Brucella Melitensis
Identification and Characterization of Potential Drug Targets
- 1st Edition - February 25, 2021
- Editors: Jangampalli Adi Pradeepkiran, S.B. Sainath
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 8 1 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 9 9 9 7 - 0
Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinform… Read more

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Request a sales quoteBrucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria’s virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies.
In addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules.
- Covers the identification and characterization of vaccine targets for Brucella melitensis
- Presents in silico screening and the identification of novel drug targets
- Gives computational modeling and evaluations for potential drug targets
- Offers molecular docking and dynamics simulations for novel drug targets
- Details in silico validation and ADMET analysis for best lead molecules
Researchers and graduate students in biology, medicine, biotechnology and bioinformatics, in both academia and industry
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Overview of the book
- Chapter 1. Introduction to brucellosis
- Abbreviations
- 1.1. Brucellosis
- 1.2. Bioterrorism
- 1.3. Microbiology of Brucella
- 1.4. Summary
- Chapter 2. Identification and characterization of vaccine targets for Brucella melitensis through in silico approaches
- Abbreviations
- 2.1. Introduction to subtractive genomics
- 2.2. Methodology to identify vaccine targets
- 2.3. Identification and characterization of drug targets
- 2.4. Summary
- Chapter 3. Computational modeling and evaluation of best potential drug targets through comparative modeling
- Abbreviations
- 3.1. Introduction to protein modeling
- 3.2. Methodology for protein modeling
- 3.3. Identification of proteins as drug targets in B. melitensis and their modeling approaches
- 3.4. Discussion
- 3.5. Summary
- Chapter 4. Molecular docking and dynamics simulations of novel drug targets
- Abbreviations
- 4.1. Introduction to molecular docking
- 4.2. Methodology for molecular docking and dynamic simulations
- 4.3. Molecular docking and simulations studies of identified drug targets against selected ligands
- 4.4. Summary
- Chapter 5. In silico validation and ADMET analysis for the best lead molecules
- Abbreviations
- 5.1. Introduction to ADMET analysis
- 5.2. Methodology for ADMET analysis
- 5.3. ADMET analysis of best lead molecules against identified drug targets in B. melitensis 16M
- 5.4. Summary
- Chapter 6. Summary and conclusions
- 6.1. Major highlights of this book
- Index
- No. of pages: 200
- Language: English
- Edition: 1
- Published: February 25, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780323856812
- eBook ISBN: 9780323899970
JP
Jangampalli Adi Pradeepkiran
SS