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Elsevier

Books in Life sciences

  • Mechanobiology and Mechanomedicine

    From Fundamentals to Applications
    • 1st Edition
    • Lifang Hu + 2 more
    • English
    Mechanobiology and Mechanomedicine: From Fundamentals to Applications offers an in-depth investigation of the role mechanical stimuli plays in biological systems, from cellular behavior to disease development. Organized into three parts, the book initially covers the fundamentals of mechanobiology, exploring cellular and molecular mechanobiology including mechanical force types, mechanosensors and transducers, mechanosensitive signaling pathways and nuclear mechanotransduction. In addition, the application of finite element modeling techniques in studying multiscale mechanobiology of bone are included. The second section focuses on mechanobiology more broadly in health and disease, spanning its role across bone, cartilage, the dental and periodontal tissues, muscle, the cornea and sclera, and in airways. Each chapter considers the molecular and cellular mechanisms of mechanotransduction in these areas, as well as its significance for associated physiological and pathological conditions. The final section examines novel technologies like high-resolution mechanical imaging, organoids and artificial intelligence, concluding with the translational potential of mechanomedicine and its therapeutic applications.Mechano... and Mechanomedicine: From Fundamentals to Applications serves as a comprehensive and systematic overview of mechanobiology, sharing insights into the latest research advances and clinical relevance. Taking an interdisciplinary approach, this book is ideal for scientists, researchers and advanced students working across a range of areas including molecular biology, cell biology, translational medicine, biomechanics, biomedical engineering, biotechnology and related fields.

  • Theranostics for Cancer Targeting

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    This groundbreaking Theranostic book delivers the definitive roadmap for the next generation of precision oncology by systematically detailing the clinical, regulatory, and drug delivery landscapes of theranostics—the revolutionary integration of therapy and diagnostics—across 20-22 major cancer types. Designed for medical publishers, clinicians, and biotech researchers, this chapter is a structural framework for each malignancy, bridging laboratory breakthroughs in nanotechnology, green nanochemistry, drug delivery, diagnostics, and AI with real-world clinical applications. It serves as an essential commercial and academic asset, offering unprecedented depth on FDA/EMA regulatory hurdles, technology transfer pathways, and actionable data tables that track active clinical trials and global research groups. By addressing key market trends and regulatory challenges, it serves as an essential, multidisciplinary resource for driving personalized oncology and improving patient outcomes

  • Artificial Intelligence in Agricultural Systems

    Fundamentals and Advances
    • 1st Edition
    • Mohammad Mehdizadeh
    • English
    Artificial Intelligence in Agricultural Systems: Fundamentals and Advances focuses on advancements in AI in and draws upon the multi-faceted challenges of modern agriculture. This book curates the latest strands of AI applications that are reshaping agricultural systems, including current trends and emerging technologies. It offers an overview of the evolving agricultural landscape and foregrounds the critical role of AI in driving innovation and enhancing productivity in this essential sector. Organized into four parts, it introduces agricultural systems and AI fundamentals, including machine learning, deep learning, natural language processing, and robotics. It then pivots to data collection and processing techniques, explicating the use of sensors, IoT devices, remote sensing, and UAVs. Core applications in crop and livestock management receive emphasis, covering yield prediction, pest detection, precision irrigation, and sustainable farming practices. The final sections address the limitations of AI in agriculture, future trends, and policy recommendations, providing an overarching understanding of AI's responsible adoption. Artificial Intelligence in Agricultural Systems is an important resource for upper-level undergraduate and graduate students studying the impact of AI technologies on agriculture and food production. Researchers, practitioners, and policymakers studying the intersections of agriculture, environmental science, data science, and engineering will find this book compelling as well.

  • Quercetin in Drug Discovery

    • 1st Edition
    • Gautam Sethi + 2 more
    • English
    Quercetin in Drug Discovery is a detailed reference exploring the multifaceted pharmacological potential of quercetin, a naturally occurring flavonoid with significant therapeutic promise. Addressing the critical need for consolidated knowledge, this guide highlights quercetin’s diverse biological activities and the translational challenges limiting its clinical applications, making it essential for researchers and pharmaceutical scientists. The comprehensive table of contents covers quercetin’s pharmacological properties, molecular docking studies, and ADME profiles, alongside therapeutic applications in cardiovascular diseases, cancer, and other conditions. It further examines bioavailability enhancement strategies, drug formulation, innovative delivery systems, and clinical trial evidence. Contributions from leading experts provide detailed insights into signaling pathways, molecular targets, and synthetic derivatives. Quercetin in Drug Discovery equips pharmacologists, medicinal chemists, and pharmaceutical scientists with critical information to advance research and drug development. By addressing bioavailability issues and regulatory considerations, this reference supports the translation of quercetin from bench to bedside, fostering innovation in natural product-based therapeutics.

  • Biomaterials in Cancer Therapy

    Innovations and Applications
    • 1st Edition
    • Alok Raghav
    • English
    Biomaterials in Cancer Therapy: Innovations and Applications explores the critical role of functional biomaterials in addressing one of today’s most pressing health challenges—cancer. Despite advancements in therapies, cancer continues to claim millions of lives annually, necessitating innovative approaches that integrate engineering and pharmaceutical sciences. This book highlights the potential of engineered biomaterials to enhance drug delivery, minimize side effects, and promote tissue regeneration, ultimately improving patient outcomes. The content examines cutting-edge innovations in functional biomaterials, including their applications in targeted drug delivery and immunotherapy, while emphasizing the role of nanotechnology in developing effective cancer theranostics with minimal toxicity. Targeted at academicians, physicians, and industry professionals, this book serves as a vital resource for understanding the transformative potential of functional biomaterials in oncology. By addressing real-world challenges and incorporating diverse perspectives, it inspires innovative solutions that enhance global healthcare outcomes for cancer patients.

