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Elsevier

Precision Medicine and Artificial Intelligence

The Perfect Fit for Autoimmunity

  • 1st Edition - March 12, 2021
  • Latest edition
  • Editor: Michael Mahler
  • Language: English

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examp… Read more

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Description

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine.

More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options.

Key features

  • Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions
  • Provides background, milestone and examples of precision medicine
  • Outlines the paradigm shift towards precision medicine driven by value-based systems
  • Discusses future applications of precision medicine research using AI
  • Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Readership

This book targets the scientific community at the interface between medicine, biotechnology as well as computer science (i.e., artificial intelligence). From the readers profile perspective, the book is geared towards scientist in academia and in the biotech as well as in the pharmaceutical industry (translational research and biomarker discovery groups / small molecules / drug target discovery). Some of the higher-level chapters of the book provide valuable information for functional heads in the industry (e.g., C-suite, executive level, business development).

Table of contents

1. History, current status, and future directions of artificial intelligence
Olga Kubassova, Faiq Shaikh, Carlos Melus, and Michael Mahler

2. Precision medicine as an approach to autoimmune diseases
Marvin J. Fritzler and Michael Mahler

3. Biomarker and data science as integral part of precision medicine
Carlos Melus, Brenden Rossin, Mary Ann Aure, and Michael Mahler

4. Companion and complementary diagnostics: A key to precision medicine
Jan Trøst Jørgensen

5. Checkpoint inhibitors: Interface of cancer and autoimmunity: Opportunity for second level precision medicine
Savino Sciascia, Marie Hudson, Marvin J. Fritzler, Minoru Satoh, and Michael Mahler

6. The evolving potential of precision medicine in the management of autoimmune liver disease
Gary L. Norman, Nicola Bizzaro, Danilo Villalta, Diego Vergani, Giorgina Mieli-Vergani, Gideon M. Hirschfield, and Michael Mahler

7. Precision medicine in autoimmune disease
Kevin D. Deane

8. Development of multi-omics approach in autoimmune diseases
May Y. Choi, Marvin J. Fritzler, and Michael Mahler

9. N-of-1 trials: Implications for clinical practice and personalized clinical trials
Joanne Bradbury and Michael Mahler

10. Health risk assessment and family history: Toward disease prevention
Lily W. Martin, Lauren C. Prisco, Laura Martinez-Prat, Michael Mahler, and Jeffrey A. Sparks

11. Regulatory aspects of artificial intelligence and machine learning-enabled software as medical devices (SaMD)
Michael Mahler, Carolina Auza, Roger Albesa, Carlos Melus, and Jungen Andrew Wu

12. Precision medicine from the patient’s perspective: More opportunities and increasing responsibilities
Kim MacMartin-Moglia and Michael Mahler

Product details

  • Edition: 1
  • Latest edition
  • Published: March 17, 2021
  • Language: English

About the editor

MM

Michael Mahler

Michael Mahler received his Ph.D. from the institute of molecular genetics at the University of Heidelberg (Germany). During his Ph.D. thesis, Michael Mahler worked at The Scripps Research Institute in the laboratory of Prof. Mike Pollard and Prof. Eng Tan. He is currently Vice President of Research at Inova Diagnostics. His research is focused on the B-cell autoimmune response in autoimmune diseases and the discovery of novel autoantigens which resulted in more than 300 peer reviewed journal articles as well as several patents. In addition, he works on the development and characterization of novel diagnostic assays for the diagnosis of autoimmune diseases. In the scientific community, he serves as Editor of different scientific journals and as reviewer for more than 40 journals. Michael Mahler became exposed to and interested in Artificial Intelligence as well as Precision Medicine and as a consequence, co-founded the Precision Medicine in Autoimmunity (PMA) (www.precisionmedicineautoimmunity.org) conference.
Affiliations and expertise
Inova Diagnostics, San Diego, CA, USA

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