Molecular Mechanisms of Neural Development and Insights into Disease
- 1st Edition, Volume 142 - March 9, 2021
- Imprint: Academic Press
- Editor: Greg J. Bashaw
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 5 2 8 1 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 5 2 8 2 - 9
Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting intere… Read more
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Request a sales quoteNeural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Current Topics in Developmental Biology series
Clinicians in the fields of endocrinology, rheumatology, orthopedics, pediatrics and dentistry; basic scientists in anatomy, cell and developmental biology; students and postdoctoral fellows who would like to enter these fields and make further discoveries as well as improve the treatment of major bone-related disorders
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgments
- Chapter One: The regulation of cortical neurogenesis
- Abstract
- 1: Introduction
- 2: Cerebral cortex development
- 3: Regulation of neurogenesis in apical progenitors
- 4: Regulation of neurogenesis in BPs
- 5: Regulation of cortical neuron fate
- 6: Intrinsic factors—Key transcriptional mechanisms
- 7: Signaling pathways regulating progenitor cell lineage
- 8: Extrinsic signals
- 9: Genome-wide transcriptomic and epigenomic regulation
- 10: Evolution of cortical neurogenesis
- 11: Human disease
- 12: Concluding remarks
- Acknowledgments
- Chapter Two: Ontogeny of adult neural stem cells in the mammalian brain
- Abstract
- 1: Introduction
- 2: Embryonic origins of adult neural stem cells
- 3: Transformation of neural stem cell properties from development to adulthood
- 4: Establishment of adult neurogenic niches
- 5: Mechanisms regulating establishment of the adult neural stem cell pool
- 6: Concluding remarks and future perspectives
- Acknowledgments
- Chapter Three: The essential role of primary cilia in cerebral cortical development and disorders
- Abstract
- 1: Introduction
- 2: Progenitors, primary cilia, and associated brain developmental malformations
- 3: Migrating neurons and primary cilium in the developing cerebral cortex
- 4: Dendrites, axons, neuronal connectivity and primary cilium
- 5: Primary cilia's impact on neural circuit maintenance and function
- 6: Glial diversity (astrocytes, oligodendrocytes, microglia), function, and primary cilia in the developing cerebral cortex
- 7: Future directions: Primary cilia's role in brain development and neurodevelopmental disorders
- Acknowledgments
- Declaration of competing financial interests
- Chapter Four: New insights into the molecular mechanisms of axon guidance receptor regulation and signaling
- Abstract
- 1: Introduction
- 2: Mechanisms of axon guidance receptor regulation
- 3: Downstream signaling of axon guidance receptors
- 4: Actin binding proteins
- 5: Microtubule associated proteins
- 6: Spatiotemporal signaling
- 7: Concluding remarks
- Acknowledgments
- Chapter Five: Dorsal commissural axon guidance in the developing spinal cord
- Abstract
- 1: Introduction
- 2: Specification of the dI1 population of dorsal spinal neurons
- 3: Guidance of dI1 axons away from the dorsal midline
- 4: Guidance of dI1 axons around the ventricular zone
- 5: Guidance of commissural axons toward and across the FP
- 6: Commissural axons exit the FP and turn rostrally into the ventral funiculus
- 7: Conclusions and speculations
- Acknowledgments
- Chapter Six: Molecular mechanisms that mediate dendrite morphogenesis
- Abstract
- 1: Introduction
- 2: The cell biology of dendrite morphogenesis
- 3: Transcriptional control of dendrite morphogenesis
- 4: Regulation of dendritic arbor growth and size
- 5: Space-filling mechanisms to optimize dendritic field distribution
- 6: Regulation of dendrite targeting and synapse selectivity
- 7: Altered dendritic development in neurodevelopmental disorders (NDDs)
- 8: Conclusions and future directions
- Acknowledgments
- Chapter Seven: Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment
- Abstract
- 1: Introduction
- 2: Mature organization of inputs in the SC and dLGN
- 3: Developmental timing of subcortical visual circuit wiring
- 4: Mechanisms of retinofugal topographic map assembly
- 5: Mechanisms of laminar-specific targeting
- 6: Mechanisms of visual map alignment
- 7: Concluding remarks
- Chapter Eight: Synaptic recognition molecules in development and disease
- Abstract
- 1: Introduction
- 2: Wiring neuronal partners through adhesive recognition
- 3: Restrictive recognition cues shape neuronal connectivity
- 4: Beyond making connections: Creating synapse diversity
- 5: Refining neuronal connectivity through eliminating synapses
- 6: Aberrant synaptic recognition and brain disorders
- 7: Outlook
- Acknowledgments
- Chapter Nine: Role of astrocytes in synapse formation and maturation
- Abstract
- 1: Introduction
- 2: Astrocyte maturation occurs concurrently with the peak period of synaptogenesis
- 3: Astrocyte-secreted proteins regulate synapse formation
- 4: Astrocyte-secreted factors regulate postsynaptic function and maturation
- 5: Astrocyte-secreted factors regulate presynaptic release properties
- 6: Astrocyte-neuron contact-dependent mechanisms regulating synapse formation and maturation
- 7: Conclusions and future directions
- Chapter Ten: Development of motor circuits: From neuronal stem cells and neuronal diversity to motor circuit assembly
- Abstract
- 1: Introduction
- 2: Motor circuits
- 3: Neuronal stem cells in the motor system
- 4: From neuronal diversity to motor circuit assembly
- 5: What are the relationships between neuronal stem cell lineage and motor circuits?
- 6: Why is neuron birth timing an important factor in motor circuit assembly?
- 7: Role of Hox in generating anterior–posterior (A–P) motor circuit diversity
- 8: Open questions
- 9: Conclusion
- Acknowledgments
- Chapter Eleven: The development of somatosensory neurons: Insights into pain and itch
- Abstract
- 1: Introduction
- 2: Molecular classification of nociceptor subtypes
- 3: Sensory neurogenesis and early nociceptor development
- 4: Specification of nociceptor subtypes
- 5: Developmental disorders of somatosensory neurons and human disease
- 6: Conclusions
- Chapter Twelve: Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease
- Abstract
- 1: Introduction
- 2: Generation of region-specific brain organoids from human stem cells
- 3: Advancements in cellular complexity of brain organoids
- 4: Modeling neurological diseases using brain organoids
- 5: Limitations and perspectives
- 6: Summary
- Acknowledgments
- Conflict of interest
- Edition: 1
- Volume: 142
- Published: March 9, 2021
- No. of pages (Hardback): 546
- No. of pages (eBook): 546
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128152812
- eBook ISBN: 9780128152829
GB
Greg J. Bashaw
Greg J. Bashaw works at the University of Pennsylvania in PA, USA.
Affiliations and expertise
University of Pennsylvania, PA, USARead Molecular Mechanisms of Neural Development and Insights into Disease on ScienceDirect