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Elsevier

Books in Life sciences

  • Stem Cells and Aging

    • 1st Edition
    • Surajit Pathak + 1 more
    • English
    Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.

  • Sustainable Food Processing and Engineering Challenges

    • 1st Edition
    • Charis M. Galanakis
    • English
    Sustainability is becoming a major item for the food industry around the world, as resources become more restricted and demand grows. Food processing ensures that the resources required producing raw food materials and ingredients for food manufacturing are used most efficiently. Responding to the goals of sustainability requires the maximum utilization of all raw materials produced and integration of activities throughout all the production-to-consum... stages. To maximize the conversion of raw materials into consumer products, food engineering and food processing challenges should be met. Sustainable Food Processing and Engineering Challenges covers the most trend topics and challenges of sustainable food processing and food engineering, giving emphasis in engineering packaging for a sustainable food chain, food processing technologies, Industry 4.0 applied to food, food digestion engineering, sustainable alternative food processing technologies, physico-chemical aspects of food, cold plasma technology, refrigeration climate control, non-thermal pasteurisation and sterilization, nanotechnology and alternative processes requiring less resources, sustainable innovation in food product design etc. Edited by a multiple team of experts, the book is aimed at food engineers who are seeking to improve efficiency of production systems and also researchers, specialists, chemical engineers and professionals working in food processing.

  • Neurocognitive Mechanisms of Attention

    Computational Models, Physiology, and Disease States
    • 1st Edition
    • Golnaz Baghdadi + 2 more
    • English
    Neurocognitive Mechanisms of Attention: Computational Models, Physiology, and Disease States describes the brain mechanisms underlying the attention control system, how those mechanisms are examined, how they operate in different disease states, and methods for improving them. Conceptual models of attention further explore their functional operation. Coverage includes the different types of attention, processing paths, brain anatomy, and attention’s role in memory and movement. Factors affecting attention are explored including nutrition, exercise, and genetics. Neurocognitive disorders impacting attention are discussed including autism, ADHD, OCD, depression, anxiety, schizophrenia, Alzheimer’s and Parkinson’s Disease. Assessment methods and treatments are uniquely set against the backdrop of current conceptual, computational, and oscillatory-based models to encourage researchers to pursue continued development of new diagnostic and therapeutic tools.

  • Systems Immunology and Infection Microbiology

    • 1st Edition
    • Bor-Sen Chen
    • English
    Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches.

  • Fungi Bio-prospects in Sustainable Agriculture, Environment and Nano-technology

    Volume 3: Fungal Metabolites, Functional Genomics and Nano-technology
    • 1st Edition
    • Vijay Kumar Sharma + 3 more
    • English
    Fungi Bio-prospects in Sustainable Agriculture: Fungal metabolites and Nano-technology is a three-volume series that has been designed to explore the huge potential of the many diverse applications of fungi to human life. The series unveils the latest developments and scientific advances in the study of the biodiversity of fungi, extremophilic fungi, and fungal secondary metabolites and enzymes, while also presenting cutting-edge molecular tools used to study fungi. Readers will learn all about the recent progress and future potential applications of fungi in agriculture, environmental remediation, industry, food safety, medicine, and nanotechnology.Volum... 3 provides a comprehensive account of fungal metabolites, including bioactive and host origin compounds, along with other biomolecules, and mycotoxins. This book includes the applications, limitations, and prospects of working with fungal secondary metabolites. The authors explore fungi in the myco-mediated synthesis of nanoparticles along with their biotechnological, industrial, and agricultural uses. This book also discusses advancements in medical mycology for the diagnosis and treatment of fungal infections. Furthermore, this book provides up-to-date and in-depth knowledge about the adoption of advanced CRISPR-Cas9 technology in fungi for gene editing

  • Multifunctional Theranostic Nanomedicines in Cancer

    • 1st Edition
    • Malay K. Das
    • English
    Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer.

  • A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy

    • 1st Edition
    • Mariappan Rajan
    • English
    A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy examines drug carrier development for controlled, targeted, pH and stimuli responsive drug releases for tuberculosis. The book provides in-depth information about mycobacterium tuberculosis, tuberculosis formation, and synthetic procedures for carrier synthesis, characterizations and mechanistic approaches. Key topics include the properties and functions of nanomedicines and how they might be applied for clinical diagnosis and treatment. Emphasis is placed on the basic fundamentals, biomaterial formulations, design principles, fabrication techniques, and transitioning bench-to-bed clinical applications. This book is useful for new researchers who focus on nanomedicine, stem cell therapy and bone tissue engineering. In addition, it introduces experienced researchers and clinicians to key trends, thus increasing their knowledge in drug discovery for tuberculosis and nanomedicine.

