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Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

    Platforms
    • 1st Edition
    • Wendy Fantl
    • English
    Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms. Understanding the intricate coordination of highly diverse cell types within healthy tissues and organs is essential for grasping their functionality. This coordination, often disrupted in disease, hinges on proteins—the primary drivers of cellular function. By examining protein abundance and activation states in single cells, researchers can identify key cell populations involved in both healthy and diseased states, including those influencing disease initiation, progression, and therapeutic responses. Single-cell multiplex proteomic platforms have recently emerged as powerful tools for biomedical research. Their strengths lie in revealing cell types that are rare or subtly different and would otherwise go undetected in bulk cellular analyses. This unique capability enables deeper insights into cellular behavior and disease mechanisms.This book offers comprehensive overviews of technologies developed for multiplex single-cell proteomic analyses. It begins with the pioneering work from Professors Scott Tanner, Mitchell Winnick and Garry Nolan resulting in the development and early application of the mass cytometer, (CyTOF). The instrument merges flow cytometry with time-of-flight mass spectrometry and analyzes cells labelled with metal tagged antibodies. These components work together to enable CyTOF to perform highly multiplexed protein analysis at the single-cell level, offering a powerful tool for understanding complex cellular behaviors and interactions.Recogni... that cellular organization is critical for tissue function, subsequent chapters explore advanced multiplex imaging platforms including Imaging Mass Cytometry (IMC), Multiplexed Ion Beam Imaging (MIBI), CODetection by InDExing, and Chip Cytometry. Later chapters present recent advances in these imaging platforms and data analysis approaches - Combined Nucleic Acid and Protein Quantification in situ, Tissue Schematics, and High-definition CODEX for 3D Multiplex Spatial Cell Phenotyping. These techniques integrate deep phenotyping with spatial mapping to provide unprecedented insights into cellular interactions within tissues. The book also highlights computational approaches essential for managing and interpreting the vast datasets generated by these technologies. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms help researchers in many fields, including developmental biology, cancer biology, immunology, neuroscience, and drug discovery gain an understanding about the theories and detailed methodologies behind these technologies. Integrating proteomics with genetic, epigenetic, and transcriptomic platforms, this book aims to inspire new research opportunities, ultimately advancing the development of reliable biomarkers and improving patient outcomes.

  • On Epigenetics and Evolution

    • 1st Edition
    • Carlos M. Guerrero-Bosagna
    • English
    On Epigenetics and Evolution, a new volume in the Translational Epigenetics series, introduces key themes from current epigenetic evolution research, with contributions from leading scientists around the world that investigate the role of epigenetic mechanisms in evolution from a variety of different angles, with each contribution combining theory, current research overviews, and applications. This book gives researchers, students, and clinicians a better understanding of the origin of genotypic and phenotypic variability, the role of epigenetics in development and inheritance, how epigenetics may affect speciation, and the evolution of epigenetic mechanisms in different taxa, and helps them apply their learnings across new research. Other modalities and subtopics explored include epigenetics in neutral and also adaptive evolution; epigenetic evolution in plants, invertebrates, and vertebrates; and the role of epigenetics in human evolution and its societal impact.

  • Resilient Health

    Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond
    • 1st Edition
    • Judy Kuriansky + 1 more
    • English
    Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond presents game-changing and disruptive technological innovations and social applications in physical and mental healthcare around the world for the post-COVID age and beyond, addressing the urgent need for care. In this first-of-its kind comprehensive volume, experts and stakeholders from all sectors - government and the public and private sectors - offer models and frameworks for policy, programming, and financing to transform healthcare, address inequities, close the treatment gap, and “build back better,” especially for under-resourced vulnerable communities globally, to “leave no one behind” and advance development globally. Contributions from world experts cover 8 essential parts: The context and challenges for resilient health systems to shape the future; developments and directions (AI, VR, MR, IVAs and more); an innovations toolbox, also targeted for special populations and settings (women, youth, ageing, migrants, disabled persons, indigenous peoples, in the workplace); the role of stakeholders (governments, the United Nations bodies, and the public and private sector); forums and networks; innovative financing; resources, lessons learned and the way forward.

