Chromatin
Structure, Function, and History
- 1st Edition - June 15, 2024
- Imprint: Academic Press
- Author: Randall H. Morse
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 4 8 0 9 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 4 8 1 0 - 5
Chromatin: Structure, Function, and History brings the reader up to date on the remarkable progress made in chromatin research over the course of the past 50 years. Coverage… Read more
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Request a sales quoteChromatin: Structure, Function, and History brings the reader up to date on the remarkable progress made in chromatin research over the course of the past 50 years. Coverage includes the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights, and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research.
- Provides a current, expansive, and well-documented resource on chromatin and epigenetics
- Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease
- Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward
Researchers and advanced students in the fields of biochemistry, molecular biology, cell biology and genetics
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Part 1: Chromatin structure
- Chapter 1 Early history
- Abstract
- 1869–1950: Identification of nucleic acid and the “dark ages” of chromatin research
- Prelude to the nucleosome: 1950s and 1960s
- A model for the nucleosome: A new era of chromatin biology begins
- References
- Chapter 2 The nucleosome unveiled
- Abstract
- From model to structure: The nucleosome core particle
- The nucleosome unveiled: High-resolution structure of the core particle
- References
- Chapter 3 Chromatin compaction
- Abstract
- Early observations
- Factors influencing chromatin folding
- The structure of compact chromatin
- Compact chromatin in living cells
- Chromosome architecture
- Heterochromatin
- References
- Chapter 4 Nucleosomes in context: Positioning, occupancy, and spacing
- Abstract
- Overview
- Rotational vs translational nucleosome positioning
- Nucleosome spacing
- Methods for determining nucleosome positioning
- First studies of nucleosome positioning
- Nucleosome positioning in vivo
- Mechanisms of nucleosome positioning
- References
- Chapter 5 Histones and variants
- Abstract
- General considerations
- Histone variation: Early work
- Evolution of the histones
- Canonical histones: Nonallelic variants
- Histone mutants
- Specialized variants
- References
- Part 2: Chromatin function
- Chapter 6 Chromatin remodeling
- Abstract
- The SWI/SNF complex
- More remodeling machines
- Structure and mechanism of remodelers
- Function and localization of remodelers
- References
- Chapter 7 Histone modifications
- Abstract
- Overview
- Histone acetylation and deacetylation
- Histone methylation and demethylation
- Other modifications
- Cross-talk
- The histone code
- References
- Chapter 8 Chromatin and transcription
- Abstract
- Transcription: A brief review
- Early investigations
- Prokaryotic polymerases and RNA polymerase III
- Pol II
- Transcription factor access in a chromatin milieu
- Transcribing through chromatin
- Epigenetics
- References
- Epilogue
- Index
- Edition: 1
- Published: June 15, 2024
- No. of pages (Paperback): 584
- No. of pages (eBook): 250
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128148099
- eBook ISBN: 9780128148105
RM
Randall H. Morse
Randall H. Morse's interest in chromatin originated with an undergraduate course in molecular genetics in 1975. After finishing his graduate studies in biophysical chemistry at Caltech, Dr. Morse worked as a postdoctoral fellow at Columbia University and the National Institutes of Health. He continued to conduct research on chromatin and transcription in his own lab at the Wadsworth Center in Albany, New York. Additionally, he has taught chromatin structure and function to graduate students in the Department of Biomedical Sciences at the University at Albany School of Public Health since 1994. Dr. Morse has contributed his expertise and research on chromatin structure and function to numerous conferences. Furthermore, he has written articles and reviews on this subject and has received several competitive grants to fund his research.
Affiliations and expertise
Chief, Laboratory of Molecular Genetics, Wadsworth Center, NY State Department of Health and Professor, Department of Biomedical Sciences, UAlbany School of Public Health, USARead Chromatin on ScienceDirect