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Elsevier

Books in Organic chemistry

This collection offers extensive coverage of organic synthesis, reaction mechanisms, and functional group chemistry. Showcasing innovative research, green chemistry approaches, and industrial applications, it supports chemists, students, and researchers in designing new molecules and materials. Addressing drug discovery, polymers, and sustainable processes, these titles foster creativity and technical excellence in advancing organic chemistry for societal benefit.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 130
    • English
    Advances in Heterocyclic Chemistry, Volume 130, the latest release in this definitive series, provides a comprehensive review that combines descriptive synthetic chemistry and mechanistic insights to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. New chapters in this release include Recent Developments in the Radiolabeling of Heterocyclic Rings, Chemistry of Azetidines, Tricyclic Fused Bithiophenes and Related Analogues: Important Building Blocks for Conjugated Materials, Application of Electrochemical Methods in the Synthesis of Heterocyclic Compounds and Elucidation of Their Properties, Organometallic Complexes of Chelating Azines, and more.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 94
    • English
    Advances in Clinical Chemistry, Volume 94, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest technologies relating to the field of clinical chemistry, with specific chapters in this new release covering Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome, Clotting factors - Clinical biochemistry and their roles as plasma enzymes, Myokines: The endocrine coupling of skeletal muscle and bone, Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance, and more.

  • Powdered Crude Drug Microscopy of Leaves and Barks

    • 1st Edition
    • Vidhu Aeri + 2 more
    • English
    Powdered Crude Drug Microscopy of Leaves and Barks investigates various microscopic techniques used in the examination of structural and cellular features in order to determine their botanical origin. These methods are useful in identifying species with similar morphological characters. Today, there is a variety of methods available to authenticate herbal drugs, ranging from simple morphological examination to physical and chemical analysis, and DNA molecular biology. Due to cost, powder microscopy is the most practical method for primary authentication. Botanical microscopy is a unique, valuable, rapid and cost-effective assessment tool, and plays an important role in the authentication and assessment of medicinal plants. This book is an essential resource for students and researchers involved in the study of plants and natural products, as well as professionals in industries manufacturing plant-based products for use during quality control and assurance steps.

  • Small Molecule Drug Discovery

    Methods, Molecules and Applications
    • 1st Edition
    • Andrea Trabocchi + 1 more
    • English
    Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.

  • Alpha-glucosidase Inhibitors

    Clinically Promising Candidates for Anti-diabetic Drug Discovery
    • 1st Edition
    • Usman Ghani
    • English
    Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of α -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures. Drawing on the author’s expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of α -glucosidase inhibitor chemistry and activity.

  • Current Developments in Photocatalysis and Photocatalytic Materials

    New Horizons in Photocatalysis
    • 1st Edition
    • Xinchen Wang + 2 more
    • English
    Photocatalytic materials can improve the efficiency and sustainability of processes and offer novel ways to address issues across a wide range of fields—from sustainable chemistry and energy production to environmental remediation. Current Developments in Photocatalysis and Photocatalytic Materials provides an overview of the latest advances in this field, offering insight into the chemistry and activity of the latest generation of photocatalytic materials.After an introduction to photocatalysis and photocatalytic materials, this book goes on to outline a wide selection of photocatalytic materials, not only covering typical metal oxide photocatalysts such as TiO2 but also exploring newly developed organic semiconducting photocatalysts, such as g-C3N4.Drawing on the experience of an expert team of contributors, Current Developments in Photocatalysis and Photocatalytic Materials highlights the new horizons of photocatalysis, in which photocatalytic materials will come to play an important role in our day-to-day lives.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 14
    • Michael Harmata
    • English
    Strategies and Tactics in Organic Synthesis, Volume 14, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

  • Monodispersed Particles

    • 2nd Edition
    • Tadao Sugimoto
    • English
    Monodispersed Particles, Second Edition, covers all aspects of monodispersed particles, including inorganic and polymer particles and their composites. The book consists of four parts: fundamentals, preparation, analyses, and applications. Specifically, the fundamental part covers the theoretical insight into the surface energy of particles and its application to the formulation of the new theories of nucleation, growth and habit formation of monodispersed particles. In addition, the theories of recrystallization and solid-solution formation are introduced. These fundamental theories are applied to the precise control of their size, size distribution, shape, internal structure, and composition, leading to the design of diverse monodispersed functional particles widely used in basic science and modern industry.This second edition is fully updated and revised, detailing new theories and recent progress in the field of nanoparticles, including advanced nucleation theory, arrested growth mechanism for monodispersed nanoparticles, and energetics of habit formation. Additionally, the text covers in-depth insights into the anisotropic growth of Au and Ag nanoparticles, the formation mechanisms of polycrystalline Au spheres, iron oxide nanoparticles in heat-up and hot-injection processes, amorphous TiO2 spheres in a sol-gel system, anatase TiO2 in a gel-sol system and their shape control, AgCl nanoparticles in a reverse micelle system, organic-inorganic hybrid liquid crystals, and extensive biomedical applications.

  • Biological Chirality

    • 1st Edition
    • Gyula Palyi
    • English
    Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 53
    • Ian Williams + 1 more
    • English
    Advances in Physical Organic Chemistry, Volume 53, presents the latest reviews of recent work in physical organic chemistry. It provides a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines. Chapters in this updated release include Theoretical models for activation and reaction energies in chemical reactions, Chiral induction in asymmetric dual catalysis, and The transition state.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 93
    • English
    Advances in Clinical Chemistry, Volume 93, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. New chapters in this release include Lectin biosensors in cancer glycan biomarker detection, Cytokines in heart failure, Recent advances in the determination of insulins from biological fluids, Biomarkers in aggression, Evaluation of analytical performance of immunoassay methods for cTnI and cTnT: From theory to practice, Periodontal disease: From the lenses of light microscopy to the specs of proteomics and next generation sequencing, and more.

  • Progress in Heterocyclic Chemistry

    • 1st Edition
    • Volume 31
    • Gordon Gribble + 1 more
    • English
    Progress in Heterocyclic Chemistry, Volume 31 is the latest release in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature and articles on developing topics in heterocyclic chemistry. Chapters in this new release are written by leading researchers in their field and constitute a systematic survey of the important original material reported in the literature in of heterocyclic in 2018. As with previous volumes in the series, this updated volume will enable academics, industrial chemists and advanced students stay abreast of developments in heterocyclic chemistry.

  • Organometallic Chemistry of Five-Membered Heterocycles

    • 1st Edition
    • Alexander Sadimenko
    • English
    Organometallic Chemistry of Five-Membered Heterocycles explores the synthesis, coordination modes, reactivity of coordinated five-membered monoheterocycles, and organometallic complexes of their numerous derivatives, including chelating ligands, oligomers, and macrocycles. Beginning with the introduction of organometallic compounds, this book dives deep into the reactivity of coordinated five-membered monoheterocycles and the derivatives of fundamental ligands. This book is an ideal reference for researchers working in organometallic, heterocyclic, materials, or organic chemistry, and catalysis. The readers will gain a comprehensive understanding of modern synthetic methods, reactivity trends of heteroaromatic ligands, and the methods of modern materials construction.

  • Medicinal Plants of South Asia

    Novel Sources for Drug Discovery
    • 1st Edition
    • Muhammad Asif Hanif + 3 more
    • English
    Medicinal Plants of South Asia: Novel Sources for Drug Discovery provides a comprehensive review of medicinal plants of this region, highlighting chemical components of high potential and applying the latest technology to reveal the underlying chemistry and active components of traditionally used medicinal plants. Drawing on the vast experience of its expert editors and authors, the book provides a contemporary guide source on these novel chemical structures, thus making it a useful resource for medicinal chemists, phytochemists, pharmaceutical scientists and everyone involved in the use, sales, discovery and development of drugs from natural sources.