  • Advances in Host Genetics and microbiome in lifestyle-related phenotypes

    • 1st Edition
    • Volume 111
    • English
    Advances in Host Genetics and Microbiome in Lifestyle-Related Phenotypes, Volume 111 explores the recent discoveries in the interaction between Host Genetics-Microbiome and lifestyle-related phenotypes regarding precision nutrition, physical activity, sports performance, circadian rhythm, sleep, and rest. Chapters in this release include Techniques, procedures, and applications in host Genetic analysis, Techniques, procedures, and applications in Microbiome analysis, Human adaptations to diet: biological and cultural coevolution, Impact of Evolution on Lifestyle in Microbiome, Nutrition and host Genetics: nutrigenetics, Nutrition and Microbiome: microbiome nutrition, Genomic predictors of physical activity and athletic performance, physical activity and Microbiome, Microbiome and Host Genetics in Circadian Rhythm, and more.

  • Features, Transmission, Detection, and Case Studies in COVID-19

    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    Features, Transmission, Detection, and Case Studies in COVID-19 examines the effects of the virus on the body, as well as its transmission and clinical profile. This volume begins with an introduction to the virus and its pathogenesis, transmission, and avoidance, followed by sections on pulmonary and cardiovascular effects, obesity, diabetes, the liver, detection issues, and biomarkers. Vaccines and treatment are also discussed. Specific case studies covered include hypoxia, acute kidney injury, pneumonia, and neurological effects. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.

  • Chromatin

    Structure, Function, and History
    • 1st Edition
    • Randall H. Morse
    • English
    Chromatin: Structure, Function, and History brings the reader up to date on the remarkable progress made in chromatin research over the course of the past 50 years. Coverage includes the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights, and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research.

  • Advanced Biophysical Techniques for Polysaccharides Characterization

    • 1st Edition
    • Nirmal Mazumder
    • English
    Advanced Biophysical Techniques for Polysaccharides Characterization offers detailed insights into the cutting-edge techniques available for the identification, quantification, characterization. and structural analysis of polysaccharides. A wide range of techniques are covered, including scanning electron microscopy (SEM), atomic force microscopy (AFM), optical microscopy, non-linear optical microscopy and spectroscopic techniques like Fourier transform Infrared (FTIR), X ray diffraction, light scattering, and nuclear magnetic resonance (NMR). Various polysaccharides are investigated, along with their applications across a range of industries. Each chapter offers a detailed description of the techniques before delving into case studies covering the latest advances.This book provides a one-stop solution to the latest advanced microscopic and spectroscopic techniques for investigating a range of important polysaccharides and is an ideal reference for researchers in the field of biophysics, molecular biology, biochemistry, pharmaceutics, food chemistry and related areas.

  • Animal Models of Disease Part B

    • 1st Edition
    • Volume 188
    • English
    Animal Models of Disease, Part B, Volume 188 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Using C. Elegans as a model for Neurodegenerative disease: Methodology and Evaluation, Modelo Animal de Esclerosis Multiple: Encefalomielitis Autoimmune Experimental (EAE, New mouse model to study aneurysm development, Spinal Nerve Ligation: An Experimental Neuropathic Pain Model in Rats and Mice, Identifying therapeutic compounds for Autosomal Dominant Optic Atrophy (ADOA) through screening in the nematode C. elegans, Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, and much more.Other chapters cover Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis, Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models, Assessing motor development and function in mouse models of neurodevelopmental disorders, Analysis of Gut Microbiota profile targeted to multi hypervariable regions of 16S rRNA in hypertensive heart failure rat model, and more.

  • Linking Neuroscience and Behavior in COVID-19

    • 1st Edition
    • Rajkumar Rajendram + 3 more
    • English
    Linking Neuroscience and Behavior in COVID-19 examines the effect of both the virus and the pandemic on behavior and mental health. Chapters look at the burden of the COVID-19 pandemic on those with pre-existing conditions, including Parkinson’s disease and multiple sclerosis. The ongoing consequences of the pandemic on the mental health of the broad populace are discussed. As well as the neurological effects of the virus itself, chapters discuss psychological concerns including depression and anxiety. Finally, the chapters also include aspects relevant to managing care and the treatment of conditions. A broad range of conditions preceding, caused by, or emerging for the first time during the pandemic are also detailed.

  • International and Life Course Aspects of COVID-19

    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    International and Life Course Aspects of COVID-19 describes the nuances and international variations of COVID-19 in different populations and age groups. This volume details those differences in chapters examining the effects of the virus at different life stages, including newborns, children, adolescents, and older populations. Consideration of the age-specific effects of COVID-19 on the brain are a major focus unique to this resource. International observations and global outcomes are also described. This volume is relevant for all clinicians working to ensure the best outcomes for patients with COVID-19 worldwide.

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