Skip to main content
Elsevier
View Cart

Cellular and Animal Models in Human Genomics Research

  • 1st Edition - July 30, 2019
  • Latest edition
  • Editors: Katherina Walz, Juan I. Young
  • Language: English

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants… Read more

World Book Day celebration

Where learning shapes lives

Up to 25% off trusted resources that support research, study, and discovery.

Explore resources

Description

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals.

Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth.

Key features

  • Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies
  • Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health
  • Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Readership

Active researchers, basic and translational scientists, clinicians, postgraduates, and students in the areas of genetics, human genomics, pathology, cellular biology, organismal biology, molecular biology, biochemistry, and bioinformatics

Table of contents

1. Introduction to human genetics

2. Disease in a dish: Cellular models to understand human conditions

3. Tiny models to answer big questions: The worm and the yeast as tools in human genetics research

4. Understanding human genetic disease with the fly

5. Studying human genetic variation in zebrafish

6. The mouse, a model organism for biomedical research

7. CRISPR-Cas technology as a tool to create animal models for biomedical research

8. Integrative modeling and novel technologies in human genomics

9. Models to understand human genomics, final considerations

Product details

  • Edition: 1
  • Latest edition
  • Published: July 30, 2019
  • Language: English

About the editors

KW

Katherina Walz

Katherina Walz, Ph.D., is a Research Associate Professor at the Dr. John T. Macdonald Foundation Department of Human Genetics, and the Director for the Division of Human Disease Modeling at the John P. Hussman Institute for Human Genomics, University of Miami, Florida. Dr. Walz obtained her Ph.D. in Biology (1998) from the University of Buenos Aires, and did a postdoctoral training at Dr. JR Lupski’s laboratory in the Molecular and Human Genetics Department at Baylor College of Medicine, Houston, TX (1998-2004). She established her own laboratory at the Centro de Estudios Científicos (CECS), Valdivia, Chile (2005-2009) and she later moved it to the University of Miami (2009-present). She is interested in the molecular basis of human genetic conditions, from the definition of phenotypic outcomes and the validation of the genetic cause, to the elucidation of the molecular and physiological pathways related to human genetic diseases.
Affiliations and expertise
Research Associate Professor at the Dr. John T. Macdonald Foundation Department of Human Genetics, and the Director for the Division of Human Disease Modeling at the John P. Hussman Institute for Human Genomics, University of Miami, Florida

JY

Juan I. Young

Juan I. Young, Ph.D., is a Research Associate Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics and the Co-Director of the Center for Molecular Genetics at the John P. Hussman Institute for Human Genomics, University of Miami, Florida. Dr. Young obtained his Ph.D. in Biology (1998) from the University of Buenos Aires, and did his postdoctoral training at Baylor College of Medicine, Houston, TX (1998-2004). He established his own laboratory at the Centro de Estudios Científicos (CECS), Valdivia, Chile (2005-2009) and moved it to the University of Miami in 2009. Dr. Young is a neurobiologist interested in identifying epigenetic signatures of human genetic diseases and in establishing animal models of neurological diseases. He has a long-standing interest in neurodevelopmental disorders in general, and in understanding epigenetics-mediated pathogenesis processes.
Affiliations and expertise
Research Associate Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics and the Co-Director of the Center for Molecular Genetics at the John P. Hussman Institute for Human Genomics, University of Miami, Florida

View book on ScienceDirect

Read Cellular and Animal Models in Human Genomics Research on ScienceDirect