  • Phytochemicals as Lead Compounds for New Drug Discovery

    • 1st Edition
    • Chukwuebuka Egbuna + 4 more
    • English
    Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 92
    • English
    Advances in Clinical Chemistry, Volume 92, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

  • The Wolff-Kishner Reduction and Related Reactions

    Discovery and Development
    • 1st Edition
    • David E. Lewis
    • English
    The Wolff-Kishner Reduction and Related Reactions: Discovery and Development offers a detailed discussion of this reaction, its discoverers, and its development since its discovery. Derivative name reactions—including the Wharton and Shapiro reactions—are also discussed. The book is illustrated with examples from literature and corresponding references to the primary literature to aid further reading. It provides a comprehensive review of the century of chemistry that allows the reader to follow the development of this important synthetic reaction. In addition, it provides biographical details on the chemists who discovered and developed the reaction, thus adding a human dimension to the discussion.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 91
    • English
    Advances in Clinical Chemistry, Volume 91, the latest release in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, providing the benchmark for novel analytical approaches in the clinical laboratory.

  • Discovery and Development of Anti-inflammatory Agents from Natural Products

    • 1st Edition
    • Goutam Brahmachari
    • English
    Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases.

  • Chemistry of Silica and Zeolite-Based Materials

    Synthesis, Characterization and Applications
    • 1st Edition
    • Volume 2
    • Abderrazzak Douhal + 1 more
    • English
    Chemistry of Silica and Zeolite-Based Materials covers a wide range of topics related to silica-based materials from design and synthesis to applications in different fields of science and technology. Since silica is transparent and inert to the light, it is a very attractive host material for constructing artificial photosynthesis systems. As an earth-abundant oxide, silica is an ideal and basic material for application of various oxides, and the science and technology of silica-based materials are fundamentally important for understanding other oxide-based materials. The book examines nanosolvation and confined molecules in silica hosts, catalysis and photocatalysis, photonics, photosensors, photovoltaics, energy, environmental sciences, drug delivery, and health. Written by a highly experienced and internationally renowned team from around the world, Chemistry of Silica and Zeolite-Based Materials is ideal for chemists, materials scientists, chemical engineers, physicists, biologists, biomedical sciences, environmental scientists, toxicologists, and pharma scientists. --- "The enormous versatility of silica for building a large variety of materials with unique properties has been very well illustrated in this book…. The reader will be exposed to numerous potential applications of these materials – from photocatalytic, optical and electronic applications, to chemical reactivity in confined spaces and biological applications. This book is of clear interest not only to PhD students and postdocs, but also to researchers in this field seeking an understanding of the possible applications of meso and microporous silica-derived materials." - Professor Avelino Corma, Institute of Chemical Technology (ITQ-CSIC) and Polytechnical University of Valencia, Spain

  • Strategies and Solutions to Advanced Organic Reaction Mechanisms

    A New Perspective on McKillop's Problems
    • 1st Edition
    • Andrei Hent + 1 more
    • English
    Strategies and Solutions to Advanced Organic Reaction Mechanisms: A New Perspective on McKillop's Problems builds upon Alexander (Sandy) McKillop’s popular text, Solutions to McKillop’s Advanced Problems in Organic Reaction Mechanisms, providing a unified methodological approach to dealing with problems of organic reaction mechanism. This unique book outlines the logic, experimental insight and problem-solving strategy approaches available when dealing with problems of organic reaction mechanism. These valuable methods emphasize a structured and widely applicable approach relevant for both students and experts in the field. By using the methods described, advanced students and researchers alike will be able to tackle problems in organic reaction mechanism, from the simple and straight forward to the advanced.

  • The Chemistry of Heterocycles

    Nomenclature and Chemistry of Three to Five Membered Heterocycles
    • 1st Edition
    • Vishnu Ji Ram + 3 more
    • English
    Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 90
    • English
    Advances in Clinical Chemistry, Volume 90, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • The Chemistry of Heterocycles

    Chemistry of Six to Eight Membered N,O, S, P and Se Heterocycles
    • 1st Edition
    • Vishnu Ji Ram + 3 more
    • English
    The Chemistry of Heterocycles: Chemistry of Six to Eight Membered N,O, S, P and Se Heterocycles details the chemistry, behavior and potential of these important structures. The book presents a practical guide to international nomenclature, including discussions of fused ring systems, heteroatoms with abnormal valences, and bridged, spiro and polycyclic heterocycles. Three membered heterocycles are then the focus, along with their thermodynamic properties and importance in natural products, medicines, materials, and their unique aspects, such as strain, basicity and reactivity. Additional chapters cover 100 key heterocycle structures, from Azetidines, Pyrroles and Pyridines, to Benzoxepines and Oxocanes. Final chapters explore cutting-edge advances in the development of phosphorus and selenium based heterocycles.

