Multifunctional Theranostic Nanomedicines in Cancer

1st Edition - March 16, 2021
Editor: Malay K. Das
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 7 1 2 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 7 0 0 - 9

Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagn… Read more

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Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Nanoparticle-based theranostics in cancer
Abstract
1.1 Introduction
1.2 Fundamental of nanotheranostics for diagnosis and therapy
1.3 Nanoparticles in the treatment of cancer theranostics
1.4 Imaging guidance used in nanotheranostics
1.5 Role of nanotheranostics in cancer treatment
1.6 Clinical application of nanotheranostics
1.7 Conclusion and future perspective
Conflict of interest
References
Chapter 2. Multifunctional nanotheranostics for cancer diagnosis and treatments
Abstract
2.1 Introduction
2.2 Imaging modalities
2.3 Different multifunctional nanocarriers used as theranostic system
2.4 Conclusions
Acknowledgment
Conflict of interest
References
Chapter 3. Multifunctional micellar nanomedicine for cancer therapy
Abstract
3.1 Introduction
3.2 Polymeric micelles
3.3 Advanced functions of micellar nanomedicine
3.4 The multifunctional design of the micelle nanomedicine platform for cancer
3.5 Concluding remarks
List of abbreviations
References
Chapter 4. Multifunctional theranostic nanomedicine for photoacoustic imaging-guided combination tumor treatment
Abstract
4.1 Introduction
4.2 Overview of multifunctional theranostics nanomedicine
4.3 Example of MTNs in treating various forms of cancer
4.4 Role of imaging-guiding in MTNs
4.5 Photoacoustic imaging-guided combination treatment of cancer
4.6 Examples of PAI-guided MTNs-based combination tumor treatment
4.7 Multifunctional nanomedicine for cancer immunotherapy
4.8 Clinical translation of MTNs
4.9 Challenges and future prospects
4.10 Summary and Conclusion
4.11 Conflict of interest
Acknowledgments
References
Chapter 5. Multifunctional silica nanoparticle as a promising cancer theranostics
Abstract
5.1 Introduction
5.2 Synthesis of silica nanoparticles
5.3 Functionalities of nonporous silica nanoparticles
5.4 Cancer therapy using silica nanomaterials
5.5 Conclusion and perspective
List of abbreviations
References
Chapter 6. Multifunctional hypoxia imaging–guided tumor nanotheranostics
Abstract
6.1 Introduction
6.2 Nanotechnology application in hypoxia imaging
6.3 Multifunctional nanotheranostics and tumor hypoxia imaging
6.4 Hypoxia imaging–guided tumor therapeutic nanoparticles
6.5 Hypoxia imaging–guided photodynamic therapy
6.6 Hypoxia imaging–guided chemotherapy
6.7 Challenges and future perspectives
6.8 Conclusion
Acknowledgment
Conflict of interest
References
Further reading
Chapter 7. Blood–brain-barrier crossing nanotheranostics in brain cancer
Abstract
7.1 Introduction
7.2 Nanoparticles over available conventional treatment
7.3 Nanoparticles as theranostics device
7.4 Conclusion and future prospects
Conflict of interest
References
Chapter 8. Peptide-drug conjugates in targeted drug delivery to cancer
Abstract
8.1 Introduction
8.2 Selecting the proper tumor-targeting peptide to generate peptide-drug conjugates
8.3 Selection of cytotoxic drug to generate peptide-drug conjugates
8.4 Selection of linkers in peptide-drug conjugates
8.5 Other elements in peptide-drug conjugates’ design and synthesis
8.6 Examples of peptide-drug conjugates
8.7 Conclusion
Conflict of interest
References
Chapter 9. Recent advancement in photo nanotheranostics for cancer treatment
Abstract
9.1 Introduction
9.2 Basic concept on light-triggered nanotheranostics
9.3 Imaging with light-triggered therapy
9.4 Light-triggered nanotheranostics
9.5 Future challenges and opportunities
9.6 Conclusions
References
Chapter 10. Smart multifunctional nanosystem: Next-generation drug delivery platform for drug-resistant breast cancer
Abstract
10.1 Introduction
10.2 Morphology of breast