  • Management of Chronic Kidney Disease and Its Complications

    • 1st Edition
    • Thakur Gurjeet Singh + 4 more
    • English
    Management of Chronic Kidney Disease and Its Complications  presents the latest scientific advances in diagnosing and managing Chronic Kidney Disease (CKD) and its diverse complications. This authoritative text covers molecular mechanisms such as inflammation and oxidative stress, genetic and epigenetic factors, and explores cutting-edge technologies including artificial intelligence and regenerative medicine. With detailed chapters on cardiovascular, metabolic, neurological, and hematological complications, the book offers a holistic approach to understanding CKD’s complexity and evolving treatment strategies.The book’s content is organized to provide a thorough exploration of CKD, beginning with foundational topics like genetic contributions and diagnostic evaluation, progressing through specific complications such as diabetic nephropathy, hypertension, and urologic conditions. Special focus is given to management strategies, nutritional interventions, and unique considerations in pediatric, geriatric, and pregnant populations. Emerging therapies, including precision medicine, gut microbiota modulation, and AI-driven early detection, are also extensively covered to keep readers at the forefront of nephrology research and clinical practice.Management of Chronic Kidney Disease and Its Complications is an essential resource for nephrologists, general practitioners, medical students, nursing professionals, and healthcare providers involved in kidney disease care and research.

  • Principles and Practice of Nephrocardiology

    • 1st Edition
    • Parta Hatamizadeh
    • English
    Principles and Practice of Nephrocardiology provides a comprehensive introduction to the interdisciplinary subspecialty of Nephrocardiology. The book includes detailed descriptions, along with an in-depth exploration of its primary elements and topics. Coverage spans pathophysiology, epidemiology, prevention, diagnosis, prognosis, monitoring, therapy, risk factors, and the systemic diseases that involve both nephrology-related conditions and cardiovascular diseases. The book guides clinicians and general practitioners in multiple interdisciplinary specialties through diagnostic, preventive, and therapeutic approaches to a wide variety of patient populations. It also opens a myriad of new avenues for future research and guidance for approaching multiple medical topics.

  • Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B

    • 1st Edition
    • Lung-Yi Loey Mak + 1 more
    • English
    Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B offers a comprehensive examination of the therapeutic potentials of Tenofovir Alafenamide (TAF) in hepatitis B, providing a succinct and up-to-date summary of all relevant evidence for this first-line oral antiviral agent. The text delves into key topics such as the pharmacological profile of TAF, its comparative efficacy against traditional antiviral agents, safety and tolerability, and the impact of TAF on drug resistance. Additionally, it explores the use of TAF in special populations, including pediatrics, the elderly, and individuals with renal impairment, as well as future directions in hepatitis B treatment strategies.Readers will discover the diverse potential applications of TAF in chronic hepatitis B, informed by valuable lessons learned from HIV treatment while also gaining insights into future therapeutic possibilities. Authored by leading experts in the field, each chapter presents focused and insightful perspectives, making this book an indispensable resource for practitioners and researchers alike. Serving as a critical resource for physicians, researchers, pharmacologists, and biomedical scientists, this book highlights the core knowledge necessary for understanding TAF and its clinical applications.

  • The Kidney

    • 1st Edition
    • Volume 7
    • Ahmed El-Hashash + 1 more
    • English
    The Kidney, Volume Seven in the Stem Cell Innovation in Health and Disease series, explores the emerging potential of stem cell therapies in treating kidney diseases. With their natural regenerative and anti-inflammatory properties, stem cells offer a promising approach to restoring essential kidney functions and mitigating damage. This volume highlights how stem cell therapies may modulate immune responses, promote tissue repair, and replace damaged kidney cells, offering hope for chronic and acute renal conditions. Key developments include the injection of mesenchymal stem cells (MSCs) into damaged kidneys where they can differentiate into kidney cell types and aid in healing.In addition, urine-derived stem cells have also shown significant potential in improving kidney function in preclinical studies. Additionally, innovative techniques like incorporating MSCs into compact dialysis machines are explored, enabling delivery of pro-repair factors directly to the kidneys during blood filtration. While there are currently no FDA-approved stem cell treatments for kidney diseases, ongoing clinical trials aim to evaluate their safety and efficacy. This volume compiles cutting-edge research, discussing various cell sources, underlying mechanisms, observed therapeutic outcomes, and the practical challenges of clinical translation. By presenting a clear picture of current advances and future directions, this book serves as a vital resource for scientists, clinicians, and health innovators seeking to harness stem cell technology in nephrology.

  • Multiple Faces of Takotsubo Syndrome

    Clinical Presentations, Mechanisms and Advanced Diagnostic Insights
    • 1st Edition
    • Riccardo Cau + 1 more
    • English
    Multiple Faces of Takotsubo Syndrome: Clinical Presentations, Mechanisms and Advanced Diagnostic Insights offers a thorough review of Takotsubo syndrome and the role of advanced imaging techniques in improving diagnosis, monitoring, and management of this complex cardiac condition. The book begins with an introduction to Takotsubo syndrome, covering its historical background, prevalence, and key clinical characteristics. Subsequent chapters delve into epidemiology, risk factors, and psychological aspects, including the impact of COVID-19 and other viral infections. Then, clinical manifestations, management, prevention, and treatments are thoroughly discussed, along with complications and prognosis. The basic science section explores the pathophysiological mechanisms, the heart-brain axis, and multi-organ involvement.A significant focus throughout is placed on invasive and non-invasive imaging modalities, including angiography, echocardiography, cardiac MRI, computed tomography, and nuclear imaging. Future directions highlight emerging biomarkers and imaging techniques for personalized medicine, and real-world case studies provide practical insights for clinicians. The book offers invaluable benefits to scientists, researchers, and clinicians alike.

  • Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST)

    Accelerating Diagnosis and Optimizing Antimicrobial Therapy
    • 1st Edition
    • Raju Khan + 4 more
    • English
    Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST): Accelerating Diagnosis and Optimizing Antimicrobial Therapy provides a comprehensive and interdisciplinary exploration of microfluidic technologies as transformative tools in the fight against antimicrobial resistance (AMR). By integrating foundational knowledge of AMR and microfluidics with cutting-edge research, it offers readers an in-depth understanding of how microfluidic systems enable rapid, precise, and cost-effective antibiotic susceptibility testing (AST). The book addresses both the scientific principles and practical applications of these technologies, emphasizing their potential to revolutionize diagnostics, personalize treatment, and improve global health outcomes amidst the growing threat of drug-resistant infections. Organized into five key parts, the book begins with an overview of the global challenge of antimicrobial resistance and the fundamental principles of microfluidics in biomedical contexts. It then delves into various microfluidic platforms for AST, including continuous flow and droplet-based systems, as well as single-cell trapping techniques. Subsequent chapters focus on diverse detection methods—optical, electrochemical, and acoustic—for monitoring bacterial growth and antibiotic response. The book further explores specialized approaches such as paper-based point-of-care devices, biosensing strategies, and personalized medicine applications. The final section addresses clinical translation, covering validation, regulatory considerations, device design, automation, emerging technologies, ethical guidelines, and future perspectives on microfluidic AST’s role in combating antimicrobial resistance worldwide.

