Sirtuin Biology in Medicine
Targeting New Avenues of Care in Development, Aging, and Disease
- 1st Edition - February 25, 2021
- Imprint: Academic Press
- Editor: Kenneth Maiese
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 4 1 1 8 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 4 1 1 9 - 9
Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal… Read more
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Request a sales quoteSirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.
- Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease
- Details the basic and clinical role of sirtuins for the development of new clinical treatments
- Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body
- Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings
Researchers (endocrinologists, cell biologists, molecular biologists, pharmacologists, vascular biologists, neuroscientists, etc.), Physicians (all disciplines including internal medicine, oncologists, neurologists, psychiatrists, cardiologists, etc.), pharmaceutical industry experts
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- About the editor
- Preface
- Acknowledgment
- Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging
- Chapter 1. Novel treatment strategies for neurodegenerative disease with sirtuins
- Abstract
- Outline
- Abbreviations
- 1.1 Increased life expectancy and neurodegenerative disease
- 1.2 Noncommunicable diseases and neurodegenerative disease
- 1.3 Innovative avenues for the treatment of neurodegenerative disease
- 1.4 Silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) and neurodegenerative disease
- 1.5 SIRT1 and forkhead transcription factors
- 1.6 SIRT1 and the mechanistic target of rapamycin
- 1.7 SIRT1 and the circadian clock genes
- 1.8 SIRT1 and noncoding RNAs
- 1.9 Future considerations
- Acknowledgments
- References
- Chapter 2. NAD+: a crucial regulator of sirtuin activity in aging
- Abstract
- Outline
- 2.1 Introduction
- 2.2 NAD+ consumption—a key cause of NAD+ decline
- 2.3 The sirtuin reaction
- 2.4 Roles of sirtuins in aging
- 2.5 NAD+ as a principle regulator of sirtuin activity
- 2.6 Therapeutic activation of sirtuins by raising NAD+ levels
- 2.7 Conclusion
- References
- Chapter 3. Sirtuins and life span extension
- Abstract
- Outline
- 3.1 Sirtuins—a family of attractive antiaging molecules
- 3.2 Life span extension effect of sirtuins
- 3.3 Activators of sirtuin in life span extension effect
- 3.4 Conclusion and perspectives
- References
- Chapter 4. Sirtuins and aging
- Abstract
- Outline
- Abbreviations
- 4.1 Introduction
- 4.2 Overview of sirtuins
- 4.3 Functions of each sirtuin
- 4.4 Molecular genetics
- 4.5 Sirtuins as biomarkers of aging
- 4.6 Sirtuin-activating compounds
- 4.7 Epigenetics
- 4.8 Conclusions
- References
- Chapter 5. Sirtuins in the biology of aging
- Abstract
- Outline
- 5.1 Introduction
- 5.2 Mechanisms of sirtuin activation by caloric restriction
- 5.3 Functions of individual sirtuins in mammals, including humans
- References
- Chapter 6. Sirtuins as regulators and the regulated molecules of exosomes
- Abstract
- Outline
- 6.1 Introduction
- 6.2 The dual characters of exosomes
- 6.3 Sirtuins regulate exosome secretion
- 6.4 Exosomes regulate sirtuin activity in recipient cells
- 6.5 Sirtuins released by exosomes
- 6.6 Conclusion
- Acknowledgment
- References
- Chapter 7. Sirtuins in aging, age-related pathologies and their association with circadian rhythm
- Abstract
- Outline
- 7.1 Sirtuin function and localization
- 7.2 Sirtuins and calorie restriction
- 7.3 Sirtuins and aging
- 7.4 Sirtuins in eye
- 7.5 Sirtuins and age-related diseases
- 7.6 Obesity
- 7.7 Sirtuins and age-related neuronal diseases
- 7.8 Sirtuins and cardiac diseases
- 7.9 Sirtuins and circadian rhythm
- 7.10 Conclusion
- References
- Chapter 8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease
- Abstract
- Outline
- Abbreviations
- 8.1 Introduction
- 8.2 The sirtuins
- 8.3 Gut, sirtuins, and Alzheimer’s disease
- 8.4 Circadian dysregulation: mitochondria, butyrate, and ceramide
- 8.5 Integrating sirtuins into Alzheimer’s disease pathophysiology