  • Peacock Bass

    Diversity, Ecology and Conservation
    • 1st Edition
    • Kirk O. Winemiller + 2 more
    • English
    Peacock Bass: Diversity, Ecology, and Conservation is a unique scientific reference that describes not only the diversity and natural history of the various peacock bass species (fish in the genus Cichla) but also their geographic distributions, evolutionary relationships, ecology, and economic importance. Peacock bass are the most popular sport fish pursued by recreational anglers in tropical freshwaters, and they support important fisheries in rivers and lakes in their native South America as well as other regions of the world where they have been introduced. The book is written in clear prose that allows any reader to appreciate key features of the morphology, population genetics, and reproductive biology of these colorful tropical freshwater fish. Each chapter begins with a vignette introducing an aspect of peacock bass taxonomy, ecology, or conservation based on a personal account from one of the authors. Also included are color photographs of peacock bass, their habitats, other tropical fishes, and the diverse wildlife encountered in rivers and forests of the Neotropics. Photographic guides and detailed descriptions of coloration patterns are provided for species identification, along with distribution maps and essential information related to fisheries management and the economic importance of peacock bass. Biologists interested in zoogeography and the ecological role peacock bass play as major predators in biodiverse rivers and lakes will find summaries of the latest information. Peacock bass have grown in popularity among aquarists, and the book provides basic information about captive care and environmental conditions in their natural habitats. This book is essential reading for biologists, fisheries managers, anglers, naturalists, and aquarists interested in these remarkable fish and the diverse tropical rivers they inhabit.

  • Microbial Metabolism and Disease

    • 1st Edition
    • Elena L. Paley
    • English
    Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer’s disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body.

  • Biofluid Mechanics

    An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation
    • 3rd Edition
    • David Rubenstein + 2 more
    • English
    Biofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation, Third Edition shows how fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement, renal transport, and other specialty circulations. This new edition contains new homework problems and worked examples, including MATLAB-based examples. In addition, new content has been added on such relevant topics as Womersley and Oscillatory Flows. With advanced topics in the text now denoted for instructor convenience, this book is particularly suitable for both senior and graduate-level courses in biofluids.

  • Precision Medicine and Artificial Intelligence

    The Perfect Fit for Autoimmunity
    • 1st Edition
    • Michael Mahler
    • English
    Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options.

  • Gut Microbiota in Neurologic and Visceral Diseases

    • 1st Edition
    • Tahira Farooqui + 1 more
    • English
    Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disorders. Chapters cover the effect of microbiota on the development of visceral (obesity, type 2 diabetes, heart disease) and neurological disorders (Alzheimer’s disease, Parkinson’s, depression, anxiety, and autism). Sections focus on the molecular mechanisms and signal transduction processes associated with the links among microbiota-related visceral and neurological disorders. It is hoped that this discussion will not only integrate and consolidate knowledge in this field but will also jumpstart more studies on the involvement of microbiota in the pathogenesis of neurological disorders.

  • Cerebral Dural Arteriovenous Fistulas

    • 1st Edition
    • Bradley A. Gross + 3 more
    • English
    Cerebral Dural Arteriovenous Fistulas serves as an authoritative, comprehensive resource for these vascular lesions, describing their anatomy, diagnosis, natural history, and thorough treatment options. Rooted in well-illustrated anatomy and depictions of dAVFs, readers can better understand their pathophysiology, historical discovery, and avenues for treatment, including embolization, surgery, and radiosurgery. Imaging modalities are also discussed extensively as well as the management of these lesions. This reference is appropriate for neurosurgeons, neurologists, interventional radiologists and intensivists that manage these patients, providing clarity, and at the same time, comprehensiveness.

  • The Cause of Pyloric Stenosis of Infancy

    • 1st Edition
    • Ian Munro Rogers
    • English
    The Cause of Pyloric Stenosis of Infancy chronicles the debate surrounding the cause of pyloric stenosis from its earliest discovery 300 years ago to the present. The Primary Hyperacidity Theory offers a credible explanation for all the classical signs and symptoms of pyloric stenosis as well a its associated features. In addition, this book comprehensively explores the medical and surgical treatment options as well as the general features used for diagnosis. An understanding of the true cause of pyloric stenosis will thus allow for treatment that is more individualized and sensitive to patients’ needs.

