural environments.

  • Integrating the Neurobiology of Schizophrenia

    • 1st Edition
    • Volume 78
    • English
    This book examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. It also reviews all neurotransmitters that have been implicated in schizophrenia, exploring the genetic data, clinical data implicating the transmitter, and the preclinical data exploring how a transmitter may interact with dopamine and contribute to the dopaminergic phenotype observed in the illness. This book will serve as an educational tool for instructors, a guide for clinicians, and be of interest to researchers. It is a good reference for researchers specialized in one particular area and interested in learning about other areas of pathology in schizophrenia and how they may all feed into each other. The book concludes with an overall integrative model assembling as many of these elements as possible.

  • Manuel d'EEG de l'adulte

    Veille et sommeil
    • 1st Edition
    • Chantal Hausser-Hauw
    • French
    Quelle est la place, aujourd'hui, de l'électroencéphalogr... ? Non invasif et peu coûteux, l'EEG rend compte de l'activité électrique cérébrale du patient à l'instant même où elle est enregistrée et apporte une analyse immédiate du fonctionnement correct du cerveau ou de son atteinte. Sa place dans l'étude du sommeil est primordiale. L'EEG nécessite un minimum de compréhension des principes physiques et des techniques d'enregistrement des rythmes cérébraux et du sommeil. Cet ouvrage a été conçu chapitre par chapitre pour familiariser le lecteur à l'intérêt de l'EEG dans le diagnostic des épilepsies, des complications neurologiques des maladies systémiques, des encéphalopathies, de l'éthylisme, de la grossesse et des effets médicamenteux, des traumatismes crâniens en phase aiguë et chronique. Le rôle médico-légal de l'EEG dans l'anoxie et la mort cérébrale et son aide dans le diagnostic des démences sont également détaillés. L'étude du sommeil des maladies dégénératives est particulièrement développée. Les maladies pour lesquelles l'EEG offre un supplément d'information par rapport à l'imagerie en cas de crises épileptiques, de confusion ou de troubles de la vigilance sont exposées. Une partie est consacrée à l'intérêt de l'EEG en psychiatrie. Enfin, l'ouvrage détaille l'usage de l'EEG lors d'événements transitoires comme la migraine, l'ictus amnésique, la plongée, la privation sensorielle et lors des états volontairement modifiés de la conscience (biofeedback, méditation, hypnose).

  • Consciousness and Cognition

    Fragments of Mind and Brain
    • 1st Edition
    • Henri Cohen + 1 more
    • English
    What were the circumstances that led to the development of our cognitive abilities from a primitive hominid to an essentially modern human? The answer to this question is of profound importance to understanding our present nature. Since the steep path of our cognitive development is the attribute that most distinguishes humans from other mammals, this is also a quest to determine human origins. This collection of outstanding scientific problems and the revelation of the many ways they can be addressed indicates the scope of the field to be explored and reveals some avenues along which research is advancing. Distinguished scientists and researchers who have advanced the discussion of the mind and brain contribute state-of-the-art presentations of their field of expertise. Chapters offer speculative and provocative views on topics such as body, culture, evolution, feelings, genetics, history, humor, knowledge, language, machines, neuroanatomy, pathology, and perception. This book will appeal to researchers and students in cognitive neuroscience, experimental psychology, cognitive science, and philosophy.

  • Handbook of Microdialysis

    Methods, Applications and Perspectives
    • 1st Edition
    • Volume 16
    • English
    Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience.

  • The Pharmacology of Neurogenesis and Neuroenhancement

    • 1st Edition
    • Volume 77
    • English
    Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume. Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well. The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research. Consequently, this will be an indispensable resource for many years to come.

  • Appetite and Body Weight

    Integrative Systems and the Development of Anti-Obesity Drugs
    • 1st Edition
    • Tim Kirkham + 1 more
    • English
    There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.

