Gut Microbiota in Neurologic and Visceral Diseases

1st Edition - March 11, 2021
Imprint: Academic Press
Editors: Tahira Farooqui, Akhlaq A. Farooqui
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 0 3 9 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 0 4 0 - 6

Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disord… Read more

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Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disorders. Chapters cover the effect of microbiota on the development of visceral (obesity, type 2 diabetes, heart disease) and neurological disorders (Alzheimer’s disease, Parkinson’s, depression, anxiety, and autism). Sections focus on the molecular mechanisms and signal transduction processes associated with the links among microbiota-related visceral and neurological disorders. It is hoped that this discussion will not only integrate and consolidate knowledge in this field but will also jumpstart more studies on the involvement of microbiota in the pathogenesis of neurological disorders.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Acknowledgments
Chapter 1: Gut microbiota: Implications on human health and diseases
Abstract
1: Introduction
2: Classification
3: Factors affecting the composition of the gut microbiota
4: Functional aspects of the gut microbiota
5: Manipulation of the gut microbiota
6: Conclusion
Chapter 2: Effect of different types of diet patterns on the gut microbiota composition
Abstract
1: Introduction
2: Microbiota-derived metabolites in host tissues
3: Effects of long-term consumption of various types of diets on the host
4: Effects of long-term consumption of the Western diet
5: Effects of long-term consumption of the Mediterranean diet
6: Effects of long-term consumption of the vegetarian diet
7: Effects of long-term consumption of the ketogenic diet
8: Conclusion
Chapter 3: Importance of fiber in human diet: Contribution of microbiota in human health
Abstract
1: Introduction
2: Beneficial effects of dietary fiber consumption on human health
3: Gut microbiota and human health
4: Effects of gut microbiota-derived metabolite in host tissues
5: Role of microbiota-derived short-chain fatty acids
6: Role of microbiota-derived trimethylamine and trimethylamine-N-oxide
7: Role of tryptophan and its metabolites in metabolism
8: Conclusion
Chapter 4: Importance of fermented foods on human health
Abstract
1: Introduction
2: Beneficial effects of fermented foods
3: Importance of fermented foods on human health
4: Adverse effects of fermented foods
5: Conclusion
Chapter 5: Contribution of gut microbiota in the pathogenesis of amyotrophic lateral sclerosis and Huntington’s disease
Abstract
1: Introduction
2: Pathogenesis of familial ALS
3: Involvement of the kynurenine pathway in the pathogenesis of sporadic ALS
4: Contribution of gut microbiota in the pathogenesis of amyotrophic lateral sclerosis
5: Molecular mechanisms contributing to neurodegeneration in Huntington’s disease
6: Contribution of gut microbiota in Huntington’s disease
7: Conclusion
Chapter 6: The gut microbiome in neurodegenerative disorders
Abstract
1: Introduction
2: The microbiome: Development and function
3: Overview of the gut-brain axis
4: Microbiota-gut-brain axis
5: Microbiota and neurodegenerative diseases
6: Role of diet in the microbiome and neurodegenerative disease
7: Potential therapies
8: Conclusion
Chapter 7: The contribution of gut microbiota in the pathogenesis of Parkinson’s disease
Abstract
1: Introduction
2: Gut microbiota dysbiosis in Parkinson’s disease
3: Microbiota gut-brain axis role in Parkinson’s disease
4: Synuclein propagation from gut to brain
5: Targeting of GBA in Parkinson’s disease by probiotics, prebiotics, and/or symbiotics
6: Conclusion
Chapter 8: The contribution of microbiota, cerebral blood flow, and sleep deprivation in the pathogenesis of Alzheimer’s disease
Abstract
1: Introduction
2: Factors affecting human gut microbiota
3: Effect of microbiota on immune system
4: Contribution of microbiota in the pathogenesis of Alzheimer’s disease
5: Association of cerebral blood flow in Alzheimer’s disease
6: Contribution of sleep deprivation in the pathogenesis of Alzheimer’s disease
7: Conclusion
Chapter 9: Implications of microbiota in the pathogenesis of diabetes mellitus and cardiovascular disease
Abstract
1: Introduction
2: Microbiota and diabetes
3: Microbiota and cardiovascular disease
4: Investigative tools
5: Treatment and future perspective
6: Conclusion
Chapter 10: Link between gut microbiome and cardiometabolic diseases
Abstract
1: Introduction
2: CMDs
3: Effects of diet on gut microbiota
4: Gut microbial dysbiosis
5: Gut microbial dysbiosis and CMDs
6: Conclusion
Chapter 11: Contribution of microbiota in obesity and obesity-related chronic diseases
Abstract
1: Introduction
2: Molecular mechanism of obesity
3: Effects of diet and microbiota on chronic diseases
4: Obesity, microbiota composition, and type2 diabetes
5: Obesity, microbiota, and metabolic syndrome
6: Obesity, microbiota, and cardiovascular disease
7: Obesity, microbiota, and neurological disorders
8: Conclusion
Chapter 12: Contribution of microbiota in the pathogenesis of ischemic stroke
Abstract
1: Introduction
2: Molecular aspects of ischemic stroke
3: Contribution of gut microbiota in poststroke injury
4: Conclusion
Chapter 13: Bioactive lipids and gut microbiota interact to regulate health and disease
Abstract
1: Introduction
2: Essential fatty acids and their clinical significance
3: EFA deficiency suppresses autoimmune diseases: But how and why?
4: Gut microbiota
5: Potential interaction between EFAs, their metabolites and gut microbiota
6: BALs influence gut microbiota
7: Conclusion
Chapter 14: Contribution of gut microbiota and multiple organ failure in the pathogenesis of COVID-19 infection
Abstract
1: Introduction
2: COVID-19 infection associated changes in respiratory tract and lungs
3: COVID-19 associated changes in gut microbiota and digestive tract
4: COVID-19 infection associated changes in cardiovascular system
5: COVID-19 associated changes in kidney
6: Role of cytokine storm and multiple organ failure in COVID-19 associated death
7: Conclusion
Chapter 15: Contribution of gut microbiota in the pathogenesis of migraine headache
Abstract
1: Introduction
2: Theories underlying migraine headache
3: Gut microbiota dysbiosis and migraine
4: Gastrointestinal disorders, gut microbiota dysbiosis, and migraine
5: The gut-brain axis and migraine
6: Conclusion
Chapter 16: Insights on the modulatory role of Ayurveda-based herbal preparations on gut microbiome and neuroprotection
Abstract
Acknowledgment
1: Introduction
2: Gut microbes and brain health
3: Evidence of GM involvement in specific NDD
4: Ayurveda and NDD
5: Recent approaches in microbiome research
6: Conclusions and future perspective
Chapter 17: The emerging roles of gut microbiome on neurotoxic outcomes: Implications for neurological disorders
Abstract
1: Introduction
2: The link between gut and brain
3: Neurotoxicity–microbiota interactions
4: Microbiome and neurotoxicants
5: Microbiome implications for mitigating neurotoxicity
6: Conclusions and future perspective
Chapter 18: Summary and perspective for future research on the contribution of microbiota in visceral and neurological disorders
Abstract
1: Introduction
2: Contribution of gut microbiota in the pathogenesis of visceral and neurological disorders
3: Future studies on gut dysbiosis and chronic visceral and neurological disorders
4: Directions for future studies
5: Conclusion
Index