  • Wild Germplasm for Genetic Improvement in Crop Plants

    • 1st Edition
    • Muhammad Tehseen Azhar + 1 more
    • English
    Wild Germplasm for Genetic Improvement in Crop Plants addresses the need for an integrated reference on a wide variety of crop plants, facilitating comparison and contrast, as well as providing relevant relationships for future research and development. The book presents the genetic and natural history value of wild relatives, covers what wild relatives exist, explores the existing knowledge regarding specific relatives and the research surrounding them and identifies knowledge gaps. As understanding the role of crop wild relatives in plant breeding expands the genetic pool for abiotic and biotic stress resistance, this is an ideal reference on this important topic.

  • Pore-Forming Toxins

    • 1st Edition
    • Volume 649
    • English
    Pore Forming Toxins, Volume 649 in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by field leaders. Chapters in this new release include X-ray crystallography shines a light on pore-forming toxins, Giant unilamellar vesicles for studying activity of pore forming proteins, Combined applications of fluorescence spectroscopy and molecular dynamics simulations in studies of Diphtheria Toxin translocation domain, Biophysical approaches to study actinoporin-lipid interactions, Molecular basis for activation of Actinoporins by lipids, Engineered ClyA for detection of biological molecules, Pore-forming Toxins for the Size-Discrimination of Polymers and Biopolymers: Towards Biomolecules Sequencing, and much more.

  • Applications of Big Data in Healthcare

    Theory and Practice
    • 1st Edition
    • Ashish Khanna + 2 more
    • English
    Applications of Big Data in Healthcare: Theory and Practice begins with the basics of Big Data analysis and introduces the tools, processes and procedures associated with Big Data analytics. The book unites healthcare with Big Data analysis and uses the advantages of the latter to solve the problems faced by the former. The authors present the challenges faced by the healthcare industry, including capturing, storing, searching, sharing and analyzing data. This book illustrates the challenges in the applications of Big Data and suggests ways to overcome them, with a primary emphasis on data repositories, challenges, and concepts for data scientists, engineers and clinicians. The applications of Big Data have grown tremendously within the past few years and its growth can not only be attributed to its competence to handle large data streams but also to its abilities to find insights from complex, noisy, heterogeneous, longitudinal and voluminous data. The main objectives of Big Data in the healthcare sector is to come up with ways to provide personalized healthcare to patients by taking into account the enormous amounts of already existing data.

  • Molecular Mechanisms of Neural Development and Insights into Disease

    • 1st Edition
    • Volume 142
    • English
    Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more.

  • Correlative Light and Electron Microscopy IV

    • 1st Edition
    • Volume 162
    • English
    Correlative Light and Electron Microscopy IV, Volume 162, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Besides the detailed description of protocols for CLEM technologies including time-resolution, Super resolution LM and Volume EM, new chapters cover Workflow (dis)-advantages/spi... Serial section LM + EM, Platinum clusters as CLEM probes, Correlative Light Electron Microscopy with a transition metal complex as a single probe, SEM-TEM-SIMS, HPF-CLEM, A new workflow for high-throughput screening of mitotic mammalian cells for electron microscopy using classic histological dyes, and more.

  • Sea Cucumbers

    Aquaculture, Biology and Ecology
    • 1st Edition
    • Mohamed Mohsen + 1 more
    • English
    Sea Cucumbers: Aquaculture, Biology and Ecology presents the latest scientific research on sea cucumbers and their ecological and nutritional benefits. This practical reference helps professionals and students understand basic biology and farming methods by presenting the basic knowledge needed to not only promote aquaculture and fisheries management in different environments, but to also improve the management of sea cucumber health and successful aquaculture operations. Information in this book includes a variety of sea cucumber species, population status, aquaculture development, and the explored benefits of sea cucumbers in unique regions, including Egypt, Turkey, Iran and Arabian countries of the Persian Gulf.

  • Epigenetics in Cardiovascular Disease

    • 1st Edition
    • Volume 24
    • Yvan Devaux + 1 more
    • English
    Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease.

