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Advances in Design of Microbial Cell Factories

  • 1st Edition - April 1, 2027
  • Latest edition
  • Authors: Dibyajit Lahiri, Farshad Darvishi Harzevili
  • Language: English

Advances in Design of Microbial Cell Factories presents a comprehensive overview of the latest innovations in engineering microbial platforms for sustainable production of bioche… Read more

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Description

Advances in Design of Microbial Cell Factories presents a comprehensive overview of the latest innovations in engineering microbial platforms for sustainable production of biochemicals, biofuels, pharmaceuticals, and industrial enzymes.

The book opens with an introduction and historical overview of microbial cell factories, followed by a wide spectrum of topics including omics-driven design and engineering of microbial cell factories, metabolic flux analysis, genome-scale metabolic modeling, modular pathway engineering, biosensors, adaptive laboratory evolution, protein engineering and enzyme optimization in microbial hosts. The latest developments in designing bacterial, yeast, mold and microalagae cell factories are covered, as well as current challenges to be considered in scale-up of microbial cell factories. Chapters are supported by real-world case studies that demonstrate translation from laboratory research to industrial-scale applications across a diverse range of sectors.

This reference consolidates foundational knowledge with emerging technologies, equipping researchers, graduate students, and industry professionals with practical insights to accelerate their own development of microbial platforms.

Key features

  • Covers the application of genomics, transcriptomics, proteomics, and metabolomics in microbial cell factory design
  • Addresses the use of artificial intelligence and machine learning tools to highlight advanced design strategies
  • Demonstrates the implementation of microbial cell factories across a diverse range of industrial sectors
  • Highlights the latest developments in engineering non-conventional microbes with unique metabolic capacities, such as Pseudomonas, Corynebacterium, Yarrowia, and extremophiles

Readership

Researchers and advanced students working with microbial cell factories and those focused on their design and optimization across various fields including microbial biotechnology, synthetic biology, metabolic engineering, biochemical engineering, and systems biology

Table of contents

1. Introduction to microbial cell factories

2. X-omics for design of microbial cell factories

3. Omics-guided engineering of microbial metabolism

4. Omics-guided engineering of microbial metabolism, modular pathway and protein engineering

5. Metabolic Flux Analysis

6. Genome-scale metabolic modeling

7. Modular pathway engineering

8. Promoter libraries, RBS tuning, and genetic circuits

9. Biosensors and logic gates in microbial cells

10. Adaptive laboratory evolution for trait enhancement

11. Protein engineering

12. Enzyme optimization in microbial hosts

13. Recent advances in design of bacterial cell factories

14. Progresses in design of yeast cell factories

15. New insights in design of mold cell factories

16. Developments in design of microalgae cell factories

17. Fermentation scale-up challenges, multiple stress factors in strain engineering, techno-economic comparative analysis

18. AI-assisted design of microbial cell factories

Product details

  • Edition: 1
  • Latest edition
  • Published: April 1, 2027
  • Language: English

About the authors

DL

Dibyajit Lahiri

Dr. Dibyajit Lahiri is an Associate Professor in the Department of Biotechnology at the University of Engineering & Management, Kolkata, India, where he conducts advanced interdisciplinary research in microbiology, biofilms, antimicrobial resistance, and microbial biotechnology. His scholarly work emphasizes understanding the mechanisms of microbial biofilm formation and inhibition, particularly on medically relevant surfaces and environmental substrates, and exploring innovative strategies for combating biofilm-associated antimicrobial resistance.

Dr. Lahiri has authored and co-authored a substantial body of scholarly work, with over 100 publications including high-impact journal articles, book chapters, and reviews. His research portfolio covers topics such as biofilm-mediated degradation of environmental pollutants, novel antibiofilm agents (including nanoscale and natural compounds), and biotechnological applications of microbial systems, with an h-index around 38 reflecting significant citation impact and academic influence.

He has contributed to major scientific discussions on microbial biofilms in diverse contexts, including their roles in chronic infections, environmental microplastic degradation, and biofuel production, demonstrating both fundamental and applied research orientations. His collaborative research outputs also include contributions to antimicrobial peptide studies and microbial electrochemical systems.

Dr. Lahiri serves as editor and contributor to scholarly publications in his field, and he participates actively in international research networks and editorial activities. His work is regularly presented at scientific forums and continually contributes to advancing microbial biotechnology and strategies to mitigate biofilm-associated challenges in health, industry, and the environment.

Affiliations and expertise
Department of Biotechnology, Institute of Engineering and Management, University of Engineering and Management, Kolkata, West Bengal, India

FH

Farshad Darvishi Harzevili

Farshad Darvishi Harzevilii, PhD, is Full Professor in the Department of Microbiology at Alzahra University, Iran. His research interests include the biotechnological and environmental applications of yeasts for the production of valuable compounds, as well as metabolic engineering and synthetic biology of yeasts. He has published several books and serves as Series Editor for the Elsevier book series Developments in Microbial Cell Factories: From Design to Commercial Production.
Affiliations and expertise
Professor, Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran