
Linking Neuroscience and Behavior in COVID-19
- 1st Edition - June 13, 2024
- Imprint: Academic Press
- Editors: Rajkumar Rajendram, Victor R Preedy, Vinood Patel, Colin R. Martin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 6 5 0 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 6 5 1 - 2
Linking Neuroscience and Behavior in COVID-19 examines the effect of both the virus and the pandemic on behavior and mental health. Chapters look at the burden of the COVID-… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quote- Discusses the impact of the COVID-19 pandemic and the virus itself on behavior and psychology
- Examines comorbidities including Parkinson’s disease, neuroinflammation, and autism spectrum disorders
- Outlines the management and care for coexisting conditions including brain tumors, multiple sclerosis, and ischemic stroke
- Features chapters on the severe damage to the nervous system which may be caused by SARS-CoV-2 infection including myelitis
- Contains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Section A: Introductory chapters and setting the scene
- Chapter 1 The historical aspects of the SARS-CoV-2 virus and the ensuing pandemic
- Abstract
- Introduction
- Viral pandemic history
- Zoonotic origin of pathogenic viruses
- Origin of coronaviruses
- Genomic organization of coronaviruses
- Evolution relationship of SARS-CoV-2
- Conclusion
- Mini-dictionary of terms
- Summary points
- References
- Chapter 2 Different variants of SARS-CoV-2
- Abstract
- Introduction
- SARS-CoV-2 classification
- Various SARS-CoV-2 variants
- Challenges of novel variants on diagnosis and therapy
- Conclusion
- Mini-dictionary of terms
- Summary points
- References
- Chapter 3 Lateral flow assay for SARS-CoV-2 infection: Uses and limitations
- Abstract
- Introduction
- Lateral flow strip components
- Lateral flow assay types
- Lateral flow assay: Clinical perspective
- Conclusions
- Mini-dictionary of terms
- Summary points
- References
- Chapter 4 Linking community participation, mobility disabilities, and the COVID-19 pandemic
- Abstract
- Introduction
- Policies and procedures
- Community participation
- Education
- Employment
- Health
- Pandemic adaptations
- COVID-19 vaccines and boosters
- Long-term consequences
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 5 Influence of the sources used to obtain information on COVID-19 and their impact on mental health
- Abstract
- Introduction
- Sources of information during the COVID-19 pandemic
- Infodemic and disinformation: Social media as a source of information
- Impact of information received about COVID-19 on people's health
- Beliefs about COVID-19
- Knowledge on preventive measures to be adopted against COVID-19
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Section B: Impact on behavior and psychology
- Chapter 6 The psychological experiences and distress of defined populations in the COVID-19 pandemic: Doctors
- Abstract
- Introduction
- Prepandemic mental health and working conditions
- Types and prevalence of mental health symptoms during the COVID-19 pandemic
- Factors driving poor mental health during COVID-19
- Responding to the COVID-19 pandemic
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 7 Impact of COVID-19 on behavior in autism spectrum disorder
- Abstract
- Introduction
- COVID-19 pandemic challenges among individuals with ASD
- Conclusions
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- Conflicts of interest
- References
- Chapter 8 Prepandemic stressors in mental health responses to the COVID-19 pandemic: Early life adversities and beyond
- Abstract
- Introduction
- Stress and mental health: A brief overview
- Early life stressors
- Major life stressors
- COVID-19-related stressors
- Exploring the neurobiological basis of stress
- Vulnerable populations
- Psychosocial resources acting as mediators and moderators in stress responses
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 9 Compulsive hoarding in the COVID-19 pandemic
- Abstract
- Introduction
- Impact of COVID-19 on hoarding behaviors
- Differences between panic buying and hoarding
- Studies investigating panic buying during the pandemic
- Impact of the pandemic on the clinical population
- Protective and risk factors associated with hoarding behaviors
- Conclusions
- Mini-dictionary of terms
- Summary points
- References
- Chapter 10 The psychological experiences and distress in Japan and Sweden during the COVID-19 pandemic
- Abstract
- Coronavirus disease 2019 (COVID-19) pandemic
- Unique countermeasures against COVID-19 in Japan
- Unique countermeasures against COVID-19 in Sweden
- Mental health impact of COVID-19 in Sweden
- Conclusions
- Summary points
- References
- Chapter 11 The COVID-19 pandemic, mental health, and sleep: Linking depression, anxiety, and perceived stress
- Abstract
- Introduction
- Psychiatric symptoms and sleep disturbance during COVID-19 pandemic
- Sleep quality
- Risk and protective factors related to mental health problems during the pandemic