  • The Mental Status Examination Handbook

    • 1st Edition
    • Mario F. Mendez
    • English
    The ability to effectively assess cognitive and other behavioral functions is an essential skill for neurologists, psychiatrists, geriatricians, nurses, and other clinicians who perform clinic and bedside examinations. Unique in the field, The Mental Status Examination Handbook is a user-friendly, comprehensive resource that provides practical guidance on cognitive assessment, clarifies mental status testing procedures, and assists with decision making for neuropsychological referrals. This detailed manual draws from the full history of behavioral neurology testing, making the complex and challenging area of cognitive assessment accessible for both students and practitioners.

  • New Targeting in The Reversal of Resistant Glioblastomas

    • 1st Edition
    • Volume 14
    • Ali Syed Arbab
    • English
    New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field.

  • Genome Editing

    A Practical Guide to Research and Clinical Applications
    • 1st Edition
    • Kiran Musunuru
    • English
    Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research.

  • The Neuroscience of Depression

    Features, Diagnosis, and Treatment
    • 1st Edition
    • Colin R. Martin + 4 more
    • English
    The Neuroscience of Depression: Features, Diagnosis and Treatment, is a comprehensive reference to the diagnosis and treatment of depression. This book provides readers with the mechanisms of depression reflecting on the interplay between depression and the biological and psychosocial processes. A detailed introduction to various episodes of depression, from PTSD to post-partum depression is provided, followed by a thorough discussion on biomarkers in depression and how to diagnose depression including the Hamilton Depression Rating scale. This book also includes three full sections on treatment options for depression, including pharmacological, behavioral and other novel regimes. The Neuroscience of Depression: Features, Diagnosis and Treatment is the only resource for researchers and practitioners studying, diagnosis and treating of depression.

  • Advances in CRISPR/Cas and Related Technologies

    • 1st Edition
    • Volume 178
    • Dipanjan Ghosh
    • English
    Advances in CRISPR/Cas and related technologies, Volume 179, the latest release in this ongoing series, deals with a wide variety of research topics related to recent advancement in the genome editing techniques. Associated chapters in this new release include Challenges for Therapeutic application of CRISPR Cas techniques, Mitochondrial DNA modification by CRISPR Cas System: Challenges and future direction, Trends in CRISPR Cas technology application in cancer, Modified CRISPR-Cas for next generation application, Application of CRISPR Cas in Synthetic Biology: Challenges and Scopes, History of CRISPR Cas system from bacterial Adaptive Immune System to research application, and more.

  • The Neuroscience of Depression

    Genetics, Cell Biology, Neurology, Behavior, and Diet
    • 1st Edition
    • Colin R. Martin + 4 more
    • English
    The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

  • Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression

    A Selection of Readings for Health Services Providers
    • 1st Edition
    • Robert Fried + 2 more
    • English
    Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression — A Selection of Readings for Health Services Providers presents an edited and annotated collection of recent medical journal publications and abstracts illustrating new approaches to treatment derived from the metabolic theory of cancer. It intends to shed an early light on a relatively new approach to our understanding of the cancer cell idiosyncratic metabolic dysfunction, and on evidence-based new treatment strategies derived from that understanding. The book discusses topics such as tumor starvation by L-arginine deprivation; L-canavanine depriving tumors of L-arginine in pancreatic, multiple myeloma and breast cancer; glucose deprivation and intermittent fasting; glutamine uptake in cancer; the relation of oxygen-starved cancer cells with aspartate; and reducing tolerance of tumor cells to nutrition starvation. The content is presented in a contextualized and practical way in order to facilitate the transition from bench to bedside. This is a valuable resource for practitioners, oncologists and other members of healthcare chain who are interested in learning more about the most recent tumor cell starvation strategies and how they can improve overall treatment outcome.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 101
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 101, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release including chapters on Exosomes in cancer, Parathyroid hormone, Clinical relevance of biochemical and metabolic changes in osteoarthritis, Early diagnosis with ultrasensitive ELISA, Cytokines and the immune response in obesity-related disorders, Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases, and more.

  • Immunopathology of Celiac Disease

    • 1st Edition
    • Volume 358
    • English
    Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covered in this new volume include Omics of Celiac Disease, Implication of HLA genes in Celiac Disease, Macrophages & Dendritic Cells in Celiac Disease, Tight junction disruption in the development of celiac disease, Implication of epithelial cell dysfunction in CeD, Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response, The biology of refractory celiac disease, Involvement of lncRNAs in Celiac disease pathogenesis, and more.

