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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Nervous System Drug Delivery

    Principles and Practice
    • 1st Edition
    • Russell R. Lonser + 2 more
    • English
    Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

  • Handbook of Sleep Research

    • 1st Edition
    • Volume 30
    • English
    Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.

  • Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms

    • 1st Edition
    • Volume 248
    • English
    Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms, Volume 248, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Mathematical modeling in clinical and basic motor neuroscience, The math of medicine - the computational lessons learned from the human disease, Mathematical models - an extension of the clinician's mind, From differential equation to linear control systems: the study of the VOR, Closed lop and nonlinear systems, State-space equations and learning, Integrators and optimal control, and much more.

  • Arousal in Neurological and Psychiatric Diseases

    • 1st Edition
    • Edgar Garcia-Rill
    • English
    Arousal in Neurological and Psychiatric Diseases focuses on the dysregulation of arousal found in many neurological and psychiatric disorders. Chapters describe the physiology of each process, how it presents in each disorder, and the most appropriate treatment(s). The book also imparts the understanding of the RAS as a system that not only modulates waking, but also survival mechanisms, such as fight vs. flight responses and other reflexes. This book helps neuroscientists, sleep researchers, neurologists and psychiatrists understand the basic mechanisms that modulate arousal in health and disease. In addition, it promotes therapies that can alter the severity and manifestation of multiple disorders.

  • Translational Medicine in CNS Drug Development

    • 1st Edition
    • Volume 29
    • George G. Nomikos + 1 more
    • English
    Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans.

  • Oligodendroglioma

    Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment
    • 1st Edition
    • Nina A. Paleologos + 1 more
    • English
    Oligodendroglioma: Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment features the latest "cutting-edge" molecular biology, molecular therapeutics, imaging, immunotherapy, and research methods on the topic of oligodendrogliomas. The most detailed and comprehensive resource on the subject, it provides up-to-date information on clinical presentation, pathology, molecular biology, and treatment methods, including immunotherapy. This book is a critical for students, physicians and researchers in the fields of neuroscience, neuro-oncology, neurosurgery, radiation oncology, medical oncology, and others working in research or with patients.

  • Neuroscience, Selflessness, and Spiritual Experience

    Explaining the Science of Transcendence
    • 1st Edition
    • Brick Johnstone + 1 more
    • English
    Neuroscience, Selflessness, and Spiritual Transcendence conveys the manner by which selflessness serves as a neuropsychological and religious foundation for spiritually transcendent experiences. The book combines neurological case studies and neuroscience research with religious accounts of transcendence experiences from the perspective of both the neurosciences and the history of religions. Chapters cover the subjective experience of transcendence, an historical summary of different philosophical and religious perspectives, a review of the neuroscience research that describes the manner by which the brain processes and creates a self, and more. The book presents a model that bridges the divide between neuroscience and religion, presenting a resource that will be critical reading for advanced students and researchers in both fields.

  • The Serotonin System

    History, Neuropharmacology, and Pathology
    • 1st Edition
    • Mark Tricklebank + 1 more
    • English
    The Serotonin System: History, Neuropharmacology, and Pathology provides an up-to-date accounting on the physiology and pathophysiology of serotonin and the role it plays in behavioral functions. In addition, the book explores the potential roles of 5-HT1 in neurodevelopmental disorders and summarizes the history of the discovery and development of serotonergic drugs for the treatment of neuropsychiatric disorders. This concise, yet thorough, volume is the perfect introduction to this critical neurotransmitter. It is ideal for students and researchers new to the study of behavior, neuropsychiatry or neuropharmacology, but is also a great resource for established investigators who want a greater perspective on serotonin.

  • Receptors in the Evolution and Development of the Brain

    Matter into Mind
    • 1st Edition
    • Richard E. Fine
    • English
    Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer’s, Parkinson’s, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.

  • Mitochondrial Neuropathies

    • 1st Edition
    • Volume 145
    • English
    Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation.

