Hormones and Aging

1st Edition, Volume 115 - February 26, 2021
Imprint: Academic Press
Editor: Gerald Litwack
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 5 4 8 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 5 4 9 - 5

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothala… Read more

Purchase options

BLOOM INTO SPRING SAVINGS

Save up to 25% on books and eBooks!

Shop now

Institutional subscription on ScienceDirect

Request a sales quote

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more.

Cover image
Title page
Table of Contents
Copyright
Former Editors
Contributors
Preface
Chapter One: Aging and the hypothalamic-pituitary-thyroid axis
Abstract
1: Introduction
2: Search strategy and selection criteria
3: Is aging a disease?
4: The field of geroscience and the thyroid
5: HPT axis morphology in aging
6: Hypothalamic and pituitary physiology and rhythmicity
7: Thyroid diseases and the hypothalamic-pituitary axis
8: Conclusions
Chapter Two: Hypothalamic aging and hormones
Abstract
Highlights
1: The introduction
2: The senescent degeneration of reproductive system
3: The special aging of skin and its causing SCN aging via SWS
4: The peripheral aging under the regulation of the GH/IGF1 axis
5: The peripheral aging under the regulation of PVN
6: The aging later in brain and later off leptin
7: The preliminary classification
8: The conclusions
The conflict of interest
Chapter Three: Hypothalamic gene transfer of BDNF promotes healthy aging
Abstract
1: Metabolic problems of aging
2: CNS energy regulation and the hypothalamic-sympathoneural-adipocyte axis
3: Molecular therapy of obesity with an autoregulatory BDNF vector
4: Hypothalamic gene transfer of BDNF promotes healthy aging
5: Conclusions and future directions
Chapter Four: Melatonin and healthy aging
Abstract
1: Introduction
2: Melatonin as a chronobiotic
3: Use of melatonin in sleep aging
4: Cytoprotection by melatonin in animal models of MS and AD
5: Use of melatonin in MS and AD patients
6: Conclusions
Chapter Five: Luteinizing hormone and the aging brain
Abstract
1: Introduction
2: Central LH synthesis in aging and CNS function as a unifying hypothesis
3: Conclusion
Chapter Six: Leptin regulation of hippocampal synaptic function in health and disease
Abstract
1: Leptin
2: Leptin receptor and its signaling pathways
3: Leptin regulation of hippocampal synaptic function
4: Leptin and the aging brain
5: Leptin and Alzheimer's disease risk
6: Neuroprotective actions of leptin
7: Therapeutic potential of leptin
Chapter Seven: Endocannabinoids and aging—Inflammation, neuroplasticity, mood and pain
Abstract
1: Endocannabinoids
2: Neuroinflammation, disease, eCB and oxylipins
3: Exercise effects on eCB: Differences and similarities in human and animal studies
4: The role of N-3 PUFA in brain and aging
5: Conclusions
Acknowledgment
Chapter Eight: Parathyroid hormone levels and aging: Effect on balance
Abstract
1: Aging, frailty and sarcopenia
2: Falls and balance
3: Aging and parathyroid hormone (PTH) levels
4: The biological effects of PTH on muscle
5: What is known about the role of PTH in balance?
6: Conclusion
Chapter Nine: Insulin and aging
Abstract
1: Introduction
2: Insulin secretion and aging
3: Insulin clearance and aging
4: Insulin sensitivity and aging
5: Insulin action in the healthy longevity
6: Conclusion
Acknowledgments
Chapter Ten: Sirtuins and the prevention of immunosenescence
Abstract
1: Immunosenescence
2: Hematopoiesis in young and old age
3: Innate immunosenescence
4: Hormones and immunosenescence
5: Sirtuins
6: Future directions and perspectives
Aknowledgments
Chapter Eleven: Alterations in cyclic nucleotide signaling are implicated in healthy aging and age-related pathologies of the brain
Abstract
1: Introduction
2: Healthy aging
3: Alzheimer's disease, dementia, and mild cognitive impairment (MCI)
4: Parkinson's disease
5: Huntington's disease
6: Conclusions and future directions
Acknowledgments
Chapter Twelve: Aging and FGF23-klotho system
Abstract
1: Discovery of the klotho gene
2: Klotho protein function
3: Structure of Klotho protein
4: FGF23 and kidney
5: FGF23 and parathyroid
6: FGF23 and chronic kidney disease
7: Evolution of Klotho
8: Phosphate and aging
9: Concluding remarks
Chapter Thirteen: Aging and sex hormones in males
Abstract
1: Introduction
2: Influence of aging on testosterone and its metabolites: Findings from the literature
3: Mechanisms underlying age-related testosterone decline
4: Hormonal assays: Tips, tricks and pitfalls
5: The clinical diagnosis of hypogonadism in aging men
6: Management of LOH
7: Conclusions