  • Imides

    Medicinal, Agricultural, Synthetic Applications and Natural Products Chemistry
    • 1st Edition
    • Frederick A. Luzzio
    • English
    Imides: Medicinal, Agricultural, Synthetic Applications and Natural Products Chemistry provides a comprehensive overview of imides being developed as pharmaceuticals or experimental therapeutics. Featuring a diverse range of experts in the field of imides, each chapter reviews the state-of-the-art, including the isolation and identification of naturally-occurring imides, as well as the total synthesis of imide natural products. As there is a need for a comprehensive review of imides as a class of naturally-occurring, biologically active molecules, this book will be invaluable to those in pharmaceuticals, academia, and anyone looking for clinical applications.

  • Total Synthesis of Bioactive Natural Products

    • 1st Edition
    • Goutam Brahmachari
    • English
    Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products.

  • Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

    • 1st Edition
    • Goutam Brahmachari
    • English
    Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.

  • Modern Applications of Cycloaddition Chemistry

    • 1st Edition
    • Paolo Quadrelli
    • English
    Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 129
    • English
    Advances in Heterocyclic Chemistry, Volume 129 is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive, updated release includes chapters on Metal-Catalyzed Direct Arylation of 1,2-Azoles, The Literature of Heterocyclic Chemistry, Part XVII, 2017, Pyrrolo-, Imidazoquinolines and Pyrroloquinazolines with a Bridgehead Nitrogen, Synthesis and Reactions of Arsole, Stibole, and Bismole, Advances in Synthesis and Chemistry of Aziridines, and more.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 58
    • English
    Progress in Medicinal Chemistry, Volume 58, provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors. Topics covered in this new release include Amyotrophic lateral sclerosis (ALS), Covalent-binding Drugs, Natural Product Drug Delivery – A Special Challenge?, and SMN2 gene splicing modifier, and more.

  • Sialic Acids, Part II: Biological and Biomedical Aspects

    • 1st Edition
    • Volume 76
    • David C. Baker
    • English
    Sialic Acids, Volume 76, the most recent release in the Advances in Carbohydrate Chemistry and Biochemistry series, is the second volume of a two-volume set devoted to the sialic acids. Vol. 76, devoted to the biological and biomedical aspects of sialic acids, includes chapters on "Sialic Acids in Neurology," "Sialic Acids in Nonenveloped Virus Infections," and "The Biology of Gangliosides," all written by leading experts in their fields.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 128
    • English
    Advances in Heterocyclic Chemistry, Volume 128, is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is being used more frequently in explanations. Written by established authorities in the field from around the world, this updated volume includes sections on Recent Advances in 1,2,4-Triazolo-[1,5-... Chemistry, Fluorescent Heterocycles: Recent Trends and New Developments, and Reactions of 3-Pyrrolin-2-ones.

  • The Alkaloids

    • 1st Edition
    • Volume 82
    • English
    The Alkaloids, Volume 82 is the newest release in a series that has covered the topic for more than 60 years. As the esteemed, leading reference in the field of alkaloid chemistry, this series covers all aspects of alkaloids, including their chemistry, biology and pharmacology. Sections are presented as high-quality, timeless reviews written by renowned experts in the field, with this new release focusing on Recent Progress in the Chemistry of Pandanus Alkaloids, Alkaloids - Derivatives and Applications, Alkaloids of the Lauraceae, and more.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 89
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 89, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 62
    • English
    Studies in Natural Products Chemistry, Volume 62 discusses natural products in the plant and animal kingdom that offer a huge diversity of chemical structures resulting from biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This series covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • The Alkaloids

