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Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

  • 1st Edition - April 1, 2027
  • Latest edition
  • Editors: Cheng Xue, Jing Xu, Bo Yang, Lyu Jiayi, Lujiang Yi
  • Language: English

Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine… Read more

Description

Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals.

From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine. Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

Key features

  • Explores the latest advancements in molecular signatures, providing insights on how urine biomarkers outshine traditional diagnostics and offers unprecedented insights into diseases affecting multiple bodily systems
  • Uncovers real-world applications of urine biomarkers through engaging case studies, thus demonstrating their effectiveness in clinical settings
  • Navigates the future of healthcare diagnostics by exploring emerging trends and technological frontiers in urine biomarker research
  • Includes a focus on personalized medicine and integration with other diagnostic modalities

Readership

Clinical researchers and healthcare professionals specializing in nephrology, urology, oncology, cardiology, and endocrinology. This book is specifically designed to cater to professionals engaged in both research and clinical practice, providing in-depth insights into the molecular aspects of urine biomarkers and their applications in disease diagnostics across various bodily systems

Table of contents

Section I. Introduction

1. Background and Significance and Historical Perspective of Urine Biomarkers in Medicine

2. Rationale for Exploring Urine Biomarkers

Section II. Fundamentals of Urine Biomarkers

3. Definition and Types of Biomarkers

4. Characteristics of Ideal Urine Biomarkers

Section III. Molecular Signatures in Urine

5. Cellular Components in Urine

6. Genetic and Epigenetic Markers

7. Proteomic and Metabolomic Signatures

8. MicroRNA and Non-Coding RNA Profiles

Section IV. Urine Biomarkers Across Body Systems

9. Renal System

10. Urological System

11. Cardiovascular System

12. Endocrine System

13. Musculoskeletal System

14. Immune System

15. Respiratory System

16. Blood system

17. Digestive system

18. J. Nervous system

Section V. Techniques for Urine Biomarker Detection

19. Laboratory Techniques

20. Point-of-Care Testing

Section VI. Clinical Implications and Applications

21. Diagnosis and Prognosis

22. Monitoring Disease Progression

23. Treatment Response Assessment

24. Personalized Medicine Approaches

Section VII. Challenges and Limitations

25. Standardization Issues

26. Variability in Urine Composition

27. Ethical Considerations

28. Cost-effectiveness

Section VIII. Future Directions and Emerging Trends

29. Advances in Technology

30. Integration with Other Diagnostic Modalities

31. Potential Therapeutic Targets

Section IX. Case Studies

32. Real-world Applications of Urine Biomarkers

33. Success Stories and Lessons Learned

Section X. Conclusion

34. Implications for Future Research and Clinical Practice

35. Summary of Key Findings

Product details

  • Edition: 1
  • Latest edition
  • Published: April 1, 2027
  • Language: English

About the editors

CX

Cheng Xue

Cheng Xue is Deputy Chief Physician and Professor in the Department of Nephrology at Shanghai Changzheng Hospital, Naval Medical University, and a visiting scholar at the Medical College of Georgia. Dr. Xue holds 11 national patents and has led multiple nationally funded research projects.

Affiliations and expertise
Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, China

JX

Jing Xu

Dr. Jing Xu, M.D., Ph.D., is Associate Professor in the Department of Nephrology at Shanghai Changzheng Hospital. With extensive expertise, she specializes in diagnosing and treating both acute and chronic kidney dysfunction stemming from conditions such as chronic glomerulonephritis, diabetes, and hypertension. Dr. Xu’s research focuses on decoding the mechanisms of chronic kidney fibrosis and persistent inflammation following acute kidney injury, particularly centering on the Hippo pathway and its components. Her contributions have been recognized with several grants from the National Science Foundation and the local medical ministry.

Affiliations and expertise
Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, China

BY

Bo Yang

Bo Yang, MD, PhD, is a nephrologist in the Department of Nephrology at the Naval Medical Center of PLA, Naval Medical University, Shanghai, China, and has served as a visiting scholar at Duke University. His clinical and research interests focus on acute kidney injury, chronic kidney disease, dialysis, renal nutrition, and polycystic kidney disease. Dr. Yang has been actively involved in clinical and translational research in nephrology and has contributed to studies addressing disease mechanisms, nutritional management, and complications of kidney disease.

Affiliations and expertise
Naval Medical Center of PLA, Second Military Medical University, China

LJ

Lyu Jiayi

Lyu Jiayi, MD is Associate Chief Physician within the Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, China. Dr. Jiayi’s research is focused on pathogenesis, diagnosis, and treatment of autosomal dominant polycystic kidney disease (ADPKD) as well as clinical management of acute and chronic kidney diseases.

Affiliations and expertise
Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, China

LY

Lujiang Yi

Dr. Lujiang Yi is Associate Senior Technologist at the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China. His research focuses on urinary biomarkers, pre-analytical standardization of urine specimens, and mass spectrometry-based clinical proteomics and metabolomics. His work also includes the optimization and standardization of urine sample pretreatment and analytical workflows to improve the detection and screening of urological diseases.
Affiliations and expertise
The First Affiliated Hospital of Nanjing Medical University, China