  • Development of the Nervous System

    • 4th Edition
    • Dan H. Sanes + 3 more
    • English
    Development of the Nervous System, Fourth Edition provides an informative and up-to-date account of our present understanding of the basic principles of neural development as exemplified by key experiments and observations from past and recent times. This book reflects the advances made over the last few years, demonstrating their promise for both therapy and molecular understanding of one of the most complex processes in animal development. This information is critical for neuroscientists, developmental biologists, educators, and students at various stages of their career, providing a clear presentation of the frontiers of this exciting and medically important area of developmental biology. The book includes a basic introduction to the relevant aspects of neural development, covering all the major topics that form the basis of a comprehensive, advanced undergraduate and graduate curriculum, including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and plasticity.

  • Omega Fatty Acids in Brain and Neurological Health

    • 2nd Edition
    • Ronald Ross Watson + 1 more
    • English
    Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases.

  • Synaptic Transmission

    • 1st Edition
    • Stephen D. Meriney + 1 more
    • English
    Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winni... researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders.

  • Handbook of Nutrition, Diet, and the Eye

    • 2nd Edition
    • Victor R. Preedy + 1 more
    • English
    Handbook of Nutrition, Diet, and the Eye, Second Edition, thoroughly addresses common features and etiological factors on how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss are devastating. There are a range of ocular defects that have either their origin in nutritional deficiencies/excess or have been shown to respond favorably to nutritional components. Featuring a new section on animal model studies where both the ocular problem and dietary remedies can be varied, there are also new chapters on dietary supplements.

  • Introduction to Addiction

    Addiction, Animal Models, and Theories
    • 1st Edition
    • Volume 1
    • George F. Koob + 3 more
    • English
    Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse.

  • Emotion and Cognition

    • 1st Edition
    • Volume 247
    • English
    Emotion and Cognition, Volume 246, consists of 16 chapters on recent scientific advances in emotion and cognition research. The chapters include theoretical, review, and empirical chapters presenting original data on interactions between emotion and cognition. Chapters touch on a variety of topics, including Common and different mechanisms underlying the processing of extrinsic and intrinsic emotion, Looming fear stimuli broadens attention in a local-global letter task, Reading thoughts and feelings in other people – how age shapes empathic accuracy, How does aging influence emotion-cognition links?, and The Motivational Dimensional Model of affect: A review of the past 10 years, and more.

  • Neuroscience of the Nonconscious Mind

    • 1st Edition
    • Rajendra Badgaiyan
    • English
    Neuroscience of the Nonconscious Mind includes novel concepts and insights on the brain mechanisms that control nonconscious mental functions, some of which were developed in the author’s laboratory. The book describes neuroscience of conventional nonconscious mental functions, along with not so conventional functions like creativity, hypnosis and extrasensory perception, thus making it a very unique reference. This thought provoking book for students of mind, brain and consciousness will help explain concepts and introduce the science behind the nonconscious.

  • Human Brainstem

    Cytoarchitecture, Chemoarchitecture, Myeloarchitecture
    • 1st Edition
    • George Paxinos + 2 more
    • English
    Human Brainstem: Cytoarchitecture, Chemoarchitecture, Myeloarchitecture explores how the human brainstem has been impeded by the unavailability of an up-to-date, comprehensive, diagrammatic and photographic atlas. Now, with the first detailed atlas on the human brainstem in more than twenty years, this book presents an accurate, comprehensive and convenient reference for students, researchers and pathologists.

  • Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates, Compact

    The Coronal Plates and Diagrams
    • 5th Edition
    • Keith B.J. Franklin + 1 more
    • English
    Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Compact Fifth Edition, is the compact version of the most widely used and cited atlas of the mouse brain in print. It emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The compact edition provides the coronal plates and diagrams of the full mouse atlas in a smaller, more convenient spiral format and at a student friendly price. High resolution digital photographs of the coronal plane of section from the full 5th edition complement the coronal drawings. Unique to the compact, it includes an introduction to the use of the atlas in stereotaxic surgery.