10.3 Different types of breast cancers
10.4 Development of drug resistance in breast cancer
10.5 Current treatment regimen for breast cancer therapy
10.6 Different types of nanocarriers for breast cancer therapy
10.7 Multifunctional nanosystems in drug-resistant breast cancer
10.8 Marketed formulation and clinical trial
10.9 Conclusion and future prospect
Acknowledgment
Conflict of interest
References
Further Reading
Chapter 11. Stimulus-responsive gold nanotheranostic platforms for targeting the tumor microenvironment
Abstract
11.1 Introduction
11.2 Tumor microenvironment
11.3 Nanotheranostics
11.4 Gold nanoparticles
11.5 Conclusion
Conflict of interest
Abbreviations
References
Chapter 12. Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemotherapy in cancer
Abstract
12.1 Introduction
12.2 Gold nanoparticles
12.3 Gold nanostars
12.4 Toxicity of gold nanoparticles
12.5 Conclusion
References
Chapter 13. Nanotargeted radiopharmaceuticals for cancer theranostics
Abstract
13.1 Introduction
13.2 Nanoliposomes as a carrier for development of nanotargeted radiopharmaceuticals
13.3 Nanoparticles as a carrier for development of nanotargeted radiopharmaceuticals
13.4 Carbon nanotubes as a carrier for development of nanotargeted radiopharmaceuticals
13.5 Dendrimers as a carrier for development of nanotargeted radiopharmaceuticals
13.6 Polymeric micelles as a carrier for development of nanotargeted radiopharmaceuticals
13.7 Nanotargeted radiopharmaceuticals for improved tumor localization and retention
13.8 Conclusions
Conflict of interest
References
Chapter 14. Nanoparticle-based radio immune therapy in cancer care
Abstract
14.1 Introduction
14.2 Emergence of nanoparticles for radioimmunotherapy
14.3 Radiolabeling strategies for antibodies
14.4 Radiolabeling of nanoparticles
14.5 Different nanomaterial-based radio immune therapies (RIT)
14.6 Pretargeted radio immune therapy with nanomaterials
14.7 Future perspective of nano radio immune therapy
Abbreviations
References
Further reading
Chapter 15. Image-guided Biodistribution and pharmacokinetic studies of theranostics
Abstract
15.1 Introduction
15.2 Nanotheranostics-based imaging techniques
15.3 Conclusion
Acknowledgment
Conflicts of interest
References
Chapter 16. Technological challenges of theranostics in oncology
Abstract
16.1 Introduction
16.2 Theranostic systems in the field of oncology
16.3 Biomarker approach to theranostic development
16.4 Imaging guidance for theranostic platforms
16.5 Nanotechnology-mediated theranostic platforms and its targeting potentiality
16.6 Technological challenges associated with the theranostics in oncology
16.7 Conclusion and future perspectives
Acknowledgment
Conflicts of interest
References
Chapter 17. Theranostic nanoparticles engineered for clinic and pharmaceutics
Abstract
17.1 Introduction
17.2 Engineering aspects of theranostic nanoparticles
17.3 Toxicological considerations of the theranostic nanoparticles
17.4 Scenario of theranostic nanoparticles in clinic
17.5 Conclusions and future perspectives
Acknowledgements
Conflict of interest
References
Chapter 18. Multifunctional nanoparticles—cost versus benefit of adding targeting and imaging capabilities
Abstract
18.1 Introduction
18.2 Significance of cell targeting and imaging
18.3 Targeting strategies of nanoparticles
18.4 Multifunctional nanoparticles and their bio-fate
18.5 Mechanism of action of multifunctional nanoparticle
18.6 Advantages of site-specific multifunctional nanoparticles
18.7 Advantages of theranostic nanoparticles
18.8 Challenges in developing site-specific multifunctional nanoparticles
18.9 Challenges facing the employment of theranostic nanoparticles
18.10 Conclusion and future prospects
Conflict of interest
References
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Multifunctional Theranostic Nanomedicines in Cancer

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Malay K. Das

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