Current Research on Biofilm Mediated Chronic Diseases
Immunological Background and Clinical Interpretations
- 1st Edition - April 1, 2027
- Latest edition
- Editors: Dibyajit Lahiri, Moupriya Nag, Gargi Bhattacharya, Leonard Ionut Atanase
- Language: English
Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations is an in-depth exploration of the complex interplay between biofil… Read more
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Description
Description
This comprehensive book investigates the formation, characteristics, and profound impact of biofilms on human health. Coverage spans the fundamentals of biofilm formation, immune evasion, and antimicrobial resistance (AMR); the role of biofilms in chronic diseases including periodontal disease, chronic wounds, and respiratory and urinary tract infections; their involvement in cancer development and neural disorders via the gut-brain axis; emerging therapeutic strategies such as nanotechnology, phage therapy, and immunomodulatory approaches; and the growing application of artificial intelligence (AI) and machine learning to biofilm-immune interactions and personalized medicine.
Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations provides essential insights for researchers, undergraduates, and postgraduates seeking to understand and combat the challenges posed by biofilms in chronic disease pathology. This book offers valuable knowledge on recent techniques for detecting and mitigating antimicrobial resistance (AMR) and biofilm formation, making it an indispensable resource for scientists and clinicians alike.
Key features
Key features
- Explores biofilm formation and immune evasion mechanisms
- Addresses recent aspects of antimicrobial resistance
- Highlights the role of biofilms in chronic diseases and cancer
- Discusses innovative therapeutic strategies against biofilm-associated infections
- Utilizes AI and machine learning for personalized medicine approaches
Readership
Readership
Table of contents
Table of contents
1. Introduction to Biofilms: Definition, Formation, and Characteristics
2. Biofilms in Nature and Medicine: From Environmental to Clinical Settings
3. Host-Pathogen Interactions: Immune Evasion by Biofilms
4. The Role of Innate Immunity in Biofilm Recognition and Response
5. Adaptive Immune Responses to Biofilm-Associated Infections
6. Inflammation and Chronicity: How Biofilms Drive Persistent Infections
7. Microbiome and Biofilms: Friend or Foe?
8. Quorum Sensing and Biofilm Development: Implications for Disease
9. Genetic and Epigenetic Regulation of Biofilm-Associated Pathogens
10. Biofilms in the Context of Antimicrobial Resistance (AMR)
Section 2: Biofilms in Chronic Diseases
11. Biofilms and Periodontal Disease: Mechanisms and Clinical Impact
12. Chronic Wound Infections: Biofilm Formation and Healing Impairment
13. Respiratory Infections: The Role of Biofilms in Cystic Fibrosis and COPD
14. Biofilms in Otitis Media: Chronic Ear Infections and Treatment Challenges
15. Urinary Tract Infections: Biofilm-Mediated Persistence and Recurrent Infections
16. Gastrointestinal Biofilms: Role in Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD)
17. Biofilms in Endocarditis: A Persistent Cardiac Threat
18. Implant-Associated Biofilm Infections: Orthopedic and Dental Perspectives
19. Biofilms in Chronic Sinusitis: Implications for Therapeutic Strategies
20. Catheter-related blood stream infections
21. Sexually Transmitted Infections and Biofilms: A Hidden Factor in Chronicity
Section 3: Immunological Perspectives and Biofilms in Cancer Development
22. Biofilms and Cancer: A New Frontier in Tumor Biology
23. The Role of Bacterial Biofilms in Gastrointestinal Cancers
24. Oral Biofilms and Head & Neck Cancers: Immunological Implications
25. Urinary and Reproductive Biofilms in the Development of Bladder and Cervical Cancer
26. Microbial Dysbiosis, Biofilms, and Colorectal Carcinogenesis
27. Immunosuppressive Mechanisms of Biofilms in Cancer Progression
28. Biofilms, Immune Evasion, and Chemoresistance in Cancer Therapy
29. Potential Immunotherapies Targeting Biofilm-Mediated Tumor Growth
Section 4: Immunological Response of Biofilms in Neural Disorders
30. Neuroinflammation and Biofilms: Bridging the Gap
31. The Gut-Brain Axis: Role of Biofilms in Neurological Disorders
32. Biofilm-Associated Infections in Alzheimer’s Disease: A Hidden Contributor?
33. Parkinson’s Disease and the Influence of Chronic Biofilm Infections
34. Multiple Sclerosis and Bacterial Biofilms: A New Perspective on Autoimmunity
35. Neuropsychiatric Disorders and Biofilm-Driven Dysregulation of Immunity
36. Meningitis, Encephalitis, and Biofilm-Associated Pathogens in the CNS
37. Biofilms, Blood-Brain Barrier Integrity, and Neuroimmune Dysfunction
38. Chronic Lyme Disease and Biofilm-Mediated Neurological Complications
39. Targeting Biofilms in Neurological Disorders: Immunotherapy and Emerging Strategies
Section 5: Therapeutic Challenges and Emerging Strategies
40. Vaccine Development Against Biofilm-Forming Pathogens
41. The Role of Probiotics and Prebiotics in Modulating Biofilm Formation
42. Nanotechnology and Biofilm Disruption: Advances in Antimicrobial Strategies
43. Phage Therapy and Enzymatic Degradation of Biofilms
44. Immunomodulatory Therapies: Enhancing Host Defense Against Biofilms
45. Biomaterials and Coatings to Prevent Biofilm Formation in Medical Devices
46. Combination Therapy: Antibiotics, Immunotherapy, and Novel Antibiofilm Agents
47. Emerging Anti-Biofilm Strategies: Future Research Directions
48. Conclusion: Translating Research into Clinical and Therapeutic Strategies
Section 6: AI and Machine Learning in Understanding Biofilm-Associated Immune Responses
49. The Role of AI in Immunological Research: Transforming Biofilm Studies
50. Machine Learning Models for Predicting Biofilm Formation and Immune Interactions
51. AI-Driven Analysis of Host-Pathogen Interactions in Biofilm Infections
52. Big Data and Computational Immunology: Unlocking Biofilm-Immune Dynamics
53. Neural Networks for Identifying Biofilm-Associated Biomarkers in Chronic Disease
54. AI-Guided Drug Discovery and Immunotherapy Targeting Biofilms
55. Personalized Medicine: AI-Driven Approaches to Treating Biofilm-Related Diseases
Product details
Product details
- Edition: 1
- Latest edition
- Published: April 1, 2027
- Language: English
About the editors
About the editors
DL
Dibyajit Lahiri
Dr. Dibyajit Lahiri is an Associate Professor in the Department of Biotechnology at the University of Engineering & Management, Kolkata, India, where he conducts advanced interdisciplinary research in microbiology, biofilms, antimicrobial resistance, and microbial biotechnology. His scholarly work emphasizes understanding the mechanisms of microbial biofilm formation and inhibition, particularly on medically relevant surfaces and environmental substrates, and exploring innovative strategies for combating biofilm-associated antimicrobial resistance.
Dr. Lahiri has authored and co-authored a substantial body of scholarly work, with over 100 publications including high-impact journal articles, book chapters, and reviews. His research portfolio covers topics such as biofilm-mediated degradation of environmental pollutants, novel antibiofilm agents (including nanoscale and natural compounds), and biotechnological applications of microbial systems, with an h-index around 38 reflecting significant citation impact and academic influence.
He has contributed to major scientific discussions on microbial biofilms in diverse contexts, including their roles in chronic infections, environmental microplastic degradation, and biofuel production, demonstrating both fundamental and applied research orientations. His collaborative research outputs also include contributions to antimicrobial peptide studies and microbial electrochemical systems.
Dr. Lahiri serves as editor and contributor to scholarly publications in his field, and he participates actively in international research networks and editorial activities. His work is regularly presented at scientific forums and continually contributes to advancing microbial biotechnology and strategies to mitigate biofilm-associated challenges in health, industry, and the environment.MN
Moupriya Nag
Moupriya Nag is presently working as Associate Professor in the Department of Biotechnology, University of Engineering & Management, Kolkata. Her research interests includes single molecule Biophysics of protein unfolding/refolding and protein aggregation kinetics and its mechanism of action especially the amyloid proteins in neurodegenerative disorders. Recently, her research focuses on functional amyloids in bacteria and their relation in forming biofilms. Her work deals with developing novel antimicrobial and anti-biofilm compounds from natural sources including plants, microbes and green synthesized nanoparticles. She has about seven years of teaching experience in Biophysics, Bioinformatics, Bioprocess and Biotechnology, Enzyme Technology, Computing, Molecular Modelling and Drug Design. She has also published many research articles in the peer-reviewed international journals and authored/edited or co-authored/edited numerous books/book chapters. She is also a member of many scientific societies like Indian Biophysical Society and Indian Science Congress Association.
GB
Gargi Bhattacharya
Dr. Gargi Bhattacharya is a Microbiologist with over nine years of post-MD professional experience in clinical microbiology, serology, molecular biology, and infection control. She completed her MBBS from North Bengal Medical College and MD in Microbiology from the Calcutta School of Tropical Medicine, where she was a Gold Medalist, followed by DNB in Microbiology. She is currently associated with Ruby General Hospital and has previously worked with Ashok Laboratory and Nursing Home and Medinova Diagnostic Services. Her expertise includes NABL-accredited laboratory quality systems and infection control, with specialized training from JIPMER, Puducherry. Her research interests include antimicrobial resistance, bacterial persistence, biofilm-associated infections, and antimicrobial stewardship. She has published research and case reports on multidrug resistance, Staphylococcus aureus, Staphylococcus cohnii, anthrax, and urinary tract infections. She is a member of IAMM and the Antimicrobial Stewardship Society, India.
LA
Leonard Ionut Atanase
Leonard Ionuț Atanase, PhD, is Full Professor at the Faculty of Medicine, Apollonia University of Iași, Romania, and Member of the Academy of Romanian Scientists. His research focuses on polymer chemistry, biomaterials, and nanomedicine, with particular emphasis on polymeric drug delivery systems, electrospun nanofibers, hydrogels, and stimuli-responsive biomaterials for biomedical applications. He coordinates national and international research projects, including Horizon Europe, M-ERA.NET, and Erasmus+ initiatives, and supervises doctoral and postgraduate research. His current work is dedicated to developing advanced polymer-based nanocarriers for targeted drug delivery, cancer therapy, and regenerative medicine.