  • Advances in Noncoding RNA Diagnostics and Therapeutics in Immunity and Cancer

    • 1st Edition
    • Afsar Naqvi + 1 more
    • English
    Advances in Noncoding RNA Diagnostics and Therapeutics in Immunity and Cancer explores the critical role of noncoding RNAs in immune-mediated diseases and cancers, providing an essential resource on their diagnostic and therapeutic potential. The book contributes valuable insights into the pathobiology of noncoding RNAs and their application in various diseases, delving into the latest research on noncoding RNAs, including their mechanisms, interactions, and roles in disease. In addition, it examines how noncoding RNAs influence immune responses, inflammation, and cancer progression. With a focus on both diagnostic and therapeutic applications, this book highlights the potential of noncoding RNAs as biomarkers and therapeutic targets. Across comprehensive chapters, the book covers a wide range of topics, including the role of virus-encoded microRNAs in immune evasion, the therapeutic aspects of non-coding RNA in hepatocellular carcinoma, the impact of microRNAs in periodontal inflammation, and the involvement of miRNAs and lncRNAs in regulating the tumor microenvironment in HCC. Other chapters explore the functions and clinical value of tumor-derived exosomes and miRNAs in cancer immune response, the interaction of noncoding RNA in cancer metastasis, and a panorama of non‐coding RNA in prostate cancer. This book is an invaluable resource for basic science researchers in the noncoding RNA field, cancer biologists, immunologists and RNA biologists interested in the latest advancements in noncoding RNA research.

  • Baleen Whales

    Ridgway and Harrison's Handbook of Marine Mammals: Volume 4
    • 1st Edition
    • Thomas Allen Jefferson
    • English
    Some of the world's most beautiful, intelligent, and highly adapted mammals inhabit our seas and oceans and have stirred the human imagination for many centuries. As our knowledge of marine mammals grows, the need exists for a reliable and complete reference to the ecology and biology of these fascinating creatures. To address this need, the Handbook of Marine Mammals series has been founded. Scientists, conservationists, and informed laypersons alike will be able to find definitive reviews of all the world's living whales, dolphins, porpoises, seals, sea lions, sea cows, and marine otters and bears. Seven volumes cover all the living species of marine mammals.This fourth volume in the series, Baleen Whales, consists of species review chapters written by leading global experts on whale species that have baleen plates instead of teeth. Each chapter includes a description of the species, followed by sections on distribution and abundance, anatomy, physiology, behavior, ecology, reproduction, parasites and diseases, and the impacts of human activities on the species.

  • Advances in Design of Microbial Cell Factories

    • 1st Edition
    • Dibyajit Lahiri
    • English
    Advances in Design of Microbial Cell Factories presents a comprehensive overview of the latest innovations in engineering microbial platforms for sustainable production of biochemicals, biofuels, pharmaceuticals, and industrial enzymes.The book opens with an introduction and historical overview of microbial cell factories, followed by a wide spectrum of topics including omics-driven design and engineering of microbial cell factories, metabolic flux analysis, genome-scale metabolic modeling, modular pathway engineering, biosensors, adaptive laboratory evolution, protein engineering and enzyme optimization in microbial hosts. The latest developments in designing bacterial, yeast, mold and microalagae cell factories are covered, as well as current challenges to be considered in scale-up of microbial cell factories. Chapters are supported by real-world case studies that demonstrate translation from laboratory research to industrial-scale applications across a diverse range of sectors.This reference consolidates foundational knowledge with emerging technologies, equipping researchers, graduate students, and industry professionals with practical insights to accelerate their own development of microbial platforms.

  • Plant Development

    • 1st Edition
    • Volume 172
    • English
    Plant Development provides an overview of the fundamental processes that govern the growth, differentiation, and organization of plants throughout their life cycle. The book explores key developmental stages, from embryogenesis and seed germination to organ formation, flowering, and senescence, highlighting the genetic, molecular, cellular, and environmental factors that regulate these events. By integrating classical concepts with modern advances in developmental biology, the volume offers valuable insight into how plants establish form, adapt to their surroundings, and coordinate growth in response to internal and external signals. It serves as a useful resource for researchers, students, and professionals interested in plant biology, developmental mechanisms, and related fields.

  • Nanotechnology in Brain Tumor Treatment

    Unveiling Molecular Mechanisms and Pioneering Therapies
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Nanobiotechnology in Brain Tumor Treatment: Unveiling Molecular Mechanisms and Pioneering Therapies is a groundbreaking resource that addresses the formidable challenges posed by brain tumors in oncology. This comprehensive book explores the etiology, symptoms, diagnosis, and treatment options for brain tumors, with a particular focus on the revolutionary impact of nanobiotechnology. By integrating cutting-edge research on nanotechnology with practical applications in neuro-oncology, this book offers a unique perspective on enhancing patient outcomes and advancing brain cancer treatment strategies.By offering a comprehensive overview of nanobiotechnology in brain tumor treatment, this resource serves as a vital tool for those involved in the research, diagnosis, and treatment of brain cancers, paving the way for innovative and personalized therapeutic approaches.

  • Human-AI Interaction for Digital Healthcare Systems

    • 1st Edition
    • Jinwoo Kim
    • English
    Human-AI Interaction for Digital Healthcare Systems defines Human‑AI Interaction (HAII) as the next evolutionary phase of Human‑Computer Interaction, addressing the shift from reactive systems to proactive AI agents. Using digital healthcare as its primary application domain, it introduces a rigorous, evidence‑based methodology for designing AI systems that are effective, safe, and trusted in real‑world clinical contexts. The text integrates the Sensing–Reasoning–Ac... (SRA) loop into human‑centered design, balancing system efficacy with environmental conformance. It provides structured guidance across the full lifecycle, analysis, planning, design, and evaluation,ensuring AI systems deliver measurable clinical and user value. Beyond theory, the book emphasizes empirical validation, detailing controlled experiments (e.g., RCTs) and real‑world performance analysis using Real‑World Data (RWD) and Real‑World Evidence (RWE), with explicit consideration of regulatory requirements for Software as a Medical Device (SaMD).