Chapter Fourteen: Sexual dimorphism, aging and immunity
Abstract
1: Introduction
2: Epigenetics in sex-bias response
3: Regulation of epigenetics by sex hormones
4: Sex chromosome and dimorphic immune response
5: Sex hormones and immunity
6: Sex-hormones in autoimmunity
7: Sex-bias in mucosal immunity
8: Infections, aging and sex-bias
9: Conclusions
Acknowledgments
Chapter Fifteen: Hormones and bone loss across the menopause transition
Abstract
1: Osteoporosis and the menopause transition
2: Sex hormones changes over the menopause transition
3: Sex hormones and onset of rapid bone loss
4: Bone resorption markers and the rapid phase of bone loss
5: Summary and future directions
Acknowledgments
Chapter Sixteen: Relaxin abrogates genomic remodeling of the aged heart
Abstract
1: Introduction
2: Biochemistry of the aging heart
3: Structural changes in the aging heart
4: Relaxin
5: Relaxin signaling
6: Effects of relaxin in the aged heart
7: Tissue remodeling
8: Electrical remodeling
9: Mechanistic aspects of the effects of RLX in the heart
10: Relaxin in the clinic
11: Concluding remarks
Acknowledgment
Chapter Seventeen: Role of FoxO transcription factors in aging-associated cardiovascular diseases
Abstract
1: Introduction
2: Role of FoxO in cardiac remodeling
3: Role of FoxO transcription factors in vascular remodeling and dysfunction
4: Role of FoxO in myocardial ischemia and ischemia-reperfusion injury
5: Role of FoxO in regulating metabolic homeostasis of heart
6: Role of FoxO in regulating diet-induced alterations in heart
7: Role of FoxO in modulating autophagy and proteasomal degradation
8: Role of FoxO in regulating age-dependent cardiac functions in flies
9: Conclusion
Chapter Eighteen: Ghrelin and adipokines: An overview of their physiological role, antimicrobial activity and impact on cardiovascular conditions
Abstract
1: Introduction
2: Ghrelin, the “hunger hormone”
3: Adipokines
4: Antibacterial activity of ghrelin and adipokines
5: The role of ghrelin and its impact on cardiovascular systems and conditions
6: Role of adipokines in cardiovascular diseases
7: Conclusion
Chapter Nineteen: Sex hormones and cognition in aging
Abstract
1: Introduction
2: Sex hormones and their associations with cognition
3: Endogenous hormones and cognition in women of reproductive age
4: Sex hormones and cognition during healthy aging
5: Sex hormones and cognitive changes in menopause
6: Sex hormones and their role in neurodegenerative disorders
7: Hormone therapy and cognition
8: Conclusion
Chapter Twenty: Role of hormones in sarcopenia
Abstract
1: Introduction
2: The GH-IGF-I axis
3: Insulin resistance and glucose regulation
4: Adrenal hormones
5: Gonadal steroids
6: Adipokines
7: Angiotensin II
8: Vitamin D
9: Thyroid hormones
10: Concluding remarks
Chapter Twenty-one: Sources of lumbar back pain during aging and potential therapeutic targets
Abstract
1: Introduction
2: Paravertebral muscles and ligaments stabilize the FSU
3: Pathophysiology of lumbar back pain
4: Facet joint degeneration as a source of pain
5: Intervertebral disc disruption as a source of pain
6: Vertebral endplate degeneration as a source of pain
7: Roles of transforming growth factor–β (TGFβ) and parathyroid hormone (PTH) in maintaining the homeostasis of the FSU
8: Conclusion
Acknowledgment
Chapter Twenty-Two: Leydig cell aging: Molecular mechanisms and treatments
Abstract
1: Introduction: Testosterone production and the aging testis
2: Cell biology of Leydig cell steroidogenesis
3: Steroidogenic cholesterol: Sources, trafficking and targeting to CYP11A1
4: SITE proteins in cholesterol import machinery and steroidogenesis
5: Oxidant/antioxidant imbalance and reductions in testosterone production
6: Existing treatments to increase serum T levels
7: Targeting critical protein-protein interactions to reverse LOH
8: Conclusions and future directions
Acknowledgments
Chapter Twenty-Three: Adiponectin/AdipoRs signaling as a key player in testicular aging and associated metabolic disorders
Abstract
1: Introduction
2: Regulatory nexus between aging, obesity hormones, and male reproduction
3: Essential role of adipokines in regulating male reproductive physiology
4: Adiponectin/AdipoRs: History, structure, and metabolic role
5: Adiponectin/AdipoRs as a regulator of male reproductive physiology
6: Impact of aging on male reproduction
7: Adiponectin/AdipoRs in testicular aging
8: Summary

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Hormones and Aging

Purchase options

BLOOM INTO SPRING SAVINGS

Institutional subscription on ScienceDirect

Gerald Litwack

Related books