  • A Tribute to Paul Greengard (1925-2019)

    • 1st Edition
    • Volume 90
    • English
    A Tribute to Paul Greengard, Volume 90, the latest release in the Advances in Pharmacology series presents a variety of chapters from the best authors in the field, with this release presenting a tribute to Paul Greengard.

  • Clinical DNA Variant Interpretation

    Theory and Practice
    • 1st Edition
    • Conxi Lázaro + 2 more
    • English
    Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practical chapters discuss genomic variant interpretation, terminology and nomenclature, international consensus guidelines, population allele frequency, functional evidence transcripts for RNA, proteins, and enzymes, somatic mutations, somatic profiling, and much more.

  • Hormones and Aging

    • 1st Edition
    • Volume 115
    • Gerald Litwack
    • English
    Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more.

  • Sirtuin Biology in Medicine

    Targeting New Avenues of Care in Development, Aging, and Disease
    • 1st Edition
    • Kenneth Maiese
    • English
    Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

  • Brucella Melitensis

    Identification and Characterization of Potential Drug Targets
    • 1st Edition
    • Jangampalli Adi Pradeepkiran + 1 more
    • English
    Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria’s virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies. In addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules.

  • Advances in Genetics

    • 1st Edition
    • Volume 107
    • English
    Advances in Genetics, Volume 107, provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Advances in Asthma Genetics: Filling persistent gaps, Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans, Genetic determinants of climate-resilience traits in millets, Founder variants and population genomes - towards precision medicine, and much more.

  • Neurobiology of Addiction and Co-Morbid Disorders

    • 1st Edition
    • Volume 157
    • English
    Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction.

  • Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment

    • 1st Edition
    • Volume 260
    • English
    Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment, Volume 261, the latest release in the Neuropharmacology of Neuroprotection series, presents the latest research on the topic of Progress in Brain Research. This series highlights new advances in the field, providing comprehensive and timely chapters written by an international board of esteemed authors.

  • Encyclopedia of Virology

    • 4th Edition
    • Dennis H. Bamford + 1 more
    • English
    Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public.

  • Heart and Neurologic Disease

    • 1st Edition
    • Volume 177
    • English
    The Handbook of Clinical Neurology series volumes provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. Cardiac disorders and diseases may often co-occur with, or cause, subsequent neurological disorders. Heart and Neurologic Disease identifies the top cardiac diseases and disorders most likely to have neurological disorders, how they will present, and how they are best treated. It identifies the mechanisms of action explaining why the conditions co-occur, and what clinicians should look for symptom wise, and how risk may be assessed. Coverage includes genetic cardiac disorders, cardiac trauma, surgery, infection, disease, and arrhythmia.

  • Protein Kinases in Drug Discovery

    • 1st Edition
    • Volume 124
    • Rossen Donev
    • English
    Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.

  • Goodman's Basic Medical Endocrinology

    • 5th Edition
    • Elizabeth H. Holt + 4 more
    • English
    Goodman's Basic Medical Endocrinology, Fifth Edition, has been student tested and approved for decades. This essential textbook provides up-to-date coverage of rapidly unfolding advances in the understanding of hormones involved in regulating most aspects of bodily functions. It is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. This is a classic reference for moving forward into advanced study.

  • Recent Advances in iPSC-Derived Cell Types

    • 1st Edition
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells.Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, βpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field.

  • Applications of Nanobiotechnology for Neglected Tropical Diseases

    • 1st Edition
    • Fabio Rocha Formiga + 2 more
    • English
    Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs. Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.

  • Sirtuin Biology in Cancer and Metabolic Disease

    Cellular Pathways for Clinical Discovery
    • 1st Edition
    • Kenneth Maiese
    • English
    Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

  • Phytomedicine

    A Treasure of Pharmacologically Active Products from Plants
    • 1st Edition
    • Rouf Ahmad Bhat + 2 more
    • English
    Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequentially regarding phytochemistry, biological activity and the serviceable aspects of bioactive compounds. The book also addresses various advancements and achievements of novel drugs from plants using molecular and enzymatic activities, and various technological tools in an ecofriendly fashion.

  • Epidemiology of Endocrine Tumors

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology.