  • Understanding Molecular Processes using Electrochemical Methods

    • 1st Edition
    • Ashis Kumar Satpati + 1 more
    • English
    Understanding Molecular Processes using Electrochemical Methods offers a detailed compendium of techniques for molecular analysis. The book considers step and sweep techniques, scanning electrochemical microscopy, spectroelectrochemic... techniques, electrochemiluminesc... and scanning probe techniques while also exploring COSMOL multiphysics simulation, electroanalysis in biomedical and clinical applications, and future prospects for electrochemical techniques. Chapters focus on evaluating redox reactions, biological interactions, kinetics, quorum sensing, biofilm formation, surface modification and more molecular aspects. This volume offers a deep-dive into the fundamental principles behind the latest electrochemical techniques, equipping researchers with practical guidance for their own experiments.Users will find this to be an ideal reference for researchers working across a range of disciplines including molecular biology, bioanalytical chemistry, biomedical science, and translational medicine.

  • Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

    • 1st Edition
    • Cheng Xue + 4 more
    • English
    Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals.From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine. Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

  • Geographic Atrophy in Age-related Macular Degeneration

    • 1st Edition
    • Jay Chhablani + 1 more
    • English
    Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinical trials, differential diagnoses, and both established and emerging treatment options. The book details diagnostic processes using techniques such as visual acuity tests, dilated eye exams, fundus photography, optical coherence tomography (OCT), and fluorescein angiography, emphasizing the importance of early detection. It also differentiates geographic atrophy from other retinal conditions with similar symptoms, such as dystrophies, equipping practitioners with the knowledge for accurate diagnosis.Additional... it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.

  • Rare and Complex Liver Diseases

    • 1st Edition
    • Ansgar Wilhelm Lohse + 2 more
    • English
    Rare and Complex Liver Diseases is a comprehensive guide that fills a critical gap in the literature, providing up-to-date, practical advice. The book is organized into distinct sections, each dedicated to a specific category of liver diseases. Topics covered include Autoimmune Liver Diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC); Cholestatic Liver Diseases including Biliary Atresia and Alagille Syndrome; Vascular Liver Diseases like Budd-Chiari Syndrome and Non-cirrhotic Portal Hypertension; Metabolic Liver Diseases such as Wilson Disease and Alpha-1 Antitrypsin Deficiency; Structural Liver Diseases including Polycystic Liver Disease; and Rare Liver Tumors like Cholangiocarcinoma and Hemangioendothelioma... chapters cover Liver Disease in Pregnancy and delve into Quality of Life issues, offering evidence-based insights and practical strategies for improving patient well-being. This book serves as an indispensable resource for gastroenterologists, hepatologists, internists, and researchers specializing in liver diseases. It equips these professionals with the knowledge and practical advice necessary to improve patient outcomes and advance their field of study.

  • Transesophageal Echocardiography

    Basic and Advanced Aspects and Clinical Field of Application
    • 1st Edition
    • Antonello D’Andrea
    • English
    Transesophageal Echocardiography: Basic and Advanced Aspects and Clinical Field of Application provides clinicians and echocardiography professionals with a thorough and practical resource covering both the fundamental principles and advanced clinical uses of TEE. It benefits the audience by delivering step-by-step guidance on image acquisition, interpretation of valve and ventricular pathology, and real-world applications in perioperative, emergency, and interventional settings. Richly illustrated and supplemented by instructional videos, the book’s contents include diagnostic techniques, perioperative management, assessment of prosthetic and congenital heart conditions, and specialized topics such as TEE in sports cardiology and critical care—empowering readers to improve patient outcomes and master the latest advancements in cardiovascular imaging.

  • An Essential Guide to Radiation Dosimetry for Medical Applications

    Principles, Technologies, and Clinical Applications
    • 1st Edition
    • Jayachandran Venkatesan + 1 more
    • English
    An Essential Guide to Radiation Dosimetry for Medical Applications: Principles, Technologies, and Clinical Applications provides a comprehensive overview of the fundamental concepts, advanced methodologies, and emerging technologies in radiation dosimetry. This book serves as an essential resource for researchers, clinicians, and students involved in cancer research, bioinformatics, medical physics, radiology, material scientists and radiation therapy, offering in-depth insights into both theoretical principles and practical applications. The content covers core topics such as radiation interactions, dosimetry materials, and simulation techniques, alongside clinical and diagnostic applications.In addition, it also explores innovative approaches like artificial intelligence, nanodosimetry, and quality assurance, ensuring readers stay current with technological advancements. This book benefits the academic audience by enhancing their knowledge of dosimetry science and fostering the development of safer, more effective radiation practices. It supports education, research, and clinical decision-making, ultimately advancing the field of radiation physics and improving patient outcomes.

  • Surgical Care of the Critically Ill During Pregnancy

    • 1st Edition
    • Jorge Hidalgo + 2 more
    • English
    Surgical Care of the Critically Ill During Pregnancy, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women in all surgical aspects including trauma. The book's authors offer best practices and evidence-based material explicitly focused on the most common complications in pregnant patients that may occur to improve patient care. It not only covers critical care investigation from medical-surgical complications that any patient can present, but also how to prepare and anticipate complications in the critical care unit.

  • Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care

    • 1st Edition
    • Neha Raina + 2 more
    • English
    Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care presents a comprehensive, biomarker-driven exploration of how natural and engineered biopolymers are transforming the management of acute, chronic, and non-healing wounds. Positioned at the intersection of biomaterials science, pharmaceutical innovation, and clinical practice, the book addresses one of the central challenges in wound care: persistent inflammation that delays tissue repair and regeneration. Beginning with the biological and clinical foundations of wound healing, the book systematically examines inflammatory pathways and key biomarkers such as TNF-α, IL-6, ROS, and VEGF.It then advances into in-depth coverage of natural biopolymers—includin... collagen, chitosan, hyaluronic acid, silk-derived polymers, and marine polysaccharides—and their roles in immune modulation, macrophage polarization, and redox balance. Dedicated sections explore advanced delivery platforms such as nanofibers, smart hydrogels, nanozymes, and stimuli-responsive dressings, alongside emerging precision technologies including 3D printing and AI-guided material design. With a strong translational focus, the book bridges laboratory research and real-world application, addressing regulatory pathways, manufacturing scalability, and commercialization challenges.