    • 1st Edition
    • Volume 81
    • English
    The Alkaloids, Volume 81, the newest release in a series that has covered the topic for more than 60 years, covers all aspects of alkaloids, including their chemistry, biology and pharmacology. Sections in this new release cover Bisbenzylisoquinolin... Alkaloids, Alkaloids of the Lauraceae, and The Chemical Synthesis and Applications of Tropane Alkaloids, amongst other topics.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 127
    • English
    Advances in Heterocyclic Chemistry, Volume 127, the latest release in this definitive series in the field highlights the areas where biology and organic chemistry increasingly intersect. This updated volume includes chapters on The Pictet-Spengler Reaction (1990-2017): A Powerful Strategy for the Synthesis of Heterocycles, Organometallic Complexes of Polyazines, Recent Developments in the Chemistry of Boron- dipyrromethene (BODIPY) Fluorescent Dyes and their Aza analogues, Reactions of 3-Pyrrolin-2-ones, Arsole, Stibole, Bismole, and fused systems , The Chemistry of Dihydrothienopyrrolo... the Application of the Baylis-Hillman Reaction in Heterocyclic Chemistry, and 5-Endo Cyclisation, amongst other topics.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 88
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 88, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Phosphines as Reagents and Catalysts in Organic Synthesis

    • 1st Edition
    • Hongchao Guo + 1 more
    • English
    Phosphines as Reagents and Catalysts in Organic Synthesis provides comprehensive coverage of metal-free organic reactions with phosphines as reagents or catalysts, as well as their synthetic uses. The work begins with a historical overview of the use of phosphines in metal-free organic reactions, followed by details of their physical properties and the source and preparation methods for representative phosphines and chiral variants. The applications of phosphines as reagents and catalysts in organic synthesis are discussed, along with case studies organized according to reaction type. Researchers, graduate students and undergraduates working in organic synthesis will find this work an invaluable resource.These reactions include halogenation under Appel conditions, Wittig reaction, Staudinger reaction, Mitsunobu reaction, alcohol acylation and kinetic resolution, Rauhut-Currier reaction, Morita-Baylis-Hillma... reaction, conjugate addition, umpolung additions, annulation reactions, allylic substitution, allylic amination, and isomerization reactions. For each reaction an overview of the state-of-the-art is presented along with the reaction data, enantioselective version using chiral phosphine, and its application in the synthesis of biologically active compounds and total synthesis of natural products. The work concludes with a summary that highlights the most promising reactions for future development in this field of research.

  • Sialic Acids, Part I: Historical Background and Development and Chemical Synthesis

    • 1st Edition
    • Volume 75
    • English
    Sialic Acids, Volume 75, a recent release in the Advances in Carbohydrate Chemistry and Biochemistry series, is the first volume of a two-volume set devoted to the sialic acids. Vol. 75 includes a broad-based historical overview of the field by two pioneers in the identification, structural development, and chemistry and biochemistry of the sialic acids. A second chapter is devoted to the finer aspects of the modern, up-to-date chemical synthesis of the all-important glycosides of N-acetylneuraminic acid, a class of sialic acid derivatives with a myriad of functions.