- Neurobiology of psychiatric symptoms in COVID-19
- Resilience
- Policies
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 12 The COVID-19 pandemic and the occupational overload of health professionals: Indicators of burnout
- Abstract
- Introduction
- Burnout conceptual models
- Impacts on health professionals’ emotional overload at different times during the COVID-19 pandemic
- Diverse burnout prevalence rates, measurement instruments, and associated conditions
- Diverse burnout rates and epidemiological statuses
- Diverse burnout rates and the different countries and continents
- Diverse burnout rates and the number of cases among different countries and type of patient care
- Diverse burnout rates and different professions
- Risk factors for burnout among health professionals
- Risk factors associated with burnout among different professions
- Prevention and interventions concerning burnout—Recommendations for practice
- Future studies addressing burnout
- Policies and procedures
- Implications for other fields
- Summary
- References
- Chapter 13 Neurocognitive sequelae of SARS-CoV-2 infection: Pathogenesis, risk factors, assessment, and implications
- Abstract
- Introduction
- Neurocognitive sequelae of COVID-19
- Pathophysiology of cognitive dysfunction
- Risk factors for cognitive dysfunction in COVID-19
- Method of assessment
- COVID-19 and dysexecutive syndrome
- COVID-19 and memory deficits
- COVID-19 and attention problems
- Impacts on other cognitive domains
- Consequences of neurocognitive sequelae
- Management
- Conclusion
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 14 Acute neurocognitive disorder as a presenting manifestation of COVID-19
- Abstract
- Introduction
- Evaluation
- CSF analysis
- Management
- Conclusions
- Future directions
- Summary points
- References
- Chapter 15 Mental health and the impact of confinement
- Abstract
- Introduction
- Impact on lifestyle
- Impact on anxiety and stress
- Impact on mood disorders
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 16 Cannabis use in the COVID-19 pandemic: Changes in different populations and implications for policy
- Abstract
- Introduction
- Regional prevalence and trends of cannabis use during the pandemic
- Factors contributing to cannabis use change
- Impacted populations
- Health implications
- Implications for policy
- Applications to other areas
- Limitations
- Conclusion
- Mini-dictionary of terms
- Summary points
- References
- Chapter 17 Impact of COVID-19 on women's mental health: Socioeconomic groups and global aspects
- Abstract
- Introduction
- About the brain
- Maternal health
- The mental health of women from different parts of the world
- The mental health of women belonging to different socioeconomic groups
- Neurological behavior of women from different age groups
- Societal and economic impact on women
- Conclusion
- Policies
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 18 Quality of life assessment of patients after COVID-19
- Abstract
- Introduction
- Policy and procedure
- Applications in other regions
- Mini-dictionary of terms
- Summary points
- Health-related QoL
- Psychometric tools for measuring health-related quality of life
- General health level questionnaires
- Special questionnaires of health-related quality of life
- Long post-COVID-19 syndrome
- The impact of the SARS-CoV-2 virus on quality of life after the end of acute COVID-19
- Review of studies on post Long-COVID-19 induced quality of life
- Conclusion
- References
- Chapter 19 COVID-19 pandemic and remote working: Toward a new way of working
- Abstract
- Introduction
- The rise of remote working during the pandemic
- Between benefits and challenges: Notes for post-COVID-19 remote working
- The future of remote working: Toward a hybrid work model
- Conclusion
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 20 Long COVID-19 and its persistence: A focus on mental health
- Abstract
- Introduction
- Policies and procedures
- Long COVID-19 and mental health
- Pathophysiology
- Long COVID-19 and fatigue
- Stress
- Depression and anxiety
- Sleep disturbances
- Cognitive impairment
- Monitoring and treating mental health issued in long COVID-19
- Applications to other areas
- Conclusions
- Summary points
- Mini-dictionary of terms
- References
- Chapter 21 The impact of the COVID-19 pandemic on behavioral and psychological features of vulnerable groups: Patients with multiple sclerosis and their quality of life
- Abstract
- Introduction
- Behavioral effects of the COVID-19 pandemic on MS patients
- Psychological effects of the COVID-19 pandemic on MS patients
- COVID-19 and the quality of life in MS patients
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 22 The COVID-19 pandemic and the interlink with psychological distress and eating behaviors
- Abstract
- COVID-19 and the associated challenges
- COVID-19 and psychological distress
- COVID-19 and disordered eating behaviors
- Stress: The hidden culprit
- Is the COVID-19 pandemic the mediating link between DEBs and psychological distress?