  • Edible Electronics

    Principles, Fundamentals, and Applications in Smart Food Packaging and Biomedical Innovations
    • 1st Edition
    • Arun Kumar Gupta + 1 more
    • English
    Edible Electronics: Principles, Fundamentals, and Applications in Smart Food Packaging and Biomedical Innovations addresses the growing global demand for sustainable technologies and environmentally responsible solutions. Conventional electronic devices often rely on toxic, non-biodegradable materials that contribute significantly to electronic waste, posing environmental and health risks, particularly in developing regions and areas with limited waste management systems. By introducing the concept of edible electronics and emphasizing the use of biocompatible and biodegradable materials, this book highlights innovative approaches to reducing electronic waste and mitigating the effects of environmental degradation. It advocates the adoption of sustainable technological practices that can support the needs of an expanding global population while promoting both human and environmental well-being.The book provides a comprehensive exploration of edible electronic materials, including conductors, dielectrics, and semiconductors, and examines their integration into functional electronic systems. It discusses the development of sensors for both in-body and external applications, along with energy storage and supply systems such as batteries and supercapacitors. In addition, the text covers advanced communication methods, including radio-frequency, intra-body, and optical technologies, demonstrating the broad potential of edible electronics across food packaging, healthcare, and biomedical applications.A detailed overview of fabrication techniques is also presented, including deposition, filming, patterning, printing, and carbonization processes. These methods are examined with an emphasis on ensuring the safety, performance, and reliability of edible electronic systems. Furthermore, the book explores regulatory considerations, safety standards, and environmental impacts associated with the development and deployment of such technologies.

  • Network Pharmacology in Natural Products Drug Discovery

    • 1st Edition
    • Devesh Tewari + 1 more
    • English
    Network Pharmacology in Natural Products Drug Discovery addresses the critical intersection of network pharmacology and natural product research, a rapidly evolving field essential for modern drug discovery. The book's content begins with foundational concepts of network pharmacology followed by an exploration of natural products as therapeutic agents. Its comprehensive Table of Contents covers a diverse range of topics, including omics integration, metabolomics, and case studies on various health conditions, thus ensuring a holistic understanding of the subject matter. Each chapter not only presents theoretical insights but also emphasizes practical applications, case studies, and emerging trends in network pharmacology related to natural products.The book empowers its audience by providing them with essential tools and methodologies to integrate network pharmacology into their research. It highlights the advantages of utilizing computational approaches alongside experimental validation, enabling researchers to uncover the mechanisms of action of natural compounds. With a focus on real-world applications, this reference is invaluable for advancing drug discovery and therapeutic development.

  • Animal Stress Biology

    Applications across Natural and Man-made Systems
    • 1st Edition
    • Edward Narayan
    • English
    Animal Stress Biology: Applications across Natural and Man-made Systems provides the fundamental aspects of stress endocrinology with a major focus on the applications of stress research in animal welfare. Early sections introduce the basics of animal stress biology in major taxa. Latter sections explore how animal stress varies across species and settings and how this research can be applied to improve animal welfare. The book incorporates chapter summaries, key term definitions, global case studies, and discussion sections throughout, making it an indispensable resource to students and early career professionals, as well as specialists in agriculture, zoos, clinical research settings, and resource management.Stress plays an integral part in the maintenance of homeostasis in animals and is a useful measure of animal responses to management interventions across natural, agricultural, and clinical settings. Written by experts in the field of animal stress biology, this book is systematically structured for easy student navigation.

  • RED: Women's Health From Menarche to Menopause

    • 1st Edition
    • Diana Vaamonde + 3 more
    • English
    RED: Women’s Health and Wellness from Menarche to Menopause provides a comprehensive, unique and holistic perspective on women’s health and wellbeing. From a contemporary health and behavioral science perspective, it presents an accessible and engaging exploration of the biological, psychological, behavioral, and sociocultural changes and challenges women may experience from menarche through menopause.The book offers a fresh perspective by highlighting lifestyle modification, emotional wellbeing, and social and environmental influences as important complements to conventional healthcare approaches. It addresses key dimensions of women’s health, including gender medicine, sexual health, trauma, lifestyle, eating behaviors and the influence of social constructs and technologies, while considering their implications for health and wellbeing.With contributions that bridge scientific evidence and practical application, this book provides a valuable reference for students and graduates, academics, researchers, healthcare professionals, and anyone interested in advancing knowledge and understanding of women’s health.

  • Fermented Foods in Health and Disease Prevention

    • 2nd Edition
    • Juana Frías + 2 more
    • English
    Fermented Foods in Health and Disease Prevention, Second Edition examines the significance of fermented foods to public health. The book presents the latest scientific evidence, showing the health-promoting components produced upon fermentation from a diversity of food matrices. The content includes the definition and characterization of traditional and innovative fermented foods, their mechanisms of action, and the evidence for effects on health and disease in humans. Putative health effects associated with direct interactions between the ingested live microorganisms and the host (probiotic effect), or indirectly, through ingestion of microbial metabolites and products of fermentation (biogenic effect) are discussed.This book will provide the food industry with new insights on the development of value-added fermentation, while also presenting nutritionists and dieticians with a useful resource to help them develop strategies to assist in the prevention of disease or to slow its onset and severity.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1st Edition
    • Deepak Kumar + 4 more
    • English
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • Endovascular Therapy for Intracranial Atherosclerotic Stenosis

    • 1st Edition
    • Ning Ma + 1 more
    • English
    Endovascular Therapy for Intracranial Atherosclerotic Stenosis presents selected cases of endovascular treatment for intracranial atherosclerotic stenosis (ICAS), providing detailed information on periprocedural medical management, endovascular strategies, device selection, and follow-up outcomes. The book serves to improve understanding of ICAS and share clinical experiences from high-volume stroke intervention centres with neuro-interventional... The book reviews recent developments in ICAS management and presents evidence that appropriate patient selection and peri-operative planning may contribute to the effectiveness of endovascular therapy for ICAS