  • EEG-Based Experiment Design for Major Depressive Disorder

    Machine Learning and Psychiatric Diagnosis
    • 1st Edition
    • Aamir Saeed Malik + 1 more
    • English
    EEG-Based Experiment Design for Major Depressive Disorder: Machine Learning and Psychiatric Diagnosis introduces EEG-based machine learning solutions for diagnosis and assessment of treatment efficacy for a variety of conditions. With a unique combination of background and practical perspectives for the use of automated EEG methods for mental illness, it details for readers how to design a successful experiment, providing experiment designs for both clinical and behavioral applications. This book details the EEG-based functional connectivity correlates for several conditions, including depression, anxiety, and epilepsy, along with pathophysiology of depression, underlying neural circuits and detailed options for diagnosis. It is a necessary read for those interested in developing EEG methods for addressing challenges for mental illness and researchers exploring automated methods for diagnosis and objective treatment assessment.

  • Sleep Deprivation and Cognition

    • 1st Edition
    • Volume 246
    • English
    Sleep Deprivation and Cognition, Volume 247, the latest release in the Progress in Brain Research series, covers the effects of sleep deprivation, with this new release featuring sections on the Impact of sleep deprivation on long-term memory, Adolescent sleep restriction effects on cognition and mood, Self- regulation and social behavior during sleep deprivation, Experiential decision-making and the effects of sleep loss, Sleep deprivation and dynamic attentional control, a Pharmacogenetic approach to understanding sleep deprivation and cognition, Neuroimaging of functional connectivity in the sleep-deprived brain: what does it tell us?, and more.

  • The Little Black Book of Neurology

    • 6th Edition
    • Osama O. Zaidat + 2 more
    • English
    Widely known and well-respected, The Little Black Book of Neurology has been a thorough yet portable reference in this complex field for more than 30 years, presenting definitions, classifications, and guidance on diagnosis and management for a wide range of neurological disorders. The 6th Edition offers updated and expanded coverage of neuropharmacology and neuroimaging – plus a new, more user-friendly, fast-access format that makes the book ideal for quick clinical consultation or as a refresher for the Boards.

  • Les troubles du sommeil

    • 3rd Edition
    • Yves Dauvilliers
    • French
    La médecine du sommeil est une discipline récente et les manuels qui lui sont consacrés sont peu nombreux. Les troubles du sommeil et de l’éveil touchent pourtant une part importante de la population et ont de graves répercussions sur la santé physique et mentale, ainsi que sur la qualité de vie.La 3e édition de cet ouvrage de référence, entièrement mis à jour et agrémenté de questionnaires, d’échelles et d’un glossaire étendu :• fait le point sur le sommeil normal (aspects neurobiologiques et physiologiques chez l’enfant, l’adulte et le sujet âgé),• présente les différentes méthodes d’exploration,• propose une synthèse sur les multiples troubles (insomnie, hypersomnie, troubles du rythme circadien, parasomnie…),• établie le lien entre les troubles du sommeil et les spécialités médicales : neurologie, cardiologie, pneumologie, endocrinologie, pédiatrie, psychiatrie, ORL….Cet ouvrage s’adresse aux médecins généralistes et spécialistes. Ils y trouveront des réponses à leurs questions, ainsi que de nombreuses indications pour la prise en charge des patients et la prescription de traitements. Il s’adresse également à tous les professionnels de santé, chercheurs et étudiants désireux de s’ouvrir à un domaine encore peu enseigné dans les facultés et écoles.