- Lessons for the future
- Summary points
- References
- Section C: Effects on neurological structures and mechanisms
- Chapter 23 Linking pediatric COVID-19 with basal ganglia and dentate nucleus
- Abstract
- Introduction
- Dentate nucleus
- Pathogenesis
- Clinical features
- Persistent neurological symptoms post SARS-CoV-2 infection
- Discussion
- Conclusion
- Summary
- References
- Chapter 24 Sensory disorders, neuroinflammation, and COVID-19
- Abstract
- Introduction
- Pathophysiology of sensory disorders
- Treatment
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 25 The effects of COVID-19 isolations on nonmotor features of Parkinson’s disease
- Abstract
- Introduction
- Neuropsychiatric symptoms
- Sleep disturbances
- Quality of life
- Pain
- Autonomic dysfunctions
- Conclusions
- Summary points
- References
- Chapter 26 Myelitis following COVID-19
- Abstract
- Introduction
- Definition
- Epidemiology
- Pathophysiology
- Demographic characteristics
- Clinical features
- Laboratory features
- Neuroimaging findings
- Treatment
- Prognosis
- Conclusions
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 27 The corpus callosum: Effects due to SARS-CoV-2 infection and the mRNA vaccine
- Abstract
- Introduction
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 28 Assessing the impact of prenatal SARS-CoV-2 exposure on infants’ neurodevelopment: A comprehensive analysis of current evidence
- Abstract
- Introduction
- Understanding COVID-19 at the beginning of the pandemic
- Exploring the social and lifestyle changes generated by the COVID-19 pandemic and their possible impact on neurodevelopment in infants
- Can prenatal exposure to SARS-CoV-2 truly impact the neurodevelopment of infants?
- Pending questions around babies with prenatal exposure to SARS-CoV-2
- Conclusions
- Policies
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 29 Electroencephalographic features with COVID-19
- Abstract
- Introduction
- EEG findings in acute phase encephalopathy
- EEG findings in seizures and status epilepticus in adults
- Pediatric population
- EEG in persistent COVID-19
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 30 Survivors of COVID-19 and clinical neuropsychological domain characteristics
- Abstract
- Introduction
- Policies and procedures
- Summary and discussion
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 31 Neuroinflammation following SARS-CoV-2 infection
- Abstract
- Acknowledgments
- Mechanisms of SARS-CoV-2 neuroinvasion
- Impact of SARS-CoV-2 infection on neurogenesis
- Neuropathology of COVID-19
- Postmortem evidence of glial activation
- Soluble biomarker studies
- Long-COVID-19 and the brain
- Neuroinflammation as a mechanism of neuropsychiatric sequelae of COVID-19
- COVID-19 lasting cognitive impairment?
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 32 Functional magnetic resonance imaging and depressive symptoms in subjects with COVID-19
- Abstract
- Introduction
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 33 Impact of COVID-19 on the brain: Antibodies against brain stem antigens
- Abstract
- Introduction
- Brain stem damage in COVID-19
- Autoantibodies and COVID-19
- Evidence for brain stem autoantigens in COVID-19
- Future perspectives and brain stem damage in long-COVID-19
- Mini-dictionary of terms
- Summary points
- References
- Chapter 34 The kynurenine pathway and role in mental health of post-COVID-19 patients
- Abstract
- Introduction
- Abnormalities in tryptophan-kynurenine pathway in the development of mental health conditions
- The psychological consequences of viral pandemics
- Neuropsychiatric symptoms in COVID-19 patients: The possible underlying mechanisms
- Conclusion and future directions
- Mini-dictionary of terms
- Summary points
- References
- Section D: Management, support and treatments
- Chapter 35 Management of brain tumors in the COVID-19 pandemic
- Abstract
- Introduction
- Policies and procedures
- Consortia guidelines
- Patient prioritization
- Treatment and investigation-based considerations
- Discussion
- Applications to other areas
- Conclusions
- Mini-dictionary
- Summary points
- References
- Chapter 36 The impact of the COVID-19 pandemic on ischemic stroke management: From hyperacute to chronic phase
- Abstract
- Introduction
- Prehospital management
- In-hospital management
- Rehabilitation, outpatient management, and stroke outcome
- Conclusions
- Policy and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 37 Long COVID-19 and the potential use of palmitoylethanolamide
- Abstract
- Introduction
- Pathophysiology of SARS-CoV-2
- Long-COVID-19 symptoms
- Therapy
- Antiinflammatory therapy
- Clinical trials
- Conclusions
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 38 Cognitive assessments in post-COVID-19 syndrome: A focus on the neuropsychological tests and protocols
- Abstract
- Concepts of neuropsychological assessment
- Importance of neuropsychological assessment in post-COVID-19 syndrome
- Objectives of neuropsychological assessment in PCS
- Assessment of cognitive domains in post-COVID-19 syndrome
- Concluding remarks: Diagnosis of cognitive impairment associated with COVID-19
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 39 Supporting those with intellectual and developmental disabilities during the COVID-19 pandemic
- Abstract
- Introduction
- Policies and procedures
- Applications to other areas
- Discussion
- Mini-dictionary of terms
- Summary points
- References
- Chapter 40 Preserving well-being and quality of life through school-based interventions focused on physical activity during the COVID-19 pandemic
- Abstract
- Introduction
- Subjective well-being and health-related quality of life
- Physical activity in children and adolescents
- Physical inactivity and sedentary behavior
- WHO guidelines
- COVID-19 and psychophysical effects
- School-based intervention
- School-based intervention during the pandemic
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 41 Hesitancy in using COVID-19 prevention behaviors among African Americans: Strategies to build confidence
- Abstract
- Introduction
- About the COVID-19 pandemic
- African Americans and COVID-19
- Structural racism and COVID-19: Exacerbation of existing inequities and disparities
- African American hesitancy: Past research experiences matter too
- Top COVID-19 preventive behaviors: Why the hesitancy in engagement?
