Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Back to School Savings: Save up to 30% on print books and eBooks. No promo code needed.
Back to School Savings: Save up to 30%
1st Edition - September 5, 2018
Author: Al Postigo
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological… Read more
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.
1. Introduction and Highlights2. 18F radiolabeling of bioactive compounds 3. Electrophilic and oxidative fluorination of aromatic compounds4. Enantioselective fluorination5. Visible-Light-Mediated C-F bond Activation6. Photocatalytic fluorination reactions7. Fluorination of allylic positions towards the synthesis of fluorinated bioactive compounds8. Difluoromethylation of Bioactive Compounds9. Fluorination of Bioactive Compounds by Electron Transfer Reactions10. Fluorine-Containing Pharmaceuticals and the Phenomenon of Self-Disproportionation of Enantiomers (SDE)
AP