  • The Comorbidities of Epilepsy

    • 1st Edition
    • Marco Mula
    • English
    Epilepsy is one of most frequent neurological disorders affecting about 50 million people worldwide and 50% of them have at least another medical problem in comorbidity; sometimes this is a the cause of the epilepsy itself or it is due to shared neurobiological links between epilepsy and other medical conditions; other times it is a long-term consequence of the antiepileptic drug treatment. The Comorbidities of Epilepsy offers an up-to-date, comprehensive overview of all comorbidities of epilepsy (somatic, neurological and behavioral), by international authorities in the field of clinical epileptology, with an emphasis on epidemiology, pathophysiology, diagnosis and management. This book includes also a critical appraisal of the methodological aspects and limitations of current research on this field. Pharmacological issues in the management of comorbidities are discussed, providing information on drug dosages, side effects and interactions, in order to enable the reader to manage these patients safely. The Comorbidities of Epilepsy is aimed at all health professionals dealing with people with epilepsy including neurologists, epileptologists, psychiatrists, clinical psychologists, epilepsy specialist nurses and clinical researchers.

  • Molecular Mechanisms of Dementia

    Biomarkers, Neurochemistry, and Therapy
    • 1st Edition
    • Akhlaq A. Farooqui
    • English
    Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists... and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases.　

  • Social Cognition in Psychosis

    • 1st Edition
    • Kathryn Eve Lewandowski + 1 more
    • English
    Social Cognition in Psychosis combines current research on phenotypes, neurobiology, and existing evidence on the assessment and treatment of various forms of psychoses. The book presents various treatment options, including assessment approaches, tools and training methods that aid in the rehabilitation of patients with psychotic disorders. Social cognition is a set of psychological processes related to understanding, recognizing, processing and appropriately using social stimuli in one's environment. Individuals with psychotic disorders consistently exhibit impairments in social cognition. As a result, social cognition has been an important target for intervention, with recent efforts trying to enhance early recovery among individuals with psychotic disorders.

  • Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates

    • 5th Edition
    • George Paxinos + 1 more
    • English
    Paxinos and Franklin’s The Mouse Brain in Stereotaxic Coordinates, Fifth Edition, emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience.

  • The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle

    • 1st Edition
    • Eric Murillo-Rodriguez
    • English
    The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep – mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon. Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science – why we sleep and why we cannot survive without it.

  • Neuroscience of Nicotine

    Mechanisms and Treatment
    • 1st Edition
    • Victor R. Preedy
    • English
    Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse. With an estimated one billion individuals worldwide classified as tobacco users—and tobacco use often being synonymous with nicotine addiction—nicotine is one of the world’s most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process.

  • Neuroscience of Alcohol

    Mechanisms and Treatment
    • 1st Edition
    • Victor R. Preedy
    • English
    Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance.

  • Curcumin for Neurological and Psychiatric Disorders

    Neurochemical and Pharmacological Properties
    • 1st Edition
    • Tahira Farooqui + 1 more
    • English
    Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium.

  • Central Serous Chorioretinopathy

    • 1st Edition
    • Jay Chhablani
    • English
    Central Serous Chorioretinopathy discusses the mechanisms, pathogenesis and risk factors of CSCR, findings on various imaging modalities, available treatment options, and translational research into new treatment options for CSCR management. This comprehensive book is written for retina specialists and surgeons, researchers and clinical practitioners in sensory systems (vision), and ophthalmologists. Central Serous Chorioretinopathy (CSCR) is a common disorder across the world with a variable prognosis without any standard of care. Recently, advancements in imaging have led to a better understanding of the pathogenesis and mechanisms of this disease.

  • Handbook of Sleep Disorders in Medical Conditions

    • 1st Edition
    • Josee Savard + 1 more
    • English
    Handbook of Sleep Disorders in Medical Conditions reviews the current knowledge on the nature and manifestations of sleep disorders associated with a variety of common medical conditions, including epilepsy, traumatic brain injury and dementia. It also provides clinical guidelines on how to assess and treat them with pharmacological and non-pharmacological interventions. Although the general principles of sleep medicine may be applied to some extent to patients with comorbid medical conditions, this book makes the case that an adaptive approach is warranted when considering the particularities of each condition. In addition, clinicians must also be cautious when prescribing sleep medications as some pharmacological agents are known to exacerbate symptoms associated with the medical condition, such as cognitive deficits (i.e. difficulties with memory and attention) in cancer patients experiencing chemo brain, or in persons with neurologic conditions (e.g. mild cognitive impairment, dementia, stroke, brain injury). A differential approach to evaluating and treating sleep is thus warranted.