  • An AGI Brain for a Robot

    • 1st Edition
    • John H. Andreae
    • English
    An AGI Brain for a Robot is the first and only book to give a detailed account and practical demonstration of an Artificial General Intelligence (AGI). The brain is to be implemented in fast parallel hardware and embodied in the head of a robot moving in the real world. Associative learning is shown to be a powerful technique for novelty seeking, language learning, and planning. This book is for neuroscientists, robot designers, psychologists, philosophers and anyone curious about the evolution of the human brain and its specialized functions. The overarching message of this book is that an AGI, as the brain of a robot, is within our grasp and would work like our own brains. The featured brain, called PP, is not a computer program. Instead, PP is a collection of networks of associations built from J. A. Fodor’s modules and the author’s groups. The associations are acquired by intimate interaction between PP in its robot body and the real world. Simulations of PP in one of two robots in a simple world demonstrate PP learning from the second robot, which is under human control. "Both Professor Daniel C. Dennett and Professor Michael A. Arbib independently likened the book　‘An AGI Brain for a Robot’　to Valentino Braitenberg’s 1984 book　‘Vehicles: Experiments in Synthetic Psychology’." Daniel C. Dennett, Professor of Philosophy and Director of Center for Cognitive Studies, Tufts University. Author of "From Bacteria to Bach and Back: The Evolution of Minds."　 "Michael Arbib, a long time expert in brain modeling, observed that sometimes a small book can catch the interest of readers where a large book can overwhelm and turn them away. He noted, in particular, the success of Valentino Braitenberg’s ‘Vehicles’ (for which he wrote the foreword). At a time of explosive interest in AI, he suggests that PP and its antics may be just the right way to ease a larger audience into thinking about the technicalities of creating general artificial intelligence." Michael A Arbib, Professor Emeritus of Computer Science, Biomedical Engineering, Biological Sciences and Psychology, University of Southern California. Author of "How the Brain Got Language". "Robots seem to increasingly invade our lives, to the point that sometimes seems threatening and other-worldly. In this small book, John Andreae shows some of the basic principles of robotics in ways that are entertaining and easily understood, and touch on some of the basic questions of how the mind works." Michael C. Corballis, Professor of Psychology, University of Auckland. Author of "The Recursive Mind". "A little book that punches far beyond its weight." Nicholas Humphrey, Emeritus Professor of Psychology, London School of Economics. Author of "Soul Dust: The Magic of Consciousness". "A bold and rich approach to one of the major challenges for neuroscience, robotics and philosophy. Who will take up Andreae’s challenge and implement his model?" Matthew Cobb, Professor of Zoology, University of Manchester. Author of "The Idea of the Brain". "Here is a book that could change the direction of research into artificial general intelligence in a very productive and profitable way. It describes a radical new theory of the brain that goes some way towards answering many difficult questions concerning learning, planning, language, and even consciousness. Almost incredibly, the theory is operational, and expressed in a form that could—and should—inspire future, novel, research in AI that transcends existing paradigms." Ian H. Witten, Professor of Computer Science, Waikato University. Author with Eibe Frank of "Data Mining: Practical Machine Learning Tools and Techniques".

  • Cellular and Molecular Immunology

    • 10th Edition
    • Abul K. Abbas + 2 more
    • English
    Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists.

  • Second-Order Consensus of Continuous-Time Multi-Agent Systems

    • 1st Edition
    • Huaqing Li + 6 more
    • English
    Second-Order Consensus of Continuous-Time Multi-Agent Systems focuses on the characteristics and features of second-order agents, communication networks, and control protocols/algorithms in continuous consensus of multi-agent systems. The book provides readers with background on consensus control of multi-agent systems and introduces the intrinsic characteristics of second-order agents’ behavior, including the development of continuous control protocols/algorithms over various types of underlying communication networks, as well as the implementation of computation- and communication-effici... strategies in the execution of protocols/algorithms... The book's authors also provide coverage of the frameworks of stability analysis, algebraic criteria and performance evaluation. On this basis, the book provides an in-depth study of intrinsic nonlinear dynamics from agents’ perspective, coverage of unbalanced directed topology, random switching topology, event-triggered communication, and random link failure, from a communication networks’ perspective, as well as leader-following control, finite-time control, and global consensus control, from a protocols/algorithms... perspective. Finally, simulation results including practical application examples are presented to illustrate the effectiveness and the practicability of the control protocols and algorithms proposed in this book.

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