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Books in Comparative genetics

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Twentieth Century Mouse Genetics

  • 1st Edition
  • August 26, 2021
  • Robert P. Erickson
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 4 0 1 6 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 4 0 1 7 - 5
Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.

Cellular and Animal Models in Human Genomics Research

  • 1st Edition
  • July 30, 2019
  • Katherina Walz + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 6 5 7 3 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 6 5 7 4 - 4
Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth.