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Elsevier

Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST)

Accelerating Diagnosis and Optimizing Antimicrobial Therapy

  • 1st Edition - February 1, 2027
  • Latest edition
  • Editors: Raju Khan, Tanmay Vyas, Mohd. Abubakar Sadique, Saikat Das, Abhijeet Joshi
  • Language: English

Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST): Accelerating Diagnosis and Optimizing Antimicrobial Therapy provides a comprehensive and interd… Read more

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Description

Microfluidic Platforms for Rapid Antibiotic Susceptibility Testing (AST): Accelerating Diagnosis and Optimizing Antimicrobial Therapy provides a comprehensive and interdisciplinary exploration of microfluidic technologies as transformative tools in the fight against antimicrobial resistance (AMR). By integrating foundational knowledge of AMR and microfluidics with cutting-edge research, it offers readers an in-depth understanding of how microfluidic systems enable rapid, precise, and cost-effective antibiotic susceptibility testing (AST). The book addresses both the scientific principles and practical applications of these technologies, emphasizing their potential to revolutionize diagnostics, personalize treatment, and improve global health outcomes amidst the growing threat of drug-resistant infections. Organized into five key parts, the book begins with an overview of the global challenge of antimicrobial resistance and the fundamental principles of microfluidics in biomedical contexts. It then delves into various microfluidic platforms for AST, including continuous flow and droplet-based systems, as well as single-cell trapping techniques. Subsequent chapters focus on diverse detection methods—optical, electrochemical, and acoustic—for monitoring bacterial growth and antibiotic response. The book further explores specialized approaches such as paper-based point-of-care devices, biosensing strategies, and personalized medicine applications. The final section addresses clinical translation, covering validation, regulatory considerations, device design, automation, emerging technologies, ethical guidelines, and future perspectives on microfluidic AST’s role in combating antimicrobial resistance worldwide.

Key features

  • Explain the global threat of antimicrobial resistance and the fundamental principles of microfluidics to establish a strong foundation for understanding rapid diagnostic technologies
  • Describe various microfluidic technologies and techniques—including continuous flow systems, droplet-based methods, and single-cell manipulation—for performing antibiotic susceptibility tests with high precision and throughput
  • Illustrate diverse detection and quantification methods for bacterial growth, such as optical, electrochemical, and acoustic techniques, to enable accurate and rapid antibiotic susceptibility analysis
  • Present specialized approaches for point-of-care and personalized antibiotic susceptibility testing using paper-based devices, biosensors, and tailored microfluidic platforms
  • Address clinical translation by detailing validation processes, device design, automation, ethical considerations, and emerging technologies to facilitate implementation and future advancements in microfluidic antibiotic susceptibility testing.

Readership

Principal investigators, research scientists, postdoctoral fellows, and graduate students in microbiology, immunology, biomedical research, molecular biology, nanotechnology, and bioengineering

Table of contents

Part 1: Fundamentals and Foundations

1. Understanding the Global Threat of Antimicrobial Resistance

2. Principles of Microfluidics for Biomedical Applications

Part 2: Microfluidic Technologies for Antibiotic Susceptibility Test (AST)

3. Continuous Flow Microfluidic Systems for Antibiotic Susceptibility Test (AST)

4. Droplet-based microfluidics for Antibiotic Susceptibility Test (AST)

5. Cell Trapping and Manipulation Techniques

Part 3: Detection and Quantification of Bacterial Growth 6. Optical Methods for Bacterial Growth Monitoring

7. Electrochemical Methods for Antibiotic Susceptibility Test (AST)

8. Acoustic Methods for Bacterial Detection

Part 4: Specialized Approaches for AST

9. Paper-Based Microfluidic Devices for Point-of-Care AST

10. Sensing Strategies for Rapid Antibiotic Susceptibility Test (AST)

11. Microfluidics for Personalized Medicine in Antibiotic Susceptibility Test (AST)

Part 5: Clinical Translation and Future Directions

12. Clinical Validation and Regulatory Considerations for Microfluidic Antibiotic Susceptibility Test (AST)

13. Point-of-Care AST Devices: Design and Implementation

14. Automation and Integration of Microfluidic AST Systems

15. Challenges and Limitations of Microfluidic AST

16. Emerging Technologies in Microfluidic Antibiotic Susceptibility Test (AST)

17. Self-Powered Microfluidic for Antibiotic Susceptibility Test (AST)

18. Ethical and Regulatory Guidelines for design of Microfluidics system for Antibiotic Susceptibility Test (AST)

19. The Future of Microfluidic AST in Combating Antimicrobial Resistance

Product details

  • Edition: 1
  • Latest edition
  • Published: February 1, 2027
  • Language: English

About the editors

RK

Raju Khan

Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.

Affiliations and expertise
Senior Principal Scientist and Professor, CSIR-Advanced Materials & Processes Research Institute, Bhopal, Madhya Pradesh, India

TV

Tanmay Vyas

Dr. Tanmay Vyas is currently a Post Doctoral Research Associate at CSIR-Advanced Materials and Processes Research Institute (AMPRI) in Bhopal, India. He earned his PhD in Biosciences and Biomedical Engineering from the Indian Institute of Technology (IIT) Indore, Madhya Pradesh, India. He was an awardee of the prestigious Prime Minister Research Fellowship (PMRF) and DST-INSPIRE fellowship. He is currently working on a research project at CSIR-AMPRI Bhopal on the “Design and development of a microfluidics-based device to determine antimicrobial susceptibility directly in clinical samples.” His current research includes the design and development of microfluidics-based devices, 3D bioprinting devices, and electrochemical and optical sensing platforms for environmental and healthcare monitoring. Dr. Vyas has a particular interest in carbon dots, quantum dots-based nanocomposites, and their effective application in the purview of theragnostics, biosensors, and chemical sensors for environmental and healthcare monitoring. Dr. Vyas has published several research articles, review articles, and book chapters during his research tenure.

Affiliations and expertise
Post Doctoral Research Associate, CSIR-Advanced Materials and Processes Research Institute (AMPRI), Bhopal, Madhya Pradesh, India

MS

Mohd. Abubakar Sadique

Mohd. Abubakar Sadique is a Ph.D. research scholar under the supervision of Dr. Raju Khan at CSIR-AMPRI, Bhopal. India. He has worked as a Senior Project Fellow at CSIR-CEERI, Pilani, Rajasthan, India, on a mission-mode project titled "Design and Fabrication of a Microfluidic-Based Bio-Sensor for Biochemical Detection." His recent research includes the use of nanotechnology for healthcare applications. Mr. Sadique’s research interests include green synthesis, electrochemical studies of nanomaterials, their characterization, and their healthcare applications. Mr. Sadique has a particular interest in carbon-based nanostructures for their effectiveness in the purview of bio-sensing, diagnostics, therapeutics, and healthcare applications. He has been associated with various research and development projects funded by different agencies, which include the Department of Science and Technology and the Council of Scientific and Industrial Research (CSIR), India. Mr. Sadique has published several review and research articles, three books edited, and numerous book chapters during his brief research tenure.

Affiliations and expertise
Junior Research Fellow, CSIR-Advanced Materials and Processes Research Institute, Bhopal, Madhya Pradesh, India

SD

Saikat Das

Dr Saikat Das is working as Additional Professor, Department of Radiation Oncology, and Associate Dean (Nursing and Allied Health Sciences) AII India Institute of Medical Sciences Bhopal. He has made significant contribution in the field of Radiation Oncology and Bio-Engineering. His research work is focused on the development of newer treatment paradigms through translational approach. He is principal investigator and co-Principal Investigator in many extramural projects funded by all major funding agencies including DBT, DST, SERB, BIRAC, ICMR. Considering his contributions in the Field of Radiation Oncology, based on academic accomplishments and peer recognition, he was selected as Fellow, Indian College of Radiation Oncology (FICRO) 2023.

Affiliations and expertise
Additional Professor, Department of Radiation Oncology, Associate Dean (Nursing and Allied Health Sciences, All India Institute of Medical Sciences Bhopal, India

AJ

Abhijeet Joshi

Dr. Abhijeet Joshi is currently an Associate Professor in the Department of Biosciences and Biomedical Engineering at the Indian Institute of Technology (IIT) Indore, Madhya Pradesh, India. He has a Bachelor of Pharmacy, MS Pharm degree, and earned his PhD degree in Biomedical Engineering. His research interests focus on interdisciplinary areas of biosensors, drug delivery, novel materials for biomedical applications, nano-biotechnology, and theragnostics. He has published over 70 publications in reputed journals, filed about 8 patents with over 1100 citations, and contributed over 8 book chapters from various international publishers including CRC Press, Springer, Elsevier, and RSC. He has secured several awards including the Technology Development Award, SERB Early Career Award, DST INSPIRE Faculty Award, TR35 Young Investigator Award, DBT Innovative Young Biotechnologist Award, and the Gandhian Young Technology Award. In his research group, he supervises over 10 PhD students and graduated over 15 post-graduate students.

Affiliations and expertise
Associate Professor, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Madhya Pradesh, India