  • Advances in Bioorganometallic Chemistry

    • 1st Edition
    • Toshikazu Hirao + 1 more
    • English
    Advances in Bioorganometallic Chemistry examines the synthesis, structure and reactivity of bioorganometallics, their pharmaceutical applications, hydrogenase, vitamin B12-like systems, and metalloproteins. It is written by the top researchers in the field and compiled by editors Toshikazu Hirao and Toshiyuki Moriuchi. Developments in this new field of bioorganometallic chemistry, a hybrid between biology and organometallic chemistry, happen very quickly and this comprehensive reference offers the latest research and findings in the field. The book features a discussion of the synthesis, structure, and reactivity of bioorganometallics, and an examination of hydrogenase-like systems, which were designed to demonstrate catalytic activities and functional properties. Advances in Bioorganometallic Chemistry also includes a discussion of bioorganometallics as they relate to medicinal chemistry, specifically applications of metalloproteins, metalloenzymes, and applications in bioimaging. The book concludes with coverage of vitamin B12-like systems, including the latest developments in derivatives designed to perform bio-inspired catalytic reactions. This work is a valuable resource for chemists working in organometallic chemistry and biology, including biochemists, bioorganic chemists, bioinorganic chemists, as well as pharmaceutical scientists, medicinal chemists, and students studying in these areas. Representative authors: R. H. Fish, T. Moriuchi, T. Hirao, H.-B. Kraatz, H. Takaya, T. P. Curran, G. van Koten. E. Rosenberg, J. M. Lynam, C. G. Hartinger, U. Schatzschneider, G. S. Smith, R. Alberto,S. Takenaka, T. Ihara, T. Hayashi, T. Ueno, P. Schollhammer, Y. Shomura, Y. Hisaeda, H. Shimakoshi, B. Kräutler

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 60
    • English
    Studies in Natural Products Chemistry, Volume 60 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 61
    • English
    Studies in Natural Products Chemistry, Volume 61 discusses natural products in the plant and animal kingdom that offer a huge diversity of chemical structures resulting from biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This series covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Third Generation EGFR Inhibitors

    Overcoming EGFR Resistance and Toxicity Problems
    • 1st Edition
    • Harun M. Patel + 2 more
    • English
    Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics.

  • Kinetic Control in Synthesis and Self-Assembly

    • 1st Edition
    • Munenori Numata + 2 more
    • English
    Kinetic Control in Synthesis and Self-Assembly provides a unique overview of the fundamental principles, novel methods and practical applications for researchers across organic synthesis, supramolecular chemistry and materials sciences. The book examines naturally occurring molecular systems in which kinetic processes are more ubiquitous than thermodynamic processes, also exploring the control of reactions and molecular self-assemblies, through kinetic processes, in artificial systems. These methods currently play a crucial role for tuning materials functions. From organic synthesis, to supramolecular assemblies, and from restricted spaces, to material synthesis for hierarchical structures, the book offers valuable coverage for researchers across disciplines. Interesting topics include how to regulate kinetic pathways more precisely, essential molecular design for kinetic traps, and how molecular environments surrounding molecules (i.e., solvent, temperature, and pressure effects) influence kinetic control in reactions and self-assemblies.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 52
    • Ian Williams + 1 more
    • English
    Advances in Physical Organic Chemistry, Volume 52 in the series, is the definitive resource for authoritative reviews of work in physical organic chemistry. It aims to provide a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines.

  • Progress in Heterocyclic Chemistry

    • 1st Edition
    • Volume 30
    • Gordon Gribble + 1 more
    • English
    Progress in Heterocyclic Chemistry (PHC), Volume 30, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), contains both highlights of the previous year’s literature on heterocyclic chemistry and articles on new and developing topics of interest. Chapters in this updated volume are all written by leading researchers in their field, providing a systematic survey of the important, original material reported in literature in 2017. As with previous volumes in the series, this update will enable academics, industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient resource.

  • Neglected Diseases: Extensive Space for Modern Drug Discovery

    • 1st Edition
    • Volume 51
    • English
    Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 87
    • English
    Advances in Clinical Chemistry, Volume 87, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Anionic Annulations in Organic Synthesis

    A Versatile and Prolific Class of Ring-Forming Reactions
    • 1st Edition
    • Dipakranjan Mal
    • English
    Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the main annulations for the construction of cyclic structures and their use in the total synthesis of functional molecules. The book explores in detail the Hauser, Robinson, Sammes, and Myers annulations, all of which are beneficial to constructing substrates with complex molecular structures suitable for pharmaceutical purposes. This volume begins with an in-depth introduction on the history and perspectives of annulations. It then covers different categories of annulation in each chapter, examining their application to drug synthesis for a range of different medicinal compounds. Anionic Annulations in Organic Synthesis delivers a thorough analysis of the topic and provides the tools necessary to master anionic organic chemistry. It is a valuable resource for chemists, researchers, and students seeking a complete and detailed understanding of anionic annulations.

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