Twentieth Century Mouse Genetics
A Historical and Scientific Review
- 1st Edition - August 26, 2021
- Imprint: Academic Press
- Author: Robert P. Erickson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 0 1 6 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 0 1 7 - 5
Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Ro… Read more
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Request a sales quoteTwentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.
- Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century
- Includes updates connecting historic research to ongoing advances
- Authored by a thought-leader in the field
Active researchers and students of genetics, biochemistry, molecular biology, cellular biology, lab animal science, and pharmacology
- Cover Image
- Title Page
- Copyright
- Dedication
- Table of Contents
- Preface
- Acknowledgements
- Introduction
- 1 The origins of mouse genetics and the discovery of the T-locus
- Abstract
- Introduction
- France
- United Kingdom
- Germany
- The United States
- The discovery of the T-locus
- Notes
- References
- 2 The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation
- Abstract
- Genetics and natural selection–the search for mutants in the wild
- The Re-discovery of t alleles in wild mice
- Studies on prezygotic species isolation in Mus musculus and domesticus
- Update
- T/t complex effects on odorant discrimination
- Update on other odorant systems and subspecies isolation
- Haldane's rule, sex-chromosomal hybrid sterility genes
- Update on sex chromosomes and hybrid sterility
- The T/t complex and hybrid sterility
- Notes
- References
- 3 Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions—an over-the-Century Project
- Abstract
- General linkage studies in mice
- General cytogenetic studies in mice
- t-allele linkage and cytogenetic studies
- Notes
- References
- 4 Developmental genetics and recessive t-lethals
- Abstract
- Early studies of the developmental genetics of the T/t complex
- Other early developmental genetic models
- New tools for mouse developmental genetics
- Studies of T/t complex developmental genes, continued
- Notes
- References
- 5 More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion
- Abstract
- Notes
- References
- 6 Mutation studies including those targeting the T/t-complex—a century long project
- Abstract
- Mutagenesis by ionizing radiation
- Chemical mutagenesis
- Insertional mutagenesis
- Mutagenic studies of the T/t complex
- Notes
- References
- 7 Immunogenetics and the failed search for t-antigens–from mid-century and continuing to it’s end
- Abstract
- Blood groups and the major histocompatability complex
- Tolerance
- A well-studied minor histocompatibility antigen: H-Y
- Association of the T/t-complex with histocompatibility antigens
- The failed search for t-complex antigens
- Notes
- References
- 8 Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion
- Abstract
- Oogenesis
- Spermatogenesis
- Spermatozoal RNA
- The genetics of spermatozoa
- X-inactivation during spermatogenesis and sex chromosome transmission ratio distortion
- Separation of X- and Y-bearing spermatozoa
- t-allele transmission ratio distortion
- Notes
- References
- 9 The cloning era and the cloning of Brachury and other T/t complex genes
- Abstract
- Introduction
- The cloning of Brachury and other T/t complex genes
- Notes
- References
- 10 X-inactivation, epigenetics, and imprinting, including of the T/t complex
- Abstract
- X-inactivation
- Imprinting
- Maternal effects found at the T/t complex
- Mouse genetics and rare human diseases lead to the notion of gametic imprinting
- Epigenetics
- Chromosomal 17 imprinting and the T/t complex
- Notes
- References
- 11 Sex determination, sex differentiation, and the Y chromosome—a mostly last quarter of the century effort
- Abstract
- Sex determination
- Sexual differentiation
- The mouse Y chromosome
- T/t complex-associated sex reversal and sex effects on elements of the complex
- Notes
- References
- 12 Pharmacogenetics—a mostly last half of the century effort
- Abstract
- Introduction
- Xenobiotic detoxification
- Other enzymes involved in metabolic degradations
- Membrane transporters
- Receptor variation
- Note
- References
- Book Bibliography
- Index
- Edition: 1
- Published: August 26, 2021
- Imprint: Academic Press
- No. of pages: 344
- Language: English
- Paperback ISBN: 9780128240168
- eBook ISBN: 9780128240175
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Robert P. Erickson
Dr. Robert P. Erickson is the Holsclaw Family Professor Emeritus of Human Genetics and Inherited Diseases, Department of Pediatrics, University of Arizona College of Medicine. He has had a 50 year career of research in human and murine genetics, especially molecular, and patient care. He is author of over 400 scientific and medical papers and has co-authored or co-edited 5 books. He has received Guggenheim and Eleanor Roosevelt Fellowships, was made an honorary visiting fellow of Hughes Hall, University of Cambridge, and a visiting research professor at Universita Roma de la Sapienza. His public service includes being an appointee by then Governor Napolitano to the Arizona Biomedical Research Committee, membership of the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health and membership of the Scientific Board of Advisors of the International Institute of Molecular and Cellular Biology in Warsaw. He is listed in Who’s Who of America.
Affiliations and expertise
Holsclaw Family Professor Emeritus of Human Genetics and Inherited Diseases, and Professor Emeritus of Pediatrics, University of Arizona, Health Sciences, College of Medicine, Tucson, Arizona, USARead Twentieth Century Mouse Genetics on ScienceDirect