  • Genes, Brain Function, and Behavior

    What Genes Do, How They Malfunction, and Ways to Repair Damage
    • 1st Edition
    • Douglas Wahlsten
    • English
    Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior.

  • Neural Stem Cells and Adult Neurogenesis

    • 1st Edition
    • Arie S. Mobley
    • English
    Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons’ contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format.

  • Meditation

    • 1st Edition
    • Volume 244
    • English
    Meditation, Volume 244, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume presenting interesting chapters on The effect of meditation on attentional processes, State-trait influences of Vipassana meditation practice on P3 EEG dynamics, What could teachers learn from the neuroscience of self-experience?, Training Attention for Conscious Non-REM Sleep: The Yogic Technique of Yoga Nidrā and Its Implications for Neuroscience Research, CNV and P3 modulations following sensorimotor training, Analytical meditation: a characterization of a reasoning-based meditation training, Buddhist meditation and the regulation of brain networks, Mindfulness-based Emotional Balance Training in Military Spouse, and more.

  • Role of Inflammation in Environmental Neurotoxicity

    • 1st Edition
    • Volume 3
    • English
    Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics.

  • Cognitive Rehabilitation of Memory

    A Clinical-Neuropsychological Introduction
    • 1st Edition
    • Helmut Hildebrandt
    • English
    Cognitive Rehabilitation of Memory: A Clinical-Neuropsycho... Introduction comprehensively reviews evidence-based research for each clinical tool, defining guidelines on how to assess patients and set treatment goals and best practices for creating individualized rehabilitation programs. The book also provides essential background knowledge on the nature and causes of memory impairment. Dr. Helmut Hildebrandt describes a wide range of interventions, including memory aids, learning strategies and non-cognitive treatment options

  • Alzheimer’s Disease Theranostics

    • 1st Edition
    • Magisetty Obulesu
    • English
    Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work.

  • Imaging in Movement Disorders: Imaging in Movement Disorder Dementias and Rapid Eye Movement Sleep Behavior Disorder

    • 1st Edition
    • Volume 144
    • English
    Imaging in Movement Disorders: Imaging in Movement Disorder Dementias and Rapid Eye Movement Sleep Behavior Disorder, Volume 144 provides an up-to-date textbook on the use of imaging modalities across the spectrum of movement disorders and dementias. The book brings together lessons learned from neuroimaging tools in the content of movement disorders, including chapters on Molecular Imaging of Dementia with Lewy Bodies, Structural and Functional Magnetic Resonance Imaging of Dementia with Lewy Bodies, Network Imaging in Parkinsonian and Other Movement Disorders: Network Dysfunction and Clinical Correlates, Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder, Hybrid PET-MRI Applications in Movement Disorders, and more.

  • Stress: Physiology, Biochemistry, and Pathology

    Handbook of Stress Series, Volume 3
    • 1st Edition
    • George Fink
    • English
    Approx.406 pages

  • Neuroblastoma

    Molecular Mechanisms and Therapeutic Interventions
    • 1st Edition
    • Swapan K. Ray
    • English
    Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions.

  • The Auditory Brain and Age-Related Hearing Impairment

    • 1st Edition
    • Jos J. Eggermont
    • English
    The Auditory Brain and Age-Related Hearing Impairment provides an overview of the interaction between age-related hearing impairments and cognitive brain function. This monograph elucidates the techniques used in the connectome and other brain-network studies based on electrophysiological methods. Discussions of the manifestations of age-related hearing impairment, the causes of degradation of sound processing, compensatory changes in the human brain, and rehabilitation and intervention are included. There is currently a surge in content on aging and hearing loss, the benefits of hearing aids and implants, and the correlation between hearing loss, cognitive decline and early onset of dementia. Given the changing demographics, treatment of age-related hearing impairment need not just be bottom-up (i.e., by amplification and/or cochlear implantation), but also top-down by addressing the impact of the changing brain on communication. The role of age-related capacity for audio-visual integration and its role in assisting treatment have only recently been investigated, thus this area needs more attention.

  • The Orexin/Hypocretin System

    Functional Roles and Therapeutic Potential
    • 1st Edition
    • Jim R. Fadel + 1 more
    • English
    The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 1st Edition
    • Joao L. de Quevedo + 2 more
    • English
    Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.

  • Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain

    • 1st Edition
    • Michael Petrides
    • English
    Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain provides a comprehensive identification of the sulci and gyri of the human brain on a series of coronal sections of the average MNI brain and identifies the likely location of the cytoarchitectonic areas of the cerebral cortex. Presentation in MNI Stereotaxic Space enables the atlas to serve as a useful working tool for structural/functiona... neuroimagers attempting to identify the sulcus or gyrus and the likely cytoarchitectonic area within which a functional activation or a structural change has occurred. A brief introductory section discusses the history and current state of studies of the sulcal and gyral morphology and cytoarchitecture of the human cerebral cortex.

  • Imagining the Brain: Episodes in the History of Brain Research

    • 1st Edition
    • Volume 243
    • Chiara Ambrosio + 1 more
    • English
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • The Chick Brain in Stereotaxic Coordinates and Alternate Stains

    Featuring Neuromeric Divisions and Mammalian Homologies
    • 2nd Edition
    • Luis Puelles + 4 more
    • English
    This atlas – and its accompanying text - is the most comprehensive work on avian neuroanatomy available so far. It identifies more than 900 hundred structures (versus ca. 250 in previous avian atlases), 180 of them for the first time. It correlates avian and mammalian neuroanatomy on the basis of homologies and applies mammalian terms to homologous avian structures. This is the first atlas that represents the fundamental histogenetic domains of the vertebrate neuroaxis on the basis of sound fate-mapping and gene expression data. This results in a substantial increase in accuracy of delineations. Developmental molecular biologists will find it easier to extrapolate early neural tube patterns into mature structures. The modern trend to shift avian neuroanatomical nomenclature toward mammalian terminology by reference to postulated homologies has been expanded to the entire brain, but is not yet complete. This creates a new standard for comparative cross-reference, which can also be applied to reptilian-mammalian comparisons.

  • Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders

    • 1st Edition
    • Lindsay M. Oberman + 1 more
    • English
    Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders provides a comprehensive overview of neurotechnological devices as potential treatments for psychiatric and neurodevelopmental disorders in children and adolescents. Many neuropsychiatric disorders are covered such as Autism Spectrum Disorder, ADHD, Depression, Tourette’s Syndrome, and OCD. Different device-based treatments are discussed such as Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, Deep Brain Stimulation, Chronotherapy, and Neurofeedback.

  • Neurosensory Disorders in Mild Traumatic Brain Injury

    • 1st Edition
    • Michael E. Hoffer + 1 more
    • English
    Mild traumatic Brain Injury (mTBI or Concussion) is an increasingly common public health issue in sports, military environments, and life in today’s active world. Despite a great deal of study and public attention to this disorder, knowledge about optimal diagnostic, prognostic, and treatment information remains lacking. Neurosensory symptoms have been shown to be the most frequent complications of mTBI in both the acute and chronic setting. Neurosensory Disorders in Mild Traumatic Brain Injury brings together both the basic science work as well as the clinical work in mTBI into one volume to provide a comprehensive examination of the neurosensory issues associated with this disorder. Coverage includes chapters on defining mild Traumatic Brain Injury, neurosensory consequences, neurosensory disorders in clinical practice, and diagnosis and treatment for neurosensory disorders in mTBI. This book is written for clinicians, researchers, residents and students in neurology and neuroscience.

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