Molecular Mechanisms of Neural Development and Insights into Disease

1st Edition, Volume 142 - March 9, 2021
Editor: Greg J. Bashaw
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 2 8 1 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 2 8 2 - 9

Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting intere… Read more

Molecular Mechanisms of Neural Development and Insights into Disease

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Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Acknowledgments
Chapter One: The regulation of cortical neurogenesis
Abstract
1: Introduction
2: Cerebral cortex development
3: Regulation of neurogenesis in apical progenitors
4: Regulation of neurogenesis in BPs
5: Regulation of cortical neuron fate
6: Intrinsic factors—Key transcriptional mechanisms
7: Signaling pathways regulating progenitor cell lineage
8: Extrinsic signals
9: Genome-wide transcriptomic and epigenomic regulation
10: Evolution of cortical neurogenesis
11: Human disease
12: Concluding remarks
Acknowledgments
Chapter Two: Ontogeny of adult neural stem cells in the mammalian brain
Abstract
1: Introduction
2: Embryonic origins of adult neural stem cells
3: Transformation of neural stem cell properties from development to adulthood
4: Establishment of adult neurogenic niches
5: Mechanisms regulating establishment of the adult neural stem cell pool
6: Concluding remarks and future perspectives
Acknowledgments
Chapter Three: The essential role of primary cilia in cerebral cortical development and disorders
Abstract
1: Introduction
2: Progenitors, primary cilia, and associated brain developmental malformations
3: Migrating neurons and primary cilium in the developing cerebral cortex
4: Dendrites, axons, neuronal connectivity and primary cilium
5: Primary cilia's impact on neural circuit maintenance and function
6: Glial diversity (astrocytes, oligodendrocytes, microglia), function, and primary cilia in the developing cerebral cortex
7: Future directions: Primary cilia's role in brain development and neurodevelopmental disorders
Acknowledgments
Declaration of competing financial interests
Chapter Four: New insights into the molecular mechanisms of axon guidance receptor regulation and signaling
Abstract
1: Introduction
2: Mechanisms of axon guidance receptor regulation
3: Downstream signaling of axon guidance receptors
4: Actin binding proteins
5: Microtubule associated proteins
6: Spatiotemporal signaling
7: Concluding remarks
Acknowledgments
Chapter Five: Dorsal commissural axon guidance in the developing spinal cord
Abstract
1: Introduction
2: Specification of the dI1 population of dorsal spinal neurons
3: Guidance of dI1 axons away from the dorsal midline
4: Guidance of dI1 axons around the ventricular zone
5: Guidance of commissural axons toward and across the FP
6: Commissural axons exit the FP and turn rostrally into the ventral funiculus
7: Conclusions and speculations
Acknowledgments
Chapter Six: Molecular mechanisms that mediate dendrite morphogenesis
Abstract
1: Introduction
2: The cell biology of dendrite morphogenesis
3: Transcriptional control of dendrite morphogenesis
4: Regulation of dendritic arbor growth and size
5: Space-filling mechanisms to optimize dendritic field distribution
6: Regulation of dendrite targeting and synapse selectivity
7: Altered dendritic development in neurodevelopmental disorders (NDDs)
8: Conclusions and future directions
Acknowledgments
Chapter Seven: Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment
Abstract
1: Introduction
2: Mature organization of inputs in the SC and dLGN
3: Developmental timing of subcortical visual circuit wiring
4: Mechanisms of retinofugal topographic map assembly
5: Mechanisms of laminar-specific targeting
6: Mechanisms of visual map alignment
7: Concluding remarks
Chapter Eight: Synaptic recognition molecules in development and disease
Abstract
1: Introduction
2: Wiring neuronal partners through adhesive recognition
3: Restrictive recognition cues shape neuronal connectivity
4: Beyond making connections: Creating synapse diversity
5: Refining neuronal connectivity through eliminating synapses
6: Aberrant synaptic recognition and brain disorders
7: Outlook
Acknowledgments
Chapter Nine: Role of astrocytes in synapse formation and maturation
Abstract
1: Introduction
2: Astrocyte maturation occurs concurrently with the peak period of synaptogenesis
3: Astrocyte-secreted proteins regulate synapse formation
4: Astrocyte-secreted factors regulate postsynaptic function and maturation
5: Astrocyte-secreted factors regulate presynaptic release properties
6: Astrocyte-neuron contact-dependent mechanisms regulating synapse formation and maturation
7: Conclusions and future directions
Chapter Ten: Development of motor circuits: From neuronal stem cells and neuronal diversity to motor circuit assembly
Abstract
1: Introduction
2: Motor circuits
3: Neuronal stem cells in the motor system
4: From neuronal diversity to motor circuit assembly
5: What are the relationships between neuronal stem cell lineage and motor circuits?
6: Why is neuron birth timing an important factor in motor circuit assembly?
7: Role of Hox in generating anterior–posterior (A–P) motor circuit diversity
8: Open questions
9: Conclusion
Acknowledgments
Chapter Eleven: The development of somatosensory neurons: Insights into pain and itch
Abstract
1: Introduction
2: Molecular classification of nociceptor subtypes
3: Sensory neurogenesis and early nociceptor development
4: Specification of nociceptor subtypes
5: Developmental disorders of somatosensory neurons and human disease
6: Conclusions
Chapter Twelve: Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease
Abstract
1: Introduction
2: Generation of region-specific brain organoids from human stem cells
3: Advancements in cellular complexity of brain organoids
4: Modeling neurological diseases using brain organoids
5: Limitations and perspectives
6: Summary
Acknowledgments
Conflict of interest

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Greg J. Bashaw