Multifunctional Theranostic Nanomedicines in Cancer
- 1st Edition - March 16, 2021
- Imprint: Academic Press
- Editor: Malay K. Das
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 1 2 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 0 0 - 9
Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagn… Read more
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Request a sales quoteMultifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer.
- Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines
- Discusses treatment options from a pharmaceutical sciences perspective
- Includes translational science and targeted CNS cancer treatment
Scientist, researchers, and students in Pharmaceutical Sciences, Biotechnology, Pharmaceutical Nanotechnology, Biomaterials, Nanomedicines, Cancer Theranostics, and Anti-Cancer Drug Delivery as well as clinicians treating cancer. Formulation scientists in Pharmaceutical Companies
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Nanoparticle-based theranostics in cancer
- Abstract
- 1.1 Introduction
- 1.2 Fundamental of nanotheranostics for diagnosis and therapy
- 1.3 Nanoparticles in the treatment of cancer theranostics
- 1.4 Imaging guidance used in nanotheranostics
- 1.5 Role of nanotheranostics in cancer treatment
- 1.6 Clinical application of nanotheranostics
- 1.7 Conclusion and future perspective
- Conflict of interest
- References
- Chapter 2. Multifunctional nanotheranostics for cancer diagnosis and treatments
- Abstract
- 2.1 Introduction
- 2.2 Imaging modalities
- 2.3 Different multifunctional nanocarriers used as theranostic system
- 2.4 Conclusions
- Acknowledgment
- Conflict of interest
- References
- Chapter 3. Multifunctional micellar nanomedicine for cancer therapy
- Abstract
- 3.1 Introduction
- 3.2 Polymeric micelles
- 3.3 Advanced functions of micellar nanomedicine
- 3.4 The multifunctional design of the micelle nanomedicine platform for cancer
- 3.5 Concluding remarks
- List of abbreviations
- References
- Chapter 4. Multifunctional theranostic nanomedicine for photoacoustic imaging-guided combination tumor treatment
- Abstract
- 4.1 Introduction
- 4.2 Overview of multifunctional theranostics nanomedicine
- 4.3 Example of MTNs in treating various forms of cancer
- 4.4 Role of imaging-guiding in MTNs
- 4.5 Photoacoustic imaging-guided combination treatment of cancer
- 4.6 Examples of PAI-guided MTNs-based combination tumor treatment
- 4.7 Multifunctional nanomedicine for cancer immunotherapy
- 4.8 Clinical translation of MTNs
- 4.9 Challenges and future prospects
- 4.10 Summary and Conclusion
- 4.11 Conflict of interest
- Acknowledgments
- References
- Chapter 5. Multifunctional silica nanoparticle as a promising cancer theranostics
- Abstract
- 5.1 Introduction
- 5.2 Synthesis of silica nanoparticles
- 5.3 Functionalities of nonporous silica nanoparticles
- 5.4 Cancer therapy using silica nanomaterials
- 5.5 Conclusion and perspective
- List of abbreviations
- References
- Chapter 6. Multifunctional hypoxia imaging–guided tumor nanotheranostics
- Abstract
- 6.1 Introduction
- 6.2 Nanotechnology application in hypoxia imaging
- 6.3 Multifunctional nanotheranostics and tumor hypoxia imaging
- 6.4 Hypoxia imaging–guided tumor therapeutic nanoparticles
- 6.5 Hypoxia imaging–guided photodynamic therapy
- 6.6 Hypoxia imaging–guided chemotherapy
- 6.7 Challenges and future perspectives
- 6.8 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Further reading
- Chapter 7. Blood–brain-barrier crossing nanotheranostics in brain cancer
- Abstract
- 7.1 Introduction
- 7.2 Nanoparticles over available conventional treatment
- 7.3 Nanoparticles as theranostics device
- 7.4 Conclusion and future prospects
- Conflict of interest
- References
- Chapter 8. Peptide-drug conjugates in targeted drug delivery to cancer
- Abstract
- 8.1 Introduction
- 8.2 Selecting the proper tumor-targeting peptide to generate peptide-drug conjugates
- 8.3 Selection of cytotoxic drug to generate peptide-drug conjugates
- 8.4 Selection of linkers in peptide-drug conjugates
- 8.5 Other elements in peptide-drug conjugates’ design and synthesis
- 8.6 Examples of peptide-drug conjugates
- 8.7 Conclusion
- Conflict of interest
- References
- Chapter 9. Recent advancement in photo nanotheranostics for cancer treatment
- Abstract
- 9.1 Introduction
- 9.2 Basic concept on light-triggered nanotheranostics
- 9.3 Imaging with light-triggered therapy
- 9.4 Light-triggered nanotheranostics
- 9.5 Future challenges and opportunities
- 9.6 Conclusions
- References
- Chapter 10. Smart multifunctional nanosystem: Next-generation drug delivery platform for drug-resistant breast cancer
- Abstract
- 10.1 Introduction
- 10.2 Morphology of breast
- 10.3 Different types of breast cancers
- 10.4 Development of drug resistance in breast cancer
- 10.5 Current treatment regimen for breast cancer therapy
- 10.6 Different types of nanocarriers for breast cancer therapy