  • Current Research on Biofilm-Mediated Chronic Diseases

    Immunological Background and Clinical Interpretations
    • 1st Edition
    • Dibyajit Lahiri + 3 more
    • English
    Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations is an in-depth exploration of the complex interplay between biofilms, the immune system, and chronic diseases. These microbial communities, encased in self-produced extracellular polymeric substances (EPS), adhere to surfaces and resist environmental stresses, including host immune responses and antimicrobial agents.This comprehensive book investigates the formation, characteristics, and profound impact of biofilms on human health. Coverage spans the fundamentals of biofilm formation, immune evasion, and antimicrobial resistance (AMR); the role of biofilms in chronic diseases including periodontal disease, chronic wounds, and respiratory and urinary tract infections; their involvement in cancer development and neural disorders via the gut-brain axis; emerging therapeutic strategies such as nanotechnology, phage therapy, and immunomodulatory approaches; and the growing application of artificial intelligence (AI) and machine learning to biofilm-immune interactions and personalized medicine.Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations provides essential insights for researchers, undergraduates, and postgraduates seeking to understand and combat the challenges posed by biofilms in chronic disease pathology. This book offers valuable knowledge on recent techniques for detecting and mitigating antimicrobial resistance (AMR) and biofilm formation, making it an indispensable resource for scientists and clinicians alike.

  • Zebrafish Model of Neurodegenerative Disorders

    Knowing the Unknown
    • 1st Edition
    • Wael Mohamed
    • English
    Zebrafish Model of Neurodegenerative Disorders: Knowing the Unknown reveals a ground-breaking method for decoding neurodegenerative disorders such as Parkinson's, Alzheimer's, ALS, and Huntington's through the lens of the zebrafish. This volume bridges the divide between fundamental science and clinical innovation, demonstrating how the genetic malleability, transparent embryos, and conserved neural pathways of zebrafish provide unparalleled insights into neurodegeneration. It illustrates the potential to uncover concealed pathological mechanisms, expedite drug discovery, and surmount the translational failings that impede current research using this gold-standard model species. Featuring contributions from global experts, this volume is systematically structured into five topical sections for ease of navigation. These sections explore the role of cutting-edge tools such as CRISPR-Cas9, AI-driven phenotyping, and high-throughput drug screening in the study of α-synuclein aggregation in Parkinson's Disease and amyloid-β toxicity in Alzheimer's Disease. The volume offers real-world applications, comparative analyses of zebrafish and mammalian models, and actionable protocols that translate zebrafish discoveries to clinical trials. Zebrafish Model of Neurodegenerative Disorders is designed to empower researchers, clinicians, and healthcare professionals by addressing existing gaps in knowledge, particularly fragmentation in protocols and the translational disconnect between preclinical models and human trials. By fostering an integrated understanding of zebrafish as a model for neurodegeneration, it enhances research reproducibility, accelerates drug discovery, and promotes ethical, scalable research practices. Whether used as a teaching resource or a reference for experimental design, this volume offers invaluable insights to advance the understanding and treatment of devastating neurodegenerative diseases.

  • Synthetic Biology in Medicine

    Tools and Transformative Therapies
    • 1st Edition
    • Xie Zhen
    • English
    Synthetic Biology in Medicine: Tools and Transformative Therapies covers the design and optimization of artificial biological components, gene editing systems, principles for designing and constructing artificial gene circuits, cell engineering, delivery systems of artificial biomolecules, and the prospects and challenges of synthetic biology technologies applied in drug development. The book contains many application cases related to clinical practice and industry, offering references for solving industrial pain points.

  • Endometriosis and Associated Pain

    Bridging Theory and Practice
    • 1st Edition
    • Chi Chiu Wang
    • English
    Endometriosis and Associated Pain: Bridging Theory and Practice is a comprehensive professional resource comparing Eastern and Western perspectives on endometriosis-relate... pain and co-morbidities. It addresses a significant gap by summarizing clinical, pathological, and social aspects, highlighting strengths and weaknesses in both traditions synthesizing existing evidence. The book targets basic science researchers and clinicians in women’s health, reproductive biology, and pain medicine, providing detailed reviews, recent developments, and future directions. Structured into six sections covering clinical features, pathology assessments, treatments, alternative therapies, and global health guidelines, bringing together extensive expertise in reproductive medicine. This book is a vital, up-to-date reference for professionals seeking a cross-cultural understanding of endometriosis pain management.

  • Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities

    Evidence-Based Molecular Mechanisms and Clinical Outcomes
    • 1st Edition
    • Debidas Ghosh + 3 more
    • English
    Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities: Evidence-Based Molecular Mechanisms and Clinical Outcomes is a comprehensive, interdisciplinary reference addressing the complex link between diabetes mellitus and infertility in both men and women. This edited volume synthesizes molecular insights into diabetes-induced reproductive dysfunction—such as oxidative stress, inflammation, endocrine disruption, and tissue damage—with evidence-based evaluations of medicinal plants and their bioactive phytochemicals. It bridges laboratory research and clinical trials to highlight how plant-derived compounds can regulate glycemic control, restore hormonal balance, reduce oxidative damage, and improve gametogenesis. Targeting clinicians, researchers, and postgraduate students in biomedical and pharmaceutical sciences, the book offers detailed therapeutic profiles, safety assessments, and translational applications. By consolidating fragmented knowledge, it empowers healthcare professionals and scientists to develop integrative, cost-effective strategies for managing diabetes-related infertility.

  • Viticulture and Climate Change

    Challenges and Opportunities
    • 1st Edition
    • Stefano Poni
    • English
    Accelerating atmospheric shifts are redefining grape production worldwide in complex and often unpredictable ways, disrupting long-established practices while opening the door to new possibilities. Viticulture and Climate Change examines how rising temperatures, irregular rainfall patterns, and increasingly frequent extreme events influence cultivation outcomes, including vine seasonal development, berry composition, and overall vineyard performance. It presents a forward-looking panorama that translates scientific insight into applied guidance, enabling the effective implementation of adaptive and sustainable grape-growing practices.Rather than treating individual factors in isolation, the text adopts a whole-system view. The volume is organized to follow the vineyard lifecycle, from establishment through routine operations to long-term planning, with case studies aptly embedded throughout. It addresses variety and rootstock selection, spacing, training systems, soil care, canopy handling, water use, and innovative inputs. Dedicated sections explore frost, heatwaves, drought, flooding, and hail scenarios, alongside appropriate responses such as pruning adjustments, shading solutions, and protective materials. Emerging topics—such as manipulation of ripening dynamics for low- and no-alcohol wines, carbon cycling, and renewable energy integration—are also considered.Advances in sensing, mapping, automation, and modeling are presented within interconnected digital platforms, offering new ways to monitor conditions and guide interventions. Biotic threats from pathogens and insects are discussed in the context of variable climatic pressures, with emphasis on tolerance and robustness-enhancing measures.Drawing on a broad body of research and experience by a leading expert in the field, Viticulture and Climate Change interprets findings with clarity and purpose, transforming technical information into accessible knowledge with practical relevance across diverse regions in support of improved real-world, cost-effective decision-making.