  • Research Funding in Neuroscience

    A Profile of the McKnight Endowment Fund
    • 1st Edition
    • Gabrielle Strobel
    • Sylvia Lindman
    • English
    The book is a history of the McKnight Endowment Fund for Neuroscience and an assessment of its effectiveness in advancing neuroscience. The book discusses the Fund's early and steady commitment to basic science as well as it's tradition of leveraging relatively modest dollars to make a big difference in careers and the field overall. The fund exists strictly to give awards and create a community of peers through an annual conference dedicated to research. In near unison, scientists who have received awards say they were able to test a risky idea, get their career off the ground, or make a significant change in their career because of McKnight's flexible dollars. The book consists of three parts: (1) origins--including both the funder and the scientists who shaped the program; (2) a review of the science to show how McKnight awardees have advanced the field; and (3) 10 keys to success. We also have an interview with Julius Axelrod (one of the early advisors, done shortly before his death in 2004) and stories of how awardees used their McKnight grants, plus other information.

  • Signal Processing for Neuroscientists

    An Introduction to the Analysis of Physiological Signals
    • 1st Edition
    • Wim van Drongelen
    • English
    Signal Processing for Neuroscientists introduces analysis techniques primarily aimed at neuroscientists and biomedical engineering students with a reasonable but modest background in mathematics, physics, and computer programming. The focus of this text is on what can be considered the ‘golden trio’ in the signal processing field: averaging, Fourier analysis, and filtering. Techniques such as convolution, correlation, coherence, and wavelet analysis are considered in the context of time and frequency domain analysis. The whole spectrum of signal analysis is covered, ranging from data acquisition to data processing; and from the mathematical background of the analysis to the practical application of processing algorithms. Overall, the approach to the mathematics is informal with a focus on basic understanding of the methods and their interrelationships rather than detailed proofs or derivations. One of the principle goals is to provide the reader with the background required to understand the principles of commercially available analyses software, and to allow him/her to construct his/her own analysis tools in an environment such as MATLAB®.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 36
    • H. Jane Brockmann + 5 more
    • English
    The aim of Advances in the Study of Behavior is to serve scientists engaged in the study of animal behavior, including psychologists, neuroscientists, biologists, ethologists, pharmacologists, endocrinologists, ecologists, and geneticists. Articles in the series present critical reviews of significant research programs with theoretical syntheses, reformulation of persistent problems, and/or highlighting new and exciting research concepts. Advances in the Study of Behavior is now available online at ScienceDirect — full-text online of volumes 30 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier’s extensive researcher network. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.scie...

  • A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates

    • 1st Edition
    • Kadharbatcha S. Saleem + 1 more
    • English
    This atlas maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This book presents the detailed mapping of the architectonic areas in the horizontal plane of sections with reference to the MRI that has not been reported previously in macaque monkeys. In the second part of the atlas, the coronal plane is presented using the same technique. A third part shows the quick identification of several important cortical and subcortical areas (around 30 areas) in horizontal, coronal and sagittal MR images. This atlas is unlike anything else available as it includes and compares each section to imaging data. This is a significant progress, as the vast majority of research in the field now routinely work with fMRI images.

  • Temporal Lobe Epilepsy and the Mind-Brain Relationship: A New Perspective

    • 1st Edition
    • Volume 76
    • Shirley Ferguson
    • English
    This book is devoted to the surgical treatment of epilepsy and its consequences, and provides an extraordinary perspective on the fascinating question of the relationship between brain and mind. Contrary to the current emphasis on statistics and objectivity, this book is dedicated to understanding the whole person, the life and experiences of the individual. It reports on cutting-edge technical skills provided with a human touch. This book reflects the understanding that the temporolimbic seizure originates in tissue providing the substrate for the emotional life and memory. Finally, it emphasizes the value of clinical research – here, conducted in the course of the diagnosis and surgical treatment of epilepsy – in helping to elucidate the relationship between brain and mind.

Related subjects