- 10.7 Multifunctional nanosystems in drug-resistant breast cancer
- 10.8 Marketed formulation and clinical trial
- 10.9 Conclusion and future prospect
- Acknowledgment
- Conflict of interest
- References
- Further Reading
- Chapter 11. Stimulus-responsive gold nanotheranostic platforms for targeting the tumor microenvironment
- Abstract
- 11.1 Introduction
- 11.2 Tumor microenvironment
- 11.3 Nanotheranostics
- 11.4 Gold nanoparticles
- 11.5 Conclusion
- Conflict of interest
- Abbreviations
- References
- Chapter 12. Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemotherapy in cancer
- Abstract
- 12.1 Introduction
- 12.2 Gold nanoparticles
- 12.3 Gold nanostars
- 12.4 Toxicity of gold nanoparticles
- 12.5 Conclusion
- References
- Chapter 13. Nanotargeted radiopharmaceuticals for cancer theranostics
- Abstract
- 13.1 Introduction
- 13.2 Nanoliposomes as a carrier for development of nanotargeted radiopharmaceuticals
- 13.3 Nanoparticles as a carrier for development of nanotargeted radiopharmaceuticals
- 13.4 Carbon nanotubes as a carrier for development of nanotargeted radiopharmaceuticals
- 13.5 Dendrimers as a carrier for development of nanotargeted radiopharmaceuticals
- 13.6 Polymeric micelles as a carrier for development of nanotargeted radiopharmaceuticals
- 13.7 Nanotargeted radiopharmaceuticals for improved tumor localization and retention
- 13.8 Conclusions
- Conflict of interest
- References
- Chapter 14. Nanoparticle-based radio immune therapy in cancer care
- Abstract
- 14.1 Introduction
- 14.2 Emergence of nanoparticles for radioimmunotherapy
- 14.3 Radiolabeling strategies for antibodies
- 14.4 Radiolabeling of nanoparticles
- 14.5 Different nanomaterial-based radio immune therapies (RIT)
- 14.6 Pretargeted radio immune therapy with nanomaterials
- 14.7 Future perspective of nano radio immune therapy
- Abbreviations
- References
- Further reading
- Chapter 15. Image-guided Biodistribution and pharmacokinetic studies of theranostics
- Abstract
- 15.1 Introduction
- 15.2 Nanotheranostics-based imaging techniques
- 15.3 Conclusion
- Acknowledgment
- Conflicts of interest
- References
- Chapter 16. Technological challenges of theranostics in oncology
- Abstract
- 16.1 Introduction
- 16.2 Theranostic systems in the field of oncology
- 16.3 Biomarker approach to theranostic development
- 16.4 Imaging guidance for theranostic platforms
- 16.5 Nanotechnology-mediated theranostic platforms and its targeting potentiality
- 16.6 Technological challenges associated with the theranostics in oncology
- 16.7 Conclusion and future perspectives
- Acknowledgment
- Conflicts of interest
- References
- Chapter 17. Theranostic nanoparticles engineered for clinic and pharmaceutics
- Abstract
- 17.1 Introduction
- 17.2 Engineering aspects of theranostic nanoparticles
- 17.3 Toxicological considerations of the theranostic nanoparticles
- 17.4 Scenario of theranostic nanoparticles in clinic
- 17.5 Conclusions and future perspectives
- Acknowledgements
- Conflict of interest
- References
- Chapter 18. Multifunctional nanoparticles—cost versus benefit of adding targeting and imaging capabilities
- Abstract
- 18.1 Introduction
- 18.2 Significance of cell targeting and imaging
- 18.3 Targeting strategies of nanoparticles
- 18.4 Multifunctional nanoparticles and their bio-fate
- 18.5 Mechanism of action of multifunctional nanoparticle
- 18.6 Advantages of site-specific multifunctional nanoparticles
- 18.7 Advantages of theranostic nanoparticles
- 18.8 Challenges in developing site-specific multifunctional nanoparticles
- 18.9 Challenges facing the employment of theranostic nanoparticles
- 18.10 Conclusion and future prospects
- Conflict of interest
- References
- Index
- Edition: 1
- Published: March 16, 2021
- No. of pages (Paperback): 426
- No. of pages (eBook): 426
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128217122
- eBook ISBN: 9780128217009
MD
Malay K. Das
Malay K. Das (MPharm, PhD) is a Professor of Pharmaceutics at the Department of Pharmaceutical Sciences, Dibrugarh University, in India. His research interests include novel drug delivery systems, pharmaceutical nanotechnology, nanomedicine, and transdermal and targeted drug delivery systems. He has handled several major research projects sponsored by the DST, DBT, ICMR, UGC, and AICTE. Professor Das has been honored with the prestigious DBT-Biotechnology Overseas Associateship at the University of South Florida, Tampa, United States and the DST-UKIERI Research Award in collaboration with the Institute of Pharmaceutical Sciences, King’s College, London, United Kingdom. He has several publications including peer-reviewed research and review articles in various international journals, as well as chapters in various books published by international publishers.
Affiliations and expertise
Professor of Pharmaceutics, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, IndiaRead Multifunctional Theranostic Nanomedicines in Cancer on ScienceDirect