- Compliance with preventative behaviors
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 42 New strategies for psychological well-being at work
- Abstract
- Introduction
- Individual-level strategies
- Team-level strategies
- Organizational-level strategies
- Technology-based strategies
- Challenges and future directions
- Conclusion
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 43 Mitigating mental health changes with virtual reality technology during COVID-19 outbreak
- Abstract
- Introduction
- Mental illness during COVID-19 pandemic
- Virtual reality concept
- VR development framework in mental health
- Application of virtual reality for mental illness during the COVID-19 pandemic
- Challenges and future recommendations
- Summary points
- References
- Chapter 44 Music therapy for patients with neurological disorders during COVID-19 pandemic
- Abstract
- Introduction
- The role of music therapist during the COVID-19 outbreak
- Telemusic therapy in people with dementia
- Online dancing therapy in people with Parkinson’s disease
- Music therapy at home for children with neurological disabilities
- Discussion
- Summary points
- References
- Chapter 45 Mental health and the modulating effects of receiving the COVID-19 vaccination
- Abstract
- Introduction
- Can vaccination improve mental health?
- Data from the large cohort surveys
- Healthcare professionals
- Who most benefited from vaccination on mental health?
- Summary of the modulating effects of receiving the COVID-19 vaccination on mental health
- Policies
- Procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 46 Personalized cognitive behavioral therapy on patients with obesity in COVID-19 pandemic
- Abstract
- Introduction
- An overview of personalized CBT-OB
- Data on personalized CBT-OB effectiveness before and during COVID-19 pandemic
- Problems and potential opportunities of using personalized CBT-OB during COVID-19
- Remote delivery of personalized CBT-OB during the COVID-19 pandemic
- Adapting CBT-OB for remote delivery
- Conclusions
- Policies and procedures
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 47 Social anxiety disorder and COVID-19: Treatment with cognitive behavioral therapy
- Abstract
- Introduction
- Social anxiety disorder
- The course of social anxiety disorder during COVID-19
- Unique concerns of SAD in the context of a pandemic
- Treatment with cognitive behavioral therapy in the backdrop of the pandemic
- Applications to other areas
- Mini-dictionary of terms
- Summary points
- References
- Chapter 48 Burnout during the COVID-19 pandemic: Modulating role of mindfulness
- Abstract
- Introduction
- Policies and procedures
- Applications to other areas
- Conclusion
- Mini-dictionary of terms
- Summary points
- References
- Section E: Case studies with mini review
- Chapter 49 Case study: Evaluation of a Long Covid Assessment Service (LCAS)
- Abstract
- Introduction
- Methods
- Findings
- Conclusions
- Summary points
- References
- Chapter 50 Case study: Navigating youth mental health and addictions care in the context of the COVID-19 pandemic
- Abstract
- Introduction
- The Family Navigation Project
- Client story
- Discussion
- Summary points
- References
- Chapter 51 Case study: Restless leg syndrome associated with COVID-19
- Abstract
- Introduction
- Mechanisms of RLS
- COVID-19 RLS case reports
- Conclusion
- Summary points
- Conflict of interest
- Author contributions
- Ethical approval
- Data availability statement
- References
- Section F: Resources
- Chapter 52 Recommended resources linking neuroscience and behavior in coronavirus disease 2019 (COVID-19)
- Abstract
- Acknowledgments (in alphabetical order)
- Introduction
- Resources
- Other resources
- Summary points
- References
- Index
- Edition: 1
- Published: June 13, 2024
- Imprint: Academic Press
- No. of pages: 630
- Language: English
- Hardback ISBN: 9780323956505
- eBook ISBN: 9780323956512
RR
Rajkumar Rajendram
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.
VP
Victor R Preedy
VP
Vinood Patel
CM