- 8.6 Future research directions
- 8.7 Treatment implications
- 8.8 Conclusion
- Acknowledgment
- Conflicts of interest
- References
- Further reading
- Chapter 9. Sirtuins, melatonin, and the relevance of circadian oscillators
- Abstract
- Outline
- 9.1 Introduction
- 9.2 Sirtuins and the circadian system
- 9.3 Melatonin and the circadian system
- 9.4 Sirtuins and melatonin in the context of metabolic sensing
- 9.5 Mitochondrial relevance of melatonin and sirtuins
- 9.6 Effects of melatonin on sirtuin expression in nontumor cells
- 9.7 Contrasting findings of melatonin on SIRT1 expression in tumor cells
- 9.8 Secondary signaling of melatonin via SIRT1
- 9.9 Conclusion
- References
- Chapter 10. Epigenetic role of sirtuins in neurodegenerative brain disorders
- Abstract
- Outline
- Abbreviations
- 10.1 Introduction
- 10.2 Regulation of SIRT1: posttranslational modifications versus subcellular translocation and activity
- 10.3 Sirtuins as epigenetic regulators
- 10.4 SIRT1 and SIRT3 in neurodegenerative brain disorder
- 10.5 Concluding remarks
- Acknowledgment
- Author declaration
- References
- Chapter 11. Sirtuins and stem cell maintenance, proliferation, and differentiation
- Abstract
- Outline
- Abbreviations
- 11.1 Introduction
- 11.2 Mesenchymal stromal/stem cells
- 11.3 Hematopoietic stem cells
- 11.4 Embryonic and induced pluripotent stem cells
- 11.5 Conclusions
- References
- Chapter 12. Sirtuins in mechanistic target of rapamycin complex 1 signaling
- Abstract
- Outline
- 12.1 Introduction
- 12.2 The role of sirtuins in type 2 diabetes mellitus
- 12.3 The role of sirtuins in aging
- 12.4 The role of sirtuins in thermogenesis
- 12.5 The role of sirtuins in neurodegeneration
- 12.6 Sirtuins in cancer
- References
- Chapter 13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliability
- Abstract
- Outline
- 13.1 Introduction: a historical synopsis
- 13.2 Reliability engineering and biological robustness: basic terms and ideas
- 13.3 Free radical malfunctions in oxidative metabolism
- 13.4 Preset reliability as the background of limited life span
- 13.5 Free radical timer of aging: quantitative aspects
- 13.6 Free radical timer of aging: the sirtuin way
- 13.7 Sirtuins as mediators in the antioxidant biomedicine
- 13.8 Conclusions
- Acknowledgments
- References
- Chapter 14. Sirtuins, mitochondria, and exercise in health and disease
- Abstract
- Outline
- Abbreviations
- 14.1 Introduction
- 14.2 Regulatory elements of energy production
- 14.3 Sirtuins and exercise: impact on aging and disease
- 14.4 Conclusion
- References
- Section II: Sirtuins, cardiovascular disease and end-organ disease
- Chapter 15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications
- Abstract
- Outline
- Abbreviations
- 15.1 Introduction to sirtuins
- 15.2 Role of sirtuins in cardiac diseases
- 15.3 Role of sirtuins in cardiac hypertrophy
- 15.4 Sirtuins and ischemia/reperfusion injury
- 15.5 Sirtuins in cardiac function and heart failure
- 15.6 Sirtuins in oxidative stress and cardiac diseases
- 15.7 Sirtuin in autophagy
- 15.8 Sirtuins in cardiometabolic diseases
- 15.9 Clinical studies of sirtuins-activating compounds in cardiac diseases
- 15.10 Clinical studies with nicotinamide adenine dinucleotide boosters in the context of cardiovascular diseases
- 15.11 Conclusion and future perspective
- Acknowledgment
- References
- Chapter 16. Role of sirtuins in cardiovascular diseases
- Abstract
- Outline
- 16.1 Introduction
- 16.2 SIRT1
- 16.3 SIRT2
- 16.4 SIRT3
- 16.5 SIRT4
- 16.6 SIRT5
- 16.7 SIRT6
- 16.8 SIRT7
- 16.9 Conclusion
- References
- Chapter 17. Targeting sirtuins to modulate energy metabolism in heart disease
- Abstract
- Outline
- 17.1 Introduction
- 17.2 Conclusions
- Acknowledgment
- References
- Chapter 18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury
- Abstract
- Outline
- 18.1 Free radicals, reactive oxygen species, and oxidative stress
- 18.2 SIRT1 and oxidative stress
- 18.3 SIRT1-activating compounds
- 18.4 Xenobiotic-induced hepatotoxicity
- 18.5 Findings and comments
- 18.6 Conclusion
- Acknowledgments
- References
- Chapter 19. Sirtuins as key players in aging and kidney dysfunction