Tahira Farooqui

Tahira Farooqui has published extensively on drug receptor interactions, biogenic amines in vertebrate and invertebrate nervous systems, biogenic amines mediated signaling, neural plasticity, as well as neuromoulatory roles of octopamine in the reinorcepathway involved in learning and memory, glycerophospholipid and sphingolipid metabolism and molecular signaling mechanisms in the brain. She is the author of 65 peer-reviewed research articles, one monographs and 8 edited books. She has coauthored a monograph in 2008 Metabolism and Function of Bioactive Ether Lipids in the Brain, 2008, by Springer, and have edited 8 Life Sciences books:1) Biogenic Amines: Pharmacological, Neurochemical, and Molecular Aspects in CNS, 2010, NOVA Science Publishers; 2) Phytochemicals and Human Health: Pharmacological and Molecular Aspects, 2011, NOVA Science Publishers; 3) Molecular Aspects of Neurodegeneration and Neuroprotection, 2011, Bentham Science Publishers; 4) Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Oxidative Stress on Cell Signaling, 2012, John Wiley & Sons, Inc; 5) Beneficial effects of propolis on human health and chronic diseases. Vol I, 2012, NOVA Science Publishers, Hauppage, New York; 6) Tahira Farooqui and Akhlaq A. Farooqui, Beneficial effects of propolis on human health and chronic diseases. Vol II, 2012, NOVA Science Publishers, Hauppage, New York; 7) Metabolic Syndrome and Neurological Disorders, 2013, John Wiley & Sons, Inc.; and 8) Diet and Exercise in Cognitive Function and Neurological Diseases, 2015, John Wiley & Sons, Inc.

Affiliations and expertise

Research Scientist, Department of Entomology/Center for Molecular Neurobiology, College of Biological Sciences, The Ohio State University, Columbus, OH, USA

Akhlaq A. Farooqui

Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.

Affiliations and expertise

Research Scientist, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health