  • Primer on Cerebrovascular Research

    • 1st Edition
    • Dong-Eog Kim + 3 more
    • English
    Primer on Cerebrovascular Research provides both clinical and basic cerebrovascular knowledge that is required for physicians, vascular researchers, biomedical students, and trainees to understand or conduct evidence-based clinical practice and cutting-edge experimental research. This book outlines how to a design experimental cerebrovascular research in the context of clinical relevance, conduct the study using proper methods, analyze the data accurately, and make conclusions in an unbiased and statistically correct way. Chapters will include representative examples and experimental protocols.

  • Molecular Chaperones in Neurodegenerative Diseases

    • 1st Edition
    • Volume 156
    • English
    Molecular Chaperones in Neurodegenerative Diseases explores the roles of molecular chaperones in maintaining protein homeostasis and their involvement in the onset and progression of neurodegenerative disorders. The book highlights current research on chaperone-mediated mechanisms, disease pathology, and emerging therapeutic approaches targeting protein misfolding and aggregation.

  • The Evolution of Artificial Intelligence in Healthcare and Medicine

    From Basic Methods to Clinical Practice
    • 1st Edition
    • Mario Cannataro
    • English
    The Evolution of Artificial Intelligence in Healthcare and Medicine: From Basic Methods to Clinical Practice explores revolutionary technological advancements in the medical and healthcare realms due to generative AI and Deep Learning. This comprehensive guide not only explores cutting-edge technologies such as transformers and large language models for newcomers but also demystifies advanced applications like sequential decoding techniques and segmentation algorithms rarely explored in other literature. Sections cover foundational concepts and terminologies, explore deep learning and generative AI, provide AI's role in biomedical research, examine its integration into clinical practice, scrutinize its applications in public health, and discuss challenges and future prospects.This is an indispensable resource for healthcare professionals, scientists, researchers, students, and enthusiasts seeking to deepen their understanding of this rapidly evolving field.

  • Endoscopic Ultrasound in Pancreatic Diseases

    Best Practices and Recent Innovations in Technology and Techniques
    • 1st Edition
    • Masayuki Kitano
    • English
    In Endoscopic Ultrasound in Pancreatic Diseases: Best Practices and Recent Innovations in Technology and Techniques, leading experts share their insights, best practices, and the latest technological innovations revolutionizing the approach to pancreatic diseases. This practical reference provides step-by-step guidance, case presentations, and detailed images and procedures on advanced techniques in diagnosis and treatment with endoscopic ultrasound for pancreatic diseases.Organized into four sections, this book reviews the latest advances in endoscopic ultrasound equipment, techniques, complications, scanning methods, microbubbles and contrast harmonic imaging, elastography, fine needle tissue acquisition, and classification and safety management of interventional endoscopic ultrasound. Tumor detection, characterization, and diagnosis are reviewed, and pancreatic diseases treatment and intervention methods are covered extensively. The book concludes with the examination of groundbreaking methods and discussion of education and future directions. Endoscopic Ultrasound in Pancreatic Diseases: Best Practices and Recent Innovations in Technology and Techniques fully equips endoscopists with the most recent developments in endoscopic ultrasound and is a vital resource for navigating the evolving landscape, enabling practitioners to excel in advanced clinical practices and contribute to the field’s growth.

  • Hereditary Syndromes Associated with Endocrine Tumors

    • 1st Edition
    • Volume 134
    • English
    Volume 134, Hereditary Syndromes Associated with Endocrine Tumors, provides a comprehensive and up-to-date overview of the genetic, molecular, clinical, diagnostic, and therapeutic aspects of inherited endocrine neoplasia syndromes. Over the past two decades, remarkable advances in genomics, molecular diagnostics, and precision medicine have transformed the understanding and management of hereditary endocrine tumor syndromes, enabling earlier diagnosis, individualized surveillance strategies, targeted therapies, and improved patient outcomes. This volume brings together contributions from internationally recognized experts to review the current state of knowledge on both well-established and emerging hereditary syndromes affecting the endocrine system. The chapters cover the genetic basis, genotype–phenotype correlations, clinical manifestations, screening recommendations, multidisciplinary management, and future therapeutic perspectives for syndromes predisposing to tumors of the adrenal glands, pituitary, thyroid, parathyroid, pancreas, and neuroendocrine tissues. Special emphasis is placed on recent discoveries in cancer predisposition genes, advances in molecular pathology, the integration of next-generation sequencing into clinical practice, and the implications of hereditary cancer syndromes for patients and their families.

  • RNA-Binding Proteins Part D

    • 1st Edition
    • Volume 746
    • English
    A central theme of this volume is the dynamic relationship between RNA structure, RNA-binding proteins, and cellular organization. The chapters integrate experimental, computational, biochemical, biophysical, imaging, and systems-level approaches to investigate how RNA–protein interactions regulate RNA processing, translation, localization, stability, phase separation, and cellular stress responses. As Volume 746 of the Methods in Enzymology series, the volume emphasizes the integration of methodological innovation with biological applications, providing researchers with practical approaches to dissect how RNA–protein interactions govern RNA fate and function, biomolecular condensate formation, and stress granule assembly.Overall, this collection highlights the transition of RNA biology from a primarily sequence-centered discipline toward a more dynamic view in which RNA structure, molecular interactions, phase separation, cellular organization, and signaling are intimately connected. It will therefore be a valuable resource for researchers and students seeking both practical methodologies and mechanistic insights into the rapidly expanding field of RNA biology.

  • Cell Death Part H

    • 1st Edition
    • Volume 215
    • English
    Cell Death Part H presents current methods and experimental approaches for studying the mechanisms, regulation, and biological significance of cell death. The volume covers advanced protocols and model systems used to investigate diverse cell death pathways in health and disease, making it a valuable resource for researchers in cell biology, molecular biology, and biomedical science.

  • The Human Nervous System

    • 4th Edition
    • George Paxinos + 2 more
    • English
    The 4th Edition of the classic book The Human Nervous System continues to assemble contributions from world leaders in research on the brain, spinal cord and peripheral nervous system. This book has been edited by the best-known team of brain cartographers, and it has been completely revised to present the cutting edge of human neuroscience. The structure, connections and function are explained in depth, making this book essential to any student or scientist interested in brain anatomy and function.

  • CRISPR Therapeutics Delivery Strategies

    • 1st Edition
    • Prashant Kesharwani
    • English
    CRISPR Therapeutics Delivery Strategies is a structured and comprehensive resource in the rapidly evolving field of CRISPR technology. As CRISPR-Cas systems translate to therapeutics, this reference provides critical insights into the challenges and advancements in effective delivery mechanisms. The book captures the essence of CRISPR's transformative potential in gene therapy, targeted cancer treatments, and personalized medicine, while also highlighting the importance of innovative delivery strategies to overcome existing barriers. The contents of the book offers a systematic exploration of CRISPR technology, beginning with foundational concepts and progressing to targeted drug delivery strategies. Each chapter explore specific applications, including CRISPR in cancer therapy, gene editing for rare diseases, and overcoming delivery barriers such as the blood-brain barrier. Additionally, ethical and regulatory considerations are addressed, providing a holistic view of the current landscape and future directions in CRISPR research. CRISPR Therapeutics Delivery Strategies serves as an essential resource for students, researchers, and professionals in the fields of pharmacology, biotechnology, and gene therapy. By compiling cutting-edge research and expert perspectives, this reference helps pharmaceutical scientists to navigate the complexities of CRISPR technology and its applications.

  • RNA-binding Proteins Part C

    • 1st Edition
    • Volume 745
    • English
    This volume of Methods in Enzymology presents a practical and multidisciplinary collection of contemporary methods for investigating RNA biology, RNA-binding proteins (RBPs), RNA–protein interactions, ribonucleoprotein (RNP) complexes, biomolecular condensates, liquid–liquid phase separation, RNA processing, translation, and RNA-mediated regulation. The chapters integrate complementary experimental and computational approaches, including biochemical reconstitution, quantitative microscopy, transcriptomics, proteomics, interactomics, NMR spectroscopy, structural biology, computational analysis, and tissue-based techniques.Together, these methods provide a versatile framework for elucidating how RNA and RBPs regulate cellular organization, gene expression, RNA metabolism, RNA processing, translation, and biomolecular phase behavior. Particular emphasis is placed on emerging applications in disease-associated molecular pathways, including neurodegeneration and neurological disorders, with coverage of topics relevant to Alzheimer’s disease, Tau biology, and HIV-associated neurocognitive disorders. This volume provides researchers with practical methodological strategies for dissecting RNA–protein interactions and defining RBP function across molecular, cellular, and disease contexts. The collection is designed to serve as a valuable methodological resource for researchers investigating the mechanisms by which RNA–protein networks govern cellular processes and contribute to human disease.

  • Advances in Nanocarriers for Biofilm-Associated Infections

    From Research to Clinical Practice
    • 1st Edition
    • Neeraj Mishra + 2 more
    • English
    Advances in Nanocarriers for Biofilm-Associated Infections: From Research to Clinical Practice addresses the critical challenge of treating biofilm-associated infections, which are resistant to conventional antibiotics due to their protective microbial communities. This reference compiles cutting-edge research on nanocarriers, including nanoparticles, liposomes, dendrimers, and polymeric micelles, emphasizing their design and application to penetrate biofilms and enhance antimicrobial delivery. The comprehensive content covers biofilm formation, resistance mechanisms, and multidrug resistance, followed by detailed chapters on nanocarrier synthesis, functionalization, and therapeutic efficacy. Clinical and translational aspects are examined through case studies on chronic wounds, medical device infections, and respiratory biofilms, alongside regulatory hurdles and future research directions. The book features contributions from international experts, providing a multidisciplinary perspective on nanotechnology’s role in infection control.It equips researchers, clinicians, and pharmaceutical professionals to understand complex biofilm biology, apply novel drug delivery systems, and navigate clinical challenges, ultimately supporting the development of improved treatments for persistent biofilm-related infections.

  • Chronic Kidney Disease Management Through Herbal Phytoceuticals

    Mechanistic Findings and Phyto-Based Therapy for Chronic Kidney Disease Management
    • 1st Edition
    • Kalicharan Sharma
    • English
    Chronic Kidney Disease Management Through Herbal Phytoceuticals: Mechanistic Findings and Phyto-Based Therapy for Chronic Kidney Disease Management examines chronic kidney disease (CKD) through the lens of plant-, marine-, and microbe-derived compounds. The field increasingly requires safer, non-invasive therapies that complement existing regimens while clarifying mechanisms of action. By combining ethnobotanical knowledge with contemporary computational methods, this work serves as a translational resource for researchers, clinicians, and students seeking evidence-based, mechanism-driven phytopharmaceutical approaches to nephroprotection and disease modification. Readers gain a framework for integrating traditional knowledge with modern drug discovery pipelines. The table of contents outlines a progression from foundational concepts to translational applications. Chapters 1–3 cover the global burden, pathophysiology, and current management of CKD. Chapter 4 identifies druggable molecular targets. Chapters 5–7 survey plant-based phytoceuticals for CKD management, marine natural products as emerging CKD therapies, and microbial-derived candidates as potential CKD agents, supported by efficacy and safety data. Chapters 8–9 apply molecular docking and docking-based mechanistic insights to plant, marine, and microbial compounds. Chapters 10–12 address clinically validated phytopharmaceuticals... formulation science, and global regulatory considerations. Chapter 13 presents clinical and preclinical case studies to illustrate practical applications. This book delivers clear benefits to end users by providing integrated, mechanism-driven insights that connect basic science to clinical decision-making. Readers gain access to curated data on plant-, marine-, and microbial-derived compounds along with their targets, efficacy, and safety, supported by docking-based mechanistic validation. It also addresses formulation challenges, regulatory pathways, and quality-control considerations essential for translating phytopharmaceuticals from bench to bedside, including safety assessment and scalable product development. This blend of theory and practical guidance supports researchers designing studies, clinicians implementing evidence-based phytotherapy, and educators teaching multidisciplinary approaches to CKD management across academic and clinical settings.

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