- Abstract
- Outline
- 19.1 Introduction
- 19.2 Mammalian sirtuins
- 19.3 Sirtuins and aging
- 19.4 Sirtuins in physiology, pathophysiology, and disease of the kidney
- 19.5 Perspectives
- Acknowledgments
- References
- Chapter 20. Role of sirtuins in liver diseases
- Abstract
- Outline
- 20.1 Introduction
- 20.2 General roles of sirtuins in liver homeostasis
- 20.3 Sirtuins role in liver inflammation
- 20.4 Sirtuins role in fatty liver diseases
- 20.5 Sirtuins role in liver fibrosis and cirrhosis
- 20.6 Sirtuins role in hepatocellular carcinoma
- 20.7 Sirtuins role in viral hepatitis
- 20.8 Sirtuins regulators in clinical trials for liver diseases
- 20.9 Concluding remarks and future directions
- References
- Chapter 21. Sirtuins in bone and cartilage biology
- Abstract
- Outline
- 21.1 Sirtuin family and their roles in cellular biology
- 21.2 SIRT1 as an energy sensor in cellular energy metabolism
- 21.3 Interaction of SIRT1 with AMPK in energy metabolism
- 21.4 Stress response and SIRT1 activity in biology
- 21.5 Sirtuin 2 as a biomarker monitoring health conditions and aging
- 21.6 Role of SIRT1 in the regulation of transcription factors and DNA repair enzymes in bone and cartilage metabolisms
- References
- Chapter 22. Vitagenes in avian biology: protective functions of sirtuins
- Abstract
- Outline
- 22.1 Introduction
- 22.2 Stresses in poultry production
- 22.3 Antioxidant defense systems
- 22.4 Vitagene network
- 22.5 Protective functions of sirtuins
- 22.6 Sirtuins and oxidative stress
- 22.7 From stress detection to oxidative stress management: role of vitagenes
- 22.8 Conclusions
- Acknowledgments
- References
- Chapter 23. Sirtuins in hematopoiesis and blood malignancies
- Abstract
- Outline
- 23.1 Sirtuins and hematopoiesis
- 23.2 Sirtuins and nuclear factor kappa B signaling in immune response and inflammation
- 23.3 Sirtuins and hematological malignancies
- 23.4 Conclusions
- References
- Index
- Edition: 1
- Published: February 25, 2021
- Imprint: Academic Press
- No. of pages: 420
- Language: English
- Paperback ISBN: 9780128141182
- eBook ISBN: 9780128141199
KM
Kenneth Maiese
Kenneth Maiese, MD, is an internationally recognized physician-scientist whose investigations are designed to translate basic science into successful therapeutic treatments. He maintains therapeutic and scientific expertise in multiple medical disciplines and has been fortunate to receive recognition with outstanding teaching and investigator awards, election to America’s Top Physicians and The Best of U.S. Physicians, recipient of Albert Nelson Marquis Lifetime Achievement Award, and elected as an America’s Health Insurance Plans (AHIP) Executive Leadership Fellow. His work has received the distinction of “High Impact Research and Potential Public Health Benefit” by the National Institutes of Health. As an internationally recognized physician researcher and “C-suite” healthcare leader, he has extensive experience in academic medicine, healthcare delivery, business development, managed care, biotechnology, and drug development holding positions as member and advisor for the National Institutes of Health Biotechnology and Venture Capital Development, National Institutes of Health Innovation Network, Chief Medical Officer, tenured Professor and Chair and Chief of Service of the Department of Neurology and Neurosciences of Rutgers University, Global Head of Translational Medicine and External Innovation, Board Member of the Cancer Institute of New Jersey, Steering Committee Member for the Foundation for the National Institutes of Health, tenured Professor in Neurology, Anatomy & Cell Biology, Molecular Medicine, the Barbara Ann Karmanos Cancer Institute, and the National Institute of Health Center at Wayne State University, and Founding Editor and Editor-in-Chief of multiple highly successful international journals.
Affiliations and expertise
Biotechnology and Venture Capital Development, Office of Translational Alliances and Coordination, National Heart, Lung, and Blood Institute; Cellular and Molecular Signaling, New York, NY, United StatesRead Sirtuin Biology in Medicine on ScienceDirect